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All Journal Journal of Food and Pharmaceutical Science JURNAL KIMIA SAINS DAN APLIKASI Farmaka Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Journal of Pharmacopolium Jurnal Mandala Pharmacon Indonesia Jurnal Hexagro Pharmacoscript Health Information : Jurnal Penelitian Jurnal Midpro Jurnal Abdi Insani Jurnal Insan Farmasi Indonesia Berkala Ilmiah Kimia Farmasi Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmacy Genius Prosiding Seminar Nasional Universitas Ma Chung Media Informasi Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Srie Rezeki Nur Endah
Universitas Perjuangan Tasikmalaya
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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Antidiarrhea Activity of Ethanol Extract of Rambutan Leaves (Nephelium lappaceum L.) in Capsule Form on Male Mice Nurul Fadilah, Nitya; Ali Nofriyaldi; Ayu Rahmawati; Srie Rezeki Nur Endah; Widya Nurul Aini; Vincent O. Imieje
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.291-297

Abstract

Background: Diarrhea is characterized by changes in stool form to soft or liquid, with an intensity of bowel movements more than three times a day. One of the plants used as an alternative treatment for diarrhea is rambutan, particularly its leaves. Previous studies have shown that rambutan leaf extract can treat diarrhea. Objective: The purpose of this study was to determine the antidiarrhea activity of ethanol extracts of rambutan leaves containing tannins and flavonoids that inhibit intestinal motility. Methods: This study was conducted experimentally using the intestinal transit method, which measures the length of the intestine passed through a marker. The smaller the ratio between the length of the intestine and the marker, the greater the decrease in intestinal motility in the mice. Group 1: loperamide HCl at a dose of 4 mg/kg BW; Group 2:  placebo; Group 3: FI, FII, and FIII capsules at doses of 50 mg, 100 mg, and 150 mg. Results: The test results showed that Formulations 1, 2, and 3 had activities of 23.3%, 26.8%, and 32.3%, respectively. The capsule with the best results was formulation 3, at a dose of 150 mg. Compared with the positive control, the effectiveness of this capsule was 22% higher than that of loperamide. Conclusion: The results of this study showed that rambutan leaves extracted in capsule form effectively treats diarrhea. The one-way ANOVA test showed a significant difference between the FI, FII, and FIII groups (p <0.05).
Co-Authors Ai Parida Mutiara Aida, Yopi Amelia Aprini AYU RAHMAWATI Ayu Rahmawati Ayu Rahmawati Bachtiar, Kamiel Roesman C Shintia Cheryl Alodya Citra Shintia Eddy Suhardiana Eddy Suhardiana Eddy Suhardiana Elin Fauziah, Elsa Fauziah, Nurma Sari Firiani, Yuli Hakim, Sidiq Alimul Hisyam Arief Indah Pitaloka Sari Indri, Eneng Kamiel Roesman Bachtiar Kamiel Roesman Bachtiar Lina Rahmawati Rizkuloh Nitya Nurul Fadilah Nofriyaldi, Ali Nurfadilah Yusuf Nurul Aini, Widya Resti Hastuti Richa Mardianingrum Rizky Farhan Pratama Roesman, Kamiel Ruswanto, Ruswanto Sa'banah, Nonah Salsabila Adlina Selvia Maslamah Aan Septiani, Gina Shofuro Sholihah Sudiarjo, Aso Suhardiana, Eddy Susanti Susanti Susanti Susanti Vikandari, Sonya Nurizki Vincent O. Imieje Widya Nurul Aini