Garuda - Garba Rujukan Digital

ASAP ROKOK KONVENSIONAL DAN ELEKTRONIK MEMBERIKAN GAMBARAN KERUSAKAN STRUKTUR ALVEOLUS YANG SAMA Jenny Lauvita; Tena Djuartina; Dyonesia Ary; Iskandar Rahardjo Budianto; Robi Irawan
Bahasa Indonesia Vol 21 No 1 (2022): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v21i1.2093

Introduction: Cigarettes have become the cause of health problems and even death, especially in developing countries like Indonesia. Cigarettes contain various free radical components for the body, thereby increasing inflammation in various organs and tissues, especially the lungs. This will trigger proteolysis so that the alveoli lose elasticity. Electronic cigarettes are then introduced as an alternative to reduce smoking. However, there has been not enough research conducted on their safety and long-term effects of e-cigarettes, so researcher aim to compare the impact of conventional and electronic cigarettes on alveolar damage. Methods: This research was conducted experimentally, using 30 male Sprague Dawley rats aged 10-12 weeks and weighing 150-250 grams as sample. These rats were necropsed after being exposed to cigarettes smoke and e-cigarettes vapor for 2 weeks and 4 weeks to make lung tissue preparations with HE staining. These preparations were observed under a microscope to measure the degree of alveolar damage based on the edema, alveolar septal destruction, and inflammatory cell infiltration. Finally, the data was analyzed using Kruskal-Wallis followed by one-Mann-Whitney statistical tests with STATA. Results: Rats exposed to conventional cigarette smoke and e-cigarette vapor in the second week already showed significant alveolar damage compared to the control group. (p<0.05). However, there was no significant difference between exposure for 2 weeks and 4 weeks. (p>0.05) Between rats given conventional cigarette smoke and electronic cigarette vapor, there was no significant difference in degree of alveolar damage at week 2 and week 4. (p>0.05) Discussion: As a result, both conventional cigarette smoke and e-cigarette vapor have the same effect on alveolar damage. This is because both conventional cigarette smoke and e-cigarette vapor contain nicotine which will trigger the release of fibronectin so that it can trigger fibrosis in the lung parenchyma. In addition, the carbon monoxide contained in both can inhibit fibroblast proliferation and damage the elastin in the alveolar wall, so that the alveoli lose its elasticity and tend to expand. Keywords: Lung inflammation, cigarettes effect on lungs, e-cigarettes, tobacco cigarette, lung damage

Paneth Cell Hyperplasia and Metaplasia in Hirschsprung-associated Enterocolitis in An Aganglionosis Rat Model Iskandar Rahardjo Budianto; Agus Firmansyah; Yefta Moenadjat; Ahmad Aulia Jusuf; Vivian Soetikno
The Indonesian Biomedical Journal Vol 14, No 4 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i4.2007

BACKGROUND: Many hypotheses regarding the pathophysiology of enterocolitis in aganglionic megacolon or Hirschsprung disease (HSCR) has been proposed. Paneth cells are columnar intestinal epithelial cells that have an important role in maintaining of intestinal homeostasis as a bactericide. Since enterocolitis in HSCR may have association with Paneth cells metaplasia and hyperplasia, current study investigated Paneth cells metaplasia and hyperplasia in the sigmoid colon of HSCR rat model and its products, namely a-defensins and IL-1b, in the sigmoid colon tissues.METHODS: Aganglionosis-induced and control Sprague-Dawley rats were euthanized on Day (D)-7, -14, -17, -19, -21, -23, -25, and -28. Sigmoid colon tissue was isolated at each time point, and degree of enterocolitis as well as Paneth cells metaplasia and hyperplasia were analyzed by Hematoxylin-eosin staining, then protein levels of a-defensins and interleukin (IL)-1b were determined by enzyme-linked immunosorbent assay (ELISA).RESULTS: Enterocolitis scores increased with time. The Paneth cells metaplasia and hyperplasia were observed on D14 until D28 (p<0.01 vs. control group) followed by an increased in the levels of IL-1b. The levels of a-defensins protein expression were initially increased (D7-D14; p<0.01 vs. control group) but then undergo reciprocal changes on D19 until D28 (p<0.01 vs. D7 and D14). Positive correlations between the degree of enterocolitis and Paneth cells number were detected in the sigmoid colon (r=0.42).CONCLUSION: Paneth cells underwent metaplasia and hyperplasia in the sigmoid colon of HSCR rats corresponding to an increase in the degree of enterocolitis, but not followed by an increase in the level of a-defensins as well as IL-1b, suggesting that there is an involvement of Paneth cells in the pathophysiology of enterocolitis due to HSCR.KEYWORDS: Hirschsprung, enterocolitis, defensins; metaplasia, Paneth cell, animal model

Pengaruh Durasi Pengobatan dan Preferensi Pasien Kanker Stadium Akhir terhadap Layanan Homecare di Rumah Sakit Medistra pada Tahun 2021-2023 Putra, Peter Brian Sutanto, Dr; Suwangto, Erfen Gustiawan, Dr; Djuartina, Tena, Dr; Budianto, Iskandar Rahardjo, Dr; Lesmana, C. Rinaldi A.
Jurnal Penyakit Dalam Indonesia Vol. 11, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Introduction. Cancer is still an enormous health problem in the world and rank second as the most common cause of mortality. End-stage cancer requires end-of-life or palliative care to improve the patient’s quality of life before death. Homecare services have become an option for providing palliative care to avoid long-term hospital stays. The study aimed to provide an overview of the treatment duration and other factors in end-stage cancer patients regarding the selection of homecare services at Medistra Hospital during the period of 2021-2023. Methods. This study with a cross-sectional design analyzed medical records of end-stage cancer patients who received palliative homecare services at Medistra Hospital from 2021 to 2023. Chi-square analysis was used to describe the association between gender, treatment duration, and cancer type with the decision to choose homecare services. The Mann-Whitney test was conducted to describe the relationship between age and the decision to choose homecare. Results. Out of 595 end-stage cancer patients, 429 chose to undergo palliative homecare. Males represented the majority in both the homecare group (53.1%) and the non-homecare group (56.6%). Patients who chose homecare were generally older (median age 65 years) compared to those who did not (median age 61 years, p = 0.002). Hematologic cancers were most common in the non-homecare group (25.3%), while gastrointestinal cancers were the most prevalent in the homecare group (39.9%). Patients with a treatment duration of less than 8 weeks from diagnosis were more likely to choose homecare, while those with a duration of 8 weeks or more were more likely to decline homecare (98.6% vs. 3.6%, p <0.001). Conclusion. Treatment duration and age are significant factors that related to the decision of end-stage cancer patients to choose homecare services.

Peran Bakti Sosial (Baksos) Dalam Pengenalan Penyakit Sejak Dini Pada Masyarakat: - Uinarni, Herlina; Djuartina, Tena; Sasmita, Poppy K.; Santi, Bryani Titi; R. Budianto, Iskandar
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 2 No. 2 (2024)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v2i2.5543

Bakti sosial sangat membantu dalam mendeteksi penyakit di masyarakat, serta meningkatkan kesadaran akan kesehatan pribadi. Inisiatif ini dilakukan di Cipinang bekerja sama dengan tim klinik dari Gereja Keluarga Kudus Rawamangun dan Kepolisian St. Petrus Cipinang, yang melibatkan 50 peserta dengan rerata usia 53 tahun (88% perempuan, 12% laki-laki). Selama kegiatan, peserta mengisi kuesioner dan melakukan pengukuran tekanan darah, gula darah, asam urat, dan kolesterol, diikuti dengan konsultasi berdasarkan hasilnya. Hasil survei menunjukkan bahwa 82% belum pernah didiagnosis penyakit sebelumnya dan menunjukkan tingkat kesadaran kesehatan masyarakat yang tinggi. Sebanyak 76% hadir atas kesadaran diri dengan 52% melakukan pemeriksaan kesehatan baru-baru ini. Sebanyak 76% memutuskan untuk minum obat atau berobat secara teratur setelah kegiatan. Selain itu, konsultasi dengan dokter meningkatkan pengetahuan kesehatan pada 96% peserta, dengan 94% merasa lebih mengetahui kondisi kesehatan diri. Kesimpulannya, bakti sosial terkait kesehatan tetap penting bagi masyarakat, serta menekankan perlunya inisiatif tersebut secara berkelanjutan.

Peran Bakti Sosial (Baksos) Dalam Pengenalan Penyakit Sejak Dini Pada Masyarakat: - Uinarni, Herlina; Djuartina, Tena; Sasmita, Poppy K.; Santi, Bryani Titi; R. Budianto, Iskandar
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 2 No. 2 (2024)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v2i2.5543

Bakti sosial sangat membantu dalam mendeteksi penyakit di masyarakat, serta meningkatkan kesadaran akan kesehatan pribadi. Inisiatif ini dilakukan di Cipinang bekerja sama dengan tim klinik dari Gereja Keluarga Kudus Rawamangun dan Kepolisian St. Petrus Cipinang, yang melibatkan 50 peserta dengan rerata usia 53 tahun (88% perempuan, 12% laki-laki). Selama kegiatan, peserta mengisi kuesioner dan melakukan pengukuran tekanan darah, gula darah, asam urat, dan kolesterol, diikuti dengan konsultasi berdasarkan hasilnya. Hasil survei menunjukkan bahwa 82% belum pernah didiagnosis penyakit sebelumnya dan menunjukkan tingkat kesadaran kesehatan masyarakat yang tinggi. Sebanyak 76% hadir atas kesadaran diri dengan 52% melakukan pemeriksaan kesehatan baru-baru ini. Sebanyak 76% memutuskan untuk minum obat atau berobat secara teratur setelah kegiatan. Selain itu, konsultasi dengan dokter meningkatkan pengetahuan kesehatan pada 96% peserta, dengan 94% merasa lebih mengetahui kondisi kesehatan diri. Kesimpulannya, bakti sosial terkait kesehatan tetap penting bagi masyarakat, serta menekankan perlunya inisiatif tersebut secara berkelanjutan.

Effects of Aloe Vera Extract on Basal Cell Thickness and Lymphocyte Infiltration at the Gastroesophageal Junction in a Rat Model of Gastroesophageal Reflux Disease Shella Violita; Tena Djuartina; Vetinly Vetinly; Iskandar Rahardjo Budianto
Althea Medical Journal Vol 13, No 1 (2026)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v13n1.4208

Background: Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal disorder with increasing global prevalence. Aloe vera contains bioactive compounds with potential anti-inflammatory properties. This study aimed to evaluate the anti-inflammatory effects of Aloe vera extract in a Sprague-Dawley rat model of GERD.Methods: This experimental study included 32 male Sprague-Dawley rats randomly divided into eight groups: normal (N), negative control (NC), two positive controls receiving pantoprazole for 7 or 14 days (PCI and PCII), and four treatment groups receiving Aloe vera extract at doses of 250 or 500 mg/kg body weight for 7 or 14 days (DI–DIV). After treatment, the rats were euthanized and gastroesophageal junction (GEJ) tissues were collected for histopathological analysis. Basal cell thickness and lymphocyte infiltration were assessed. Data were analyzed using one-way ANOVA followed by post hoc testing.Results: Administration of Aloe vera extract at doses of 250 and 500 mg/kg body weight significantly reduced basal cell thickness compared with the untreated GERD group (p<0.05). However, no significant reduction in lymphocyte infiltration was observed (p>0.05).Conclusions: Aloe vera extract exhibits anti-inflammatory effects in GERD-induced rats by reducing basal cell thickness at the GEJ. These findings suggest its potential as a complementary therapeutic approach for GERD, although further studies are needed to evaluate long-term efficacy and safety.

Tingkat Pengetahuan Penyakit Ginjal pada Jemaat Gereja Keluarga Kudus, Paroki Rawamangun: Studi Deskriptif Tena Djuartina; V Dwi Jani Juliawati; Iskandar R Budianto
Smart Society Empowerment Journal Vol 6, No 1 (2026): Maret
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v6i1.115724

Pendahuluan: Penyakit ginjal merupakan salah satu masalah kesehatan kronis yang prevalensinya terus meningkat, terutama pada kelompok usia dewasa dan lanjut usia, serta pada individu dengan penyakit tidak menular, seperti hipertensi dan diabetes melitus. Pengetahuan masyarakat mengenai penyakit ginjal berperan penting dalam upaya pencegahan dan deteksi dini, namun data mengenai tingkat pengetahuan pada komunitas berbasis keagamaan masih terbatas. Oleh karena itu, penelitian ini bertujuan untuk menggambarkan tingkat pengetahuan jemaat tentang penyakit ginjal di Gereja Keluarga Kudus ParokiMetode: Studi deskriptif dengan pendekatan potong lintang pada 39 responden jemaat Gereja Keluarga Kudus Paroki Rawamangun pada Bulan November 2025. Pengumpulan data dilakukan menggunakan kuesioner terstruktur. Data dianalisis secara deskriptif dan disajikan dalam bentuk distribusi frekuensi dan persentaseHasil dan pembahasan: Rerata usia responden 62 tahun (26–85 tahun) dengan mayoritas perempuan (92,3%). Sebagian besar responden memiliki faktor risiko penyakit tidak menular. Sebanyak 82,0% responden berada pada kategori pengetahuan baik dan sangat baik mengenai kesehatan ginjal.Kesimpulan: Tingkat pengetahuan jemaat tentang penyakit ginjal tergolong baik. Hasil ini dapat menjadi dasar perencanaan program edukasi kesehatan ginjal di komunitas gereja.

Title

Found 7 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 7 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 7 Documents
Search