Article Per Year (5 Year)
p-Index From 2021 - 2026
1.756
P-Index
This Author published in this journals
All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Majalah Kedokteran Bandung The Journal of Pure and Applied Chemistry Research BIO-SITE |BIOLOGI Sains Terapan MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Abdi Dosen : Jurnal Pengabdian Pada Masyarakat ARSY : Jurnal Aplikasi Riset kepada Masyarakat Jurnal Litbang Edusaintech Jurnal Pengabdian Masyarakat Kedokteran
Dina Fatmawati
Universitas Islam Sultan Agung
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

Published : 17 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 17 Documents
Search

 1   2 
The Level of SGOT and SGPT after The Administration of Powdered Colorant Pigment Isolated from Kesumba Keling’s (Bixa Orellana) Seed Coats An experimental study in Balb/C Mice Suparmi, Suparmi; Isradji, Israhnanto; Fatmawati, Dina
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.703 KB) | DOI: 10.30659/sainsmed.v3i1.411

Abstract

Background: There has been an effort to explore pigment from kesumba keling’s (Bixa orellana) seed coats for a source of natural food colorant. Consumption of pigment from kesumba keling (Bixa orellana) was assumed to cause adverse effects on heart as an important organ in detoxification or inactivation of drugs or other toxic compounds. This study conducted to determine the levels of SGOT and SGPT blood serum of mice (Mus musculus) Balb/C after administration of colorant powder pigment of B. orellana seed coat’s at various concentrations.Design and Methods: The research is an experimental research with Factorial Design with 2 factors. Food Colorant Powder was made from bixin, norbixin, and crude extract pigment isolated from B. orellana seed coat’s. A total of 60 male mice were divided into 10 treatment groups. Powdered colorant solution at the concentration of 0% (control), 1%, 5%, and 10% were orally administered using gavage as much as 1 ml a day for 30 days.Results: Kruskal Wallis test results shows a not significant difference SGOT and SGPT level among the groups (p > 0.05), thus consumption of colorant powder of bixin, norbixin, and the crude extract with various concentrations did not affect the SGOT and SGPT.Conclusion: Colorant powder isolated from B. orellana seed coat’s has been shown to have no effect on the liver function, so it is safe as food colorant (Sains Medika, 3(1):69-77).
Pengaruh Lendir Bekicot (Achatina fulica) terhadap Jumlah Sel Fibroblas pada Penyembuhan Luka Sayat Studi Eksperimental pada Kulit Mencit (Mus musculus) Purnasari, Perez Wahyu; Fatmawati, Dina; Yusuf, Iwang
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.648 KB) | DOI: 10.30659/sainsmed.v4i2.376

Abstract

Background: Wound healing is very important to return skin as soon as possible and the integration is a complex and dynamic process. Proliferation phase involving fibroblasts is one of important step-on wound healing. Use of drugs such as povidone iodine on cuts aims to accelerate wound healing is still being debated. Healing by land snails’ mucus can be an alternative because it has many benefits. This study wants to know about the influence of land snails’ mucus on the number of fibroblasts in healing cuts.Design and methods: The study is an experimental research with post test only randomized control group design. The subjects were 18 Mus musculus strain mice that were divided into 3 groups. 1st group as a control group of untreated, 2nd group was given povidone iodine 10%, and 3rd group was given land snails’ mucus during 5th days. On the 6th day the mices were killed for histological study.Results: The data showed that average number of fibroblast in 1st group is 93,85; 2nd group is 126,37; and 3rd is group 217,5. The results of one way anova statistical test showed significant difference among the three groups p = 0,000. The results of post hoc test showed significant difference in all groups (p < 0,05).Conclusion: The mucus of land snail is influence the number of fibroblast in healing cuts (Sains Medika, 4(2):195-203).
Cytotoxic Effect of Ethanolic Extract of Sarang Semut (Myrmecodia pendens) on HeLa Cervix Cancer Cell Line In Vitro Experimental Study Fatmawati, Dina; Puspitasari, Prista Karina; Yusuf, Iwang
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.338 KB) | DOI: 10.30659/sainsmed.v3i2.393

Abstract

Background: Sarang semut (Myrmecodia pendens) is a traditional plant that has been known to contain anti cancer components. Flavonoids and tannins were contained in sarang semut plant which are believed has cytotoxic effect against cancer cell line. This study aims at cytotoxic effect ethanolic extract of sarang semut at various concentrations on HeLa cervical cancer cell line.Design and Method: The method was quasi experimental with post test only non equivalent control group design. HeLa cell was divided into two groups. The first group as positive control with doxorubicin, second group as treatment with ethanolic extract of sarang semut at various concentrations. Ethanolic extract of sarang semut concentrations used were 3,91 μg/ml; 7,81 μg/ml; 15,63 μg/ml; 31,25 μg/ml; 62,50 μg/ml; 125 μg/ml; 250 μg/ml; 500 μg/ml; 1000 μg/ml. Cytotoxic effect was evaluated by direct counting method with tryphan blue dye then using probit regression analysis to find IC50 value.Result: Inhibitory concentration 50 (IC50) value ethanol extract of sarang semut was 33,28 μg/ml. Ethanol extract of sarang semut had a cytotoxicity effect categorized as the moderately active (20 ìg/ml< IC50< 100ìg/ ml). Inhibitory concentration 50 (IC50) value doxorubicin was 5,56 μg/ml. Cytotoxicity effect of doxorubisin higher than cytotoxicity effect of ethanolic extract of sarang semut.Conclusion: Ethanolic extract of sarang semut (Myrmecodia pendens) had a cytotoxic effect categorized as the moderately active on HeLa cell (Sains Medika, 3(2):112-120).
Phagocytic Index of Peritoneal Macrophages after Propolis Suplementation in Mice (Mus musculus) Mustafiah, Siti Eva; Fatmawati, Dina; Yusuf, Iwang
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.499 KB) | DOI: 10.30659/sainsmed.v3i2.394

Abstract

Background: Various diseases depend on individual’s immunity. Many of which nowadays have not had the effective and formal therapy that makes experts researches the best and the most effective way for it; the use of Propolis as immunomodulator is one of them. This research aims for knowing the effect of propolis towards peritoneal macrophage phagocytic index on mice.Design and Method: This research is an experiment with post test study design randomized control group design. This study used mice that were divided into four groups randomly. The first group / Group-I were for negative control (standard feed and aquadest); The second group/Group-II were fed standard-feed, aquadest, and propolis at a dose of 1.25 mg/kgBM; the third group/group-III were fed standard-feed, water, and propolis at a dose of 2.5 mg/KgBM; The fourth group/Group-IV were fed standard feed, water, and propolis at a dose of 5 mg/KgBM. Treatment where conducted for 3 days.Result: The average macrophage phagocytic index, were at the highest level of it (7.82 1.63) while the lowest one were the first group 3.43 0.13. The Kruskall Wallis result stated that there is index difference among various groups with p 0.002 (p < 0.05).Conclusion: Propolis effected on mice peritoneal macrophage phagocytosis index (Sains Medika, 3(2):121-128).
Membangun Kewaspadaan Munculnya Komplikasi Neuropati Perifer pada Gangguan Metabolik di Lingkungan Klinik Pratama Soetoko, Anita Soraya; Fatmawati, Dina
Jurnal Pengabdian Masyarakat Kedokteran Vol 4, No 1 (2025): Januari
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/abdimasku.4.1.25-32

Abstract

Gangguan metabolik merupakan salah satu penyakit kronis yang banyak dijumpai di Klinik Pratama. Komplikasi yang umum dijumpai pada penyakit ini berupa neuropati perifer. Membangun kewaspadaan melalui peningkatan pengetahuan dan kegiatan deteksi dini terhadap neuropati perifer pada penderita gangguan metabolik dapat mencegah penurunan kualitas hidup penderita akibat komplikasi ini. Tujuan dari kegiatan ini adalah untuk meningkatkan pengetahuan dan deteksi dini neuropati perifer pada penderita gangguan metabolik di Klinik Pratama. Kegiatan ini dilakukan dengan metode penyuluhan mengunakan media power point (PPT) dan pemeriksaan gejala dan tanda neuropati perifer menggunakan tes Michigan dan monofilamen. Kegiatan ini dihadiri oleh 38 peserta yang berasal dari 2 Klinik Pratama di Semarang. Hasil evaluasi setelah selesai kegiatan penyuluhan, didapatkan 70% peserta memiliki pengetahuan yang baik tentang definisi dan mekanisme, 90% mengetahui tanda dan gejala, serta 100% peserta memahami cara mencegah terjadinya neuropati perifer. Hasil tes Michigan, didapatkan 13 peserta memiliki gejala subjektif dan 4 peserta memiliki tanda objektif neuropati perifer, sedangkan pada hasil tes monofilamen didapatkan 5 peserta terdiagnosis neuropati perifer dan 7 memiliki risiko tinggi dalam kurun waktu 4 tahun ke depan. Kegiatan ini menunjukan kemanfaatannya dalam meningkatkan pengetahuan dan mampu mendeteksi dini gejala neuropati perifer pada penderita gangguan metabolik di Klinik Pratama.Metabolic disorders are one of the chronic diseases commonly found in primary clinics. The common complication found in this disease is peripheral neuropathy. Building awareness through increased knowledge and early detection for peripheral neuropathy in patients with metabolic disorders can prevent a decline in the quality of life of patients. The aim of this activity is to enhance knowledge and early detection of peripheral neuropathy in patients with metabolic disorders at the primary clinic. This activity was conducted by giving health education using PowerPoint (PPT) media and examination of peripheral neuropathy symptoms and signs using the Michigan test and monofilament. This activity was attended by 38 participants from 2 primary clinics in Semarang. The evaluation results after giving health education showed that 70% of the participants had a good understanding of the definition and mechanism, 90% knew the signs and symptoms, and 100% of the participants understood how to prevent peripheral neuropathy. The results of the Michigan test showed that 13 participants had subjective symptoms and 4 participants had objective signs of peripheral neuropathy, while the results of the monofilament test indicated that 5 participants were diagnosed with peripheral neuropathy and 7 were at high risk within the next 4 years. This activity demonstrates its usefulness in increasing knowledge and being able to detect early symptoms of peripheral neuropathy in patients with metabolic disorders at the primary clinic.
INTRODUCTION TO NUTRITION AND EXCERSICE ON PKK CADRES DURING THE COVID-19 PANDEMIC TIME IN GAJI VILLAGE, DEMAK Sumarawati, Titiek; Chodidjah, Chodidjah; Widayanti, Eni; Fatmawati, Dina
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 6 No. 3 (2022): SEPTEMBER
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.962 KB) | DOI: 10.32832/abdidos.v6i3.1262

Abstract

Corona Virus Disease 2019 or commonly abbreviated as COVID-19 is an infectious disease caused by SARS-CoV-2. People with COVID-19 may experience fever, dry cough, and difficulty breathing. With the outbreak, the government gives appealed to the community to leave the house as necessary, work from home and maintain health. Salary village is a village located in Demak Regency, Central Java. Public knowledge about the COVID 19 pandemic is still limited, most people do not know that nutrition and physical exercise can improve the body's immune system and prevent COVID 19 disease. Community service is carried out in Gaji Village due to low public knowledge about nutrition and physical exercise (exercise) during the Covid 19 pandemic. Activities were carried out by providing pre and post-tests, counseling to increase public knowledge, and measuring Body Mass Index with 23 participants. Knowledge about Covid 19 increased but not very significantly while increasing knowledge about nutrition and physical exercise experienced a significant increase among the pre and post-test participants. The results of the BMI measurement of 23 respondents had an ideal body weight of 9 people (39.13 %), overweight 12 people (52.17%), and 2 people obese (8.70%). BMI ideal body weight 39.13%; overweight 52.17% and 8.70% fat.
Changes in Astigmatism After Phacoemulsification with a Superior Incision Pritasari, Alteriana Mydriati Sita; Giza, Putri Arifkha; Fatmawati, Dina; Suparmi, Suparmi
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4364

Abstract

Surgically induced astigmatism (SIA) is a common phacoemulsification procedure for senile cataracts. The size, location, and incision type significantly influence the SIA degree. This study aimed to evaluate the effect of a superior incision on astigmatism levels in patients both before and after phacoemulsification for senile cataracts. This retrospective analytical observational study utilized a cohort at Sultan Agung Islamic Hospital, Semarang, Indonesia, between November 2023 and May 2024. The accessible population consisted of patients treated during the study period. A total of 65 eyes from patients who underwent phacoemulsification with a superior incision were included in the study. Twenty-five patients (38.5%) exhibited against-the-rule (ATR) astigmatism before the surgical procedure, which decreased to 16 patients (24.6%) following surgery. In contrast, after phacoemulsification with a superior incision, the number of patients with with-the-rule (WTR) astigmatism increased from 61.5% to 75.4%. The astigmatism value before phacoemulsification with a superior incision was 1.274±1.02, while the value was 0.945±1,02 afterwards. The Wilcoxon Test revealed a significant difference (p<0.05) in the mean of astigmatism values before and after the procedure with a superior incision, indicating the surgical effect on reducing astigmatism. This study confirms that phacoemulsification using a superior incision significantly reduces postoperative astigmatism, particularly in patients with WTR astigmatism. Combining small incisions and sutureless techniques enhances corneal stability, accelerates healing, and improves surgical outcomes.
Co-Authors Andriana Tjitria Widi Anita Soetoko Anita Soraya Soetoko Anita Soraya Soetoko Atik Rahmawati Chodidjah Chodidjah Dini Amelia Rahmah Dwi Endah Kusumawati Giza, Putri Arifkha Idiah Hapsari Ratnaningrum Indra Indra Wahyuni1 Israhnanto Isradji Israhnanto Isradji Israhnanto Isradji Iwang Yusuf Iwang Yusuf Iwang Yusuf Perez Wahyu Purnasari Prista Karina Puspitasari Pritasari, Alteriana Mydriati Sita Renny Swasti Wijayanti Shamrotul Fuadiyah Siti Eva Mustafiah Suparmi Suparmi Suparmi Titiek Sumarawati Widayanti, Eni