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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina E-Jurnal Medika Udayana WMJ (Warmadewa Medical Journal) Smart Medical Journal Jurnal Epidemiologi Kesehatan Komunitas ISM (Intisari Sains Medis) : Jurnal Kedokteran JURNAL ILMIAH KESEHATAN SANDI HUSADA INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Journal of Telenursing (JOTING) Journal Of World Science Jurnal Locus Penelitian dan Pengabdian Public Health and Preventive Medicine Archive Eduvest - Journal of Universal Studies Jurnal Ilmiah Kesehatan Sandi Husada
Agung Nova Mahendra
Departemen Farmakologi Dan Terapi, Fakultas Kedokteran, Universitas Udayana, Bali, Indonesia
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Health Professions Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Comparative Phytochemical Profile and Antioxidant Activity of Cocoa Beans Methanol Extract and its N-Butanol Fraction Obtained from Jembrana, Bali, Indonesia Ari Chandra Wibawa, Agung; Nova Mahendra, Agung; Bagus Putra Manuaba, Ida; Nyoman Mantik Astawa, I
Journal of World Science Vol. 3 No. 4 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i4.588

Abstract

This study aims to evaluate the differences in phytochemical profiles and antioxidant activity between the methanol extract of cocoa beans and the n-butanol fraction obtained from Jembrana, Bali. Maceration technique was used in this research. The crude extract of cocoa beans was partitioned based on polarity to determine which fraction has the most potential as a source of bioactive compounds. The n-butanol fraction was evaporated to obtain a polar fraction from the methanol extract of cocoa beans. UV-Vis spectrophotometry was used to measure the total content of flavonoids and tannins in the methanol extract of cocoa beans and the n-butanol fraction. Research found that the methanol extract of Balinese cocoa beans had a total flavonoid content of 0.34 g/100 g and tannins of 0.37 g/100 g. However, the n-butanol fraction had a total flavonoid content of 15.34 g/100 g and tannin 20.16 g/100 g. The IC50 value of the methanol extract was 29.66 ?g/ml, while the n-butanol fraction was 2.63 ?g/ml. The AAI of the methanol extract was 1.35 and the n-butanol fraction was 2.63, indicating that the n-butanol fraction had stronger antioxidant activity with higher flavonoid and tannin content than the methanol extract. The implication of this research is that the n-butanol fraction of cocoa bean methanol extract has the potential as a source of bioactive compounds that can be utilized in the development of high added value products, especially in the context of food pharmaceuticals or other health product.
The Struggling Nightingales: Determinants of Resilience and Intention to Stay Among Nurses in a Type C Hospital In Gianyar, Bali, Indonesia Ary Puspitasari, Made; Darma, Gede Sri; Mahendra, Agung Nova
Eduvest - Journal of Universal Studies Vol. 4 No. 7 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i7.1348

Abstract

Intention to stay in the nursing profession is a complex phenomenon related to hospital operational management. This study aimed to investigate the relationship between various potential determinants in influencing the intention to stay in nurses who work at a type C private hospital in Gianyar, Bali, Indonesia. This research was an questionnaires-based analytical descriptive study, involving nurses (work period more than one year) from all medical units in the hospital. The relationships between determinants were modeled and analyzed using path analysis. In conclusion, age and work experience have a significant negative influence on burnout levels, while the work environment has a significant negative influence on burnout. Additionally, age and work experience have a significant positive influence on job satisfaction, which is mediated by burnout. Furthermore, job satisfaction has a significant positive influence on resilience, which in turn has a significant positive influence on intention to stay.
Phytochemical Composition And In Vitro Antifungal Limitations Of Salacca Zalacca Peel Extract Against Candida Albicans Aryasa, Mahesa Ajisaka; Mahendra, Agung Nova; Ernawati, Desak Ketut; Satriyasa, Bagus Komang
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 2 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i2.5531

Abstract

Candidiasis, primarily caused by Candida albicans, continues to pose clinical challenges due to antifungal resistance and the adverse effects of synthetic agents. This study aimed to evaluate the phytochemical profile and antifungal efficacy of Salacca zalacca (Bali snakefruit) peel extract as a potential natural alternative. The extract was obtained using ethanol-based maceration and analyzed through UV-Vis spectrophotometry. The results revealed high concentrations of flavonoids (857.59 mg/100 g), phenolics (860.54 mg/100 g), vitamin C (8391.10 mg/100 g), and tannins, along with the qualitative presence of saponins. Antioxidant analysis indicated weak radical scavenging activity (IC?? = 546.19 ppm) but a high total antioxidant content (2532.17 mg GAE/L). Antifungal testing using the disk diffusion method against C. albicans showed no inhibition zones at extract concentrations of 2.5%, 5%, and 10%, whereas the ketoconazole control produced a strong inhibition zone (mean 20.33 mm). The lack of activity may be attributed to diffusion limitations or solubility issues rather than the absence of bioactive compounds. Despite the negative antifungal results, the high phytochemical content suggests potential for alternative therapeutic applications. Further studies employing alternative solvents, higher extract concentrations, and more sensitive antifungal assays are recommended.
Antidyslipidaemic effect of Ipomoea batatas L. extract with increased PCSK-9 levels in atherosclerotic rats Yasa, I Wayan Putu Sutirta; Jawi, I Made; Mahendra, Agung Nova; Wiradana, Putu Angga; I Gede Widhiantara
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.7260

Abstract

Atherosclerosis is the largest cause of mortality worldwide, and Low-Density Lipoprotein (LDL) is a primary risk factor for this illness. The purpose of this research was to determine the effect of purple sweet potato (Ipomoea batatas L.) extract on cholesterol, LDL, PCSK9, and MDA levels in rats fed a high-cholesterol diet. This true experimental study used a randomised pre-test-post-test control group design. Wistar rats were randomly assigned to three groups. Purple sweet potato extract (PSPE) was prepared by 24-hour maceration with 70% ethanol. All rats were fed a high-cholesterol diet for 14 days, followed by pre-test measurements of cholesterol, LDL, PCSK9, and MDA on day 15. Rats were then randomly divided into control (no treatment), PSPE (200 mg/day), and Simvastatin (0.9 mg/kg BW) groups. After one month of treatment, post-test analyses were performed for all parameters. The results showed an increase in serum cholesterol, LDL and MDA levels in rats fed a high-cholesterol diet (p<0.05) compared to the PSPE and Simvastatin groups. The high-cholesterol diet also resulted in a significant (p<0.05) decrease in PCSK9 when compared to the PSPE and Simvastatin groups. In the PSPE group there was a decrease in cholesterol, LDL, and MDA, and PSPE (p<0.05) compared to the control group. In the Simvastatin group, the increase in PCSK9 was very low compared to the PSPE group. PSPE has antidyslipidaemic activity by reducing total cholesterol status, LDL, and oxidative stress while promoting PCSK-9 function. Further research is still needed to provide a comprehensive understanding of the mechanism of action of PSPE as an antioxidant source in patients with atherosclerosis.
Potensi Penggunaan Materi Genetik Fetus pada Sirkulasi Maternal untuk Diagnosis Prenatal Noninvasif Penyakit Genetik Anak Agung Dewi Megawati; Ita M. Nainggolan; Agung Nova Mahendra; Nanis S. Marzuki
WMJ (Warmadewa Medical Journal) Vol 1 No 1 (2016): Mei 2016
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.1.1.4.1-9

Abstract

Diagnosis prenatal adalah teknik diagnostik untuk menentukan kondisi fetus yang belum lahir apakah memiliki kelainan genetik ataupun kelainan lainnya. Teknik ini umumnya dilakukan pada penyakit genetik yang tidak dapat diobati di mana terminasi menjadi bahan pertimbangan. Teknik ini juga dilakukan pada kasus yang memerlukan penanganan segera pada saat prenatal dan pada kondisi yang dapat menimbulkan morbiditas atau mortalitas pada ibu. Diagnosis prenatal dapat dilakukan melalui metode invasif dan noninvasif. Metode invasif seperti amniocentesis dan biopsi villi korialis (CVS) memiliki resiko menimbulkan kecacatan bahkan kematian fetus. Pendekatan nonivasif melalui ultrasonografi belum cukup akurat untuk diagnosis penyakit genetik, sehingga masih memerlukan pengambilan sampel fetus untuk menegakkan diagnosis. Pendekatan terbaru pengambilan sampel fetus secara noninvasif dilakukan melalui pengambilan sel fetus, DNA dan mRNA fetus yang terdapat dalam sirkulasi darah maternal. Pada artikel ini dipaparkan mengenai perkembangan riset, kendala, serta potensi aplikasi klinis ketiga metode pengambilan sampel fetus tersebut.Kata kunci: diagnosis prenatal nonivasif, penyakit genetik, cell-free fetal DNA/mRNA, sel fetus.  [Potential Use of Fetal Genetic Material in Maternal Circulation for Prenatal Noninvasive Diagnosis of Genetic Disease].Prenatal diagnostic technique is used to determine whether the unborn fetus is affected with a genetic disorder or other abnormality. This technique is generally carried out for a genetic disease that is not treatable, in which the termination should be considered. This technique is also performed in cases that require immediate action during the prenatal period and in conditions that can lead to morbidity or mortality of the mother. Prenatal diagnosis can be done by invasive and noninvasive methods. Invasive methods such as amniocentesis and chorionic villus sampling (CVS) have a risk of causing disability and even death of the fetus. While noninvasive approach by ultrasound is not sufficiently accurate for the diagnosis of genetic diseases, therefore further  fetal sampling is required. Noninvasive prenatal diagnosis is a new type of genetic testing done through taking fetal cells, fetal DNA and mRNA, which are found in maternal blood circulation. In this review, we present development of research, constraints, and potential clinical applications of these three methods for noninvasive sampling of the fetus.Keywords: noninvasive prenatal diagnosis, genetic disease, cell-free fetal DNA/mRNA, fetal cell.
Potensi Padina australis sebagai Marine Drug untuk Aterosklerosis Sadvika, I Gusti Ayu Stiti; Wulansari, Ni Wayan Ari; Suryaningsih, Ni Putu Elsinthia; Mahendra, Agung Nova
Smart Medical Journal Vol 5, No 1 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i1.55479

Abstract

Atherosclerosis is characterized by endothelial dysfunction, altered lipid accumulation, inflammation, and foam cells deposition. Fucoxanthin and fucoidan that are contained in Padina australis are known to have potential anti-atherosclerotic effects. This review aims to see the activity and potential of Padina australis as an anti-atherosclerotic marine drug. This literature review article was obtained through a online-based scientific database using terms or phrases relevant to the topic. Fucoxanthin reduces ROS and inhibits production of NO, PGE2, TNF-α, IL-6, and IL-1β. Meanwhile, fucoidan can regulate the development of atherosclerosis by preventing SMC from forming foam cells, LOX-1 expression, and proinflammatory molecules significantly. A decrease in total cholesterol, triglycerides, LDL, and increased HDL-c also shown to be one of the effects of fucoidan in modulating lipid metabolism. Fucoxanthin can increase thermogenesis by increasing PRDM16, UCP-1, and UCP-3 in BAT and decreasing adipocyte size, leptin, and increasing adiponectin in WAT. Fucoidan can lower the cholesterol index, triglycerides, LDL, and increase the expression of PPARγ which can increase lipid metabolism and inhibit hyperlipidemia. In conclusion, Padina australis is potential anti-atherosclerosis agent due to its fucoxanthin and  fucoidan exhibiting antioxidant, anti-inflammatory effects, and modulation of lipid metabolism.Keywords: Padina australis, fucoxanthin, fucoidan, atherosclerosis, marine drug
Co-Authors Agatha Putra, Gusti Ngurah Agung Ari Chandra Wibawa Agung Wiwiek Indrayani Agung Wiwiek Indrayanti Anak Agung Bintang Astridwiyanti Anak Agung Dewi Megawati, Anak Agung Dewi Aris Mudariani, Ni Wayan Ary Puspitasari, Made Aryasa, Mahesa Ajisaka Ayuti Bulaan Bagus Komang Satriyasa Bagus Putra Manuaba, Ida Desak Gede Vicsilia Mahambara Gita Desak Ketut Ernawati Desak Made Wihandani Dewi, Ni Wayan Sucindra Dharmajaputra, Gede Bagus Diana Putri Dinda Anggita Meiwita Sari Dwi Vedanta, I Gusti Ngurah Ananta Elvina Veronica Gede Agung Dhimasena Widyananda Gede Sri Darma Gede Wirata Gita Almira Putri Gusti Ngurah Bagus Wira Gunawan I Gede Krisna Putra Yasa I Gede Widhiantara I Gusti Ayu Artini I Gusti Made Aman I Made Jawi I P G. Adiatmika I Wayan Gede Sutadarma I Wayan Putu Sutirta Yasa I Wayan Sumardika I Wayan Surudarma I Wayan Weta Indrayan, Agung Wiwiek Irene Amelia Ita M. Nainggolan Ita M. Nainggolan Kezia Angelina Yunatan Meylana Ayu Melinda Nanis S. Marzuki Nanis S. Marzuki, Nanis S. Ni Kadek Sinta Dwi Chrismayanti Ni Made Dwi Putri Nadi Ni Wayan Sucindra Dewi Ni Wayan Sucindra Dewi Nila Wahyuni Nyoman Mantik Astawa, I Pangala, Gustinara Bakti Pratiwi, Kadek Prastiti Surya Putrawan, Ida Bagus Indra Shadnyana Putri, Kadek Wina Santhya Putu Angga Wiradana Putu Ayu Melati Widyasari Putu Diah Saraswati Rahayu Putu Resika Melarosa Sadvika, I Gusti Ayu Stiti Saraswati, Ni Made Ayu Sokawati Kesuma, Nyoman Diah Asvini Sumardika, Wayan Suryaningsih, Ni Putu Elsinthia syahida, iin kurnia Tresnayanthi, Kadek Ayu Sri Vittala, Govinda W. Riski Widya Mulyani Winanti, Kadek Dinda Ayu Sri Wulansari, Ni Wayan Ari