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All Journal Jurnal Tumbuhan Obat Indonesia Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmascience Indonesian Journal of Chemical Science Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmiah Cendekia Eksakta Jurnal Abdi Insani Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Kefarmasian Indonesia

Devi Nisa Hidayati

Universitas Wahid Hasyim

Author-ID : 281750

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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AKTIVITAS ANTIJAMUR KRIM EKSTRAK ETANOL DAUN JAMBU MONYET (Anacardium occidentale L.) DAN KULIT BATANG RAMBUTAN (Nephelium lappaceum) TERHADAP Candida albicans Devi Nisa Hidayati; Ulya Felasufah; Amaliyah Ayu Nurfitriani; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Ethanol extract of Anacardium occidentale and rambutan bark (Nephelium lappaceum) proved to have antifungal activity agains Candida albicans. Efforts to improve comfort and ease of use then made in the form of cream formulation.The aim of study is to know the antifungal activity of cream with various concentration of Anacardium occidentaleleaf extract and rambutan bark againstCandida albicans. Extraction of ethanol extractAnacardium occidentale leaf (EAOL) and rambutan bark (ERB) used maceration method. Solvents used ethanol 70% and ethanol 96%, respectively. Formulation cream of EAOL and ERB was maked 3 formulation. Formulation cream EAOL with concentration of variations extract are FI (10,5%), FII (12,5%), FIII (14,5%). Formulation cream ERB with concentration of varions extract are FI (10%), FII (15%), FIII (20%). Antifungal activity was determined in the cream using agar diffusion method and zone of inhibitionwere analyzed using descriptive. The results showed that antifungal activity against Candida albicans of cream EAOL concentration 14,5% with zone of inhibition is 7,16 ± 0,28 mm and cream ERB concentration 20% with zone of inhibition is 9,5 ± 0,5 mm. Kata Kunci : Antifungal, Anacardium occidentale, Nephelium lappaceum, Formulation ofcream

PENINGKATAN EFEK ANTIHIPERTENSI KAPTOPRIL OLEH EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) PADA TIKUS HIPERTENSI YANG DIINDUKSI MONOSODIUM GLUTAMAT Devi Nisa Hidayati; Yance Anas; Siti Nurikha
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Hypertension is one of the degenerative disease of health problem in among people. Bilimbi leaves (Averrhoa bilimbi L.) is one of plants which is have antihypertension effect and contains phytol, dietil phtalat, flavonoid. This research is aimed to know influence of ethanol extract of bilimbi leaves (EEBL) through its on the increase of the antihypertensive effect of captopril in hypertensive rats. This research used a pre-test and post-test matched control group design. Sample were 30 male Wistar rats treated with MSG 100 mg/kgBW/day (po) for 14 days to induce hypertension. Hypertensive rats were divided into six treatment groups are hypertension control group (0.5% CMC-Na 12.5 mL/kgBW/day) and positive control group (captopril 2.5 mg/kgBW/day), and treatment hypertensive rats EEBL (60 and 120) mg/kgBW/day, combination of EEBL-captopril (60+2.5)mg/kgBW/day and combination EEBL-captopril (120+2.5) mg/kgBW/day. Suspension test were given for 14 days. Observed data is a decrease in blood pressure after giving of the suspension test. Data analysis was performed with the parametric t-test paired and nonparametric Wilcoxon with 95% level of confidence. The result shows that MSG can be as inducer of hypertension. EEBL (60 and 120) mg/kgBW/day has antihypertensive effect. The increase antihypertensive effect of captopril on systolic blood pressure is showed in the treatment EEBL 120 mg/kgBW/day. Keywords: Hypertension, Monosodium glutamate, Averrhoa bilimbi L.

FORMULASI TABLET HISAP EKSTRAK ETANOLIK DAUN KEMANGI (Ocimum sanctum L.) DENGAN VARIASI PEMANIS MANITOL DAN LAKTOSA Devi Nisa Hidayati; Lusyana Setiawati Marwan; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Holy basil leaves (Ocimum sanctum L.) traditionally used by the people as a stomatitis aphtosa medication. Bacteria could cause stomatitis aphtosa. Flavonoids in holy basil leaves had antibacterial activity. The usage of holy basil leaves traditionally were not practice so formulated more acceptable such lozenges. Acceptability is influenced by a taste. This study aims was to determine sweeteners variations which is mannitol and lactose from the lozenges formulation of holy basil leaves extract on the physical properties and the level of consumer acceptance taste. Holy basil leaves extract made by maceration method using 70% ethanol. Lozenges made within 5 based on the variation concentration of mannitol and lactose are FI (100%:0%), FII (75%:25%), FIII (50%:50%), FIV (25%:75%), dan FV (0%:100%) and manufactured by wet granulation method. The granules obtained were tested for physical properties include flowability, angle of repose, and compressibility. The tablets obtained were tested for physical properties including weight uniformity, hardness, friability, dissolve time, responsive taste test, and the active substance with TLC methods. The data obtained were analyzed statistically using one way ANOVA and Kruskal Wallis, except acceptability taste analyzed descriptionally. The results showed that all formulas provide lozenges which conform the quality specification. Lozenges most accepted by the respondents was formula I. Keywords: holy basil leaves, lozenges, mannitol, lactose

UJI SITOTOKSISITAS FRAKSI ETIL ASETAT EKSTRAK ETANOL HERBA ALFALFA (Medicago sativa L.) TERHADAP SEL KANKER PAYUDARA T47D DAN SEL KANKER LEHER RAHIM (SEL HeLa) SERTA UJI KANDUNGAN SENYAWA KIMIANYA Devi Nisa Hidayati; Ibrahim Arifin; Sri Susilowati Susilowati
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif"
Publisher : Universitas Wahid Hasyim Semarang

Kanker payudara dan kanker leher rahim merupakan jenis penyakit ganas di Indonesia maupun dunia. Penelitian ini bertujuan untuk mengetahui potensi sitotoksik fraksi etil asetat dari ekstrak etanol herba alfalfa terhadap sel kanker payudara (sel T47D) dan sel kanker leher rahim (sel HeLa) serta mengetahui kandungan kimianya. Proses ekstraksi herba alfalfa dilakukan dengan metode sokletasi menggunakan pelarut etanol kemudian dilanjutkan fraksinasi secara bertingkat menggunakan n-heksan, kloroform, dietil eter dan etil asetat. Uji sitotoksisitas menggunakan metode MTT dengan seri konsentrasi fraksi uji 1000; 500; 250; 125; 62,5 µg/ml terhadap kultur sel T47D dan sel HeLa. Data berupa absorbansi sel hidup digunakan untuk menghitung persentase kehidupan sel T47D dan sel HeLa kemudian ditetapkan IC50 dengan analisis probit menggunakan SPSS 16 for Windows. Uji kandungan kimia dilakukan dengan pereaksi kimia kemudian dilanjutkan dengan kromatografi lapis tipis (KLT). Hasil penelitian menunjukkan bahwa fraksi etil asetat ekstrak etanol herba alfalfa memiliki efek sitotoksik terhadap sel T47D namun tidak memiliki efek sitotoksik pada sel HeLa. Potensi sitotoksik fraksi etil asetat ekstrak etanol herba alfalfa terhadap sel T47D yang dinyatakan dalam nilai IC50 sebesar 1893,4 µg/ml. Fraksi etil asetat dari ekstrak etanol herba alfalfa mengandung flavonoid. Kata kunci: Uji sitotoksisitas, fraksi etil asetat ekstrak etanol herba alfalfa (Medicago sativa L.), sel T47D, sel HeLa, flavonoid

IDENTIFIKASI AWAL POTENSI EKSTRAK ETANOL RIMPANG JAHE MERAH (Zingiber officinale Rosc. var. rubrum) SEBAGAI OBAT OSTEOPOROSIS Aqnes Budiarti; Devi Nisa Hidayati; Nur Aini
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Reduced bone density is an indication of osteoporosis. The study of osteoporosis is conducted by measure the influence of triggering compound to the enhancement of bone density of ovariectomized rat that have been lifted ovaries. Ovariectomy caused rats have been deficiency of estrogen hormone whose function to maintain bone density.Compound that can increase bone density has the potential as osteoporosis drug. Red ginger rhizome contains flavonoid compound as phytoestrogen whose estrogenic effect that can replace the function of estrogen. Flavonoid is easy to be solved in ethanol so that was extracted using ethanol. The purpose of this study was to measure the enhancement of bone density of ovariectomized rats due to the trigger of ethanol extract of red ginger (EERJM). Research was conducted experimentally to the female Wistar rats by the post test only controlled group design. Treatment was given for 30 days and the determination of bone density using Dual X-Ray radiography method. Data of bone density values were statistically analyzed by One Way ANOVA followed by Tukey test. The results showed that the administration of EERJM dose 500 and 1000 mg/kg BW enhanced bone density of ovariectomized rat. Keywords: bone density, ovariectomized rat, red ginger, osteoporosis

AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) DAN DAUN ANGSANA (Pterocarpus indicus Wild.) PADA MENCIT JANTAN GALUR BALB/C Yance Anas; Devi Nisa Hidayati; Aristya Kurniasih; Lalu Ksatria D.S.
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Traditionally, jackfruit leaves (Artocarpus heterophyllus Lam.) and angsana leaves (Pterocarpus indicus Wild.) have been used as an herb for diarrhea treatment. The purpose of this experimental study was to investigate the antidiarrheal effect of jackfruit leaves ethanol extract (JLEE) and angsana leaves ethanol extract (ALEE) on Balb/C male mice with castor oil-induced diarrhea method. The study design is a randomized matched two group post test-only. JLEE and ALEE produced by maceration. An antidiarrheal activity of both of extracts compared with loperamide-HCl 10 mg/Kg BW. JLEE (100, 200 and 400) mg/Kg BW and ALEE (80, 160 and 320) mg/Kg BW significantly (p <0.05) decrease the amount of liquid and soft feces, and delay the onset of diarrhea compared with controls (NaCl 0.9% 10 mL/Kg BW). The ability JLEE 400 mg/Kg BW and EEDA 320 mg/Kg BW on inhibiting the formation liquid and soft feces are higher than loperamide HCl 10 mg/Kg BW with antidiarrheal effect amounted to 72.31%, 65.47%, and 54.46% respectively. The potency of JLEE and ALEE as antidiarrheal (ED50) are (20.85 and 3.52) mg/Kg BW respectively. However, in this study, a single dose of loperamide-HCl, JLEE and ALEE treatments are not able to heal the diarrhea symptom (p> 0.05). Keywords: Antidiarrheal, castor oil-induced diarrhea,ethanol extract, Artocarpus heterophyllus Lam., Pterocarpus indicus Wild.

AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN DAN KULIT BATANG BERENUK TERHADAP Bacillus cereus Devi Nisa Hidayati; Cicih Sumiarsih; Umroh Mahmudah; Anita Dwi Puspitasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTThe plants (Crecentia cujete Linn) Are known to have antibacterial activity and can be used as a diarrhea drug due to microorganisms. Bacillus cereus is one of the bacteria that causes diarrhea.This aims to the study was antibacterial activity of ethanol extract of leaves (EL) and bark broodstock (EB) on Bacillus cereus. EL and EB were extracted with ethanol 96% using maceration method. Antibacterial activity test was carried out with disk diffusion method in EL with a concentration of 30%, 60%, 90%, 120% and 150%, and in EB using concentrations of 60%, 70%, 80%, 90% and 100% then antibacterial activity measurements were taken. by looking at the Diameter of the Inhibitory Area (DDH). The results of the EL and EB of antibacterial activity proved that EL and EB berenuk have antibacterial activity against Bacillus cereus.Keywords: Antibacterial, Crescentia cujete Linn, Bacillus cereus.

TOKSISITAS AKUT INFUSA KULIT ARI KACANG TANAH (Arachis hypogea L.) PADA MENCIT BALB/ C Risha Fillah Fithria; Ririn Lispita Wulandari; Devi Nisa Hidayati; Lilis Rejeki
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPeanut shell (PS) infusion has been shown to be antithrombocytopenia, but there has been no research on safety standards. This study aims to identify the symptoms of toxic effects, the potency of toxicity and histopathology of liver male Balb/C mice after a single dose of PS infusion. This research uses randomized matched posttest only control group design. Twenty five mice were divided into 5 orally dosage groups, ie, PS infusion with a dose of 0,026; 0.052; 0.104; 0.208 g/20gBW; and negative control of CMC Na 0.5%. The observation period is for 14 days. The results showed that single dose of PS infusion had a pseudo LD50 value ie > 0.208g/20gBW which was practically non toxic. Symptoms to watch out for the BW infusion were passive behavior, bradycnea, hair color change, hair loss, and weight loss at doses of 3 and 4. It is unclear whether liver damage ie inflammation, necrosis, and albuminous degeneration caused by PS infusion or other causes.keywords: acute toxicity, infusion, peanut shell

Co-Authors Alviani, Dwi Lutvi Amalina Firdaus Amaliyah Ayu Nurfitriani Anita Dwi Puspitasari Aqnes Budiarti Aristya Kurniasih Awal Prichatin Kusumadewi Aysah Safitri Cicih Sumiarsih Cicih Sumiarsih Dewi Andini Kunti Mulangsri, Dewi Andini Kunti Dwi Lutvi Alviani Edy Meiyanto Erika Indah Safitri Esa Evinda Fatimatuz Zahroh Fatimatuz Zahroh Fauzizah, Nisa Ferry Sandra Fikriyyah, Shafa Fini Hartanti Fitriasih Fitriasih Fitriasih Fitriasih Gharsina Ghaisani Yumni Hanik Rohmatul Maghfiroh Hartanti, Fini Ibrahim Arifin Ibrahim Arifin Jenie, Riris Istighfari K. M., Dewi Andini Komariyatun, Siti Laili Nailul Muna Laili Nailul Muna Lalu Ksatria D.S. Lilis Rejeki Lina Wahyuni Lina Wahyuni Lusyana Setiawati Marwan Masita Nur Amalia Putri Mufrod Mufrod Nenni Pratiwi Nenni Pratiwi Nilam Eka Putri NUR AINI Nur Kussamawari Ardian Nur Rahayu Fitriana Nurul Hidayati Parusiza, Intan Meyta Pasha, Salsabilla Putri Buana Pia Annisa Pramesti Dewi Putri, Masita Nur Amalia Rahayu, Putri Rahmatun, Mutia Ririn Lispita Wulandari Riris Istighfari Jenie risha fillah fithria Rumiyati Rumiyati Salsabiila, Iqna Salsabila, Unik Hanifah Siti Mega Komariah Siti Mega Komariyah Siti Nurikha Siti Wahidatun Nisa Sri Susilowati Sufa , Riisyda Faila Sugiyono - Surayya, Anis Syahrul Iqbal Setiawan Ulya Felasufah Umroh Mahmudah Umroh Mahmudah Yance Anas Yuni Antika

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