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All Journal HAYATI Journal of Biosciences Jurnal Sains dan Seni ITS IPTEK Journal of Proceedings Series Matematika dan Sains Widyariset Jurnal Riset Industri Hasil Hutan PENA SAINS Indonesian Journal of Chemistry Akta Kimia Indonesia Indonesian Journal of Electrical Engineering and Computer Science Widyariset Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Sewagati Jurnal Kefarmasian Indonesia Journal of Tropical Pharmacy and Chemistry
Taslim Ersam
Departemen Kimia, Institut Teknologi Sepuluh Nopember
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : IPTEK Journal of Proceedings Series

 1 
Acetylation of γ-mangostin Isolated from the Mangosteen Pericarp (Garcinia mangostana Linn.) and Their Antidiabetic Activity Rafsanjani, Ega Rocky Maulana; Fadlan, Arif; Ersam, Taslim
IPTEK Journal of Proceedings Series No 6 (2020): 6th International Seminar on Science and Technology 2020 (ISST 2020)
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2020i6.9185

Abstract

Mangosteen (Garcinia mangostana Linn) is one of the most well-known plants in Indonesia. Mangosteen contains many derivatives of oxygenated and prenylated xanthones from phenolics which exhibit diverse biological activities such as antioxidants, antimalarials, anti-allergies, anti-tumors, antiviral, antibacterial, anti-inflammatory, anti-fungal, anticancer, and antidiabetic. Modification of xanthone compounds is known to increase antidiabetic activity and it is known that α- and β-mangostin acetylated can be produced from the modification of α- and β-mangostin using acetic anhydride. In this study, as many as 1.43 grams (1.59%) of the γ-mangostin compound were successfully isolated from the ethyl acetate extract of mangosteen pericarp. Modification of γ-mangostin through the acetylation reaction produces acetylated γ-mangostin in the form of 3,6,7-tri-methylester-γ-mangostin as much as 32.9 mg (63%). Antidiabetic test results showed γ-mangostin had an IC50 value of 8.55 μM, while the IC50 value of 3.6.7-tri-methylester-γ-mangostin was 1.82 μM. Acarbose as a positive control has an IC50 value of 4.48 μM. This shows that modification can increase antidiabetic activity.
Isolation and antidiabetic Activity of Prenylated Xanthones from Pericarp of Mangosteen (Garacinia Mangostana Linn.) Karneg, Syahdam; Fadlan, Arif; Ersam, Taslim
IPTEK Journal of Proceedings Series No 6 (2020): 6th International Seminar on Science and Technology 2020 (ISST 2020) - IN-PRESS
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2020i6.8940

Abstract

The material used in this research was dry powder of pericarp mangosteen (Garcinia mangostana Linn.). which is a family plant of Clusiaceae. This taxa is known as the main source of prenylated xanthones derived from phenolic compounds. The compounds separation process was carried out by maceration method, 8 kg of sample macerated using n-hexane solvent, 90 g of n-hexane extract were produced. The n-hexane extract was fractionated by vacuum liquid chromatography (VLC) using silica gel, eluted by increasing the polarity of the solvent, which is a mixture of n-hexane solvent: dichloromethane (10%, 20%, 30% and 50%), resulting in three combined fractions, namely the first fraction 13,92 g, the second fraction 18,27 g, and the third fraction 23,24 g. The refraction process was then carried out in the third fraction, producing two yellow crystals with melting points respectively, 155-156 °C and 172-173 °C. The structural elucidation method was carried out using UV-Vis, IR, HR-ESI-MS, and NMR spectroscopy techniques. Based on the analysis of spectrum data from two known compounds, 8-deoxygartanin (1) and β-mangostin (2) antidiabetic bioactivity test was carried out by the method of inhibiting the enzyme α-glucosidase in vitro. The test results obtained by compound (1) with an IC50 value of 38,5 μM and compound (2) with an IC50 value of 157,9 μM indicate that the two compounds are included in the inactive category. This is indicated by the IC50 value which is much higher when compared to the acarbose as a positive control with an IC50 value of 4.5 μM.
3,6-dimethyl ester-α-mangostin Compound Modified from Isolate α-mangostin Garcinia Mangostana Linn Khoiriyah Umami; Arif Fadlan; Taslim Ersam
IPTEK Journal of Proceedings Series No 6 (2020): 6th International Seminar on Science and Technology 2020 (ISST 2020)
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2020i6.9184

Abstract

Isolate α-mangostin (1) is a phenolic compound derived from oxygenated and prenylated xanthones and major compounds obtained from the fruit peel of G. mangostana Linn., Which is stated to have inhibitory activity against α-glucosidase enzymes, serves to determine the antidiabetic activity resulting in IC50 value of 29,92 µM, is of the nature moderate to positive control (acarbose) with an IC50 value of 4.55 µM. A modified compound of α-mangostin (1) with acetic anhydride obtained by 3,6-di-methyl ester-α-mangostin (2) derivative showed the inhibitory value of α-glucosidase (IC50 13,89 μM), this value is better than the activity inhibition of α-mangostin (1), but not as active as the positive control value of the acarbose compound. The separation process to obtain α-mangostin isolates from the fruit peel of G. mangostana Linn was obtained by maceration method with ethyl acetate solvent, followed by refraction using a vacuum liquid chromatography (KCV) method over silica gel (Merck 60 G) and eluted using eluent (n-hexane: ethyl acetate) with increasing polarity, to produce as much pure crystal (21.66 g), yield (24%). While the structural characterization of the two compounds was carried out using UV-Vis, IR, HRESIMS, 1H-NMR and 13C-NMR spectroscopic methods, the antidiabetic testing was carried out using the α-glucosidase enzyme inhibition method.
Isolation of Antioxidant Compounds from Mangiferaindica L. Leaves Fitria Fitria; Sri Fatmawati; Taslim Ersam
IPTEK Journal of Proceedings Series No 1 (2015): 1st International Seminar on Science and Technology (ISST) 2015
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2015i1.1155

Abstract

The free radical scavenging activity of Mangiferaindica L. Leaves had been performed. The methanol extract showed the highest 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) free radical scavenging activity among other extracts. Bioassay guided fractionation was performed and yielded three isolated compounds. Their structures were identified as mangiferin (1), friedelin (2) and lupeol (3). Mangiferin exhibited free radical scavenging activity, with an IC50 value of 12.12 µg/mL in vitro.
Co-Authors Adi Setyo Purnomo Adityo Pratomo Putro Ahmad Ubaidillah Ihsany Amalia Zafitri Amelinda Pratiwi Ananda Krisna Aldianita Anisa Rahma Maharani Ardi Lukman Hakim Aty Widyawaruyanti Aunurohim Aunurohim Cicilia Puspa Rini Dahlena Ariyani Dheva Noveilya Dini Nur Fauzia Fadlan, Arif Fatati Nurmalasari Fatimatul Munawaroh Fatimatul Munawaroh Fatmawati Inneke Putri Fiqey Indriati Eka Sari Fitria Fitria Fredy Kurniawan Fuji Ridha Kharomah Hadi Kuncoro Healthy Kainama Herdayanto Sulistyo Putro Hesti Selfiana Dwi Jayanti Ika Febriana Syafitri Imelda Priskila Simanjuntak Kamilia Mustikasari Karneg, Syahdam Khoiriyah Umami Kholifatu Rosyidah Kuniyoshi Shimizu Kuniyoshi Shimizu Laila Khamsatul Muharrami, Laila Khamsatul Lita Amalia Lukman Atmaja M Daffa Aditya Mardi Santoso Maria Dewi Astuti Mutia Devi Hidayati Nabilah Dita Anaqah Nadia Sasanti Ni Kadek Githa Kartika Gunadyani Noer Komari Nor Farida Novi Sulistyaningrum Novi Sulistyaningrum Novi Sulistyaningrum Nurbariyah Nurlatifah Nurlatifah Pieter Kakisina Prima Lukis Putri, Devi Anggraini Rafsanjani, Ega Rocky Maulana Rahma Rahayu Dinarlita Retno Purbowati Retno Purbowati Rizaldy Nizzah Kurniawan Ruzain Rafie Sukma Putra Sri Banun Titi Istiqomah Sri Fatmawati Suprapto Suprapto Susi Agustina Wilujeng Susy Budi Astuti Vanuella Tresnaning Budi Wiwit Denny Fitriana Yaqdhan Nufal Rafi Yatim Lailun Ni’mah Zulkarnain Zulkarnain