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Journal : Science and Technology Indonesia

Synthesis of a 3D Porous Multicomponent Bioceramic Scaffold Sari, Yessie Widya; Munir, Ryaas Mishbachul; Saputra, Angga; Sari, Mona; Aminatun; Suciati, Tri; Mohamad, Che Wan Sharifah Robiah; Gunawarman; Yusuf, Yusril
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.235-243

Abstract

In this study, 3D porous multicomponent bioceramic scaffolds were fabricated. Hydroxyapatite (HA) and carbonate-substituted hydroxyapatite (CHA) synthesized from Asian moon scallop shell (Amusium pleuronectes) served as the bioceramics, whereas alginate and chitosan served as the polymeric components. The study was focused on determining whether the presence of polyvinyl alcohol (PVA) in the scaffold exerted an impact. When PVA was not included, the morphological examination revealed that the samples exhibited porous structures characterized by effective pore interconnectivity and a substantial pore size. X-ray diffraction and scanning electron microscopic analyses indicated that the inclusion of PVA led to a decrease in the crystallinity, pore size, and porosity of the scaffolds. Those containing PVA exhibited porosity levels in the range of 56%–60%, and pore sizes ranged from 42 to 90 µm. These properties may provide advantages for the scaffold with respect to the ability for cell migration and cell attachment, thus enhancing new bone formation. Moreover, the compositions of HA and chemically modified HA (CHA) within the scaffold influenced the crystallinity and uniformity of the scaffold morphology. This finding suggests the potential for crafting a customized porous bioceramic scaffold based on specific compositions.
Co-Authors Abdurrahman Bahtiar Agus Sukarto Wismogroho Agus Sukarto Wismogroho, Agus Sukarto Ahmed, Ifty Akhiruddin Maddu Akmal, Raihan Muhammad Aminatun Aminuddin Aminuddin Angga Saputra Aprilianda, Aprilianda Aribah, Putri Arief Boediono Attar, Zia Rausyanfikr Azahra, Annisa Nur Bambang Sugeng Bayah, Salsabilla Permata Berlianingtyas, Dani Indrawati Berry Juliandi Budiman, Ismail Cahayadi, Sigit Daru Charlena Cherly Firdharini Christina Winarti Dase Hunaefi Dimyati , Arbi Djaja Surya Atmadja Djarwani S. Soejoko Djarwani Soeharso Soejoko Elbersen, Wolter Faleh Setia Budi Fauji, Muhamad Iqbal Firdharini, Cherly Gunawarman Hartman, Rohul Rizki Mubaroq Hendrawan Laksono Hidayah, Mohamad Ikbal Husin Alatas Ibrahim Purawiardi, Ibrahim Ilham Akbar Ibrahim Irma Herawati Suparto Irmanida Batubara Jayadi Jayadi Julia, Siti Kiagus Dahlan laela Sari, laela Lubis, Lukmanda Evan Luthfiana, Widya Mersi Kurniati Mohamad, Che Wan Sharifah Robiah Munawaroh, Fauziyatul Munir, Ryaas Mishbachul Nabila, Pristy Tasya Noviani Rustanto Nurhayati, Retno Wahyu Nurizati Nurizati Nuzulia, Nur Aisyah Nuzulia, Nur Aisyah Purawiardi , Ibrahim Putri, Desi Alifia Reza Pahlevi Rudianto Riano, Riza Rina Mardiana Santoso, Zahra Firda Sari, Mona Savitri Damayanti Serin Imsa Arizuni Setia Utami Dewi Sharly Claudia Alghai Sani Sihono, Dwi Seno Kuncoro Sulistioso Giat Sukaryo Sulistioso Giat Sukaryo, Sulistioso Giat Tri Suciati Wahyu Bambang Widayatno Wahyu Bambang Widayatno, Wahyu Bambang Widyarani, Widyarani Wulan Islamia Wulan Tri Wahyuni Yusril Yusuf Yusuf , Yusril zuldian, prima