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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina E-Jurnal Medika Udayana WMJ (Warmadewa Medical Journal) Smart Medical Journal Jurnal Epidemiologi Kesehatan Komunitas ISM (Intisari Sains Medis) : Jurnal Kedokteran JURNAL ILMIAH KESEHATAN SANDI HUSADA Journal of Telenursing (JOTING) Jurnal Ilmiah Kesehatan Sandi Husada
Agung Nova Mahendra
Departemen Farmakologi Dan Terapi Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Efek antibakteri ekstrak etanol daun sirsak (Annona muricata L.) muda dan tua terhadap Pseudomonas aeruginosa ATCC 9027 Gede Agung Dhimasena Widyananda; Agung Nova Mahendra; I Made Jawi
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (434.911 KB) | DOI: 10.15562/ism.v12i1.915

Abstract

Background: Pseudomonas aeruginosa is an organism that is difficult to handle because it has the ability to resist various antibiotics. Two mechanisms have been studied regarding how Pseudomonas aeruginosa is resistant to both intrinsic and adaptive action of antibiotics. This study aims to determine the antibacterial effect of young and old soursop (Annona muricata L.) leaves ethanol extract against Pseudomonas aeruginosa ATCC 9027.Methods: This study uses the True Experimental Control Group Design method. Samples were divided into 3 groups, namely the control group (K), the intervention group young soursop leaves (EDM) and old soursop leaves (EDT). The control group was divided into negative and positive controls and the intervention group was divided into three groups based on the dosage of using the ethanol extract of Annona muricata L leaves in each isolate with a concentration of 25 mg/mL, 50 mg/mL, and 100 mg/mL, respectively, in group of young and old soursop leaves. Data were analyzed using SPSS version 20 for Windows.Results: The results of the Kruskal-Wallis test showed that there was a significant difference in the inhibition zone in the treatment group, namely the concentration of young and old soursop leaves ethanol extract (25%, 50%, 100%) against the inhibition zone of Pseudomonas aeruginosa bacteria (P <0.05. ).Conclusion: The ethanol extract of young soursop (Annona muricata L.) leaves did not have the effect of inhibiting the growth of Pseudomonas aeruginosa bacteria in vitro. Besides that, the ethanol extract of old soursop (Annona muricata L.) leaves did not have the effect of inhibiting the growth of Pseudomonas aeruginosa bacteria in vitro. Latar Belakang: Pseudomonas aeruginosa  merupakan organisme yang sulit untuk ditangani karena memiliki kemampuan resistensi terhadap berbagai antibiotik.  Terdapat dua mekanisme yang telah dipelajari mengenai bagaimana Pseudomonas aeruginosa resisten terhadap kerja antibiotik baik intrinsik maupun adaptif. Penelitian ini bertujuan untuk mengetahui efek antibakteri ekstrak etanol daun sirsak (Annona muricata L.) muda dan tua terhadap Pseudomonas aeruginosa ATCC 9027.Metode: Penelitian ini menggunakan metode True Experimental Control Group Design. Sampel dibagi dalam 3 kelompok yakni kelompok kontrol (K), kelompok intervensi daun sirsak muda (EDM) dan daun sirsak tua (EDT). Kelompok kontrol dibagi atas kontrol negatif dan positif serta kelompok intervensi dibagi atas tiga kelompok berdasarkan dosis penggunaan ekstrak etanol daun Annona muricata L. pada masing-masing isolat, dengan konsentrasi 25 mg/mL, 50 mg/mL, dan 100 mg/mL pada masing-masing kelompok daun sirsak muda dan tua. Data dianalisis dengan SPSS versi 20 untuk Windows.Hasil: Hasil uji Kruskal-Wallis yang dapat dilihat menunjukan terdapat perbedaan bermakna zona hambat pada kelompok perlakuan yaitu konsentrasi ekstrak etanol daun sirsak muda dan tua (25%, 50%, 100%) terhadap zona hambat bakteri Pseudomonas aeruginosa (P < 0,05).Kesimpulan: Ekstrak etanol daun sirsak (Annona muricata L.) muda tidak memiliki efek menghambat pertumbuhan bakteri Pseudomonas aeruginosa secara in vitro. Disamping itu, ekstrak etanol daun sirsak (Annona muricata L.) tua tidak memiliki efek menghambat pertumbuhan bakteri Pseudomonas aeruginosa secara in vitro.
In vitro study of red beetroot ethanol extract (Beta vulgaris L.) as xanthine oxidase inhibitor Gita Almira Putri; Agung Nova Mahendra; I Made Jawi
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (441.737 KB) | DOI: 10.15562/ism.v12i1.934

Abstract

Background: Xanthine oxidase (XO) is an enzyme that catalyzes the oxidation of xanthine to uric acid. Hyperuricemia is a condition in which uric acid levels in the blood are > 6.8 mg/dL. Hyperuricemia is managed by administering uric acid-lowering drugs that work by inhibiting the activity of XO. Allopurinol, as the first-line drug, has several side effects. Flavonoids and betalains have been shown in numerous studies to have the ability to inhibit XO. The purpose of this study is to examine the ethanol extract of red beetroot (Beta vulgaris L.) with its flavonoids and betalains content in inhibiting the activity of XO. Methods: This study was an in-vitro experimental study using UV-Vis spectrophotometry (ë 285 nm). Red beetroot was extracted with 96% ethanol solvent using the maceration method. Allopurinol was used in this study as a positive control. This study was carried out in triplicates, with a test sample consisting of 5 different concentrations. The results of this study were analyzed using the Kruskal Wallis.Results: The ethanol extract of red beetroot inhibits XO enzymatic activity (55.11%) at 1000 ?g/ml. There was a statistical difference between the control group, the ethanol extract of red beetroot group, and the allopurinol group in the inhibition of XO enzyme activity (p= 0.001).Conclusion: The ethanol extract of red beetroot (Beta vulgaris L.) can inhibit xanthine oxidase (XO). 
Uji Daya Hambat Ekstrak Etanol Daun Sambiloto (Andrographis paniculata Nees) dan Daun Kelor (Moringa oleifera L.) terhadap Bakteri Streptococcus pyogenes Pratiwi, Kadek Prastiti Surya; Jawi, I Made; Indrayani, Agung Wiwiek; Mahendra, Agung Nova
E-Jurnal Medika Udayana Vol 12 No 8 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i08.P11

Abstract

Cases of infection and antibiotic resistance by Streptococcus pyogenes are increasing. Sambiloto leaf has unique phytochemical, namely andrographolide as antibacterial and other phytochemicals such as alkaloids, flavonoids, phenols, saponins. Meanwhile, moringa leaves which are often consumed as vegetables have antibacterial activity with phytochemicals including vitamin C, alkaloids, flavonoids, phenolics, triterpenoids, and tannins. This study aimed to analyze the inhibition of the ethanolic extract of sambiloto leaf, moringa leaf, and their combination on the growth of Streptococcus pyogenes bacteria in vitro. This type of research is a research using true experimental post-test only control group design. The sample was divided into 2 groups: control group and the treatment group with variations in concentrations of 25%, 50%, 75%, and 100%. Data were analyzed using the SPSS application using Kruskal-Wallis method with p<0.05. The results showed that the ethanolic extract of sambiloto leaves had no inhibition against Streptococcus pyogenes at a concentration of 25%, but had the highest inhibitory power at a concentration of 100%, which was 8.67 mm. The highest inhibitory power of moringa leaf ethanol extract was at 100%, which was 9 mm. The inhibition zone produced by the combination of the ethanol extract of sambiloto and moringa leaves showed a synergistic effect at a concentration of 100%, which was 9.33 mm. The positive control used amoxicillin with an inhibitory zone of 26.4 mm. Sambiloto leaf extract, moringa leaf, and their combination have an inhibitory effect on the growth of Streptococcus pyogenes bacteria with different concentrations of the extracts given. Keywords: inhibition test, extract, Andrographis paniculata Nees, Moringa oleifera L., Streptococcus pyogenes
Pengaruh LAMA FERMENTASI OLEH BACILLUS SUBTILIS STRAIN FNCC 0059 TERHADAP KANDUNGAN SENYAWA FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN SECARA IN VITRO DARI KACANG UNDIS (CAJANUS CAJAN [L.] MILLSP) Winanti, Kadek Dinda Ayu Sri; Sumardika, I Wayan; Indrayani, Agung Wiwiek; Mahendra, Agung Nova
E-Jurnal Medika Udayana Vol 13 No 07 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i07.P05

Abstract

Background: Pigeon pea (Cajanus cajan [L] Millsp) is a type of legume rich in phytochemical compounds, phenolic compounds, flavonoids, tannins and anthocyanins. Bacillus subtilis is a microbe with excellent physiological characteristics. This study aims to determine the effect of pigeon pea fermentation by B. subtilis FNCC 0059 on the phytochemical characteristics and antioxidant activity of the extract in vitro. Methods: The study was a true experimental post test only control group design method. The samples were divided into 6 groups, the control group consisted of a negative control group, 1 ml of 0.1 mM DPPH plus 1 ml of methanol, and the positive control, 1 ml of quercetin solution plus 1 ml of 0.1 mM DPPH and the treatment group with variations in fermentation time of 16 hours. 24 hours, 32 hours and 40 hours, 1 ml of sample plus 1 ml of 0.1 mM DPPH (1:1). The data were analyzed using a data processing application and One Way Anova method. Results: The levels of total phenols, flavonoids and tannins increased highest at 24 hours of fermentation, while anthocyanins at 16 hours of fermentation. The best antioxidant activity test was at 40 hours of fermentation. Conclusion: Fermentation duration has no effect on the phytochemical characteristics and antioxidant activity of the extract. Keywords: Antioxidant activity, Phytochemical Compounds, Pigeon pea, Effect of fermentation time, Bacillus subtilis FNCC 0059.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BUAH JUWET (Syzygium Cumini) TERHADAP PERTUMBUHAN Staphylococcus EpidermidisPENYEBAB ACNE VULGARIS Putri, Kadek Wina Santhya; Jawi, I Made; Indrayani, Agung Wiwiek; Mahendra, Agung Nova
E-Jurnal Medika Udayana Vol 13 No 2 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i02.P01

Abstract

Acne vulgaris merupakan permasalahan yang banyak dialami oleh masyarakat baik pria dan wanita. Salah satu penyebab terjadinya acne vulgaris adalah Staphylococcus epidermidis yaitu bakteri gram positif yang normal berada di kulit, namun dalam keadaan tertentu bakteri ini dapat menyebabkan inflamasi yang kemudian menimbulkan pembentukan acne vulgaris. Pertumbuhan bakteri Staphylococcus epidermidis dapat dihambat oleh metabolit sekunder yang berasal dari bahan alami seperti buah juwet (Syzygium cumini). Ekstrak buah juwet diketahui memiliki berbagai jenis metabolit sekunder yang dapat berfungsi sebagai antibakteri. Penelitian ini bertujuan untuk menganalisis daya hambat ekstrak etanol buah juwet pada konsentrasi 40%, 60%, 80%, dan 100% terhadap pertumbuhan bakteri Staphylococcus epidermidis. Penelitian menggunakan metode true experimental post test only control group secara in vitro. Sampel penelitian ini akan dibagi menjadi enam kelompok; dua kelompok kontrol yaitu kontrol positif diberikan Gentamicin dan kontrol negatif diberikan etanol 96%, serta empat kelompok perlakuan yaitu konsentrasi 40%, 60%, 80%, dan 100%. Data hasil dari penelitian akan dianalisis menggunakan software SPSS menggunakan One Way Anova test. Berdasarkan hasil penelitian, ekstrak etanol buah juwet (Syzygium cumini) konsentrasi 40%, 60%, 80%, dan 100% memiliki diameter zona hambat sebesar 11 mm, 12.8 mm, 14.4 mm, dan 15.8 mm. Sedangkan kontrol positif Gentamicin memiliki diameter zona hambat sebesar 26.8 mm. terhadap Staphylococcus epidermidis. Ekstrak etanol buah juwet (Syzygium cumini) konsentrasi 40%, 60%, 80% dan 100% memiliki potensi dalam menghambat pertumbuhan bakteri Staphylococcus epidermidis. Kata kunci: Uji daya hambat, ekstrak, Syzygium cumini, Staphylococcus epidermidis, Acne Vulgaris
PHOTOCHEMICAL ANALYSIS AND IN VITRO ANTI BACTERIAL ACTIVITY TESTING ETHANOL EXTRACTS OF YOUNG AND OLD AVOCADO LEAF (Persea americana Mill.) AGAINST Klebsiella pneumoniae ATCC 13883 syahida, iin kurnia; Mahendra, Agung Nova; Dewi, Ni Wayan Sucindra; Ernawati, Desak Ketut
E-Jurnal Medika Udayana Vol 12 No 8 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i08.P16

Abstract

Fast translate Icon translate Fast translate Icon translate ABSTRAK Mikroorganisme dalam tubuh dapat menyebabkan suatu infeksi. Penyakit infeksi dapat ditangani dengan pemberian antibiotik, namun penggunaan antibiotik yang irrasional dapat menyebabkan masalah resistensi antibiotik. Bakteri Klebsiella pneumoniae merupakan salah satu bakteri yang sudah banyak mengalami resistensi antibiotik dan menjadi penyebab utama pada kasus pneumonia di beberapa negara di dunia. Kandungan senyawa metabolit sekunder (flavonoid, alkaloid, tanin dan saponin) yang dilaporkan pada daun alpukat (Persea americana Mill.) dipercaya memiliki aktivitas anti bakteri. Penelitian sebelumnya menunjukan bahwa ekstrak daun alpukat dapat menghambat pertumbuhan pada bakteri gram positif dan gram negatif. Tujuan penelitian ini adalah untuk mengetahui apakah ekstrak etanol daun alpukat (Persea americana Mill.) dapat menghambat pertumbuhan bakteri Klebsiella pneumoniae ATCC 13883 secara invitro. Metode yang digunakan adalah ekstraksi daun alpukat muda dan tua dengan pelarut etanol 96% yang terbagi dalam lima konsentrasi (20%, 40%, 60%, 80%, 100%). Pengujian antibakteri dilakukan secara difusi agar (Kirby Bauer) menggunakan teknik disc diffusion. Serta dilakukannya uji fitokimia metabolit sekunder secara kualitatif. Hasil menunjukan bahwa tidak ditemukan adanya clear zone disekitar cakram yang mengandung ekstrak pada semua konsentrasi. Simpulan Pada penelitian ini ekstrak daun alpukat dari kintamani tidak ditemukan aktivitas antibakteri terhadap bakteri Klebsiella pneumoniae. Kata Kunci: Antibakteri, Daun Alpukat, Klebsiella pneumoniae
- Karakteristik dan Rasionalitas Pengobatan Neuropati Diabetik Pada Lansia Dengan DMT2 Di Rumah Sakit Swasta X Denpasar Pada Bulan Maret-Mei 2021 Putrawan, Ida Bagus Indra Shadnyana; Indrayani, Agung Wiwiek; Mahendra, Agung Nova; Dewi, Ni Wayan Sucindra
E-Jurnal Medika Udayana Vol 11 No 6 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i06.P13

Abstract

Diabetic neuropathy (ND) is the very common complication caused by type 2 diabetes mellitus (DM), DM is an epidemic in the elderly group. Elderly can be defined as someone that has come to the age of > 60 years and is said to have entered the final stage of the life phase. The aging process experienced by the elderly is cued by the phase of reduction in many functions of the body's organs called degenerative. This special conditions experienced by the elderly are accompanied by several diseases or complications so that they get relatively many types of drugs called polypharmacy, this causes a clinician to consider giving treatment to the elderly in order to minimize the side effects or toxic effects of a drug. This research aims to specify the characteristics and rationality of treatment for diabetic neuropathy in the elderly. This research is a quantitative descriptive study with a cross sectional design. In this study using purposive sampling technique with a sample size of 110 samples taken at the neurology polyclinic of the private hospital x in Denpasar. All samples were processed using SPSS 22.0 and Microsoft Excel and obtained 7 types of drugs and the most drug use are 55 (50%) of gabapentin with vitamin B complex as adjuvant therapy as many as 102 (92.7%) and 106 (96.3%) ) sample received more than 1 drug. In this study, the treatment given is a rational drug choice to treat ND in the elderly.
Studi In Vivo STUDI IN VIVO EKSTRAK ETANOL KUNYIT (CURCUMA DOMESTICA VAL.) SEBAGAI NEFROPROTEKTOR TERTARGET NOX4 PADA MODEL HIPERKOLESTEROLEMIA Dharmajaputra, Gede Bagus; Sokawati Kesuma, Nyoman Diah Asvini; Aris Mudariani, Ni Wayan; Agatha Putra, Gusti Ngurah; Dwi Vedanta, I Gusti Ngurah Ananta; Mahendra, Agung Nova
E-Jurnal Medika Udayana Vol 11 No 6 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i06.P09

Abstract

ABSTRAK Hiperkolesterolemia merupakan suatu kondisi yang ditandai dengan meningkatnya kadar kolesterol di dalam darah melewati batas normal yang disebabkan oleh berbagai macam faktor salah satunya adalah pola makan yang buruk. Penyakit ini dapat meningkatkan produksi dari NOX4 sehingga terjadi peningkatan kadar Reactive Oxygen Species (ROS) dan dapat menimbulkan banyak komplikasi penyakit, salah satunya adalah penyakit ginjal. Pada rimpang kunyit terdapat senyawa aktif berupa flavonoid yang berperan sebagai antioksidan dengan meningkatkan ekspresi miR-25 sehingga dapat menurunkan jumlah NOX4. Penelitian ini memiliki tujuan untuk membuktikan peran dari senyawa flavonoid dari ekstrak etanol kunyit terhadap mencit model hiperkolesterolemia. Penelitian ini merupakan penelitian yang bersifat eksperimental secara in vivo dengan menggunakan rancangan post-test only with control group design. Mencit yang digunakan adalah sebanyak 25 ekor yang akan dikelompokkan menjadi lima kelompok sehingga satu kelompok terdapat lima ekor mencit, yaitu kelompok normal, kelompok kontrol negatif, kelompok kontrol positif, kelompok perlakuan satu dan perlakuan dua. Teknik analisis data akan dilakukan dengan menggunakan teknik analisis deskriptif, uji normalitas, uji homogenitas dan uji komparabilitas. Pada ekstrak etanol kunyit (Curcuma domestica Val.) dengan dosis 20mg/KgBB cenderung menurunkan kadar NOX4 pada mencit model hiperkolestrolemia, tetapi tidak menunjukkan efek yang signifikan. Keterbatasan penelitian ini adalah tidak dilakukan dalam periode yang lebih lama sehingga tidak dapat mengetahui potensi dari variabel lainnya. Kata kunci : rimpang kunyit, hiperkolesterolemia, NOX4, flavonoid ABSTRACT Hypercholesterolemia is a condition characterized by blood cholesterol levels exceeding the limit caused by various factors, one of which is a poor diet. This disease can increase the production of NOX4 resulting in an increase in levels of Reactive Oxygen Species (ROS) and can cause many complications, one of which is kidney disease. In turmeric rhizome there are active compounds in the form of flavonoids which act as antioxidants by increasing the expression of miR-25 so that it can reduce the amount of NOX4. This study aims to prove the role of flavonoid compounds from turmeric ethanol extract on hypercholesterolemic mice models. This study is an in vivo experimental study using a post-test only with control group design. The mice used were as many as 25 mice which would become five groups so that in one group there were five mice, namely the normal group, the negative control group, the positive group, the treatment group and the second treatment. Data analysis techniques will be carried out using descriptive analysis techniques, normality test, homogeneity test and comparability test. The ethanol extract of turmeric (Curcuma domestica Val.) with a dose of 20mg/KgBW tends to reduce NOX4 levels in hypercholesterolemic mice models, but does not show a significant effect. The limitation of this research is that it was not carried out in a longer period so that it cannot know the potential of other variables. Keywords: turmeric rhizome, hypercholesterolemia, NOX4, flavonoids
EKSTRAK ETANOL BAWANG HITAM (Allium sativum L.) MENURUNKAN KADAR ASAM URAT MENCIT JANTAN MODEL HIPERURISEMIA Pangala, Gustinara Bakti; Mahendra, Agung Nova; Jawi, I Made; Dewi, Ni Wayan Sucindra
E-Jurnal Medika Udayana Vol 11 No 8 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i8.P17

Abstract

Black garlic is garlic that goes through a heating process and has a higher bioactivity of substances. The purpose of this study was to determine the effect of black garlic extract on the reduction of uric acid in male mice with hperuricemia induced by 25 ml / kg of chicken liver juice and 250 mg / kg of potassium oxonate. The mice used were male mice with uric acid levels above 3.3 mg / dL or 6.3-6.8 mg / dL. This research is an experimental study with the method of Pre Test - Post Test Control Group Design. The treatment group was K +: Giving allopurinol suspension 10 mg / kg BW, K-: Giving aquabides to the negative control group of mice, P1: Giving black garlic ethanol extract 4.2 mg / 20gr bb, P2: Giving black garlic ethanol extract 8.4 mg / 20gr bb, P3: Provision of black garlic ethanol extract 12.4 mg / 20gr bb. Measurement of uric acid levels was carried out at D-10 after induction of a high uric acid diet, as well as D-26 after treatment of each group. Data were analyzed by One Way Anova test and post hoc LSD test. The results showed that the ethanol extract of black garlic was able to reduce uric acid levels in the blood of mice with the highest percentage reduction in the P3 group (12.4 mg / 20gr bb) by 31,2%, followed by P2 (8.4 mg / 20gr. bb) of 18,03%. The lowest percentage reduction in uric acid levels was in the P1 group (4.2 mg / 20gr bb) by 10,2%. Black garlic ethanol extract has an effect on reducing total uric acid levels in mice due to its antioxidant content such as flavonoids, polyphenols, 5-hydroxymethylfurfural (5-HMF), leucine, and isoleucine. Key words: Black garlic, hyperuricemia, antioxidants, flavonoids.
Pengaruh TINGKAT PENGETAHUAN PASIEN DIABETES MELITUS TIPE II RAWAT JALAN TERHADAP KEPATUHAN TERAPI OAD DI PUSKESMAS KABUPATEN GIANYAR SELAMA PANDEMI COVID-19 Tresnayanthi, Kadek Ayu Sri; Mahendra, Agung Nova; Indrayani, Agung Wiwiek; Sumardika, I Wayan
E-Jurnal Medika Udayana Vol 12 No 7 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i07.P07

Abstract

Type II Diabetes Mellitus dominates DM cases in primary health care. The limitations type II DM services during the COVID-19 pandemic by Puskesmas risk decreasing the level of knowledge and adherence to OAD therapy in type II patients. A good level of patient knowledge about type II DM can influence a patient’s decision to comply with OAD therapy during the COVID-19 pandemic. This study aims describe effect of knowledge level type II Diabetes Mellitus patients on OAD therapy adherence at Gianyar district health center during the COVID-19 pandemic. The method used analytic method with a cross-sectional approach during the period March-August 2022 in four health centers of Gianyar regency. The level of measurement using the Diabetes Knowledge Questionnaire (DKQ-24) and therapeutic compliance with the Morisky Medication Adherence Scales (MMAS-8) questionnaire, the data was taken using google form.Based level knowledge 96 respondents (43,7%) high knowledge, 46 people (48%) moderateknowledge, and 8 people (8,3%) low knowledge. Meanwhile based on level of compliance, there were 53 people (55,2%) with hight compliance, 35 people (36,5%) with moderate compliance, and 8 people (8,3%) with low compliance. The level knowledge and compliance to patients during COVID-19 was moderate knowledge and high compliance, may be influenced by the ease of access to information for patients in internet. Outpatient type II DM at the Gianyar district health center during the COVID-19 pandemic moderate knowledge and high compliance, and there was a significant effect between the level of knowledge to therapy adherence and a p-value of 0,000. Keywords : knowledge, compliance, influence, diabetes mellitus type II, pandemic COVID-19.
Co-Authors Agatha Putra, Gusti Ngurah Agung Wiwiek Indrayani Agung Wiwiek Indrayanti Anak Agung Bintang Astridwiyanti Anak Agung Dewi Megawati, Anak Agung Dewi Aris Mudariani, Ni Wayan Ayuti Bulaan Bagus Komang Satriyasa Desak Gede Vicsilia Mahambara Gita Desak Ketut Ernawati Desak Made Wihandani Dewi, Ni Wayan Sucindra Dharmajaputra, Gede Bagus Diana Putri Dinda Anggita Meiwita Sari Dwi Vedanta, I Gusti Ngurah Ananta Elvina Veronica Gede Agung Dhimasena Widyananda Gede Wirata Gita Almira Putri Gusti Ngurah Bagus Wira Gunawan I Gede Krisna Putra Yasa I Gusti Ayu Artini I Gusti Ayu Stiti Sadvika I Gusti Made Aman I Made Jawi I Wayan Gede Sutadarma I Wayan Putu Sutirta Yasa I Wayan Sumardika I Wayan Surudarma I Wayan Weta Indrayan, Agung Wiwiek Irene Amelia Ita M. Nainggolan Ita M. Nainggolan Kezia Angelina Yunatan Meylana Ayu Melinda Nanis S. Marzuki Nanis S. Marzuki, Nanis S. Ni Kadek Sinta Dwi Chrismayanti Ni Made Dwi Putri Nadi Ni Putu Elsinthia Suryaningsih Ni Wayan Ari Wulansari Ni Wayan Sucindra Dewi Ni Wayan Sucindra Dewi Pangala, Gustinara Bakti Pratiwi, Kadek Prastiti Surya Putrawan, Ida Bagus Indra Shadnyana Putri, Kadek Wina Santhya Putu Ayu Melati Widyasari Putu Diah Saraswati Rahayu Putu Resika Melarosa Saraswati, Ni Made Ayu Sokawati Kesuma, Nyoman Diah Asvini Sumardika, Wayan syahida, iin kurnia Tresnayanthi, Kadek Ayu Sri W. Riski Widya Mulyani Winanti, Kadek Dinda Ayu Sri