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All Journal Jurnal Kesehatan Lingkungan indonesia Jurnal Ilmu Dasar Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan Jurnal Kesehatan Andalas Indonesian Journal of Human Nutrition Journal of Agromedicine and Medical Sciences Pharmascience Jurnal Gizi Klinik Indonesia Poltekita : Jurnal Ilmu Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat Indonesia (JPPMI) Jurnal Kesehatan Kusuma Husada JKKI : Jurnal Kedokteran dan Kesehatan Indonesia International Journal of Health and Information System (IJHIS)
Hairrudin Hairrudin
Department Of Biochemistry, Faculty Of Medicine, University Of Jember, Jember, East Java, Indonesia, 68121
Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : e-Journal Pustaka Kesehatan

 1 
Aktivitas Hepatoprotektor Cuka Apel 'A' terhadap Kadar SGOT dan SGPT Serum Tikus Wistar yang Diinduksi Parasetamol Dosis Toksik (Hepatoprotector Activities of 'A' Apple Vinegar to SGOT and SGPT Serum in Wistar Rats Induced by Toxic Dose of Paracetamol) Fawziyah Putri Maulida; Hairrudin Hairrudin; Elly Nurus Sakinah
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The use of a toxic dose of paracetamol is able to generate free radicals in the form of N-acetyl-p-benzoquinoneimine (NAPQI) resulting in increased levels of hepatic transaminase enzymes, Serum glutamate oksaloasetat transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT). 'A' apple vinegar contains antioxidants such as polyphenols, and vitamin C as well as acetic acid that were thought to have hepatoprotector effect which expected to prevent liver damage caused by NAPQI. The purpose of this study was to determine hepatoprotective activity of 'A' apple vinegar to SGOT and SGPT serum levels in wistar that induced by toxic dose of paracetamol. This study used 27 wistars wich were divided into three groups. The results of this study showed that average values of SGOT/SGPT in the normal control group were 79.00/113.89, negative control group were 289.67/296.22, treatment group were 180/194.44. Statistical test performed by using One Way Anova test for SGOT data and Kruskal Wallis test for SGPT. From the results it can be concluded that the administration of 'A' apple vinegar has hepatoprotective activity to SGOT and SGPT serum levels in wistar rats induced by toxic dose of paracetamol. Keywords: Apple vinegar, hepatoprotector, antioxidant, Paracetamol, Transaminase
Efek Preventif Ekstrak Etanol Kopi Robusta (Coffea canephora) terhadap Peningkatan Kadar Kolesterol Total Tikus Jantan Galur Wistar yang Diinduksi Kuning Telur Yan Agus Achtiar; Hairrudin Hairrudin; Kristianningrum Dian Sofiana
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Kopi robusta mengandung asam klorogenat (CGA) sekitar 7-14%. Asam klorogenat diduga dapat mencegah penyerapan kolesterol diusus. Penelitian ini bertujuan untuk membuktikan efek preventif ekstrak etanol kopi robusta (Coffea canephora) terhadap peningkatan kadar kolesterol total tikus. Penelitian ini adalah penelitian eksperimental laboratorium pre-post-test dengan kelompok kontrol. Dua puluh emapt ekor tikus wistar jantan usia 3-4 bulan, dibagi menjadi kelompok perlakuan K1 diinduksi kuning telur, kelompok K2 diinduksi kuning telur dan ekstrak kopi dosis terapi (0,5 mL / ekor), kelompok K3 diinduksi kuning telur dan simvastatin, kelompok K4 diinduksi kuning telur dan ekstrak kopi dosis tinggi (1 mL / ekor) selama 35 hari. Pada awal dan akhir perlakuan diambil serum darah untuk mengetahui kadar kolesterol total darah menggunakan menggunakan metode CHOD-PAP. Dalam waktu 35 hari, pemberian ekstrak kopi robusta tidak mencegah kenaikan kadar kolesterol total. Sehingga dapat disimpulkan bahwa tidak ada efek preventif ekstrak etanol kopi robusta (Coffea canephora) terhadap peningkatan kadar kolesterol total tikus wistar jantan yang diinduksi kuning telur.   Kata kunci: Hiperkolesterolemia, asam klorogenat, kolesterol total serum
Hubungan Indeks Kepuasan Pasien tentang Mutu Pelayanan Dimensi Kehandalan dengan Minat Berobat Kembali di RSD Kalisat Kabupaten Jember Davina Amalia; Dwita Aryadina Rachmawati; Hairrudin Hairrudin
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7668

Abstract

RSD Kalisat is one of the hospital that is very concern with the quality of health services. The reliability of service quality is often perceived as the most important dimension for the customer. Quality of service is very influential on patient satisfaction. If the health care provided is good, then the patient will be satisfied and the possibility to reuse services in health care-related agencies will increase. The purpose of this study was to determine the correlation between patient satisfaction index in the reliability of service quality with utility at RSD Kalisat. This study used cross sectional design with total sample of 84 respondents. The instrument used was RSD Kalisat profile and questionnaire to determine patient satisfaction index in the reliability of service quality and statement for utility. The results of statistical test by Spearman's Rho showed a significance value (p=0.021) and the correlation coefficient (r =0.252). Thus, it can be concluded that there was a significant correlation between patient satisfaction index in the reliability of service quality with utility at RSD Kalisat Jember with a weak correlation. Keywords: index satisfaction, reliability, service quality, utility
Pengaruh Stres Fisik terhadap Kadar Kreatinin Serum Tikus Wistar Jantan (Rattus norvegicus) (The Effect of Physical Stress on Serum Creatinine of Male Rattus norvegicus) Putu Ratih Pradnyani Dewi; Hairrudin Hairrudin; Rena Normasari
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Physical stress is a condition that caused by severe physical activities which can increase free radicals production causing oxidative stress. Oxidative stress causing the organs failure include the kidney. It damage glomerulus causing decrease in GFR and tubular cell damage causing cumulation of creatinine and raise creatinine serum. This study investigated the difference of serum creatinine of male Rattus norvegicus with physical stress and without physical stress. Ten male Rattus norvegicus aged 2-3 months were divided into two groups : control and treatment group. Control group without physical stress but treatment group was given physical stress 30 minutes of swimming stress in the morning everyday for 10 days. The creatinine serum measured by Jaffe reaction. The normal range of serum creatinine for Rattus norvegicus was 0,578-1,128 mg/dl. The result of serum creatinine for control group was 0,52 mg/dl and treatment group was 0,62 mg/dl,both still in normal range. The analysis using Mann Whitney showed the significance of 0,23 (p>0,05). We can conclude that there was no difference of serum creatinine of male Rattus norvegicus with physical stress and without physical stress. Keywords: physical stress, oxidative stress, serum creatinine
Pengaruh Pemberian Natrium Bikarbonat terhadap Kelelahan dan Nyeri Otot setelah Melakukan Treadmill Fath Arina Fahma; Cholis Abrori; Hairrudin Hairrudin
Pustaka Kesehatan Vol 7 No 1 (2019): Volume 7 No. 1, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i1.17590

Abstract

Treadmill is a physical exercise that caused a metabolic transition from aerobic into anaerobic. The aim of this study was to determine the effect of sodium bicarbonate to reduce fatigue and muscle pain after treadmill. This study used a time-series design with 20 selected samples from undergraduate student population of the Faculty of Medicine, Jember University. Samples consumed 100mg/kgBW NaCl (placebo) and NaHCO3 300mg/kgBW then perform a treadmil protocol until it reached maximum muscle fatigue. The results showed that the average treadmill of the treatment group (778,1±121,21 seconds) was longer than control group (717,7±93,02 seconds). The intensity of acute pain as measured by VAS (Visual Analog Scale) treatment group was lower (44,7±22,47 units) than control (55,4±19,97 units). So this study inferred that NaHCO3 can reduce fatigue and acute pain intensity after treadmill.
Efektivitas Ekstrak Putri Malu (Mimosa pudica Linn.) sebagai Nefroprotektor pada Tikus Wistar yang Diinduksi Parasetamol Dosis Toksik Ari Setyo Rini; Hairrudin Hairrudin; Sugiyanta Sugiyanta
Pustaka Kesehatan Vol 1 No 1 (2013)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The ethanolic extract of Mimosa pudica Linn. was evaluated for its nefroprotective and antioxidant activity against paracetamol induced kidney toxicity in wistar rats. Liver damage was induced by administration of 1.350 mg paracetamol/kg body weight. The ethanolic extract of Mimosa pudica Linn. (400mg/kg, 600mg/kg, and 800 mg/kg) was administered orally to the rats for 6 days. Curcuma® was given as positive control. All of the test drugs were administered orally by suspending in 1% of Na CMC solution. The nefroprotective activity was assessed using the levels of BUN and creatinine serum. The result revealed that all doses of the extracts showed effective activity in inhibiting the increase of BUN and creatinine serum and the doses of 800 mg/kg showed the biggest percent value (9,4% of BUN level and 12,19% of creatinine level). The positive control group could prevent the increase of BUN and creatinine serum better when compared with the group of Mimosa pudica Linn.The result of the present study indicated that the ethanolic extract of Mimosa pudica Linn. significantly prevent the increase of the level BUN and creatinine serum in wistar rats induced with paracetamol toxic dose.Keywords: Antioxidant, nefrotoxic, Mimosa pudica, paracetamol, BUN, creatinine.  
Co-Authors Adji, Novan Krisno Ahlulkemal, Mohammad Daffa Ancah Caesarina Novi Marchianti Andi Muhammad, Andi Anis Talitha Damarawati Anjani Putri Retnaninggalih Anjani Putri Retnaninggalih, Anjani Putri Ari Setyo Rini Aris Prasetyo Azka Darajat Cholis Abrori Cholis Abrori, Cholis Darajat, Azka Davina Amalia Dewantari, Septiarina Putri Dina Helianti Dwita Aryadina Rachmawati Eling Nurdianti Elly Nurus Sakinah Elly Nurus Sakinah, Elly Nurus Erfan Efendi Fath Arina Fahma Fawziyah Putri Maulida Heni Fatmawati Ichlasul Mahdi Fardhani Ika Rahmawati Sutejo Isa Ma'rufi Jauhar Firdaus Jauhar Firdaus Kristianningrum Dian Sofiana Laksmi Indreswari Luh Putu Ratna Sundari Mei Syafriadi Monika Roosyidah Muhammad Hasan Muhammad Hasan Muhammad Rosyid Ridho Mushab Mushab Mushab, Mushab Nurfahimi, Yudriani Nurmaida, Eny Paulina Samuellia Pipiet Wulandari Prajesiaji Praba Kumara Purnomo, Farah Fadhila Nasywa Putri, Komang Yunita Wiryaning Putu Ratih Pradnyani Dewi Rafida, Sofia Yusnur Rayyan, Muhammad Isra Rafidin Rena Normasari Reny Ekawati Rumastika, Nindya Shinta Septyawati, Ratna Sofia Yusnur Rafida Sugiyanta Sugiyanta Sukadi Sukadi Supangat Supangat Syafa, Nahdah Ardelia Triastiana Kurbaini, Feby Yan Agus Achtiar Yulestrina Widiastuti Zahrah Febianti Zahrah Febianti Zahrox, Iin Fatimatus