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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Jurnal Respirasi (JR) Medical and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Keluwih: Jurnal Kesehatan dan Kedokteran Indian Journal of Forensic Medicine & Toxicology Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan MEDICINUS Journal of Tropical Pharmacy and Chemistry Folia Medica Indonesiana
Maranatha, Daniel
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, University Of Airlangga, General Hospital Dr. Soetomo, Jl. Mayjen Prof. Dr. Moetopo No. 6-8 Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Cost-Effectiveness of Length of Stay of Intravenous Aminophylline and Nebulized Salbutamol in Asthma Exacerbations Lorensia, Amelia; Ikawati, Zullies; Andayani, Tri Murti; Maranatha, Daniel
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 1 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i1.435

Abstract

Asthma is a heterogeneous disease which is also one of the major health problems in the world. Uncontrolled asthma symptoms will exacerbate asthma, which is the biggest cause of the patient into the ER. Salbutamol is a bronchodilator that belonged to the short-acting beta-2 agonist (SABA), which is an obligatory choice in the management of asthma exacerbations. Unlike the aminophylline group in Indonesia which is still often used widely and rarely appear in the side effects of its use. The main objective of this study was to evaluate the cost-effectiveness of nebulized salbutamol versus intravenous aminophylline for reduction in asthma symptoms, improvement in lung function, and a long hospital stay. The study involved 57 adults asthma exacerbation patients without complication who received treatment in the ER, were studied by using quasi-experimental methods in this study cost-effectiveness analysis to compare intravenous aminophylline (n:27) versus nebulized salbutamol (n:30) therapy to determine the most cost-effective. Intravenous aminophylline therapy was more cost-effective than nebulized salbutamol in reducing the symptoms of asthma and PEF value improvement. Clinical outcome of the length of hospital stay outcome both had the same effective, and cost analysis results showed intravenous aminophylline (US$5.38) cheaper than nebulized salbutamol (US$5.71). intravenous aminophylline was more effective in reducing asthma symptoms than nebulized salbutamol (Pvalue=0.001). Meanwhile, the average decrease in lung function intravenous aminophylline than nebulized salbutamol, although not significantly different (Pvalue=0.507). Aminophylline therapy was more cost-effective in reducing asthma symptoms and improvement in lung function compared nebulized salbutamol in exacerbations asthma patients. But cost-effectiveness researchers need to measure substance abuse outcomes in terms of Quality-Adjusted Life Years (QALY), as this will make their findings more relevant to the development of treatment policy.
Profile of Tuberculosis in Children in Taman District, Sidoarjo Regency, Indonesia Oktaviani, Ranti Dewanti; Lestari, Pudji; Maranatha, Daniel; Setyoningrum, Retno Asih
Folia Medica Indonesiana Vol. 58, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlight: • Pediatric tuberculosis patients profile using the medical records was determined. • The most pediatric tuberculosis patients under five years have pulmonary tuberculosis. • Pediatric tuberculosis patients received BCG immunization had a contact with adult tuberculosis patients histories. Abstract: The prevalence of tuberculosis (TB) in Indonesia is 391 per 100,000 population with the number of deaths around 110,000 cases in 2016. This study is descriptive research that aims to determine the profile of pediatric TB patients using the medical records at Taman public health center the period 2016-2019 with a total sampling technique. The sample in this study were 31 pediatric patients aged 0-14 years with a history of TB. Pediatric TB patients aged >5 years (58.1%) and who aged ≤5 years (41.9%). Pediatric TB patients had pulmonary tuberculosis (83.9%) and those who had extrapulmonary tuberculosis (16.1%). Pediatric TB patients aged ≤5 years had good nutritional status (32%) and who had poor nutritional status (27.2%). Meanwhile, pediatric TB patients aged >5 years had poor nutritional status (22.7%) and who had good nutritional status (18.1%). Pediatric TB patients who had a history of contact with adult TB patients (86.7%) and who did not have a history of contact with adult TB patients (13.3%). Pediatric TB patients who had received BCG immunization (86.2%) and who had not received BCG immunization (13.8%). This study concludes that most pediatric TB patients are >5 years old, almost all pediatric TB patients have pulmonary tuberculosis. Pediatric TB patients aged ≤5 years are more likely to have good nutrition. Meanwhile, there were more pediatric TB patients aged >5 years who had poor nutritional status. Almost all pediatric TB patients had a history of contact with adult TB patients and had received BCG immunization.
Co-Authors Adyan Donastin Amelia Lorensia Ananta Yudiarso Andayani, Tri M. Bakhtiar, Arief Bintang Bestari Cut Diana Laili Donastin, Adyan Endang Retnowati Erika Marfiani Gandhi Estrada Atmanto Hamzah Herley Windo Setiawan Ichwani, Jusri Mariana Wahjudi Mariana Wahjudi, Mariana Mariana Wahyudi Marthy Meliana Ariyanti Jalmav Mawardi Mawardi Mawardi Mawardi Muhammad Amin Muhammad Amin Novira Widajanti, Novira Nur Marleta Riza Oktaviani, Ranti Dewanti Pudji Lestari Ranti Dewanti Oktaviani Retno Asih Setyoningrum Rizki Amalia Rosyid, Alfian Nur Shinta Karina Yuniati Si Ngr. Oka Putrawan Tri M. Andayani Tri Murti Andayani Tri Murti Andayani Zullies Ikawati