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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Majalah Kedokteran Bandung The Journal of Pure and Applied Chemistry Research BIO-SITE |BIOLOGI Sains Terapan MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Abdi Dosen : Jurnal Pengabdian Pada Masyarakat ARSY : Jurnal Aplikasi Riset kepada Masyarakat Jurnal Litbang Edusaintech Jurnal Pengabdian Masyarakat Kedokteran
Dina Fatmawati
Universitas Islam Sultan Agung
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Pemberdayaan Kader PKK Desa Gaji Dalam Pemanfaatan Umbi Gembili (Dioscorea Esculenta) Sebagai Pangan Fungsional Dalam Upaya Pencegahan Stunting Anita Suroyo Soetoko; Dina Fatmawati
ARSY : Jurnal Aplikasi Riset kepada Masyarakat Vol. 3 No. 2 (2023): ARSY : Jurnal Aplikasi Riset kepada Masyarakat
Publisher : Lembaga Riset dan Inovasi Al-Matani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55583/arsy.v3i2.409

Abstract

Stunting merupakan permasalahan yang masih menjadi perhatian utama pemerintah Indonesia. Beberapa upaya pencegahan terhadap stunting telah dilakukan namun belum mencapai hasil yang diharapkan, salah satunya karena rendahnya tingkat pengetahuan terkait stunting dan upaya pencegahannya melalui perbaikan gizi. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan kader PKK desa Gaji tentang stunting dan pemanfaatan umbi gembili sebagai pangan fungsional untuk pencegahan stunting. Metode yang digunakan pada kegiatan meliputi beberapa tahap yaitu penyuluhan stunting, pemberdayaan pemanfaatan umbi gembili, dan monitoring dan evaluasi. Evaluasi tingkat pengetahuan dilakukan dengan pembagian kuisioner saat pre dan post kegiatan. Hasil kegiatan ini didapatkan peningkatan persentase jawaban benar peserta pada penilaian postest lebih dari 95%. Hasil tersebut dapat disimpulkan adanya keberhasilan kegiatan pemberdayaan ini dalam meningkatkan pengetahuan kader PKK desa Gaji tentang stunting dan pemanfaatan umbi gembili sebagai pangan fungsional untuk pencegahan stunting.  
The Level of SGOT and SGPT after The Administration of Powdered Colorant Pigment Isolated from Kesumba Keling’s (Bixa Orellana) Seed Coats An experimental study in Balb/C Mice Suparmi, Suparmi; Isradji, Israhnanto; Fatmawati, Dina
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.703 KB) | DOI: 10.30659/sainsmed.v3i1.411

Abstract

Background: There has been an effort to explore pigment from kesumba keling’s (Bixa orellana) seed coats for a source of natural food colorant. Consumption of pigment from kesumba keling (Bixa orellana) was assumed to cause adverse effects on heart as an important organ in detoxification or inactivation of drugs or other toxic compounds. This study conducted to determine the levels of SGOT and SGPT blood serum of mice (Mus musculus) Balb/C after administration of colorant powder pigment of B. orellana seed coat’s at various concentrations.Design and Methods: The research is an experimental research with Factorial Design with 2 factors. Food Colorant Powder was made from bixin, norbixin, and crude extract pigment isolated from B. orellana seed coat’s. A total of 60 male mice were divided into 10 treatment groups. Powdered colorant solution at the concentration of 0% (control), 1%, 5%, and 10% were orally administered using gavage as much as 1 ml a day for 30 days.Results: Kruskal Wallis test results shows a not significant difference SGOT and SGPT level among the groups (p > 0.05), thus consumption of colorant powder of bixin, norbixin, and the crude extract with various concentrations did not affect the SGOT and SGPT.Conclusion: Colorant powder isolated from B. orellana seed coat’s has been shown to have no effect on the liver function, so it is safe as food colorant (Sains Medika, 3(1):69-77).
Pengaruh Lendir Bekicot (Achatina fulica) terhadap Jumlah Sel Fibroblas pada Penyembuhan Luka Sayat Studi Eksperimental pada Kulit Mencit (Mus musculus) Purnasari, Perez Wahyu; Fatmawati, Dina; Yusuf, Iwang
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.648 KB) | DOI: 10.30659/sainsmed.v4i2.376

Abstract

Background: Wound healing is very important to return skin as soon as possible and the integration is a complex and dynamic process. Proliferation phase involving fibroblasts is one of important step-on wound healing. Use of drugs such as povidone iodine on cuts aims to accelerate wound healing is still being debated. Healing by land snails’ mucus can be an alternative because it has many benefits. This study wants to know about the influence of land snails’ mucus on the number of fibroblasts in healing cuts.Design and methods: The study is an experimental research with post test only randomized control group design. The subjects were 18 Mus musculus strain mice that were divided into 3 groups. 1st group as a control group of untreated, 2nd group was given povidone iodine 10%, and 3rd group was given land snails’ mucus during 5th days. On the 6th day the mices were killed for histological study.Results: The data showed that average number of fibroblast in 1st group is 93,85; 2nd group is 126,37; and 3rd is group 217,5. The results of one way anova statistical test showed significant difference among the three groups p = 0,000. The results of post hoc test showed significant difference in all groups (p < 0,05).Conclusion: The mucus of land snail is influence the number of fibroblast in healing cuts (Sains Medika, 4(2):195-203).
Cytotoxic Effect of Ethanolic Extract of Sarang Semut (Myrmecodia pendens) on HeLa Cervix Cancer Cell Line In Vitro Experimental Study Fatmawati, Dina; Puspitasari, Prista Karina; Yusuf, Iwang
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.338 KB) | DOI: 10.30659/sainsmed.v3i2.393

Abstract

Background: Sarang semut (Myrmecodia pendens) is a traditional plant that has been known to contain anti cancer components. Flavonoids and tannins were contained in sarang semut plant which are believed has cytotoxic effect against cancer cell line. This study aims at cytotoxic effect ethanolic extract of sarang semut at various concentrations on HeLa cervical cancer cell line.Design and Method: The method was quasi experimental with post test only non equivalent control group design. HeLa cell was divided into two groups. The first group as positive control with doxorubicin, second group as treatment with ethanolic extract of sarang semut at various concentrations. Ethanolic extract of sarang semut concentrations used were 3,91 μg/ml; 7,81 μg/ml; 15,63 μg/ml; 31,25 μg/ml; 62,50 μg/ml; 125 μg/ml; 250 μg/ml; 500 μg/ml; 1000 μg/ml. Cytotoxic effect was evaluated by direct counting method with tryphan blue dye then using probit regression analysis to find IC50 value.Result: Inhibitory concentration 50 (IC50) value ethanol extract of sarang semut was 33,28 μg/ml. Ethanol extract of sarang semut had a cytotoxicity effect categorized as the moderately active (20 ìg/ml< IC50< 100ìg/ ml). Inhibitory concentration 50 (IC50) value doxorubicin was 5,56 μg/ml. Cytotoxicity effect of doxorubisin higher than cytotoxicity effect of ethanolic extract of sarang semut.Conclusion: Ethanolic extract of sarang semut (Myrmecodia pendens) had a cytotoxic effect categorized as the moderately active on HeLa cell (Sains Medika, 3(2):112-120).
Phagocytic Index of Peritoneal Macrophages after Propolis Suplementation in Mice (Mus musculus) Mustafiah, Siti Eva; Fatmawati, Dina; Yusuf, Iwang
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.499 KB) | DOI: 10.30659/sainsmed.v3i2.394

Abstract

Background: Various diseases depend on individual’s immunity. Many of which nowadays have not had the effective and formal therapy that makes experts researches the best and the most effective way for it; the use of Propolis as immunomodulator is one of them. This research aims for knowing the effect of propolis towards peritoneal macrophage phagocytic index on mice.Design and Method: This research is an experiment with post test study design randomized control group design. This study used mice that were divided into four groups randomly. The first group / Group-I were for negative control (standard feed and aquadest); The second group/Group-II were fed standard-feed, aquadest, and propolis at a dose of 1.25 mg/kgBM; the third group/group-III were fed standard-feed, water, and propolis at a dose of 2.5 mg/KgBM; The fourth group/Group-IV were fed standard feed, water, and propolis at a dose of 5 mg/KgBM. Treatment where conducted for 3 days.Result: The average macrophage phagocytic index, were at the highest level of it (7.82 1.63) while the lowest one were the first group 3.43 0.13. The Kruskall Wallis result stated that there is index difference among various groups with p 0.002 (p < 0.05).Conclusion: Propolis effected on mice peritoneal macrophage phagocytosis index (Sains Medika, 3(2):121-128).
Membangun Kewaspadaan Munculnya Komplikasi Neuropati Perifer pada Gangguan Metabolik di Lingkungan Klinik Pratama Soetoko, Anita Soraya; Fatmawati, Dina
Jurnal Pengabdian Masyarakat Kedokteran Vol 4, No 1 (2025): Januari
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/abdimasku.4.1.25-32

Abstract

Gangguan metabolik merupakan salah satu penyakit kronis yang banyak dijumpai di Klinik Pratama. Komplikasi yang umum dijumpai pada penyakit ini berupa neuropati perifer. Membangun kewaspadaan melalui peningkatan pengetahuan dan kegiatan deteksi dini terhadap neuropati perifer pada penderita gangguan metabolik dapat mencegah penurunan kualitas hidup penderita akibat komplikasi ini. Tujuan dari kegiatan ini adalah untuk meningkatkan pengetahuan dan deteksi dini neuropati perifer pada penderita gangguan metabolik di Klinik Pratama. Kegiatan ini dilakukan dengan metode penyuluhan mengunakan media power point (PPT) dan pemeriksaan gejala dan tanda neuropati perifer menggunakan tes Michigan dan monofilamen. Kegiatan ini dihadiri oleh 38 peserta yang berasal dari 2 Klinik Pratama di Semarang. Hasil evaluasi setelah selesai kegiatan penyuluhan, didapatkan 70% peserta memiliki pengetahuan yang baik tentang definisi dan mekanisme, 90% mengetahui tanda dan gejala, serta 100% peserta memahami cara mencegah terjadinya neuropati perifer. Hasil tes Michigan, didapatkan 13 peserta memiliki gejala subjektif dan 4 peserta memiliki tanda objektif neuropati perifer, sedangkan pada hasil tes monofilamen didapatkan 5 peserta terdiagnosis neuropati perifer dan 7 memiliki risiko tinggi dalam kurun waktu 4 tahun ke depan. Kegiatan ini menunjukan kemanfaatannya dalam meningkatkan pengetahuan dan mampu mendeteksi dini gejala neuropati perifer pada penderita gangguan metabolik di Klinik Pratama.Metabolic disorders are one of the chronic diseases commonly found in primary clinics. The common complication found in this disease is peripheral neuropathy. Building awareness through increased knowledge and early detection for peripheral neuropathy in patients with metabolic disorders can prevent a decline in the quality of life of patients. The aim of this activity is to enhance knowledge and early detection of peripheral neuropathy in patients with metabolic disorders at the primary clinic. This activity was conducted by giving health education using PowerPoint (PPT) media and examination of peripheral neuropathy symptoms and signs using the Michigan test and monofilament. This activity was attended by 38 participants from 2 primary clinics in Semarang. The evaluation results after giving health education showed that 70% of the participants had a good understanding of the definition and mechanism, 90% knew the signs and symptoms, and 100% of the participants understood how to prevent peripheral neuropathy. The results of the Michigan test showed that 13 participants had subjective symptoms and 4 participants had objective signs of peripheral neuropathy, while the results of the monofilament test indicated that 5 participants were diagnosed with peripheral neuropathy and 7 were at high risk within the next 4 years. This activity demonstrates its usefulness in increasing knowledge and being able to detect early symptoms of peripheral neuropathy in patients with metabolic disorders at the primary clinic.
Identifikasi Peptida Umami dan Kokumi pada Rumput Laut Sargassum aquifolium dengan Pendekatan In Silico Larasati, Bernadeta Pingkan; Soedarini, Bernadeta; Hendryanti, Dea Nathania; Retnaningsih, Christiana; Fatmawati, Dina; Pratiwi, Alberta Rika
Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 20, No 1 (2025): Juni 2025
Publisher : Politeknik - Ahli Usaha Perikanan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/jpbkp.v20i1.1003

Abstract

Sargassum aquifolium memiliki kandungan protein dan asam glutamat yang tinggi, sehingga dapat dimanfaatkan menjadi bahan penyedap rasa. Rasa umami dapat dihasilkan oleh peptida taste-active yang berkontribusi dalam meningkatkan rasa umami dan memberikan sensasi rasa kokumi. Meskipun banyak penelitian mengenai peptida umami dan kokumi dalam bahan pangan, namun penelitian sejenis pada rumput laut belum banyak ditemukan. Analisis in silico telah banyak dilakukan untuk memprediksi dan mengidentifikasi peptida dengan taste-active umami dan kokumi pada bahan pangan dan efektif dalam mengevaluasi rasa peptida sebelum dilakukan evaluasi secara in vitro dan in vivo. Tujuan penelitian ini adalah memprediksi dan mengidentifikasi keberadaan peptida taste-active yang berkontribusi terhadap rasa umami dan kokumi pada rumput laut S. aquifolium dengan analisis in silico. Ekstraksi peptida S. aquifolium menggunakan pelarut air dengan metode reflux dan ultrasound, isolasi dan purifikasi peptida berdasarkan berat molekul. . Peptida hasil isolasi dianalisis berat molekulnya menggunakan Tricine-SDS-PAGE dan aktivitas sensori potensial secara in silico menggunakan database BIOPEP-UWM. Hasil penelitian menunjukkan analisis Tricine-SDS-PAGE menemukan 5 pita peptida yaitu 673 Da, 797 Da, 1.019 Da, 1.195 Da, dan 1.408 Da. Analisis in silico menunjukkan sekuen DFVEVPTGSN (1.019 Da) dan DTPDFVEVATESP (1.408 Da) diprediksi sebagai peptida umami yang ditandai adanya residu asam amino aspartat (D), dan asam amino glutamat (E), serta peptida ES, EV, TE, VE. Namun, tidak ditemukan peptida yang menunjukkan potensi kokumi. Pendekatan ekstraksi Water Soluble Extraction (WSE) menggunakan metode reflux dan ultrasound, serta pendekatan dengan in silico berhasil mengidentifikasi peptida taste-active umami, namun kurang efektif dalam mengidentifikasi peptida kokumi dari S. aquifolium .ABSTRACTSargassum aquifolium has high protein and glutamic acid to be used as a flavor enhancer. The umami taste can be produced by taste-active peptides which contribute to enhancing umami taste and providing kokumi taste sensation. Although there has been a lot of research on umami and kokumi peptides, similar research on seaweed has not been widely found. In silico analysis has been carried out to predict and identify taste-active peptides umami and kokumi in food and is effective in evaluating the taste of peptides before in vitro and in vivo evaluation. This research aimed to predict and identify taste-active peptides that contributed to umami and kokumi in S. aquifolium using in silico analysis. This research consisted of extracting S. aquifolium peptides using water with reflux and ultrasound methods, isolating and purifying peptides based on molecular weight. The isolated peptides were analyzed for their molecular weight using Tricine-SDS-PAGE and in silico potential sensory activity analysis using the BIOPEP-UWM database. Based on the Tricine-SDS-PAGE analysis, found 5 peptide bands 673 Da, 797 Da, 1,019 Da, 1,195 Da, and 1,408 Da. In silico analysis showed that the sequences of DFVEVPTGSN (1,019 Da) and DTPDFVEVATESP (1,408 Da) were predicted as umami peptides characterized by the presence of aspartate (D) and glutamic (E) amino acid residues, as well as ES, EV, TE, and VE peptides. However, no peptides were found that showed kokumi potential. The Water Soluble Extraction (WSE) approach using the reflux and ultrasound method, as well as in silico approach, succeeded in identifying the taste-active umami peptide, but was less effective in identifying the taste-active kokumi peptide from S. aquifolium.
Co-Authors Alberta Rika Pratiwi Andriana Tjitria Widi Anita Soetoko Anita Soraya Soetoko Anita Soraya Soetoko Atik Rahmawati Chodidjah Chodidjah Christiana Retnaningsih Dini Amelia Rahmah Dwi Endah Kusumawati Eni Widayanti Hendryanti, Dea Nathania Idiah Hapsari Ratnaningrum Indra Indra Wahyuni1 Israhnanto Isradji Israhnanto Isradji Israhnanto Isradji Iwang Yusuf Iwang Yusuf Iwang Yusuf Larasati, Bernadeta Pingkan Perez Wahyu Purnasari Prista Karina Puspitasari Renny Swasti Wijayanti Shamrotul Fuadiyah Siti Eva Mustafiah Soedarini, Bernadeta Suparmi Suparmi Suparmi Titiek Sumarawati