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All Journal Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Bioma : Berkala Ilmiah Biologi JURNAL ANATOMI FISIOLOGI SAINS DAN MATEMATIKA Biosaintifika: Journal of Biology & Biology Education Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Pasopati : Pengabdian Masyarakat dan Inovasi Pengembangan Teknologi Biosaintifika: Journal of Biology & Biology Education
Sri Isdadiyanto
Bagian Klinik Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Medicine & Pharmacology Public Health Veterinary Other

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The Potential of Spirulina Powder as Feed Additive on Hepatic Histomorphometry in Peking Ducks (Anas platyrhynchos) Budiwardani, Dwinanda; Sunarno, Sunarno; Budiraharjo, Kustopo; Isdadiyanto, Sri; Jaya, La Ode Irman
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 3 (2024): December 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v16i3.9246

Abstract

Providing standard feed to support and improve the growth, productivity, health, and digestibility of livestock still requires feed additives, one of which is the natural feed additive spirulina flour. Spirulina flour was one of the natural feed additives chosen because it contained bioactive compounds, had no side effects on livestock, and substitute for antibiotics for livestock, so it could increase the growth, productivity, health, and digestibility of Peking ducks. The aim of this study was to analyze the effect of spirulina flour feed additive on Peking duck liver histomorphometry. This research used a Completely Randomized Design (CRD) with 5 types of spirulina flour concentration treatments (0%, 2.5%, 5%, 7.5%, and 10%) and 5 replications including 5 ducks in each replication. The treatment groups included P0, P1, P2, P3, and P4. Measurement variables included liver weight, hepatosomatic index, hepatocyte and central vein diameter, and sinusoid width. The data obtained were analyzed by the Analysis of Variance (ANOVA) test with a confidence level of 95%. The results showed that the addition of spirulina flour as a feed additive had no effect on liver weight, hepatosomatic index, hepatocyte diameter, central vein diameter, and sinusoid width. The conclusion of this research was that added spirulina flour (Spirulina sp.) feed additive potentially maintained the histomorphometry of the Peking duck liver organ.
Therapeutic Potential of Ethanol Extract from Durian Peel on Testes Microanatomy in Diabetic Male Rats Syakera, Cinta Etna; Isdadiyanto, Sri; Sunarno , Sunarno; Ermanjaya, Laode
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 3 (2025): November 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i3.25448

Abstract

Diabetes mellitus (DM) is a degenerative disease that can lead to complications such as testicular atrophy. As DM requires lifelong treatment, natural and safe therapeutic alternatives are needed. Durian peel, as a natural material, has potential. This study investigated the effects of ethanol extract of durian peel (EEDP) on testicular histology in diabetic rats. A total of 25 male Sprague-Dawley rats, aged 2 months and weight ±200 g, were randomly assigned to five groups: healthy (K0), diabetic (K1), and diabetic+EEDP at doses of 500 (K2), 750 (K3), and 1,000 mg/kgBW (K4), given orally for 28 days. After treatment, the rats were euthanized, and their testes were removed, weighed, and examined using hematoxylin-eosin staining. Observed variables included testis weight, seminiferous tubule diameter, epithelial thickness, and spermatogenesis stages. Statistical analysis ANOVA (α=0,05) showed significant improvements (p < 0,05) in the EEDP-treated groups. It is concluded that EEDP at doses of 500-1,000 mg/kgBW improved testicular structure in diabetic rats.. The novelty of this study lies in the utilization of durian peel ethanol extract at varying doses of 500–1,000 mg/kgBW as a natural therapy to improve testicular histological damage caused by diabetes. This study serves as a basis for the development of herbal antidiabetic drugs with protective effects on the reproductive system. The findings are expected to contribute to biomedical science and provide opportunities for utilizing durian peel waste as a value-added material for public health.
Pola Perilaku Harian Anak Rusa Timor (Rusa timorensis) di Penangkaran CV. Bahtera Satwa Desa Margorejo, Dawe Kudus: Pola Perilaku Harian Anak Rusa Timor (Rusa timorensis) Febriani, Lili; Isdadiyanto, Sri; Kasiyati, Kasiyati
Acta VETERINARIA Indonesiana Vol. 13 No. 3 (2025): November 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.3.240-247

Abstract

The phenomenon of the declining population of Timor deer (Rusa timorensis) has led the Indonesian government to designate them as a protected species. Captive breeding has become an effort to conserve Timor deer, and daily behavior serves as a measure of the success of the breeding program. The objective of this research was to evaluate the daily behavior patterns of Timor deer fawns, including movement, feeding, resting, social, alert, eliminative, and grooming behavior at the CV. Bahtera Satwa Breeding Center. Data collection for the research was conducted over 14 days using the scan sampling method. The results showed significant differences (p<0.05) in movement behavior, feeding, resting, social, and eliminative behavior between morning, afternoon, and evening. The frequency of social behavior in deer fawn was observed more often than in other behaviors, while the duration of resting activities was higher compared to other activities. The conclusion of this study was that the daily behavior patterns of Timor deer fawns, consisting of social and resting behaviors, were consistently performed in the morning and afternoon. The social behavior exhibited by the fawns was an effort to interact and explore their environment, while resting behavior was used to avoid heat and recover energy after morning activities.
Gambaran Histologi Aorta Tikus Putih (Rattus norvegicus L.) dengan Asupan Pakan Tinggi Lemak dan Pemberian Ekstrak Etanol Biji Mahoni (Swietenia mahagoni) Isdadiyanto, Sri; Mardiati, Siti Muflichatun; Budianto, Emilia Yosephine
Buletin Anatomi dan Fisiologi Volume 10, Nomor 2, Tahun 2025
Publisher : Departemen Biologi Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/baf.10.2.2025.160-169

Abstract

Mahoni mengandung beragam senyawa metabolit sekunder sebagai antioksidan serta mampu menurunkan kadar kolesterol dalam darah. Kadar kolesterol dalam darah yang tinggi (hiperlipid) memicu terjadinya penyumbatan pada aorta (aterosklerosis). Tujuan penelitian ini adalah menganalisis gambaran histologi aorta hewan model hiperlipid dengan pemberian ekstrak etanol etanol biji mahoni (EEBM). EEBM diberikan secara peroral selama 32 hari. Sebanyak 30 ekor tikus jantan dibagi enam kelompok perlakuan, yaitu P0: kontrol pakan standar, P1: kontrol pakan tinggi lemak, P2: pakan tinggi lemak + simvastatin 8mg /200gBB, P3-P5: pakan tinggi lemak + EEBM 14, 28, 54 mg/200gBB berurutan. Parameter yang dianalisis meliputi tebal dinding, diameter lumen, dan gambaran histologi aorta. Hasil penelitian menunjukkan pemberian EEBM pada dosis 28 dan 54 mg/ekor menurunkan tebal dinding dan meningkatkan diameter lumen aorta secara berarti (p≤0,05) dibanding kontrol hiperlipid (P1), demikian juga gambaran histologi aorta yang tidak menunjukkan lesi aterosklerosis seperti kemunculan sel busa. Sehingga, disimpulkan biji mahoni mampu mencegah kerusakan akibat pakan tinggi lemak dan berpotensi sebagai alternatif pengobatan. Mahogany has variety of secondary metabolites as antioxidants and can lower blood cholesterol levels. High levels of cholesterol in the blood (hyperlipid) lead to blockage of the aorta (atherosclerosis). The purpose of this study was to analyzed the histological features of mahagony seeds ethanolic extract (MSEE) induction for animal models of hyperlipid. MSEE was administered orally for 32 days. Total 30 male rats were divided into 5 treatment groups, namely P0: standard feed control, P1: high-fat diet control, P2: high-fat diet + simvastatin 8 mg/200gBW, P3-P5: high-fat diet + MSEE 14, 28, 54 mg/200gBW respectively. Parameters analyzed included wall thickness, lumen diameter, and histological features of the aorta. The results showed that administration of EEBM at doses of 28 and 54 mg/200gBW reduced wall thickness and increased diameter of the aortic lumen significantly (p<0.05) compared to hyperlipid (P1), as well as aortic histology which did not show atherosclerotic lesions such as the appearance of foam cells. It concluded that mahogany seeds was able to prevent damage from high-fat diets and has the potential as an alternative treatment.  
Histopatologi Paru-Paru Tikus Putih (Rattus norvegicus B.) Galur Wistar setelah Paparan Asap Rokok Putih Riyadi, Adhitya Yoga Pradana; Sunarno, Sunarno; Isdadiyanto, Sri
Spizaetus: Jurnal Biologi dan Pendidikan Biologi Vol 7 No 1 (2026): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Program Studi Pendidikan Biologi, FKIP, Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v7i1.695

Abstract

Cigarettes are tobacco products consumed by burning and inhaling the smoke, while white cigarettes are made from pure tobacco without additional additives, resulting in a distinctive aroma and a relatively lower nicotine content. Continuous exposure to cigarette smoke can increase the risk of respiratory disorders. This study aimed to analyze the effects of white cigarette smoke exposure on changes in lung histopathology of white rats. The study employed a completely randomized design using 24 male white rats weighing 250–300 g, divided into four treatment groups: control, exposure to smoke from one cigarette per day, two cigarettes per day, and three cigarettes per day. The observed parameters included bronchiolar diameter, bronchial diameter, and organ weight as parametric data, as well as lung damage scores as non-parametric data. Parametric data were analyzed using analysis of variance followed by Duncan’s test, while non-parametric data were analyzed using the Kruskal–Wallis test followed by Dunn’s test at a 5% significance level. The results showed that white cigarette smoke exposure had a significant effect on lung damage scores but did not significantly affect bronchiolar diameter, bronchial diameter, or organ weight. It can be concluded that exposure to white cigarette smoke causes lung tissue damage and narrowing of the respiratory tract diameter, which are included in changes in lung organ biometry.
PEMANFAATAN PARALON DAN EMBER BEKAS SEBAGAI ALAT PENYARINGAN SERTA PENCACAHAN GUNA MENINGKATKAN HOMOGENITAS KOHE KAMBING UNTUK PEMBUATAN PUPUK ORGANIK Saputra, M Syauqi Finardhy; Fahrozi, Muhammad Aldi; Rosyda, Nada Fauzi; Failasofi, Muhammad Najih; Fahrezi, Virgi Achmad; Zakariya, Jaki; Hazim, M Syafiq; Isdadiyanto, Sri; Suharto, Slamet
Jurnal Pasopati Vol 8, No 1 (2026): Februari
Publisher : Fakultas Teknik Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/pasopati.2026.31417

Abstract

Proses pengolahan kotoran hewan (kohe) kambing menuai kendala, antara lain, pada aspek homogenitas material, yang diakibatkan karena ukuran partikel yang tidak seragam dan adanya pengotor. Penelitian ini bertujuan untuk mengkaji pemanfaatan paralon dan ember bekas untuk menyaring dan menghomogenkan kohe kambing sebagai bahan untuk membuat pupuk organik. Metode penelitian ini meliputi desain dan konstruksi alat dari bahan bekas, proses penyaringan untuk memisahkan kotoran dari material kasar, dan penghomogenan untuk memperkecil ukuran partikel. Evaluasi dilakukan secara kualitatif dengan pengamatan keseragaman tekstur dan kemudahan proses pemadatan (komposting) lebih lanjut. Hasil penelitian menunjukkan alat (saringan dan penghomogen) bekas memudahkan untuk mengolah kohe kambing yang lebih homogen, dan mengurangi waktu untuk pengolahan lebih lanjut pupuk organik. Selain itu, penggunaan bahan bekas pada alat saring dan homogen ini menjadikan alat ramah lingkungan, berbiaya murah, dan mudah direplikasi oleh masyarakat. Dengan demikian, inovasi sederhana ini berpotensi sebagai alat teknologi tepat guna untuk pengelolaan dan peningkatan kualitas pupuk organik secara komunitas.
Co-Authors Aetin, Entin Nur Agung Janika Sitasiwi Agus Subagio Alfatinnisa, Zalfa Andriyan, Mohammad Wahyu Baiq Miftahul Jannah Budianto, Emilia Yosephine Budiwardani, Dwinanda Chatarina Umbul Wahyuni Dina Arumsari, Dina Djaelani, M Anwar Djati, Astrid Laksmita Endah Puji Astuti, Endah Puji Enny Yusuf Wachidah Yuniwarti Enny Yusuf Wachidah Yuniwarti Ermanjaya, Laode Fahrezi, Virgi Achmad Fahrozi, Muhammad Aldi Failasofi, Muhammad Najih Fajar, Stefanus Fathoni, Nasrul Febriani, Lili Fitriani, Ratih Nur Hazim, M Syafiq Jaya, La Ode Irman Kasiyati Kasiati Khairunnisa, Najla Athallah Kustopo Budiraharjo Nuke Nur Hidayati, Nuke Nur Nursabrina, Azra Batrisyia Riyadi, Adhitya Yoga Pradana Rohman, Jihadul Hanif Fadlur Rosyda, Nada Fauzi Saputra, M Syauqi Finardhy Saputra, Muhammad Ragil Savitri, Ajeng Fatria Shinta Dwi Kurnia Sijabat, Agave Chintya Gabriella Silvana Tana Siti Muflichatun Mardiati Slamet Suharto, Slamet Sunarno , Sunarno Sunarno Sunarno Syakera, Cinta Etna Tyas Rini Saraswati Wulan Tri Lestari, Wulan Tri Zakariya, Jaki