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Alfi Muntafiah
Universitas Jenderal Soedirman
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Journal : Universa Medicina

 1 
Metalloproteinase-9 gene variants and risk for hypertension among ethnic Javanese Fitranto Arjadi; Saefuddin Aziz; Alfi Muntafiah
Universa Medicina Vol. 33 No. 3 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.213-220

Abstract

BackgroundHypertension is associated with endothelial-dependent vasodilation disorders, due to reduced nitric oxide (NO) availability and excessive angiotensin II (ANG-II) activation. The objective of this study was to determine the association between matrix metallopeptidase 9 (MMP-9) gene polymorphism and hypertension in ethnic Javanese in the 40-80 year age group. MethodsThis was a case-control study on 50 PROLANIS patients of family doctors meeting the inclusion criteria and 50 controls without hypertension. Subjects were hypertensive patients with constant systolic arterial pressure of >140 mmHg and diastolic arterial pressure of >90 mmHg, confirmed in three successive measurements The observed parameters were degree of MMP-9 polymorphism, and NO and ANG-II levels. Matrix metallopeptidase 9 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using the SmaI restriction enzyme. MMP-9 polymorphisms were indicated by variation in band patterns. Degree of polymorphism in cases and controls were compared with NO and ANG-II levels in both groups. Data analysis was done using independent t-test.ResultsThe heterozygous (3 band) to normal (2 band) MMP-9 genotype ratio was 3:1 in hypertensives, but balanced in controls. In hypertensives, heterozygous GA and homozygous AA genotype frequencies were respectively 3.198 and 1.548 times higher than that of the GG genotype (p=0.008 and p=0.726). There was a statistically significant differences of NO and Ang-II levels between cases and controls (p=0.000 and p=0.000; respectively). ConclusionMatrix metallopeptidase 9 gene polymorphisms in hypertensive ethnic Javanese are associated with NO and angiotensin II levels.
The effect of purple passion fruit juice on superoxide dismutase and malondialdehyde levels in hypercholesterolemic rats Alfi Muntafiah; Johanes Hasian Siahaan; Sofyan Hardi; Dody Novrial; Hernayanti Hernayanti
Universa Medicina Vol. 41 No. 2 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.139-148

Abstract

BackgroundHypercholesterolemia due to a high cholesterol diet can increase free radicals resulting in oxidative stress. Superoxide dismutase (SOD) and malondialdehyde (MDA) have been used as the study markers of oxidative stress in cases of hypercholesterolemia. Purple passion fruit contains various compounds that may reduce free radicals. This study aimed to determine the effect of purple passion fruit juice on SOD and MDA levels in hypercholesterolemic rats. MethodsAn experimental analysis with post-test only control group design involving 28 male Wistar rats. They were divided into 4 groups: normal control (K1), hypercholesterolemic control (K2), purple passion fruit juice treatment at 4.2 mL/200 gBW/day (K3), and simvastatin treatment at 0.018 mg/200 gBW/day (K4). The purple passion fruit juice at 4.2 mL/200 gBW/day was administered for 14 days. SOD levels were examined by enzymatic colorimetric methods using the Ransod kit and MDA levels by the TBARS method. ResultsThe Kruskal-Wallis test showed a significant difference in SOD levels between the tested groups (p<0.05). One-way ANOVA test for MDA levels showed a significant difference (p<0.05). Post Hoc test (Mann-Whitney for SOD and LSD for MDA levels) also showed significant differences: K1 vs. K2, K2 vs. K3, K2 vs. K4, and K3 vs. K4 (p<0.05). ConclusionThis study demonstrated that purple passion fruit juice significantly increases the SOD and lowers the MDA level in hypercholesterolemic male Wistar rats. Consumption of purple passion fruit juice may help to modulate oxidative stress caused by hypercholesterolemia in rats.
Co-Authors Afifah Afifah Arfi Nurul Hidayah Aulia Husna Cahyaningtyas Aulia Okhid Ariza Dita Yulianti Dody Novrial, Dody Edy Priyanto Elok Widyaningtyas Fitranto Arjadi Hani Ismi Damayanti Hernayanti Hernayanti Ika Murti Harini Irwan Nuryadin Johanes Hasian Siahaan Lantip Rujito Lily Burkon Miko Ferrine Muhamad Rifqy Setyanto Muhammad Fakih Muhammad Mukhson Nia Krisniawati Nor Sri Inayati Nor Sri Inayati Octavia Permata Sari Octavia Permata Sari Pratama, Tisna Sendy Prihatno, M. Mukhlis Rudi Qodri Santosa Qodri Santosa Rahmah Fadhilah Asrifqa Saefuddin Aziz Saefuddin Aziz Salsabil Rahmadina Setiawati Setiawati Setya Dian Kartika Sofyan Hardi Tirta Wardana Viva Ratih Bening Ati Wafa Nur Azizah Wahyudin Wahyudin Zeha Kirana