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All Journal Jurnal Sosialisasi: Jurnal Hasil Pemikiran, Penelitian dan Pengembangan Keilmuan Sosiologi Pendidikan Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Equilibrium: Jurnal Pendidikan Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Cendekia Eksakta Pinisi Business Administration Review Daengku: Journal of Humanities and Social Sciences Innovation Jurnal Ilmiah Bakti Farmasi Social Landscape Journal Media Farmasi Indonesia Pinisi Journal of Sociology Education Review The Journal of Anti Money Laundering and Countering The Financing of Terrorism (AML/CFT Journal) Jurnal Pengabdian Masyarakat Ininnawa: Jurnal Pengabdian Masyarakat PARTICIPATORY Borneo Journal of Pharmacy Paramacitra : Jurnal Pengabdian Masyarakat DISCOURSE : Indonesian Journal of Social Studies and Education EDUSOS: Jurnal Edukasi dan Ilmu Sosial Journal of Pharmascience
Ibrahim Arifin
Fakultas Farmasi, Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Ursolic Acid Enhances Doxorubicin Cytotoxicity on MCF-7 Cells Mediated by G2/M Arrest Arifin, Ibrahim; Hermawan, Adam; Ikawati, Muthi; Haryanti, Sari; Anindyajati, .; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 3, No 3 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Ursolic acid has been widely known to possess biological activity against numerous tumor cell lines. Previous studies revealed its cytotoxicity on several cancer cells  in vitro by either inducing apoptosis or cell cycle modulation. This  study was conducted to investigate ursolic  acid’s  cytotoxicity  solely  and  in  combination  with  a  chemotherapeutic  agent, doxorubicin,  on  MCF-7  breast  cancer  cells,  followed  by  observation  on  its  mechanism. Cytotoxicity of single and combinational treatment of ursolic acid and doxorubicin on MCF-7 breast cancer cells were conducted by using MTT assay. Single treatment was then evaluated by  determining  IC50  value,  while  combinational  treatment  was  evaluated  by  analyzing  cell viability  and  evaluating  combination  index  (CI).  To  explore  the  mechanism  underlying cytotoxic  effect  on  respected  cells,  further  analysis  on  cell  cycle  profile  of  single  and combinational treatment was conducted by flow cytometry. Twenty four hours treatment of ursolic  acid  inhibited  MCF-7 cells’ growth with  IC50  value  of  37  µM,  while  combinational treatment  showed  that  several  concentration  combinations  of  ursolic  acid  and  doxorubicin exhibited  synergism  of  cytotoxic  activity  on  MCF-7  cells,  giving  optimum  CI  value  of  0.54. Flow cytometric analysis showed that combinational treatment induced G2/M arrest in MCF-7  cells.  These  results  show  that  ursolic  acid  is  promising  to  be  developed  as  either  single chemopreventive  agent,  or  as doxorubicin’s co-chemotherapeutic  agent  in  breast  cancer treatment.  Observation  on  the  selectivity  as  part  of  safety  aspect  together  with  in silico,  in vitro, and in vivo study on its molecular mechanism should be conducted.Keywords: ursolic acid, doxorubicin,co-chemotherapeutic agent, breast cancer, cell cycle
EFEKTIFITAS PENGGUNAAN MEDIA PEMBELAJARAN DALAM MENINGKATKAN HASIL BELAJAR SISWA PADA MATA PELAJARAN SOSIOLOGI DI SMA NEGERI 1 SINJAI UTARA Arifin, Ibrahim
Jurnal Sosialisasi: Jurnal Hasil Pemikiran, Penelitian dan Pengembangan Keilmuan Sosiologi Pendidikan Volume 1, Edisi 1, Juli 2014
Publisher : Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26858/sosialisasi.v1i1.2530

Abstract

Tujuan yang hendak dicapai dalam penelitian ini adalah, untuk mengetahui efektifitas penggunaan media pembelajaran dalam meningkatkan hasil belajar siswa pada mata pelajaran sosiologi di SMA Negeri 1 Sinjai Utara. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian eksperimen. Metode eksperimen digunakan untuk mengetahui efektifitas penggunaan Media Pembelajaran dalam meningkatkan hasil belajar dan siswa di SMA Negeri 1 Sinjai. Desain eksperimen yang digunakan adalah Pre-Experimental. Adapun jenis desain yang digunakan oleh peneliti adalah One Group Pretest and One Group Posttest Design. Berdasarkan hasil analisis data menunjukkan bahwa nilai pretest lebih rendah dari nilai posttest. Ini memperlihatkan sebelum penggunaan Media Pembelajaran dalam proses belajar mengajar nilai rata-rata siswa hanya sebesar 57,13 yang berada dalam kategori cukup. Namun setelah memberikan perlakuan dengan menggunakan Media Pembelajran nilai rata-rata siswa pada posttest menjadi 78,01 yang berada pada kategori baik. Sehingga, terdapat peningkatan yaitu sebesar 36.54%. Hal ini membuktikan, penggunaan Media Pembelajaran pada mata pelajaran sosiologi effektif untuk meningkatkan hasil belajar siswa pada mata pelajaran sosiologi Kata Kunci: Media pembelajaran, hasil belajar, sosiologi, pre-eksperimental 
Ursolic Acid Enhances Doxorubicin Cytotoxicity on MCF-7 Cells Mediated by G2/M Arrest Ibrahim Arifin; Adam Hermawan; Muthi' Ikawati; Sari Haryanti; Anindyajati Anindyajati; Edy Meiyanto
Indonesian Journal of Cancer Chemoprevention Vol 3, No 3 (2012)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev3iss3pp410-418

Abstract

Ursolic acid has been widely known to possess biological activity against numerous tumor cell lines. Previous studies revealed its cytotoxicity on several cancer cells in vitro by either inducing apoptosis or cell cycle modulation. This study was conducted to investigate ursolic acid’s cytotoxicity solely and in combination with a chemotherapeutic agent, doxorubicin, on MCF-7 breast cancer cells, followed by observation on its mechanism. Cytotoxicity of single and combinational treatment of ursolic acid and doxorubicin on MCF-7 breast cancer cells were conducted by using MTT assay. Single treatment was then evaluated by determining IC50 value, while combinational treatment was evaluated by analyzing cell viability and evaluating combination index (CI). To explore the mechanism underlying cytotoxic effect on respected cells, further analysis on cell cycle profile of single and combinational treatment was conducted by flow cytometry. Twenty four hours treatment of ursolic acid inhibited MCF-7 cells’ growth with IC50 value of 37 µM, while combinational treatment showed that several concentration combinations of ursolic acid and doxorubicin exhibited synergism of cytotoxic activity on MCF-7 cells, giving optimum CI value of 0.54. Flow cytometric analysis showed that combinational treatment induced G2/M arrest in MCF-7 cells. These results show that ursolic acid is promising to be developed as either single chemopreventive agent, or as doxorubicin’s co-chemotherapeutic agent in breast cancer treatment. Observation on the selectivity as part of safety aspect together with in silico, in vitro, and in vivo study on its molecular mechanism should be conducted.Keywords: ursolic acid, doxorubicin,co-chemotherapeutic agent, breast cancer, cell cycle
The Effect of Marigold Leaves and Doxorubicin Toward Cell Cycle and Apoptosis of T47D Cells Anis Fauzia; Umi Any Tiyas Wati; Cahyaning Gita Rizkita; Eka Wahyuni Nurul Qori'ah; Ibrahim Arifin
Indonesian Journal of Cancer Chemoprevention Vol 7, No 3 (2016)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev7iss3pp79-86

Abstract

Doxorubicin is a commonly used chemotherapeutic agent in patients with breast cancer. The risk of side effect using of doxorubicin  such as cardiomyopathy and congestive heart failure which can lead to death. One of the  approach to overcome overloaded use of doxorubicin is the combined use with a chemopreventive agent (cochemotherapy), including the leaf extract of marigolds (Cosmos caudatus Kunth.). This research aims to reviewing the effect of the methanol extract of leaves of marigolds on the cytotoxic activity of doxorubicin in modulating cell cycle and apoptosis of breast cancer cells T47D. Determination of the cytotoxic activity of methanol extract of leaves of marigolds and doxorubicin as well as a combination of both conducted by MTT assay. modulation surveillance of cell cycle and apoptosis induction is done by using flowcytometry and analyzed by FACS Calibur program. Cytotoxicity assay single treatment of the methanol extract of leaves of marigolds produce use values of IC50 504,840 μg/ml, whereas IC50 values doxorubicin is 141,055 nM. The synergistic effect was shown a combination of methanol extract leaves marigolds and doxorubicin at concentrations of 84,17 μg/ml -23,5 nM; 84,17 μg/ml -47 nM; 126,25 μg/ml -23,5 nM; 252,5 μg/ml -35,25 nM and 252,5 μg/ml -71 nM with a combination index value (CI) consecutively of 0,5; 0,6; 0,6; 0,6 and 0,6. Observations modulation of cell cycle and apoptosis induction combination of methanol extract leaves marigolds and doxorubicin at concentrations of 84,17 μg/ml -23,5 nM, said that a combination of the methanol extract of leaves of marigolds and doxorubicin to inhibit the proliferation of cells in G2 / M phase and able to induce apoptosis of breast cancer cells T47D.Keywords: methanol extract of leaves of marigolds, doxorubicin, flowcytometry, cell cycle, apoptosis.
Decreas of BCL-2 Expression by Ethanol Extract of Ocinum basilicum L. Leaves in Breast Cancer Cells Devi Nisa Hidayati; Fatimatuz Zahroh; Lina Wahyuni; Ibrahim Arifin
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i1.2491

Abstract

Ocimum basilicum L has proven to have in vitro cytotoxic activity against breast cancer cells. Pathways that cause cell death can involve one of the proteins, which is BCL-2. This study aims to determine the decrease of BCL-2 protein expressions in breast cancer cells (T47D and MCF-7) tat are treated with the ethanol extract of Ocimum basilicum L. Ocimum basilicum L. was extracted using the maceration method with 70% ethanol solvent. The concentration of ethanol extract of Ocimum basilicum L. used to see the expression of BCL-2 protein in T47D and MCF-7 cells was 199 µg/ml and 388 µg / mL. The observation of BCL-2 protein expression is using immunocytochemical methods of T47D and MCF-7 cancer cells. The results showed that the ethanol extract of Ocimum basilicum L could reduce BCL-2 protein expression in breast cancer cells (T47D and MCF-7) at concentrations of 199 µg/ml and 388 µg/ml, respectively.
STABILITAS KIMIA MIKROEMULSI MINYAK BIJI PALA (Myristica fragrans) DENGAN TWEEN 80 DAN ETANOL SEBAGAI SURFAKTAN DAN KOSURFAKTAN Arifin, Ibrahim; Muddiin, Muhammad Imaa; Kabur, Savio Ricardus; Shabrina, Ayu
CENDEKIA EKSAKTA Vol. 9 No. 1 (2024)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v9i1.12059

Abstract

Minyak biji pala (Myristica fragrans) merupakan minyak atsiri yang memiliki stabilitas rendah dalam penyimpanan sehingga perlu diformulasikan dalam mikroemulsi. Kombinasi tween 80 dan etanol dapat meningkatkan stabilitas mikroemulsi. Penelitian ini bertujuan untuk mengetahui stabilitas kimia mikroemulsi minyak biji pala (MMBP) dengan variasi tween 80-etanol. MMBP dibuat dengan konsentrasi minyak biji pala 6,4 % dan variasi konsentrasi tween 80-etanol FI (45 %), FII (50 %), dan FIII (55 %). MMBP diuji stabilitas pada suhu ruangan 25 °C ± 2 RH 65 % ± 5 % dan suhu dingin 4°C ± 2 selama 28 hari penyimpanan. Evaluasi meliputi aktivitas antioksidan (% inhibisi) yang dianalisis secara statistik dan deteksi kandungan menggunakan Gass Chromatography Mass Spectrophotometer (GCMS) yang dijabarkan secara deskriptif. Data % inhibisi menunjukkan bahwa aktivitas antioksidan MMBP stabil selama 28 hari penyimpanan dengan kisaran 69,55 ± 2,41 hingga 76,59 ± 1,82% penghambatan. GC-MS MBP murni terdapat 25 senyawa terpene didominasi sabinene; α-Pinene; β-Phellandrene dan terpinene. Hasil GCMS pada seluruh formula menunjukkan komponen dominan dengan % area tertinggi α-Pinene(RT: 3,45-3,66) ; β-Phellandrene (RT: 4,51 dan 4,97) serta myristicine (RT: 7,66-7,98). Minyak biji pala dalam sistem mikroemulsi dengan tween 80 dan etanol (1:1) stabil selama 28 hari penyimpanan pada suhu ruang.Kata kunci: Mikroemulsi, minyak biji pala, stabilitas kimia
Penggunaan Hasil Tindak Pidana untuk Sumbangan Dana Pemilu Arifin, Ibrahim
AML/CFT Journal : The Journal Of Anti Money Laundering And Countering The Financing Of Terrorism Vol 2 No 2 (2024): Produk Intelijen Keuangan Menjawab Tantangan Pengungkapan Pidana Pencucian Uang
Publisher : Pusat Pelaporan dan Analisis Transaksi Keuangan (PPATK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59593/amlcft.2024.v2i2.169

Abstract

The utilization of proceeds from criminal activities for political campaign purposes in the context of General Elections, as donations from external sources, is feasible under money laundering practices. Relevant criminal provisions addressing this issue include Article 339, paragraph (1) of letter c of the Election Law, Article 5, paragraph (1) of the Money Laundering Law, and Article 137 of the Narcotics Law. Given that these provisions are lex specialis, it is essential to elucidate the parameters that will guide law enforcement officials in addressing the use of criminal proceeds for political campaigns and other electoral contests. This research employs normative juridical legal methods, focusing on an inventory of positive law. The findings indicate that the lex specialis derogat legi generali principle applies in implementing Article 339 paragraph (1) letter c of the Election Law, particularly concerning campaign participants receiving campaign fund donations from criminal activities. Article 5, paragraph (1) of the Money Laundering Law pertains to individuals who receive money or assets from criminal activities without the election participants' status. Election participants who accept the proceeds of crime for campaign funds may be suspected of being active perpetrators of money laundering or as parties who commit or facilitate money laundering.
The Impact of Consumer Knowledge in Making Decisions to Purchase Tupperware Environmentally Friendly Products in Makassar City Syukur, Muhammad; Seppa, Yusi Irensi; Arifin, Ibrahim
Pinisi Business Administration Review Volume 5 Nomor 2, September 2023
Publisher : Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26858/pbar.v5i2.50509

Abstract

Study This aim For know impact from knowledge consumer in taking decision purchase product friendly Tupperware environment in Makassar City. Type research used  is study qualitative descriptive that can help researcher with explain the realities on the ground. Data collection techniques in the form of Observation , Interview and Documentation . Data analysis techniques in the form of stage First data reduction process that focuses on selecting , simplifying , abstracting and transforming raw data from notes field . Stage second is presentation of data, ie drafting information become possible statement withdrawal conclusions , and the third stage is drawing conclusions based on data reduction and presentation. Research results show that knowledge consumer give impact positive in taking decision purchase product friendly Tupperware environment in Makassar City. it can seen from knowledge product , knowledge purchasing and knowledge usage which is part from knowledge consumers who have partially owned  big informants/  consumers . With own knowledge consumers , understanding , and confidence consumer about marketed Tupperware products , then will affect behavior consumer in buy so that consumer will take decision related purchase product with buy desired Tupperware product . . Keywords : Knowledge , Consumers , Purchasing Decisions 
EFEK HEPATOPROTEKTOR EKSTRAK ETANOL DAUN KENIKIR (Cosmos caudatus Kunth.) PADA TIKUS YANG DIINDUKSI DOKSORUBISIN Heroweti, Junvidya; arifin, Ibrahim; Hidayati, Nurul Arlin
Media Farmasi Indonesia Vol. 14 No. 2 (2019): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.757 KB)

Abstract

Doksorubisin merupakan agen kemoterapi yang mempunyai efek sampinghepatotoksik dengan cara pembentukan radikal bebas. Daun kenikir (Cosmos caudatusKunth.) memiliki potensi untuk mencegah efek hepatotoksik akibat penggunaan doksorubisin(DOX). Penelitian bertujian untuk membuktikan potensi Ekstrak Etanol Daun Kenikir(EEDK) sebagai hepatoprotektor pada tikus yang diinduksi DOX.Penelitian ini merupakan penelitian eksperimental menggunakan randomized matchedpost only control group design. Sebanyak 25 ekor tikus galur wistar dibagi menjadi 5kelompok secara acak. Kelompok I, control normal diberi asupan akuades, kelompok IIkontrol hepatotoksik diberikan doksorubisin dosis 5 mg/KgBB. Kelompok III, IV dan Vmerupakan kelompok perlakuan EEDK dengan dosis berturut-turut 250,500, dan 1000mg/kgBB dengan DOX dosis 5 mg/kgBB, Pemberian DOX dilakukan pada hari ke-1, ke-5,ke-9 dan hari ke-13 secara intraperitonial (ip) dan pemberian EEDK dilakukan 1 kali sehariselama 14 hari secara peroral (po). Seluruh hewan uji diambil darahnya pada hari ke-15.Kadar SGOT dan SGPT dievaluasi untuk melihat adanya kerusakan hati. Data kadar SGOTdianalisis dengan one way anova, sedangkan data kadar SGPT dianalisis menggunakanKruskall-wallis.Hasil penelitian menunjukkan bahwa DOX dapat menyebabkan hepatotoksik ditandaidengan peningkatan kadar SGOT dan SGPT. Ekstrak etanol daun kenikir mampumemberikan efek hepatoprotektor yang signifikan (p≤0,05) pada tikus yang diinduksidoksorubisin ditunjukkan dengan penurunan kadar SGOT dan SGPT.
KONSTRUKSI SOSIAL MULTIKULTURALISME DI SMA KATOLIK RAJAWALI MAKASSAR Ramadhan S, Muhammad Syahrul; Arifin, Ibrahim
Pinisi Journal of Sociology Education Review Volume 3, Nomor 3 November 2023
Publisher : Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26858/pjser.v0i2.51679

Abstract

Penelitian ini bertujuan untuk mengetahui: 1) bagaimana upaya guru dalam mengkonstruksi pendidikan multikulturalisme pada siswa di SMA Katolik Rajawali. 2) bagaimana perilaku siswa SMA Katolik Rajawali dari hasil konstruksi nilai pendidikan multikulturalisme. Jenis penelitian ini adalah jenis penelitian deskriptif dan kualitatif. Jumlah informan ditentukan melalui purposive sampling dengan kriteria yaitu guru dan siswa di SMA Katolik Rajawali Makassar. Teknik pengumpulan datanya adalah observasi, wawancara dan dokumentasi. Pengecekan keabsahan data menggunakan member check. Teknik analisis data meliputi reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa: 1) Upaya guru dalam mengkonstruksi pendidikan multikulturalisme pada siswa di SMA Katolik Rajawali. yaitu: a.) Kekuatan pengetahuan guru dalam menyebarkan virus multikultural b.) Hebituasi sebagai implementasi guru dalam membangun pendidikan multikultural c.) Modal budaya menjadi faktor pendukung pendidikan multikultural di SMA Katolik Rajawali. 2) Perilaku siswa SMA Katolik Rajawali dari hasil konstruksi nilai pendidikan multikulturalisme yaitu: a) Menghargai setiap perbedaan budaya yang dimiliki setiap siswa b) Toleransi beragama menjadi implementasi siswa dalam menerapkan nilai multikulturalisme 
Co-Authors . Anindyajati ., Muhammad Syukur A. Octamaya Tenri Awaru Abdul Rahman Adam Hermawan Agustang, Andi Dodi May Putra Ahmad Fudhail  Majid Ahmad, M Ridwan Said Ahmad, M. Ridwan Said Akbar, Muh. Aksayanti Al Faris, Risman Alimuddin, Ardawati Amirudin, Muhammad Subhan Andi Ima Kesuma Angelita, Anastasya Anindyajati Anindyajati Anis Fauzia Arifin, Ibrahim Ibrahim Arifin, Jamaluddin Arsyada, Muhammad Farih Awaru, Andi Octamaya Tenri Ayu Shabrina Bahri bahri Cahyaning Gita Rizkita Devi Nisa Hidayati Dewi Hastuti Diki, Hendrawan Edy Meiyanto Edy Meiyanto Eka Wahyuni Nurul Qori'ah Endah Subekti Ernawati Syahruddin Kaseng Fachrian, Ahmad Maulana Farikha Maharani Fatimatuz Zahroh Fatimatuz Zahroh Firdaus W Suhaeb Hasni Hasni Heroweti, Junvidya Hidayati, Nurul Arlin HUSNA, ASMA'UL Ilham Saputra Inayati, Dian Indriani Indriani Jayadi, Abd Asathin Bardan Jumadi Jumadi Kabur, Savio Ricardus Khibran, Muh Fauzan Khoirul Anwar Lina Wahyuni Lina Wahyuni Mubarak, M. Alwi Muddiin, Muhammad Imaa Muhammad Nur Muhammad Syukur Musdalifah Musdalifah Mustahar AM, Muh. Abid Muthi Ikawati Mutiani Mutiani Mutmainnah M., Ulfah N, Muh Ilham Nirwana NUR FADILAH Nur Hidayah Nurfadilla, Rizki Nurmagfira Nurul Arlin Hidayati Pratama, S.Si., M.Si., Mario Pratiwi, Nevy Ramadhan S, Muhammad Syahrul Rijal, Muh. Rizaldi Syam , Muh Rizki Suciantika Sadriani, Andi Safitri, Nurafia Samsul Alam, Andi Sari Haryanti Sari Haryanti Seppa, Yusi Irensi Sri Mastuti Sri Wahyuni Taufik, Parham Tiara Nur’aini Umi Any Tiyas Wati Wahyu Kumala Sari Wibowo, Danang Novianto Zainal Arifin Zulfafasya, Nisrina Zulkifli Arifin