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Andi Gunawan
Politeknik Negeri Ujung Pandang
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The Correlation Between IL-1β and IL-10 Levels in Estimating The Risk of Febrile Seizures Gunawan, Andi; Muid, M; Suyudi, Hidayat; wisnu, Barlianto; Subandiyah, Krisni
Journal of Tropical Life Science Vol 4, No 2 (2014)
Publisher : Journal of Tropical Life Science

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Abstract

Febrile seizures are the most common forms of seizures in children with fever. A data from clinical and experimental studies suggest the potential role of immune generate products in their genesis. The balance between proinflammatory (IL-1β) and anti-inflammatory (IL-10) cytokines influences the regulation of infections and plays a role in the pathogenesis of febrile seizures. In existing literature, there is no research on the correlation between IL-1β and IL-10 levels as well as the ratio of IL-1β to IL-10 in estimating the risk of febrile seizures in seizure prone children aged between 3 months and 5 years. In this study, IL-1β, IL-10 levels and ratio of IL-1β to IL-10 in the risk of febrile seizures were investigated, and respondents were divided into three groups: febrile seizures, febrile without seizures and healthy children without histories of febrile seizure. This study has used A cross-sectional design, and each group had 17 co-respondents. IL-1β and IL-10 levels were measured by ELISA. Data were analyzed by SPSS 15. Findings showed there were significant differences between IL-1β and IL-10 as well as in the ratio of IL-1β to IL-10 between febrile seizure patients and healthy children. It was concluded that there were significant correlations between IL-1β and IL-10 levels as well as IL-1β to IL-10 ratios in estimating the risk of febrile seizures.
Co-Authors Afifah, Silvi Nur Alhumary, Farid M Alwi Fahruzy Nasution Anas Miftah Fauzi Aprial. M, Benny Arief Rahman Aris Munandar Aris Sugiharto Asnimawati, Asnimawati Bambang Sulistyantara Beatus Tambaip Dede Ramdani, Dede Durrotun Nafisah Edi Santosa Fathur Rohman, Fathur Fitriani, Chair Anggita Gulo, Syukur Putra Abadi HIRMAN Hirman, Hirman IMASITA IMASITA, IMASITA Khrisna, Arsyad Krisni Subandiyah Luqmanul Hakim M Firdaus Mandong, Isramirawati Agus Marselina, Resya Dwi Miftahul Jannah Muid, M Mulyani, Rani Mustafid Mustafid Nahlah, Nahlah Nugrahatama, Davin Nursya’ban, Ranti Nurul Hasanah Ohan Farhan Pratiwi, Rian Adetiya Prita Indah Pratiwi Priyono Priyono Pulung Riyanto Rahmayanti, Fetty Dwi Repiyasa, I Wayan Ricesa, Wieke Siregar, Imanuddin Sri Hardianti Suldalmi, Endang Sri Sumianto Sumianto Suyudi, Hidayat Wahju Qamara Mugnisjah Wira Hadinata, Wira wisnu, Barlianto Yoana Agnesia Zlukhu, Anuarman