Article Per Year (5 Year)
p-Index From 2021 - 2026
0.817
P-Index
This Author published in this journals
All Journal Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Nexus Biomedika Nexus Kedokteran Translasional Journal of Maternal and Child Health JURNAL PENDIDIKAN SAINS SOSIAL DAN AGAMA Smart Society Empowerment Journal Plexus Medical Journal Indonesian Journal of Health Research Innovation
Lilik Wijayanti
Unknown Affiliation
Religion Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Other

Published : 15 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Nexus Biomedika

 1 
Uji Sitotoksik Ekstrak Daun Andrographis paniculata Ness. pada Kultur Limfosit T Pasien Systemic Lupus Erythematosus Dedi Febriandaru; Ratih Puspita Febrinasari; Lilik Wijayanti
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Systemic Lupus Erythematosus or SLE is a chronic autoimmune disease with varied clinical manifestations. SLE prevalence in Indonesia is being dominated with female, especially in their productive age. Certain etiology of SLE is still unknown until now, but genetic factors and immune system are being estimated as the primary factors. The first line therapy of SLE is cyclophosphamide. Unfortunately if being consumed more than six months, cyclophosphamide has several side effects, like bone marrow depression, infections, alopecia, hemorrhagic cystitis, and infertility. Because of that side effects, herbal medicine is being developed nowday. One of them is Andrographis paniculata Ness. leaf. The aim of this study was quantitative cytotoxic test for Andrographis paniculata Ness. leaf on T lymphocyte culture of Systemic Lupus Erythematosus. Methods: This study was anexperimental study. Subjects in this study were patients with SLE who appropriated SLEs criterias and normal people without allergy and autoimmune diseasess history. This study was done by doing T lymphocyte culture from intravenouss blood sample and observing cells absorbance with ELISA reader. Collected data were used for determining live cells percentage (IC50) and analyzed with Statistical Product and Service Solution (SPSS) 11.00 for Windows. Mean resistance data was tested by linear regression test. Results:The result showed that IC50 dose of Andrographis paniculata Ness. leaf extract treatment on SLE samples was smaller than the normal people. In Andrographis paniculata Ness. leafs extract treatment, IC50 in SLE = 0.00074 and in normal people = 0.19584. Conclusion: Andrographis paniculata Ness.leaf extract had stronger cytotoxic effect on T lymphocyte culture of patients with SLE than the normal people. Keywords: Systemic lupus erythematosus, Andrographis paniculata Ness. leaf extract, T lymphocytes, IC50
Efek Anti Fungi Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana, Linn.) Terhadap Pertumbuhan Candida Albicans Secara In Vitro Puspaningrum .; FX.Bambang Sukilarso S; Lilik Wijayanti
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: This study aimed to know the inhibitory effect of the etanol extract of mangosteen rind (Garcinia mangostana, Linn.) on the growth of Candida albicans in vitro. Methods: The method used in this study was quasi-experimental laboratory research. The subject was the ethanol extract of the mangosteen fruit (Garcinia mangostana Linn.) rind. Candida albicans grown on sabouraud dextrose agar were treated with 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100% of the ethanol extract of mangosteen rind (Garcinia mangostana, Linn.), as well as fluconazole 25?g (drugs that were already on the market) as positive control for 24 hours at 37 C on petri dish. The data of diameter of inhibition zone obtained were analyzed with regression-correlation test using SPSS 11.5 for windows. Results: The diameters of inhibition zone on culture of Candida albicans treated with the ethanol extract of the mangosteen fruit with concentration of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, and fluconazole 25?g were 0 mm, 0 mm, 1.75 mm, 1.75 mm, 2.00 mm, 2.00 mm, 3.00 mm, 3.50 mm, 3.75 mm, 3.75 mm and 0 mm, in a row. The regression-correlation analysis showed that the correlation (r) between the diameter of inhibition zone and the levels of ethanol extract of mangosteen rind was 0.936 (p 0.000). Conclusion: The ethanol extract of mangosteen rind (Garcinia mangostana, Linn.) had antifungal effect on the growth of Candida albicans in vitro. Keywords: antifungal effects, ethanol extract of mangosteen rind (Garcinia mangostana Linn.), Candida albicans.
Co-Authors . Suparman Abdurahman Laqif Adhi, Muhammad Alif Ibadurrohman Adhi Adinda Ferinawati Agus Soedomo Ahmad Afiyyuddin N Amanda Putri Ramadhani Auxana Qudsi Cr. Siti Utari Dedi Febriandaru Dicky Budi Nurcahya Dinda Husna Azalia Soesetyo Elga Putri Indanarta Endang Listyaningsih S Endang Listyaningsih Suparyanti Eric Edwin Yuliantara FX.Bambang Sukilarso S Hesti Sadtyadi Mohammad Fanani Muhammad Adrianes Bachnas Muhammad Riza Mutiara Rizky Ananda Puspaningrum . Ratih Puspita Febrinasari Sigit Setyawan Siti Marufah Siti Munawaroh Sri Haryati Sugeng Purnomo Sukarti Sukarti Totok Siswanto Valentina Lakhsmi Prabandari Widia Susanti Yulia Sari Yusuf Budi Hermawan Yusvick M. Hadin