Article Per Year (5 Year)
p-Index From 2020 - 2025
3.624
P-Index
This Author published in this journals
All Journal BALI MEDICAL JOURNAL (BMJ) Medicina E-Jurnal Medika Udayana WMJ (Warmadewa Medical Journal) Smart Medical Journal Jurnal Epidemiologi Kesehatan Komunitas ISM (Intisari Sains Medis) : Jurnal Kedokteran JURNAL ILMIAH KESEHATAN SANDI HUSADA Journal of Telenursing (JOTING) Jurnal Ilmiah Kesehatan Sandi Husada
Agung Nova Mahendra
Departemen Farmakologi Dan Terapi Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

Published : 32 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 32 Documents
Search

 1   2   3   4 
Profil Fitokomponen dan Aktivitas Ekstrak Metanol Daun Intaran Bali (Azadiractha indica Juss.) terhadap Candida albicans ATCC-10231 Meylana Ayu Melinda; Agung Nova Mahendra
Jurnal Epidemiologi Kesehatan Komunitas Vol 6, No 1: Februari 2021
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v6i1.9562

Abstract

Background: Candidiasis, usually caused by Candida albicans is commonly found in clinical settings. Resistance of C. albicans against antifungals is an emerging issue. This study was aimed to determine the selected quantitative phytocomponent profile and evaluate the effectiveness of intaran (Azadiractha indica A. Juss) leaf extract from Bali in inhibiting the growth of C. albicans .Methods: This experimental research was conducted at the Center for Marine Aquaculture Research and Development (Buleleng, Bali), Laboratory Service Unit, Faculty of Agricultural Technology, Udayana University, and Microbiology Laboratory, Department of Biology, Faculty of Mathematics and Natural Sciences, Udayana University, Denpasar, Bali. Our study included the preparation of the methanol extract of intaran leaves using maceration method, phytochemical analysis, and testing the antifungal activity of the extract using the diffusion disk assay against C. albicans ATCC-10231.Results: Phytochemical components in the methanol extract of intaran Bali leaves were chlorophyll (18434.47 mg/L), total antioxidants (4818.07 mg/L GAEAC), phenol (4391.16 mg/100gr GAE) and flavonoids (785.32 mg/100gr QE). The extract exhibited dose-dependent effect, with greatest inhibition against C. albicans ATCC-10231 growth was obtained at the concentration of 50%.Conclusion: Methanol extract of Balinese intaran leaves contained significant amount of chlorophyll, total antioxidants, phenol, and flavonoids. The extract showed antifungal activity against C. albicans ATCC-10231. This anticandidal effect is assumed to be related to the phytocomponents of the extract.
Potensi Padina australis sebagai Marine Drug untuk Aterosklerosis I Gusti Ayu Stiti Sadvika; Ni Wayan Ari Wulansari; Ni Putu Elsinthia Suryaningsih; Agung Nova Mahendra
Smart Medical Journal Vol 5, No 1 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i1.55479

Abstract

Atherosclerosis is characterized by endothelial dysfunction, altered lipid accumulation, inflammation, and foam cells deposition. Fucoxanthin and fucoidan that are contained in Padina australis are known to have potential anti-atherosclerotic effects. This review aims to see the activity and potential of Padina australis as an anti-atherosclerotic marine drug. This literature review article was obtained through a online-based scientific database using terms or phrases relevant to the topic. Fucoxanthin reduces ROS and inhibits production of NO, PGE2, TNF-α, IL-6, and IL-1β. Meanwhile, fucoidan can regulate the development of atherosclerosis by preventing SMC from forming foam cells, LOX-1 expression, and proinflammatory molecules significantly. A decrease in total cholesterol, triglycerides, LDL, and increased HDL-c also shown to be one of the effects of fucoidan in modulating lipid metabolism. Fucoxanthin can increase thermogenesis by increasing PRDM16, UCP-1, and UCP-3 in BAT and decreasing adipocyte size, leptin, and increasing adiponectin in WAT. Fucoidan can lower the cholesterol index, triglycerides, LDL, and increase the expression of PPARγ which can increase lipid metabolism and inhibit hyperlipidemia. In conclusion, Padina australis is potential anti-atherosclerosis agent due to its fucoxanthin and  fucoidan exhibiting antioxidant, anti-inflammatory effects, and modulation of lipid metabolism.Keywords: Padina australis, fucoxanthin, fucoidan, atherosclerosis, marine drug
Potensi Kombinasi Ekstrak Daun Kelor (Moringa oliefera) dan Artemisia (Artemisia annua) Sebagai Antimalaria Plasmodium falciparum Elvina Veronica; Irene Amelia; Kezia Angelina Yunatan; Ni Kadek Sinta Dwi Chrismayanti; Agung Nova Mahendra
Jurnal Ilmiah Kesehatan Sandi Husada Vol 9 No 2 (2020): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v12i2.415

Abstract

Malaria management like chloroquine and Artemisinin Combination Therapy can have side effects and already resistant so other alternative treatments are needed. This study method uses a literature review from a number of valid and relevant literature. Artemisinin in Artemisia annua plant inhibits PfATPase6, thus making plasmodium Ca homeostasis undisturbed and inhibiting plasmodium growth. Cysteine protease enzymes, ALLN inhibitors, Plasmepsin-2, and Plasmepsin-1 destroy plasmodium in trophozoite and schizont phases by degrading plasmodium protein. Flavonoids in Moringa oliefera leaves increase hemoglobin production and optimize the performance of artemisinin. Kaempferol and other antioxidants in moringa leaves inhibit plasmodium growth through new permeation pathways by inhibiting membrane ordering during the intraerythrocytic phase and inhibiting the degradation process of hemoglobin so that plasmodium can’t develop well. The amount of Moringa leaves can fulfill daily nutritional needs and overcome malnutrition. The combination of artemisia and moringa leaves can be used as an alternative to malaria medicine that is caused by plasmodium falciparum infection because the combination of the two substances is proven to be more effective in inhibiting Plasmodium berghei in experimental animals, enhancing the immune system, and meeting nutritional needs compared to the use of artemisinin and moringa leaves alone. Need further investigation about this thing.
Profil efek samping minor pada penggunaan OAT Kategori I pada pasien tuberkulosis paru di Poliklinik Paru RSUP Sanglah Oktober 2017 – Februari 2018 Gusti Ngurah Bagus Wira Gunawan; Agung Nova Mahendra; Ni Wayan Sucindra Dewi
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (292.769 KB) | DOI: 10.15562/ism.v11i3.261

Abstract

Background: Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Indonesia is one of the countries with a high incidence of tuberculosis. Indonesia adopted DOTS as TB control with the use of OAT. Long-term treatment with OAT can cause mild or severe side effects.Aim: This research aimed to determine the minor side effects profile of ATT category I in patients with pulmonary tuberculosis in Pulmonary Poly of RSUP Sanglah.Methods: This research was a retrospective descriptive study with a cross-sectional approach. The subjects were 35 patients diagnosed with pulmonary tuberculosis and did treatment in Pulmonary Poly of RSUP Sanglah from October 1, 2017, until January 31, 2018. This research is using primary data the questionnaire that has been validated and then adopted by the authors and secondary data using medical records obtained at Pulmonary Poly of RSUP Sanglah.Results and Conclusion: Patients with pulmonary tuberculosis was 94.3% experience sweat or urine in orange; 54.3% experienced nausea with or without vomiting, and 48.6% experienced no appetite. Adults experienced 3 to 4 minor side effects.  Latar Belakang: Tuberkulosis (TB) merupakan penyakit yang disebabkan oleh bakteri Mycobacterium tuberculosis. Salah satu negara yang memiliki angka kejadian tuberkulosis yang cukup tinggi adalah Indonesia. Indonesia mengadopsi DOTS sebagai penanggulangan TB dengan penggunaan OAT. Pengobatan jangka panjang dengan OAT dapat menimbulkan efek samping yang ringan ataupun berat.Tujuan: Penelitian ini bertujuan untuk mengetahui profil efek samping minor penggunaan OAT kategori 1 pada pasien TB paru di Poliklinik Paru RSUP Sanglah.Metode: Penelitian ini merupakan penelitian deskriptif retrospektif dengan rancangan penelitian cross sectional. Subjek penelitian adalah 35 pasien yang terdiagnosis menderita tuberkulosis paru dan melakukan pengobatan di Poli Paru RSUP Sanglah pada rentang waktu 1 Juli 2017 s.d. 31 Januari 2018. Data penelitian adalah data primer yang diperoleh dari kuisioner yang sudah tervalidasi dan kemudian diadaptasi oleh penulis dan data sekunder yang menggunkan Rekam Medis yang diperoleh di Poliklinik Paru RSUP Sanglah.Hasil dan Kesimpulan: Hasil penelitian menunjukkan bahwa pasien TB paru mengalami keringat atau urin berwarna oranye (94,3%), mual dengan atau tanpa disertai muntah (54,3%), dan mengalami tidak nafsu makan (48,6%). Lalu responden kategori umur dewasa mengalami 3 sampai 4 efek samping minor.
The effect of young pepaya leaf ethanol extract (Carica papaya L.) with concentration variants on the growth of pathogenic Streptococcus pyogenes bacteria causing pharyngitis through in vitro testing I Gede Krisna Putra Yasa; Agung Nova Mahendra; Bagus Komang Satriyasa
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.783 KB) | DOI: 10.15562/ism.v10i2.402

Abstract

Background: Pharyngitis infection issues by Streptococcus pyogenes bacteria have been increasing worldwide, and antibiotic resistance to the bacterium treatment also continues to escalate. Young papaya leaves (Carica papaya L.) have a bactericidal and bacterostatic effect (include papain, flavonoids, alkaloids (karpain alkaloids), saponins, glycosides, phenols (tacophenol), and tannins) that can be an option for treatment of pharyngitis infections other than drugs. This study aims to determine the effectiveness of ethanol extract of young papaya leaves (Carica papaya L.) in inhibiting the growth of Streptococcus pyogenes bacteria through in vitro testing.Methods: This study was a true-post experimental study using control group design. The sample was divided into 2 groups: positive and negative control groups as well as treatment groups with concentration variants of 25%, 50%, 75%, and 100%. Data were analyzed using SPSS version 17 software for windows.Results: The result obtained from this study showed that papaya leaf extract (Carica papaya L.) was proven to significantly inhibit the growth of Streptococcus pyogenes bacteria at concentrations of 25% to 100% with an average diameter of the inhibition zone of 6.4 mm to 7.4 mm (P<0.05).Conclusion: This evidences that the ethanol extract of young papaya leaves (Carica papaya L.) with various concentrations does exhibit an influence on the growth of Streptococcus pyogenes bacteria.
Uji efektivitas ekstrak etanol kulit buah naga merah (Hylocereus polyrhizus) terhadap Staphylococcus aureus ATCC 25923 secara in vitro Anak Agung Bintang Astridwiyanti; Agung Nova Mahendra; Ni Wayan Sucindra Dewi
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (599.437 KB) | DOI: 10.15562/ism.v10i3.425

Abstract

Introduction: Infectious diseases are still one of the main causes of high morbidity and mortality in tropical Indonesia. One of the causes of this disease is the staphylococcus aureus bacteria. Red dragon fruit peel contains potentially antibacterial compounds such as flavonoid, alkaloid, saponin, tannin dan terpenoid. The purpose of this study is to determine the antibacterial activity of ethanolic extract of red dragon fruit peel against staphylococcus aureus ATCC 25923.Method: The method used is true experimental post test only control group design. The activity of ethanol extract of red dragon fruit skin was tested in various concentrations (25%, 50%, 75%, and 100%) against staphylococcus aureus ATCC 25923 by measuring the inhibition zone diameter and minimum inhibitory concentration (MIC).Result: The results of this study show that red dragon fruit peel ethanolic extract has antibacterial activity against staphylococcus aureus ATCC 25923 ith the average diameter of inhibition zone ranging from 8.25 mm – 12.5 mm. The MIC is obtained at concentration of 25%. Kruskal-Wallis test found a significant comparison with a value of p = 0,000 (p value <0.05). Mann-Whitney test showed that there were significant differences between each concentration, except the concentration of 50% did not have a significant difference with a concentration of 75%.Conclusion: The minimum inhibitory concentration (MIC) is produced by extract at a concentration of 25% and the best inhibitory zone produced by 100% concentration of red dragon peel ethanol extract.
Plasmodium falciparum Serine Repeat Antigen 5 (PfSERA5): current vaccine candidate for Plasmodium falciparum malaria Ayuti Bulaan; W. Riski Widya Mulyani; Agung Nova Mahendra; I Wayan Sumardika
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (853.556 KB) | DOI: 10.15562/ism.v11i1.573

Abstract

Background: Most of the malaria cases are caused by Plasmodium falciparum infection. The prevalence of cases and high mortality rates due to malaria should be watched out globally. However, currently, efforts to prevent and treat malaria suffer obstacles due to resistance to insecticides and antimalarial drugs. For these reasons, other preventive measures are needed, such as vaccines. This study aims to review the Plasmodium falciparum Serine Repeat Antigen 5 (PfSERA5) as a potential candidate for Plasmodium falciparum malaria vaccine development. Methods: Of the 65 journals reviewed, 51 journals were found to be suitable as references for this paper. The keywords included in selected search engines are "malaria" "PfSERA5", "Plasmodium falciparum", and "malaria vaccine". Search results and studies show that the erythrocytic phase of the vaccine can fight malaria parasites that escape the liver stage while reducing or eliminating clinical symptoms. Data were analyzed and written in a narrative form.Results: PfSERA5 is an asexual erythrocytic stage antigen that accumulates in the parasitophorous vacuole. The PfSERA5, SE47 and SE36 (modified SE47) domains can induce the formation of antibodies that protect against falciparum malaria infection in vivo and in vitro. This protective mechanism, caused by PfSERA5 (anti-SE47 and anti-SE36) specific antibodies, occurs through inhibition of parasite growth and merozoite lysis. PfSERA5 also does not show antigenic variations and has limited polymorphism, so the probability of resistance can be reduced. Conclusion: Based on this, PfSERA5 has great potential as an effective erythrocytic phase vaccine candidate. However, further studies are needed regarding the toxicological and pharmacological properties of PfSERA5, both in vivo and in clinical settings.
Profil pemberian nifedipine kombinasi metildopa dan MgSO4 pada pasien pre-eklamsi berat di Rumah Sakit Daerah Mangusada Badung Diana Putri; Agung Nova Mahendra; Agung Wiwiek Indrayanti; Gede Wirata
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.979 KB) | DOI: 10.15562/ism.v11i3.690

Abstract

Background: Nifedipine are recommended as first line drug choice for gestational hypertensior or severe pre-eclampsia to reduce coroner insufisiency (pectoral angina ofter cardiac infark). Aim: The study aims to determine the usage pattern of nifedipine combined with methyldopa and MgSO4 for patients with severe pre-eclampsia in RSD Mangusada Badung.Method: This study is a descriptive study with crossectional method for using the data of patient who seek treatment for severe pre-eclampsia at RSD Mangusada Badung in 2019. Nifedipine with some kind of combination aspecially anticonvulsant MgSO4 are given in the range of  2-4 days which is nifedipine are given orally and the MgSO4 are given by using IV line as a loading dose for the first step and maintenance treathment by infusion drip with appropriate monitoring. There were no monotherapy of nifedipine are found but using MgSO4 as a protocol for all the patient (100%) with severe pre-eclampsia as a convulsion prophylaxis.Results: The condision of severe pre-eclmpsia at RSD Mangusada Badung Tahun 2019 are followed by some patient’s characteristic are most prevalent in the age group of  > 35 years as many as 9 people (56.25%),  characteristic of pre-eclmpsia’s history as many as  5 people (55.56%), characteristic of deases history as many as 14 people (87.5%), characteristic of BMI (body mass index) are obesity degree I and II there are 11 people (68.8%) dan 4 people (25,0%) for each obesity’s character, characteristic of  gestational age are most prevalent in the age group of  20-< 37 weeks as many as 10 people (62,5%) and all of them are without multiple pregnancy.Conclusion: The profile of nifedipine therapy for severe hypertension are given by using nifedipine orally combine with MgSO4 for convultion prophylaxis as a dominan result which is about 15 cases (93.75%) and all of them are showing there are no complication symptom. Nifedipine secara umum digunakan bagi pengobatan dan pencegahan insufisiensi koroner (terutama angina pektoris setelah infark jantung) dan sebagai terapi lini-1 pada hipertensi dalam kehamilan khususnya pada kejadian preeklampsia berat.Tujuan: Tujuan penelitian ini adalah untuk mengetahui profil pemberian nifedipine kombinasi metildopa dan MgSO4 pada pasien PEB (pre-eklamsi berat) di Rumah Sakit Daerah (RSD) Mangusada Badung.Metode: Penelitian ini merupakan penelitian deskriptif dengan metode crossestional pada pasien preeklamsia berat yang berobat di RSD Mangusada Badung tahun 2019. Profil pemberian nifedipine pada pasien preeklamsia berat di RSD Mangusada Badung tahun 2019 dengan pemberian terapi nifedipine dilakukan per oral dan antikonvulsan dalam hal ini MgSO4 dengan cara injeksi IV bolus dan drip. Tidak ada pemberian nifedipine monoterapi, melainkan pemberian anti konvulsan MgSO4 kepada semua pasien (100%) yang terdiagnose PEB.Hasil: Karakteristik pasien preeklamsia berat berdasarkan umur paling banyak pada kelompok usia > 35 tahun sebanyak 9 orang (56,25%) dengan pengulangan riwayat PEB/eklamsia  berjumlah 5 orang (55,56%) dan paling banyak tanpa riwayat penyakit sebelumnya sejumlah 14 orang (87,5%), dengan kondisi IMT (index massa tubuh) didapatkan dominan obesitas I dan II yaitu masing-masing 11 orang (68,8%) dan 4 orang (25,0%) serta ditemukan paling banyak pada usia 20 minggu - <37 minggu yaitu 10 orang (62,5%) serta tidak ada yang memiliki kehamilan multiple.Simpulan: Profile pemberian nifedipine kombinasi dengan anti konvulsan sebanyak 15 orang (93,75%) dengan seluruhnya tidak ditemukan efek samping dan lama pengobatan di rumah sakit dengan kurun waktu 2-4 hari perawatan.
Prevalensi dan faktor penentu prediabetes pada wanita muda obesitas di Kota Denpasar tahun 2019 Dinda Anggita Meiwita Sari; Desak Ketut Ernawati; Agung Nova Mahendra; I Wayan Weta
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.884 KB) | DOI: 10.15562/ism.v11i3.701

Abstract

Background: The prevalence of prediabetic state in population is such a hard project to be confirmed within an increased number of obese population.Aim: The study aims to define the prevalence of prediabetes among obese young women (body mass index, BMI >25 kg/m2) in Denpasar.Methods: Research variables namely physical activity, food pattern, anthropometric values for identify level of obesity (light BMI 25-30, severe BMI >30 kg/m2), tipe of obesity (perifer obesity waist circumference <80 cm,  and central obesity waist circumference ≥80 cm), as well as fasting blood glucose (normal <100 mg/dL, prediabetes -125 mg/dL).Results: the prediabetes prevalence of subjects is 38,1%. All subjects 42 (100%) have light daily physical activity, with high mean of cholesterol intake (more than 200mg) and low of PUFA intake (less than 10% of fat intake). Pre-diabetic subjects have higher waist circumference (visceral fat) than subjects with normal blood glucose (p=0.023). In contrary, that was no relationship between subcutaneous fat (bicep and tricep skinfold) to prediabetic state(p >0,05). Central obesity was significant OR 1,76 (1,33-2,33) risk of prediabetes compared to peripheral obesity (p= 0,023). However, there was not significant risk (OR 2,67 (0,738-9,63) (p= 0,130)) of severe obesity to be prediabetes compared to light obesity. Latar Belakang: Peningkatan prevalensi obesitas bersamaan dengan prevalensi diabetes melitus tipe 2. Prevalensi prediabetes sangat susah dideteksi pada suatu populasi.Tujuan: untuk mengetahui prevalensi dan faktor penentu prediabetes pada wanita muda obese (indeks massa tubuh, IMT >25) di Denpasar.Metode: Penelitian ini termasuk studi cross-sectional dengan variabel penelitian, meliputi aktivitas fisik, pola makan, antropometri pada tingkat obesitas (obesitas ringan IMT 25-30 kg/m2, obesitas berat IMT>30 kg/m2) dan jenis obesitas (obesitas perifer lingkar perut <80 cm, obesitas sentral lingkar perut >80 cm), serta kadar glukosa darah puasa (normal <100 mg/dL, prediabetes -125 mg/dL).Hasil dan Simpulan: prevalensi prediabetes dari subjek adalah 38,1%. Semua subjek 42 (100%) memiliki aktivitas fisik harian yang ringan, dengan rata-rata asupan kolesterol yang tinggi (>200mg) dan asupan PUFA (pure unsaturated fatty-acid) yang rendah (<10% dari asupan lemak). Subjek dengan prediabetes mempunyai lingkar perut (lemak visceral) lebih besar dibandingkan dengan subjek dengan kadar gua darah normal (p=0,023). Sebaliknya, tidak didapat hubungan antara lemak subkutan (lipatan kulit bisep dan trisep) dengan kejadian prediabetes (p>0,05). Obesitas sentral bermakna berisiko menderita prediabetes OR 1,76 (1,33-2,33) dibandingkan dengan obesitas perifer (p= 0,023). Namun, tidak ada risiko yang signifikan [OR 2,67; (0,738-9,63) (p= 0,130)] obesitas berat menjadi prediabetes dibandingkan dengan obesitas ringan. 
Analisis kesesuaian pemakaian obat pada pasien asma dewasa dengan Peraturan Menteri Kesehatan Nomor 5 tahun 2014 di Badan Rumah Sakit Umum Daerah Kabupaten Tabanan tahun 2018 Desak Gede Vicsilia Mahambara Gita; Desak Ketut Ernawati; Agung Nova Mahendra
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.389 KB) | DOI: 10.15562/ism.v11i3.737

Abstract

Background: Regulation of the Minister of Health of the Republic of Indonesia No. 5 of 2014 concerning asthma mentions the presence of types of asthma, medication controller, alternatives such as drugs and substances that have been determined and also other alternatives such as additional drugs. The drugs used in the guidelines were glucocorticosteroids, theophylline, chromolin, leukotriene modifiers, ventolin, and formeterol. Nowadays, the number of asthmatic patients who received asthma therapy according to that regulations had not been clearly distributed.Aim: The study aims to describe the pattern of drug use in adult asthma patients in accordance with the regulations in Tabanan General Hospital.Methods: A retrospective observational study with medical record data without providing intervention or treatment to samples in the Tabanan General Hospital in March-June 2019 aged 18-65 years and receiving asthma medication.Results and Conclusions: The three types of asthma, based on the type of drug, dosage, and dosage form are not in accordance with Regulation of Minister of Health No. 5 of 2014.  Peraturan Menteri Kesehatan (PMK) Republik Indonesia No 5 Tahun 2014 tentang asma menyebutkan adanya jenis asma, medikasi pengontrol, alternatif seperti obat dan zat yang telah ditentukan dan juga alternatif lain seperti tambahan obatnya. Obat yang digunakan pedoman PMK No 5 Tahun 2014 yaitu glukokortikosteroid, teofilin, kromolin, leukotrien modifiers, ventolin, formeterol. Sampai sekarang jumlah pasien asma yang mendapatkan terapi asma sesuai dengan PMK masih belum terdistribusi dengan jelas.Tujuan: untuk mendeskripsikan pola penggunaan obat pada pasien asma dewasa sesuai dengan PMK No 5 Tahun 2014 yang berlaku di Badan Rumah Sakit Umum Daerah (BRSUD) Kabupaten Tabanan.Metode: Penelitian observasional retrosprektif dengan data rekam medis tanpa memberikan intervensi atau perlakuan pada sampel di BRSUD Kabupaten Tabanan pada bulan Maret-Juni 2019 berusia 18-65 tahun dan mendapatkan terapi obat asma.Hasil dan Simpulan: Ketiga jenis asma, berdasarkan jenis obat, dosis, dan bentuk sediaan tidak sesuai dengan PMK No 5 Tahun 2014.
Co-Authors Agatha Putra, Gusti Ngurah Agung Wiwiek Indrayani Agung Wiwiek Indrayanti Anak Agung Bintang Astridwiyanti Anak Agung Dewi Megawati, Anak Agung Dewi Aris Mudariani, Ni Wayan Ayuti Bulaan Bagus Komang Satriyasa Desak Gede Vicsilia Mahambara Gita Desak Ketut Ernawati Desak Made Wihandani Dewi, Ni Wayan Sucindra Dharmajaputra, Gede Bagus Diana Putri Dinda Anggita Meiwita Sari Dwi Vedanta, I Gusti Ngurah Ananta Elvina Veronica Gede Agung Dhimasena Widyananda Gede Wirata Gita Almira Putri Gusti Ngurah Bagus Wira Gunawan I Gede Krisna Putra Yasa I Gusti Ayu Artini I Gusti Ayu Stiti Sadvika I Gusti Made Aman I Made Jawi I Wayan Gede Sutadarma I Wayan Putu Sutirta Yasa I Wayan Sumardika I Wayan Surudarma I Wayan Weta Indrayan, Agung Wiwiek Irene Amelia Ita M. Nainggolan Ita M. Nainggolan Kezia Angelina Yunatan Meylana Ayu Melinda Nanis S. Marzuki Nanis S. Marzuki, Nanis S. Ni Kadek Sinta Dwi Chrismayanti Ni Made Dwi Putri Nadi Ni Putu Elsinthia Suryaningsih Ni Wayan Ari Wulansari Ni Wayan Sucindra Dewi Ni Wayan Sucindra Dewi Pangala, Gustinara Bakti Pratiwi, Kadek Prastiti Surya Putrawan, Ida Bagus Indra Shadnyana Putri, Kadek Wina Santhya Putu Ayu Melati Widyasari Putu Diah Saraswati Rahayu Putu Resika Melarosa Saraswati, Ni Made Ayu Sokawati Kesuma, Nyoman Diah Asvini Sumardika, Wayan syahida, iin kurnia Tresnayanthi, Kadek Ayu Sri W. Riski Widya Mulyani Winanti, Kadek Dinda Ayu Sri