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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina E-Jurnal Medika Udayana WMJ (Warmadewa Medical Journal) Smart Medical Journal Jurnal Epidemiologi Kesehatan Komunitas ISM (Intisari Sains Medis) : Jurnal Kedokteran JURNAL ILMIAH KESEHATAN SANDI HUSADA Journal of Telenursing (JOTING) Jurnal Ilmiah Kesehatan Sandi Husada
Agung Nova Mahendra
Departemen Farmakologi Dan Terapi Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Uji Toksisitas Akut Asam Askorbat Per Oral pada Organ Ginjal dan Hepar Tikus (Rattusnorvegicus) Betina Galur Wistar Saraswati, Ni Made Ayu; Indrayan, Agung Wiwiek; Mahendra, Agung Nova; Sumardika, Wayan
Journal of Telenursing (JOTING) Vol 6 No 2 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i2.8814

Abstract

This study aims to determine the effects of acute toxicity of ascorbic acid on the kidney and liver organs of female Wistar rats. The method used in this study is an experimental method with a post-test only control group design model approach. The results showed that the average SGPT level was 61.24 ± 9.416 U / L. While the results of the mean value of blood serum creatinine levels were (1.48) (0.60 - 2.00) Based on bivariate analysis, there was no significant difference in the mean between the treatment and control groups (P <0.001). Acute administration of ascorbic acid at a dose of 9 mg / 200 grams of BW / day, 36 mg / 200 grams of BW / day, 72 mg / 200 grams of BW / day did not increase SGPT and blood creatinine levels in female Wistar rats. The results obtained using doses of 9 mg, 36 mg, 72 mg on toxicity were not too significant for the kidney and liver organs. Administration of ascorbic acid has an impact on SGPT (Serum Glutamic Pyruvic Transaminase) levels in the liver of mice. Doses of 9 mg, 36 mg, and 72 mg of ascorbic acid did not show significant toxicity effects on the kidneys and livers of mice. Keywords: Ascorbic Acid, Creatinin Serum, SGPT.
Potensi Kombinasi Ekstrak Daun Kelor (Moringa oliefera) dan Artemisia (Artemisia annua) Sebagai Antimalaria Plasmodium falciparum Elvina Veronica; Irene Amelia; Kezia Angelina Yunatan; Ni Kadek Sinta Dwi Chrismayanti; Agung Nova Mahendra
Jurnal Ilmiah Kesehatan Sandi Husada Vol 9 No 2 (2020): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v12i2.415

Abstract

Malaria management like chloroquine and Artemisinin Combination Therapy can have side effects and already resistant so other alternative treatments are needed. This study method uses a literature review from a number of valid and relevant literature. Artemisinin in Artemisia annua plant inhibits PfATPase6, thus making plasmodium Ca homeostasis undisturbed and inhibiting plasmodium growth. Cysteine protease enzymes, ALLN inhibitors, Plasmepsin-2, and Plasmepsin-1 destroy plasmodium in trophozoite and schizont phases by degrading plasmodium protein. Flavonoids in Moringa oliefera leaves increase hemoglobin production and optimize the performance of artemisinin. Kaempferol and other antioxidants in moringa leaves inhibit plasmodium growth through new permeation pathways by inhibiting membrane ordering during the intraerythrocytic phase and inhibiting the degradation process of hemoglobin so that plasmodium can’t develop well. The amount of Moringa leaves can fulfill daily nutritional needs and overcome malnutrition. The combination of artemisia and moringa leaves can be used as an alternative to malaria medicine that is caused by plasmodium falciparum infection because the combination of the two substances is proven to be more effective in inhibiting Plasmodium berghei in experimental animals, enhancing the immune system, and meeting nutritional needs compared to the use of artemisinin and moringa leaves alone. Need further investigation about this thing.
Co-Authors Agatha Putra, Gusti Ngurah Agung Wiwiek Indrayani Agung Wiwiek Indrayanti Anak Agung Bintang Astridwiyanti Anak Agung Dewi Megawati, Anak Agung Dewi Aris Mudariani, Ni Wayan Ayuti Bulaan Bagus Komang Satriyasa Desak Gede Vicsilia Mahambara Gita Desak Ketut Ernawati Desak Made Wihandani Dewi, Ni Wayan Sucindra Dharmajaputra, Gede Bagus Diana Putri Dinda Anggita Meiwita Sari Dwi Vedanta, I Gusti Ngurah Ananta Elvina Veronica Gede Agung Dhimasena Widyananda Gede Wirata Gita Almira Putri Gusti Ngurah Bagus Wira Gunawan I Gede Krisna Putra Yasa I Gusti Ayu Artini I Gusti Ayu Stiti Sadvika I Gusti Made Aman I Made Jawi I Wayan Gede Sutadarma I Wayan Putu Sutirta Yasa I Wayan Sumardika I Wayan Surudarma I Wayan Weta Indrayan, Agung Wiwiek Irene Amelia Ita M. Nainggolan Ita M. Nainggolan Kezia Angelina Yunatan Meylana Ayu Melinda Nanis S. Marzuki Nanis S. Marzuki, Nanis S. Ni Kadek Sinta Dwi Chrismayanti Ni Made Dwi Putri Nadi Ni Putu Elsinthia Suryaningsih Ni Wayan Ari Wulansari Ni Wayan Sucindra Dewi Ni Wayan Sucindra Dewi Pangala, Gustinara Bakti Pratiwi, Kadek Prastiti Surya Putrawan, Ida Bagus Indra Shadnyana Putri, Kadek Wina Santhya Putu Ayu Melati Widyasari Putu Diah Saraswati Rahayu Putu Resika Melarosa Saraswati, Ni Made Ayu Sokawati Kesuma, Nyoman Diah Asvini Sumardika, Wayan syahida, iin kurnia Tresnayanthi, Kadek Ayu Sri W. Riski Widya Mulyani Winanti, Kadek Dinda Ayu Sri