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All Journal HAYATI Journal of Biosciences POSITRON TELKOMNIKA (Telecommunication Computing Electronics and Control) Jurnal Matematika & Sains Journal of Engineering and Technological Sciences ALHAZEN Jurnal Otomasi Kontrol dan Instrumentasi Indonesian Journal of Electrical Engineering and Computer Science Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Progressive Physics Journal
Ferry Iskandar
Departemen Fisika, Fakultas MIPA Institut Teknologi Bandung
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Physics Social Sciences

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Klinostat Tiga Dimensi sebagai Simulator Mikrogravitasi untuk Berbagai Eksperimen Tanpa Bobot Indra W. Fathona; Arif Surachman; Ferry Iskandar; Khairurrijal Khairurrijal
Jurnal Otomasi Kontrol dan Instrumentasi Vol 3 No 1 (2011): Jurnal Otomasi Kontrol dan Instrumentasi
Publisher : Pusat Teknologi Instrumentasi dan Otomasi (PTIO) - Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/joki.2011.3.1.4

Abstract

Abstrak Sebuah klinostat tiga dimensi (3-D) telah dirancang untuk menyediakan sebuah lingkungan dengan gravitasi sangat kecil (mikrogravitasi) bagi berbagai percobaan tanpa bobot. Besarnya gravitasi berhubungan dengan kecepatan sudut dari perputaran klinostat tersebut. Dua buah rangka berbentuk segi empat diputar pada sumbu rotasi y-z dengan menggunakan dua motor DC dan kecepatannya diatur oleh mikrokontroler AT89S52 dengan menggunakan prinsip pulse width modulation (PWM). Alat ini telah diuji selama 8 jam tanpa henti untuk berbagai kecepatan sudut di bawah 17 rpm (rotation per minute). Telah didapatkan bahwa alat ini berfungsi dengan baik.Kata kunci: gaya sentrifugal, kecepatan sudut, klinostat, mikrogravitasi, rotasi.Abstract A three-dimensional (3-D) clinostat has been designed to provide an environment with very small gravity (microgravity) for weightless experiments. The obtained gravity is closely related to the angular speed of the clinostat rotation. Two rectangular frames are rotated by employing two DC motors around the y-z rotation axis and its angular speed is controlled by an AT89S52 microcontroller using the pulse width modulation (PWM) technique. Eight-hour continuous operations have been done for various angular speeds below 17 rpm. It has been found that the clinostat functions well.Keywords:angular velocity, centrifugal force, clinostat, microgravity, rotation.
Optimasi Parameter Pemintalan Elektrik Menggunakan Teknik Algoritma Genetika: Tegangan Listrik dan Jarak Nozzle-Kolektor S Saehana; Ferry Iskandar; Mikrajuddin Abdullah; Khairurrijal Khairurrijal
Jurnal Otomasi Kontrol dan Instrumentasi Vol 3 No 1 (2011): Jurnal Otomasi Kontrol dan Instrumentasi
Publisher : Pusat Teknologi Instrumentasi dan Otomasi (PTIO) - Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/joki.2011.3.1.5

Abstract

AbstrakStudi optimasi dua parameter pemintalan elektrik, yaitu tegangan listrik dan jarak nozzle-kolektor, telah dilakukan dengan teknik algoritma genetika dalam domain [1,60] kV dan [5,25] cm serta jumlah populasi 100 buah, peluang pindah silang (pc) 0,7 dan peluang mutasi (pm) 0,5. Jejari serat seukuran 155 nm diperoleh dari hasil subsitusi nilai optimum tegangan listrik 1,83 kV dan jarak nozzle-kolektor 23,50 cm pada simulasi pemintalan elektrik yang dimodelkan oleh Reneker, dkk. Hasil optimasi ini diharapkan dapat membantu eksperimen di laboratorium. Kata kunci: pemintalan elektrik, algoritma genetika, jejari serat, optimasi. AbstractThe study of optimizing two electrospinning parameters, i.e. electric voltage and nozzle-collector distance, was done by employing a genetic algorithm technique in the domain of [1,60] kV and [5,25] cm, the population of 100, the crossover probability of 0.7, and the mutation probability of 0.5. Fiber radius of 155 nm was obtained from the substitution of optimal values of electric voltage of 1.83 kV and nozzle-collector of 23.50 cm, which are from the simulation of a model made by Reneker, et al. This optimization result could help experiments in obtaining desired fiber radius. Keywords: electrospinning, genetic algorithm, fiber radius, optimization.
The Relationship of Pregnant Mother's Compliance with Antenatal Care with the Event of Preeclampsia in Tanjung Bingkung Puskesmas Rhandyka Rafli; Indah Salsabila; Ferry Iskandar; Debie Anggraini; Dian Ayu Hamama Pitra
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 5, No 1 (2022): Budapest International Research and Critics Institute February
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i1.4381

Abstract

Preeclampsia is an increase in blood pressure experienced by pregnant women, at gestational age above 20 weeks which is treated with routine antenatal visits, this research was conducted at the Tanjung Bingkung Health Center because there is a behavior of young mothers who are ashamed to admit their pregnancy. The purpose of this study was to determine the relationship between pregnant women's adherence to antenatal care with the incidence of preeclampsia at the Tanjung Bingkung Health Center. This research method includes obstetrics and gynecology, conducted at the Tanjung Bingkung Health Center from September to November 2020. The research design was correlation analytic and case control design. The research target population was 54 samples selected by simple random sampling. Data analysis using SPSS application. So the results of this study explain that the compliance of pregnant women in antenatal care is 67% seen from the age of the highest adherence at the age of 20-35 years (80%) and seen from the parity status the highest is multigravida (68%). The incidence of preeclampsia is 13%, judging by age, the highest incidence occurs at the age of 20-35 years (80%) and from multigravida pregnant women (70%). The relationship between adherence of pregnant women to antenatal care with the incidence of preeclampsia, found p value > 0.05 with the conclusion that there is no relationship between adherence of pregnant women to antenatal care with the incidence of preeclampsia.
Numerical Simulation of Tunneling Current in an Anisotropic Metal-Oxide-Semiconductor Capacitor Fatimah Arofiati Noor; Ferry Iskandar; Mikrajuddin Abdullah; Khairurrijal khairurrijal
Indonesian Journal of Electrical Engineering and Computer Science Vol 10, No 3: July 2012
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In this paper, we have developed a model of the tunneling currents through a high-k dielectric stack in MOS capacitors with anisotropic masses. The transmittance was numerically calculated by employing a transfer matrix method and including longitudinal-transverse kinetic energy coupling which is represented by an electron phase velocity in the gate. The transmittance was then applied to calculate tunneling currents in TiN/HfSiOxN/SiO2/p-Si MOS capacitors. The calculated results show that as the gate electron velocity increases, the transmittance decreases and therefore the tunneling current reduces. The tunneling current becomes lower as the effective oxide thickness (EOT) of HfSiOxN layer increases. When the incident electron passed through the barriers in the normal incident to the interface, the electron tunneling process becomes easier. It was also shown that the tunneling current was independent of the substrate orientation. Moreover, the model could be used in designing high speed MOS devices with low tunneling currents. DOI: http://dx.doi.org/10.11591/telkomnika.v10i3.607
Preliminary Investigation of pH-Dependent Optical Properties of Curcumin-Derived Carbon Dots Santika, Arum Sinda; Permatasari, Fitri Aulia; Iskandar, Ferry
Progressive Physics Journal Vol. 6 No. 1 (2025): Progressive Physics Journal
Publisher : Program Studi Fisika, Jurusan Fisika, FMIPA, Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/ppj.v6i1.1522

Abstract

Carbon dots (CDs) are photoluminescent nanoparticles smaller than 10 nm with excellent optical properties, including high photostability, UV and visible light absorption, water solubility, low toxicity, and good biocompatibility. These features make them attractive for biomedical, optoelectronic, and catalytic applications. Curcumin, a polyphenol from turmeric, possesses anti-inflammatory, antibacterial, anticancer, and antiviral properties, but its poor water solubility limits its biomedical use. In this study, CDs were synthesized from curcumin and urea via a solvothermal method at 140 °C for 180 minutes to improve curcumin's solubility. The effect of pH on the optical properties of CDs was investigated by adjusting acidity with citric acid and alkalinity with NaOH. UV-Vis and photoluminescence (PL) spectroscopy revealed that the optical properties of CDs are strongly influenced by pH, likely due to the presence of keto-enol tautomerism in curcumin. The pH sensitivity of these curcumin-derived CDs highlights their potential for biomedical applications such as photothermal therapy, bioimaging, drug delivery, and antiviral agents.
Development of a Fluorescence Immunoassay Based on Curcumin Carbon Dots-labeled IgY Antibodies for SARS-CoV-2 Detection Rachmadani, Nisa Amanda; Soetomo, Meilisa Keizia; Taharuddin, Audrey Angelina Putri; Santika, Arum Sinda; Abdillah, Oktaviardi Bityasmawan; Permatasari, Fitri Aulia; Iskandar, Ferry; Rachmawati, Heni; Fibriani, Azzania
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.44-57

Abstract

Carbon dots (CDs) are widely utilized in biomedical applications as fluorescent labels for imaging and diagnostics due to their excellent biocompatibility and superior optical properties. These advantages often make CDs a substitute for organic fluorescent dyes, which suffer from low emission intensity and poor photostability when interacting with biomolecules. Moreover, carbon-based materials are eco-friendly and can be synthesized from natural sources, such as curcumin, a chromophore compound abundantly available in Indonesia. Therefore, this study conducted a preliminary investigation on curcumin CDs-labeled IgY antibodies (IgY-cur CDs) for fluorescence immunoassay of SARS-CoV-2 in rapid test applications. The synthesis of the fluorescent label involved a carbodiimide coupling reaction using EDC/NHS agents to conjugate IgY antibodies with curcumin CDs. The IgY-cur CDs conjugate was confirmed to detect antigens through FRET immunosensor mechanisms, showing a significant increase in fluorescence intensity with increasing antigen concentrations (p < 0.05), with a minimum sample concentration of 10 ng. Furthermore, the IgY-CDs cur conjugate was applied as a reporter in a fluorescence-based LFIA using a sandwich assay format. The test strip successfully detected synthetic multiepitope SARS-CoV-2 antigens with an estimated detection limit of 54.28 µg and nasopharyngeal samples from confirmed COVID-19 patients within 35 minutes of operation. The test strip was evaluated to be stable under cold storage at 4°C for up to 3 weeks. In conclusion, curcumin CDs-labeled IgY antibodies demonstrate promising potential for further development as fluorescent labels in rapid diagnostic applications targeting SARS-CoV-2.
Evaluation of Curcumin-derived Carbon-dots' Inhibitory Activity as SARS-CoV-2 Antiviral Candidate Using Chemical Crosslinking Taharuddin, Audrey Angelina Putri; Yamahoki, Nicholas; Stephanie, Rebecca; Agustiyanti, Dian Fitria; Wisnuwardhani, Popi Hadi; Angelina, Marissa; Rubiyana, Yana; Ningrum, Ratih Asmana; Wardiana, Andri; Desriani, Desriani; Hariyatun, Hariyatun; Iskandar, Ferry; Permatasari, Fitri Aulia; Giri-Rachman, Ernawati Arifin; Fibriani, Azzania
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.232-239

Abstract

In our previous work, we demonstrated that curcumin-derived carbon dots (Cur-CDs) have potential as antivirals for COVID-19. However, the precise mechanism of action remains unclear. This study investigated the potential of Cur-CDs against SARS-CoV-2 by targeting the dimerization of the C-terminal domain of nucleocapsid protein (N-CTD) using chemical crosslinking. Recombinant SARS-CoV-2 N-CTD was expressed, purified, and subjected to chemical crosslinking. The dimerization inhibition ability of Cur-CDs was assessed with ligand concentrations ranging from 0 to 2,000 μg/mL. Successful inhibition —defined as a noticeable reduction in SARS-CoV-2 N-CTD dimer band intensity on SDS-PAGE—was observed when Cur-CDs were present at 8 to 16 times the protein concentration. We hypothesize that Cur-CDs bind to the dimerization residues, preventing non-covalent interactions between monomers and limiting dimer formation. Our findings suggest that Cur-CDs could be a promising antiviral strategy for SARS-CoV-2, especially targeting the dimerization of the nucleocapsid protein. Additionally, this study also highlights the use of chemical crosslinking as a valuable tool for interaction-based drug screening.
Co-Authors Abdillah, Oktaviardi Bityasmawan Abdul Waris Agustiyanti, Dian Fitria Andri Wardiana, Andri Anrokhi, Mohamad Samsul Arif Surachman Bebeh Wahid Nuryadin Debie Anggraini Desriani Desriani Destiarti, Lia Dewi Kartikasari Dian Ayu Hamama Pitra Eri Hiswara ERNAWATI ARIFIN GIRI-RACHMAN Fatimah A. Noor Fatimah Arofiati Noor Fibriani, Azzania Floweri, Octia Freddy Haryanto Hariyatun, Hariyatun HENI RACHMAWATI Hwa, Lee Myong Indah Salsabila Indra Wahyudin Fathonah Khairurrijal Khairurrijal Kikuo Okuyama Kikuo Okuyama Lee Myong Hwa Maharsi, Retno Marissa Angelina Mikrajuddin Abdullah Mikrajuddin Abdullah Mikrajuddin Abdullah Mikrajuddin Abdullah Nina Yunia Hasanah Nunung Nuraeni, Nunung Permatasari, Fitri Aulia Popi Hadi Wisnuwardhani, Popi Hadi Rachmadani, Nisa Amanda RATIH ASMANA NINGRUM Rhandyka Rafli Ricky Dwi Septianto S Saehana Santika, Arum Sinda Septia Mahen, Ea Cahya Septianto, Ricky Dwi Soetomo, Meilisa Keizia Stephanie, Rebecca Taharuddin, Audrey Angelina Putri Yamahoki, Nicholas Yana Rubiyana, Yana