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All Journal Jurnal Kedokteran Brawijaya Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Sari Pediatri Universa Medicina Paediatrica Indonesiana Jurnal Pengabdian Pada Masyarakat Scripta Biologica Dinamika Journal : Pengabdian Masyarakat Jurnal Comprehensive Health Care Poltekita: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Pada Masyarakat Medical and Health Journal

Alfi Muntafiah

Universitas Jenderal Soedirman

Author-ID : 2740619

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Evaluasi Potensi Antidiabetes Sari Buah Markisa Ungu (Passiflora edulis var edulis) pada Tikus Model Diabetes Melitus yang Diinduksi Aloksan Muntafiah, Alfi; Pratama, Tisna Sendy; Ati, Viva Ratih Bening
Jurnal Kedokteran Brawijaya Vol 30, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Markisa ungu mengandung komponen nutrisi dan fitokimia non nutrisi, dan potensinya pada beberapa kondisi medis telah dilaporkan. Penelitian ini bertujuan mengeksplorasi potensi antidiabetes sari markisa ungu. Penelitian true experimental ini menggunakan 30 ekor tikus putih (Rattus norvegicus) jantan galur Wistar, dibagi 5 kelompok: I) kontrol normal,Â II) kontrol DM, dan III, IV, V perlakuan sari markisa ungu dosis 1,05; 2,1; dan 4,2mL/200gBB/hari melalui sonde, selama 21 hari. Induksi diabetes dengan aloksan intraperitoneal 120mg/kgBB dosis tunggal. Sampel darah diambil sebelum induksi, setelah induksi dan setelah perlakuan, melalui vena infra orbita. Kadar GDP diukur menggunakan spektrofotometer. Uji Wilcoxon terhadap kadar GDP pasca induksi dan perlakuan, didapatkan p=0,000, menunjukkan perbedaan signifikan kadar GDP antar kelompok normal dan DM. Uji Kruskal-Wallis terhadap kadar GDP pasca perlakuan juga demikian, didapatkan p<0,05. Uji post hoc Mann-Whitney: I vs II p=0,006; I vs III p=0,006; I vs IV p=0,045; I vs V p=0,025; II vs III p=0,361; II vs IV p=0,917; II vs V p=0,584; III vs IV p=0,715; III vs V p=1,000; IV vs V p= 0,584, yang berarti perbedaan hanya antara kelompok normal dengan kelompok diabet dengan atau tanpa perlakuan sari markisa ungu, namun tidak ada perbedaan antar kelompok DM tanpa atau dengan perlakuan sari markisa ungu. Kesimpulan penelitian adalah tidak terdapat perbedaan kadar GDP antara kelompok kontrol DM dengan kelompok yang diberi perlakuan sari markisa ungu berbagai dosis.Â

Endothelial Nitric Oxide Synthase 3 (eNOS3) Gene Polymorphisms and Essential Hypertension in Javanese Ethnic Group Arjadi, Fitranto; Aziz, Saefuddin; Muntafiah, Alfi
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Hypertension is still a major public health problem in Indonesia and in several other countries. This disease is caused by multi factorial components involving both environmental and genetic factors. eNOS3 gene is one of the enzymes related to the high prevalence of hypertension. This gene expresses the NOS enzyme which regulates the synthesis of NO. NOS enzyme causes vasodilatation which decreases peripheral resistance and lowers blood pressure. This cross sectional study compared hypertension patients to those with normal blood pressure in the age group of 40-80 years old. The main purpose of this study is to evaluate the influence of eNOS3 gene Glu298Asp allele expression in Javanese ethnic group patients with hypertension. The samples consist of 50 respondents with hypertension and 50 respondents with normotension as control. Data of eNOS3 gene polymorphisms and NO plasma levels from the respondents were analyzed using t-test and chi-square test. Glu298Asp allele genotype variation in eNOS3 gene was detected by PCR-FRLP using primers G894TF and G894TR and the PCR products were cut using Mbol restriction enzymes. Sequencing result of each polymorphism band shows a typical nucleotide sequence compared to the nucleotide sequence of eNOS3 gene in Gen Bank. The results of this study showed no connection between Glu298Asp allele polymorphism in eNOS3 gene with hypertension in Javanese. There was also no relation between eNOS3 gene polymorphisms with high levels of respondents' NO plasma. Average NO plasma level of hypertension patients is 34,53 Âµmol/L, whereas average NO level of normal blood pressure is 32,5 Âµmol/L.Keywords: Allele Glu298Asp, eNOS3 gene, G894T, hypertension, Javanese ethnic, NO plasma levelÂ

Co-Authors Afifah Afifah Arfi Nurul Hidayah Aulia Husna Cahyaningtyas Aulia Okhid Ariza Dita Yulianti Dody Novrial, Dody Edy Priyanto Elok Widyaningtyas Fitranto Arjadi Hani Ismi Damayanti Hernayanti Hernayanti Ika Murti Harini Irwan Nuryadin Johanes Hasian Siahaan Lantip Rujito Lily Burkon Miko Ferrine Muhamad Rifqy Setyanto Muhammad Fakih Muhammad Mukhson Nia Krisniawati Nor Sri Inayati Nor Sri Inayati Octavia Permata Sari Octavia Permata Sari Pratama, Tisna Sendy Prihatno, M. Mukhlis Rudi Qodri Santosa Qodri Santosa Rahmah Fadhilah Asrifqa Saefuddin Aziz Saefuddin Aziz Salsabil Rahmadina Setiawati Setiawati Setya Dian Kartika Sofyan Hardi Tirta Wardana Viva Ratih Bening Ati Wafa Nur Azizah Wahyudin Wahyudin Zeha Kirana

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