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All Journal Ulul Albab: Jurnal Studi Islam Alchemy : Journal of Chemistry El-HARAKAH : Jurnal Budaya Islam Journal of Islamic Pharmacy Science and Technology Indonesia Walisongo Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Jurnal Tumbuhan Obat Indonesia al Kimiya : Jurnal Ilmu Kimia dan Terapan
Elok Kamilah Hayati
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Stability of Biologically Synthesized Silver Nanoparticles (AgNPs) Using Acalypha indica L. Plant Extract as Bioreductor and Their Potential as Anticancer Agents Against T47D Cells Madaniyah, Luailik; Fiddaroini, Saidun; Hayati, Elok Kamilah; Rahman, Moh. Farid; Sabarudin, Akhmad
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.101-110

Abstract

This work investigates the anticancer potential of silver nanoparticles (AgNPs) against T47D cells as well as the stability of AgNPs manufactured using extract from Acalypha indica L. used as a bioreductant. The plant extract was used to produce and stabilize AgNPs, and stability was tracked for 30 days using UV-Vis spectroscopy and Particle Size Analysis (PSA), which included evaluations of extended sun exposure. Transmission Electron Microscopy (TEM) was used to characterize the size and shape of the nanoparticles, and Fourier Transform-Infrared Spectroscopy (FT-IR) was used to determine which functional groups were responsible for stabilization. Despite a gradual size increase, the AgNPs remained stable throughout the study period. The MTT assay confirmed their potent cytotoxicity against T47D cells, underscoring the potential of Acalypha indica-derived AgNPs as stable and effective agents for cancer therapy, offering a promising alternative for novel anticancer treatments.
CYTOTOXIC ANALYSIS OF CAPSAICINOID COMPOUND FROM ROTTEN AND FRESH Capsicum frutescens L. ON T47D CELLS Abrilia, Putri Riza; Hayati, Elok Kamilah; Kadarani, Deva Krisna
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.40821

Abstract

Cayenne pepper has a distinctive spicy and hot taste that indicates the presence of capsaicinoid compounds. The content of capsaicinoid compounds is thought to increase along with the level of maturity. This study aims to distinguish between the capsaicinoid content in Rotten Capsicum Frutescens (RCF) and fresh Capsicum Frutescens (FCF) samples and their use as anticancer agents. Capsaicinoid extraction was performed by using reflux extraction and the identification processes using Thin Layer Chromatography (TLC) with a chloroform:methanol eluent. Identification was conducted by using Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR) while a cytotoxicity test on T47D breast cancer cells was conducted using the Methylthiazol Tetrazolium (MTT) assay. The results showed the presence of a capsaicinoid compound group, with Retardation Factor (Rf) values of 0.76 in RCF and 0.72 in FCF, as well as orange spots due to its reaction to Dragendorff's reagent. ATR-FTIR analysis was able to identify some of typical functional groups typical of capsaicinoid, including -OH, CH3, CH2 (stretching), C=O, C=C, -CH2- (bending), C-N, C-O, O-CH3, and -NH with the intensity value of RCF greater than FCF. The cytotoxicity test results showed that the Inhibition Concentration (IC50) value for RCF isolates was 512.37 µg/mL, while for FCF isolates was1386.82 µg/mL. These results indicate that capsaicinoid isolates from RCF have a higher cytotoxicity compared to isolates from FCF. A higher IC50 value corresponds to lower cytotoxic activity.
CYTOTOXIC ANALYSIS OF CAPSAICINOID COMPOUND FROM ROTTEN AND FRESH Capsicum frutescens L. ON T47D CELLS Abrilia, Putri Riza; Hayati, Elok Kamilah; Kadarani, Deva Krisna
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.40821

Abstract

Cayenne pepper has a distinctive spicy and hot taste that indicates the presence of capsaicinoid compounds. The content of capsaicinoid compounds is thought to increase along with the level of maturity. This study aims to distinguish between the capsaicinoid content in Rotten Capsicum Frutescens (RCF) and fresh Capsicum Frutescens (FCF) samples and their use as anticancer agents. Capsaicinoid extraction was performed by using reflux extraction and the identification processes using Thin Layer Chromatography (TLC) with a chloroform:methanol eluent. Identification was conducted by using Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR) while a cytotoxicity test on T47D breast cancer cells was conducted using the Methylthiazol Tetrazolium (MTT) assay. The results showed the presence of a capsaicinoid compound group, with Retardation Factor (Rf) values of 0.76 in RCF and 0.72 in FCF, as well as orange spots due to its reaction to Dragendorff's reagent. ATR-FTIR analysis was able to identify some of typical functional groups typical of capsaicinoid, including -OH, CH3, CH2 (stretching), C=O, C=C, -CH2- (bending), C-N, C-O, O-CH3, and -NH with the intensity value of RCF greater than FCF. The cytotoxicity test results showed that the Inhibition Concentration (IC50) value for RCF isolates was 512.37 µg/mL, while for FCF isolates was1386.82 µg/mL. These results indicate that capsaicinoid isolates from RCF have a higher cytotoxicity compared to isolates from FCF. A higher IC50 value corresponds to lower cytotoxic activity.
Metabolite Profiling Famili Asteraceae (Kenikir, Bunga Matahari, Krisan) dengan Metode HPTLC dan Principal Component Analysis (PCA) Mutiah, Roihatul; Hayati, Elok Kamilah; Andiartama, Amanda Milano
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.2315

Abstract

Tanaman dari famili Asteraceae di Indonesia memiliki berbagai potensi bioaktif yang tinggi karena kandungan senyawa seperti lakton, alkaloid, dan tanin. Penelitian ini bertujuan untuk menganalisis profil metabolit daun kenikir, bunga matahari, dan krisan yang berasal dari famili Asteraceae dengan pendekatan metabolomik. Ekstrak daun diperoleh melalui ekstraksi ultrasonik dengan etanol 96% dan dianalisis menggunakan High Performance Thin Layer Chromatography (HPTLC). Visualisasi dilakukan dengan menggunakan instrumen TLC Visualizer dan perangkat lunak ImageJ, sehingga menghasilkan densitogram. Profil metabolit dengan HPTLC dan analisis PCA berimplikasi pada penguatan kontrol kualitas dan standarisasi fitokimia melalui autentikasi spesies, identifikasi marker metabolit, serta penjaminan konsistensi mutu produk herbal berbasis Asteraceae. Hasil menunjukkan bahwa terdapat perbedaan jumlah noda dan intensitas warna antar sampel. Hasil PCA menunjukkan sebaran metabolit mengelompok pada area yang berbeda, dengan total variasi 72,5% (PC1 = 56,5% dan PC2 = 15,9%). Analisis Heatmap menunjukkan bahwa ekstrak daun bunga matahari memiliki intensitas senyawa aktif tertinggi, yang ditandai dengan area merah yang lebih pekat akibat nilai AUC tertinggi. Penelitian ini membuktikan bahwa terdeapat perbedaan profil metabolit pada ketiga tanaman yang berasal dari famili yang sama. Kata kunci: Profil Metabolit, Asteraceae, HPTLC, Principal Component Analysis
Tumbuhan dan Hewan: Alternatif Pengobatan Warisan Budaya Islam Hayati, Elok Kamilah
el Harakah: Jurnal Budaya Islam Vol 9, No 1 (2007): EL HARAKAH
Publisher : UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/el.v9i1.4662

Abstract

The use of plants extracts for medicinal purposes has been going on for thousands of years. Some of the plants products currently used, either in their natural form or as derivatives, were often used originally for other purposes, such as part of rituals, drugs, and even cosmetics. Nowadays, there is a tendency of “going back to nature” as a source of alternative medicine. There are two medicine types; first, chemistry medicine (synthetic drug) and natural medicine (natural drug). Between both, natural medicine can stay because it is more peaceful and can be accepted by body because it has small side effects and cheaper. Alquran has been explained that Allah was commanded us to make use of animal and plant as drugs, for example: honey from bee, cumin, grape, ruby, pomegranate, ginger, and olive. This proves that Alquran contains real and correct news and information. Therefore, the animals and plants were chosen as alternative medicine. Penggunaan tumbuhan dan ekstraknya untuk pengobatan telah dilakukan selama ribuan tahun. Beberapa produk tumbuhan yang sekarang digunakan, baik itu dalam bentuk asli maupun produk jadi, sering dimanfaatkan pula untuk tujuan lain seperti ritual, pengobatan, dan bahkan kosmetik. Saat ini, ada kecenderungan “kembali pada alam” sebagai sumber pengobatan alternatif. Ada dua tipe pengobatan. Pertama, kimiawi (obat sintetis) dan alami. Di antara keduanya, pengobatan alami masih bertahan karena lebih menenangkan dan dapat diterima oleh tubuh karena memiliki efek yang minim dan lebih murah. Dalam Alquran telah dijelaskan bahwa Allah menganjurkan manusia untuk memanfaatkan hewan dan tumbuhan sebagai obat-obatan, contohnya: madu dari lebah, jinten, anggur, delima, jahe, dan zaitun. Ini membuktikan bahwa Alquran mengandung berita dan informasi yang benar. Maka dari itu, hewan dan tumbuhan dipilih sebagai obat alternatif.
Effect of Ethanol-water Concentration as Extraction Solvent on Antioxidant Activity of Acalypha indica Fadhila, Salma Iza; Hayati, Elok Kamilah; Rafi, Mohamad; Sabarudin, Akhmad
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 10 No. 2 (2023): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v10i2.30081

Abstract

Acalypha indica is an abundant and obtainable wild weed plant in Indonesia. This is a possible opportunity to enhance its utility. The effect of free radicals is one of the factors that contribute to oxidative stress in the body, which can lead to cell damage and trigger various diseases. Plants rich in antioxidants can inhibit free radical reactions and protect the body from oxidative stress. In this study, we conducted the identification of major metabolite compounds using UHPLC-Q-Orbitrap HRMS from 70% ethanol extracts of Acalypha indica. We also performed phytochemical and antioxidant activity tests with various concentrations of ethanol-water solvents including water, 30%, 50%, 70% ethanol, and absolute ethanol to determine the optimal extraction conditions and the influence of solvent concentration on the antioxidant activity of Acalypha indica extract. The results of UHPLC-Q-Orbitrap HRMS identification showed that the 70% ethanol extract of Acalypha indica contains 10 major compounds suspected to correlate with its antioxidant activity. These include five flavonoids compounds (palasitrin, vitexin 2"-o-p-coumarate, isorhamnetin 3- (3",6"-di-p-coumarylglucoside), peucenin, and sulfuretin), two amino acid compounds (2-amino-3-carboxymuconic acid semialdehyde and N-Acetyl-L-phenylalanine), two carboxylic acid compound (citric acid and traumatic acid), and one phenolic compound (quinic acid). Phytochemical tests show positive results for flavonoids, tannins, alkaloids, and triterpenoids in each of water, 30%, 50%, 70% ethanol, and absolute ethanol extracts. The best antioxidant activity was obtained from the 70% ethanol extract with an IC50 value of 47.064 ppm, categorizing it as an extremely strong antioxidant.
Co-Authors Abdul Hakim Abrilia, Putri Riza Akhmad Sabarudin Akyunul Jannah Alfi Istiqomah, Alfi Andiartama, Amanda Milano Anggraini, Maulinda Putri Datin An Nisa Sukmawati Deva Krisna Kadarani Dewi Yuliani Dewi Yuliani, Dewi Ella Wulandari Fadhila, Salma Iza Fatati, Asnal Fiddaroini, Saidun Fiisyatirodiyah, Fiisyatirodiyah Hidayaty, Alfianita Nuril Himmatul Barroroh Ifaridatul Chusna, Ifaridatul Indradmojo, Chrystiaji Laksono, Muhammad Teguh Latifah Latifah M. Rafi Madaniyah, Luailik Moh. Farid Rahman Muhammad Teguh Laksono Muhibbatul Husnah Muti'ah, Ro’ihatul Muti'ah, Roihatul Nasifah, Ilmin Rachmawati Ningsih Rachmawati Ningsih Roihatul Muti'ah Roihatul Mutiah Roihatul Muti’ah Shofiyullah, Muhammad Susi Nurul Khalifah Tri Kustono Adi Yani Triastutik, Yani