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All Journal Jurnal Ilmu Pertanian Indonesia ComEngApp : Computer Engineering and Applications Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI The Journal of Pure and Applied Chemistry Research Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Chimica et Natura Acta Indonesian Journal of Chemistry Herb-Medicine Journal Chemistry Indonesian Journal of Chemical Research Jurnal Jamu Indonesia Jurnal Pengabdian Kepada Masyarakat Abdi Putra Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.) Indonesian Journal of Jamu
Rudi Heryanto
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, IPB University, Jl. Tanjung Kampus IPB Dramaga, Bogor 16680, Indonesia; Advanced Research Laboratory, Institute Of Research And Community Services, IPB University, Jl. Palem Kampus
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Journal : ComEngApp : Computer Engineering and Applications Journal

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Identification of Significant Proteins Associated with Diabetes Mellitus Using Network Analysis of Protein-Protein Interactions Usman, Muhammad Syafiuddin; Kusuma, Wisnu Ananta; Afendi, Farit Mochamad; Heryanto, Rudi
Computer Engineering and Applications Journal Vol 8 No 1 (2019)
Publisher : Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.82 KB) | DOI: 10.18495/comengapp.v8i1.283

Abstract

Computation approach to identify significance of proteins related with disease was proposed as one of the solutions from the problem of experimental method application which is generally high cost and time consuming. The case of study was conducted on Diabetes Melitus (DM) type 2 diseases. Identification of significant proteins was conducted by constructing protein-protein interactions network and then analyzing the network topology. Dataset was obtained from Online Mendelian Inheritance in Man (OMIM) and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) which provided protein data related with a disease and Protein-Protein Interaction (PPI), respectively. The results of topology analysis towards Protein-Protein Interaction (PPI) showed that there were 21 significant protein associated with DM where INS as a network center protein and AKTI, TCF7L2, KCNJ11, PPARG, GCG, INSR, IAPP, SOCS3 were proteins that had close relation directly with INS.
Co-Authors Aan Setiawati Achmad Fauzi Achmad Fauzi Amalia Yunita Aninda, Dea Aryo Tedjo Azizah, Norma Nur Budi Riza Putra Budi Riza Putra Cecep Abdurohman Putra Debby Rahmawaty Derry Permana Dewa Saepurrahman Dimas Noor Dyah Iswantini Elsa Ramadanti Ervizal AMZU Eti Rohaeti Eti Rohaeti Fadilah Fadilah Fadilah Fadilah, Fadilah Farit Mochamad Afendi Gustian, Dudih Hafshah, Nurul Hanifullah Habibie Irma Herawati Suparto Jihad Hari Katrin Roosita Latifah K Darusman Latifah Kosim Darusman Latifah Kosim Darusman Latifah Kosim Darusman Latifah Kosim Darusman M. Rafi Mardiana, Eni Masriani . Megasari Putri Mohamad Rafi Mohamad Rafi Mohamad Rafi Muhamad Amar Norma Nur Azizah Novia Rahma Noviyanti, Yuthika Rizqi Nurmaida Nurmaida Pitri, Rosiana Putri, Silvi Agusri Ragil, Ragil Ramadhanti, Desi Rany Zalvianita Rico Sihotang Sailendra, Pingkan Ramadhan Septaningsih, Dewi Anggraini Silvi Agusri Putri Siti Sa’diah Sukowati, Siski Andini SUMINAR SETIATI ACHMADI Usman, Muhammad Syafiuddin Wisnu Ananta Kusuma Wulan Tri Wahyuni Yudi Nata Yuthika Rizqi Noviyanti