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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Surya Medika PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Jurnal EDUCATIO: Jurnal Pendidikan Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) ALKIMIA : Jurnal Ilmu Kimia dan Terapan Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Ilmiah Pharmacy Jurnal Farmasi dan Sains Indonesia (JFSI) INDRA: Jurnal Pengabdian kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Lentera Negeri Sinteza Medical Sains : Jurnal Ilmiah Kefarmasian
Tri Puspita Yuliana
Universitas Hamzanwadi
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : Lumbung Farmasi : Jurnal Ilmu Kefarmasian

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Analisis Pengaruh Metode Penggerusan Kaplet Paracetamol terhadap Kadar Bahan Aktif Obat Aulia, Amanda; Febriani, Yuyun; Yuliana, Tri Puspita
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 1 (2025): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i1.29049

Abstract

One of the drugs commonly used by the general public is paracetamol. This drug has relatively mild side effects compared to other drugs, so it is common to be prescribed for compounding pulmonary drugs for patients with certain doses There are two grinding methods used, namely a mortir and a blender. The purpose of this study was determined the variation effects in the dissolution speed and particle size on decreasing levels of paracetamol potency in each grinding methods. UV-Vis Spectrofotometer was used as quantitative methode.  Based on the results, the percentage level of solubility velocity were in mortar: 70.54% aquadest, 115.49% ethanol, 96.10% acetone, 113.20% NaOH. In the blender: 65.44% aquadest, 88.14% ethanol, 48.31% acetone, 98.20% NaOH. Meanwhile, for variations in particle size, the mortar obtained: mesh20 101.82%, mesh40 117.73%, mesh80 80.91%, mesh100 113.20%. In the blender obtained: mesh20 96.98%, mesh40 88.40%, mesh80 69.06%, mesh100 99.11%. Furthermore, the statistical analysis by two-way anova obtained a significance value of 0.059 for variations in dissolution speed and 0.659 in particle size. In conclusion, there was an effect of variations in solvents but did not show an effect of variations in particle size on decreasing levels of active drug ingredients.
Efektivitas Ekstrak Etanol Daun Ciplukan (Physalis angulata L.) Terhadap Penurunan Kadar Trigliserida Pada Mencit (Mus musculus) Rafsanjani, Arief; Salsabila, Aulia; Yuliana, Tri Puspita
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.27605

Abstract

Hypertriglyceridemia is a condition when triglyceride levels in the blood increase. High triglyceride levels can cause atherosclerosis, which is a risk factor for cardiovascular disease. The ciplukan plant contains chemical compounds, namely flavonoid compounds. Flavonoid compounds can reduce triglyceride levels by increasing the activity of the lipoprotein lipase enzyme. This research aims to determine the potential of Ciplukan (Physalis angulata L) leaf extract in reducing triglyceride levels in mice (Mus musculus). This type of research is experimental research with a Pretest-Posttest Control Group design. This study consisted of a negative control group, positive control, treatment dose I (2.8 mg/20 gr BW), dose II (5.6 mg/20 gr BW), and dose III (8.4 mg/20 gr BW ). Based on the results of the pne-way ANOVA analysis test, it showed significant differences between the negative control group and the positive control group, treatment dose I, dose II, and dose III with a significance value of p<0.05. The conclusion of this research is that the ethanol extract of ciplukan leaves has the potential to reduce triglyceride levels in mice induced by quail egg yolk.
Co-Authors Aditya Noviadi Rakhmatullah Arief Rafsanjani Aulia, Amanda Baiq Maylinda Gemantari Endang Darmawan Erma Ewisa Oktresia Ersi Arviana Ihsan Fitriwati Sovia Hamdi, Muhammad Irsyadul Hartini Haritani Hasratul Kusuma Kintoko Kintoko Kusumo, Djati Wulan Kusumo, Rudy Harjo Leny Ramadhan Minawati Minawati Minawati Minawati, Minawati Muhlisun Azim Muldiyana, Tya Novasari, Novasari Nurcholid Umam Kurniawan Pulhehe, Hasni Puspawan Hariadi Salsabila, Aulia Shakila, Shakila Sulistia Ardyati Ula, Fatin Bariatul Urmatul Waznah Wahyuningsih, Dahriah Fitri Wardani, Evi Wati, Ambar Yuli Nurullaili Efendi, Yuli Nurullaili Yuyun Febriani Zulda, Nurul Fitri Erlinda