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Tantri Analisawati Sudarsono
Universitas Muhammadiyah Purwokerto
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Perbandingan Kadar HB Sebelum dan Sesudah Pengobatan Oat Fase Intensif pada Penderita Tuberkulosis Paru di Puskesmas Petanahan Kebumen Tahun 2021: The Comparison of Hemoglobin Levels Between Before and After Treatment of Intensive Phase of Anti-Tuberculosis Drug in Pulmonary Tuberculosis Patients of Petanahan Public Health Care Center, Kebumen Regency Evi Nurhayati; Arif Mulyanto; Tantri Analisawati Sudarsono; Linda Wijaya
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5192

Abstract

Treatment of tuberculosis with main anti-tuberculosis drugs (OAT) includes isoniazid (INH), rifampin (RIF), ethambutanol (EMB), streptomycin (SM), and pyrazinamide (PZA). Although most Anti-Tuberculosis Drugs (OAT) are acceptable in therapy, they have potential side effects, including the side effects of hematological reactions such as anemia. This study's purpose was to compare HB levels before and after the intensive phase of Anti-Tuberculosis Drugs treatment in TB patients at Petanahan Public Health Care Center, Kebumen Regency. This was an analytic observational study with a cross-sectional design. The sample in this study was 28 people. The result showed that the average Hb level of pulmonary TB patients at Petanahan Public Health Care Center before and after the treatment were 11.05 g/dl and 11.6 g/dl, respectively. Therefore there was an effect of comparing Hb levels before and after the intensive phase of Anti-Tuberculosis Drugs treatment in pulmonary TB patients at the Petanahan Public Health Center in 2021. The increase in the average Hb levels of patients with pulmonary TB before and after the treatment was 0.55. The sig values obtained from the analysis of Hb levels before and after the treatment were a = 0.200 (p0.005) and 0.023, respectively. Due to the P value (0.023 < 0.05), Ho was rejected. It meant that there was a difference in Hb levels before and after the Intensive Phase of Anti-Tuberculosis Drugs treatment in patients with pulmonary TB at Petanahan Public Health Care Center, Kebumen Regency.
Literature Review: Hubungan Kadar D-Dimer dengan Tingkat Keparahan Pasien Covid-19: Literature Review: The Relationship of D-Dimer Levels with the Sverity of Covid-19 Ismi Andina Pertiwi; Tantri Analisawati Sudarsono; Dita Pratiwi Kusuma Wardani; Minto Rahaju
Jurnal Surya Medika (JSM) Vol. 9 No. 2 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i2.5726

Abstract

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) causes Corona Virus Disease-19 (COVID-19). D-dimer is one of the hemostasis tests performed on patients infected with the disease, it is a product of fibrin degradation and a biomarker of platelet disorders. With the development of COVID-19 as a pandemic, D-dimer has become an indicator for prognosis in COVID-19 patients. Based on symptoms, the severity of COVID-19 patients consists of mild, moderate, and severe symptoms. The author conducted a literature review regarding the correlation between D-dimer levels and the severity of COVID-19 patients. Data and theory were taken from ten references from several databases: Google Scholar, PubMed, Semantic Scholar, Science Direct, Garuda, and Neliti. The references taken were from the 2020-2022 range. In all of these references, statistical test results were obtained with a significant value below 0.05, so it can be concluded that there is a correlation between D-dimer levels and the severity of COVID-19. In COVID-19 infections with severe symptoms, immunothrombosis can occur due to hyperinflammatory conditions and cytokine storms. Immunothrombosis occurs as a result of the body's defense against viral infections. Damage to lung tissue in COVID-19 patients triggers a procoagulant response associated with inflammatory cytokines in blood vessel tissue.
Pengaruh Pemberian Obat Anti Tuberkulosisi (OAT) Terhadap Jumlah Trombosit pada Pasien TB Paru di BKPM Purwokerto: The Effect of Anti Tuberkulosis Drug (OAT) Towards the Number of Pulmonary TB Patients at BKPM Purwokerto Ika Wulan Nuri Anggreani; Tantri Analisawati Sudarsono; Dita Pratiwi Kusuma Wardani; Minto Rahaju
Jurnal Surya Medika (JSM) Vol. 9 No. 2 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i2.5727

Abstract

Pulmonary tuberculosis (TB) is an infection of the lungs characterized by pulmonary infiltrates and the formation of caseous granulomas, fibrosis, and cavities. It can be caused by the risk of transmission of the acid-fast bacillus Mycobacterium tuberculosis. One supportive treatment for pulmonary TB is the administration of anti-tuberculosis drugs (OAT). The content of rifampicin in the anti-tuberculosis drug can cause side effects of hemorrhagic disorders, namely thrombocytopenia. This study aims to determine the effect of giving OAT on platelet counts in TB patients in treatment phases of 0, 2, and 6 months at BKPM Purwokerto (Balai Kesehatan Paru Masyarakat). This was a type of analytic observational study with a cross-sectional design. Patients with pulmonary TB in treatment phase 0 were 15 at two months and 15 at six months in this study. Sampling was carried out by purposive sampling with inclusion and exclusion criteria. From this analysis, it is known that the data used the one-way ANOVA test. The results obtained have a p-value of 0.101 (p 0.05), so it can be concluded that there is no effect of the administration of OAT on platelet counts in TB patients in the treatment phases of 0, 2, and 6 months.
Optimasi Delignifikasi Kulit Singkong (Manihot Esculenta) Dengan Pelarut Basa NaOH Menggunakan Metode Response Surface Methodology (RSM) Dini Nur Afifah; adam mufarij; Tantri Analisawati sudarsono; Ardi Wiranata
Techno (Jurnal Fakultas Teknik, Universitas Muhammadiyah Purwokerto) Vol 25, No 1 (2024): Techno Volume 25 NO.1 April 2024
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/techno.v25i1.19540

Abstract

Kulit singkong (Manihot esculenta) merupakan bagian tubuh tumbuhan singkong yang cenderung menjadi limbah karena mengandung sianida yang hingga 618.2 mg/Kg. Dalam rangka mengurangi potensi pencemaran limbah kulit singkong maka digali potensi yang terkandung di dalamnya. Berdasarkan analisis yang telah dilakukan pada penelitian sebelumnya diketahui bahwa kulit singkong dapat mengandung selulosa hingga 33%. Adanya kondisi tersebut menyebabkan terbukanya peluang kebermanfaatan kulit singkong sebagai sumber selulosa yang dapat dikembangkan lebih lanjut menjadi material biopolymer ramah lingkungan. Tantangan pengembangan material berbasis selulosa dari limbah pertanian adalah adanya struktur lignoselulosa yang menghambat penetrasi reagen kimia. Oleh karenanya perlu dilakukan proses delignifikasi untuk memecah struktur lignoselulosa, sehingga menurunkan kadar lignin. Pada penelitian ini proses delignifikasi dilakukan dengan metode alkali dengan basa NaOH. Optimasi proses dengan melibatkan variabel terikat berupa konsentrasi NaOH (%), rasio solid/liquid(S/L), waktu (menit) dan suhu (°C) dilakukan dengan metode Response Surface Methodology (RSM) model Central Composite Design. Hasil analisis desirability mendapatkan kondisi optimum delignifikasi kulit singkong dengan pelarut basa NaOH, yaitu: konsentrasi NaOH 8.14%, rasio S/L 6.6, suhu reaksi sebesar 90°C dan lama reaksi selama 111 menit. Proses delignifikasi dengan kondisi tersebut diprediksi akan menghasilkan serbuk kulit singkong dengan kadar selulosa, hemiselulosa, dan lignin berturut-turut sebesar 68.27%; 6.21%; 0.98%.
Perbedaan Kadar Glukosa Serum dan Plasma Naf Segera dan Tunda 2 Jam Pada Penderita DM Retno Sulistiyowati; Budiarti Budiarti; Minto Rahaju; Tantri Analisawati Sudarsono
ULIL ALBAB : Jurnal Ilmiah Multidisiplin Vol. 1 No. 10: September 2022
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penggunaan sampel serum dan plasma menjadi dua pilihan utama yang sering digunakan untuk mengukur kadar glukosa darah seseorang. Pemeriksaan sampel dengan penundaan perlu ditambahkan bahan pengawet. Natrium Flourida (NaF) merupakan antikoagulan yang dapat mempertahankan konsentrasi glukosa dalam darah jika terjadi penundaan. Tujuan penelitian ini untuk mengetahui efektifitas penggunaan plasma NaF terhadap kadar glukosa darah pada pasien diabetes melitus melalui mekanisme pemeriksaan segera dan ditunda 2 jam. Jenis penelitian ini adalah penelitian observasional analitik dengan menggunakan desain cross sectional. Teknik sampling pada penelitian ini menggunakan Simple Random Sampling (SRS). Hasil penelitian menunjukan nilai α = 0,000 (pemeriksaan segera serum dan plasma NaF) dan nilai α = 0,000 (pemeriksaan ditunda 2 jam serum dan plasma NaF). Terdapat hubungan yang signifikan antara pemeriksaan glukosa pada serum dan plasma NaF segera dan ditunda 2 jam.
Perbedaan Jumlah Trombosit Menggunakan Antikoagulan K3EDTA dengan Volume Sampel Berbeda pada Karyawan Puskesmas Wanadadi 1 Kab. Banjarnegara Wahyu Hidayah; Tantri Analisawati Sudarsono; Linda Wijayanti; Retno Sulistiyowati
ULIL ALBAB : Jurnal Ilmiah Multidisiplin Vol. 1 No. 10: September 2022
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Platelets (thrombocytes) form a mechanical blockage to the hemostatic response to burns through several reactions, adhesion, aggregation, release, fusion, and procoagulant activity. EDTA prevents platelets from clumping, so it is used as an anticoagulant in the platelet count. Excess concentration of K3EDTA causes shrinkage of blood cells. This study aimed to determine the difference in the number of platelets using K3EDTA anticoagulant with different sample volumes at the Wanadadi 1 Health Center employees, Kab. Banjarnegara. The study was conducted by analytical observation from February August 2022. A total of 10 respondents took 5 ml of blood samples and then divided them into K3EDTA vacutubes with sample volume of 0.5 ml, 1.5 ml, and 2.5 ml. Sample examination using the Hematology Analyzer impedanceelektrik method. The type of research design is analytic observational with a cross-sectional design. Random sampling technique. Data analysis was carried out by conducting a normality test. If the data were normally distributed, p 0.05, then the One Way ANOVA parametric test was continued. The mean number of platelets in a sample volume of 0.5 ml is 287,1000 31,14643 mm, the average number of platelets in a sample volume of 1.5 ml is 294,6000 34.67692 mm, and the average number of platelets in a sample volume of 2.5 ml of 291.1000 35.41955 mm. The lowest mean platelet count was at a volume of 0.5 ml based on statistical tests p = 0.885 (P 0.005). So, there is no significant difference in the number of platelets using K3EDTA Anticoagulants with different sample volumes for employees of Wanadadi Health Care Center 1 Banjarnegara.
Co-Authors Adam Mufarij Ardi Wiranata Arif Mulyanto Budiarti Budiarti Dhanti, Kurnia Ritma Dini Nur Afifah Dita Pratiwi Kusuma Wardani Ermi Susi Yanti Evi Nurhayati Ika Wulan Nuri Anggreani Ismi Andina Pertiwi Lilis Septiana Dewi Linda Wijaya Linda Wijayanti Linda Wijayanti Minto Rahaju Minto Rahaju Nadia Ega Haliza Nur Rizki Aprilia Utami Retno Sulistiyowati Supriyadi Supriyadi Syafira Dian Ergiana Wahyu Hidayah