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The Effect of Metanolic Extract and Ethyl Acetate Fraction of Kepel Fruits to Lipid Peroxide Concentration in Liver of CCl4-induced Rat Mitsalina Fildzah Arifah; Sudibyo Martono; Sugeng Riyanto; Claude Mona Airin
Journal of Food and Pharmaceutical Sciences Vol 7, No 3 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.661

Accumulation lipid peroxidation can lead to the formation of malondialdehyde to generatefree radicals. Antioxidant will minimize free radical related health problems, such as naturalantioxidant from meat of kepel (Stelechocarpus burahol) (Blume) Hook. F. & Thompson) fruits.Antioxidant activities of methanol extracts and acetate ethyl fractions meat of kepel fruits calculatedprofile of malondialdehyde concentration (ng/mL) in CCl4 induced acute liver toxicity in femaleSprague Dawley rats using ELISA competitively method. All of groups induced CCl4 i.p. at 0 h, exceptuntreated and solvent control group, then vitamin C , methanol extracts and acetate ethyl fractionsp.o. once daily for 72 h. Identification of secondary metabolite was using phytochemical screeningand Thin Layer Chromatography (TLC). Liver weighed and calculated relative organ weight (ROW)of liver, then all of data analyzed using statistic tests, One Way ANOVA and Kruskall Wallis. Thisstudy showed methanol extracts can decrease MDA concentration, ALT and AST were more potent(significantly p<0.05) than acetate ethyl fractions and vitamin C. The TLC analysis identified methanolextracts have same polarity with quercetin (Rf = 0,26) and acetate ethyl fractions showed otherflavonoid class, except rutin and quercetin. ROW of acute liver toxicity in rats increased significantlyin CCl4 and vitamin C groups.

The Effect of Metanolic Extract and Ethyl Acetate Fraction of Kepel Fruits to Lipid Peroxide Concentration in Liver of CCl4-induced Rat Mitsalina Fildzah Arifah; Sudibyo Martono; Sugeng Riyanto; Claude Mona Airin
Journal of Food and Pharmaceutical Sciences Vol 7, No 3 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.661

Accumulation lipid peroxidation can lead to the formation of malondialdehyde to generatefree radicals. Antioxidant will minimize free radical related health problems, such as naturalantioxidant from meat of kepel (Stelechocarpus burahol) (Blume) Hook. F. & Thompson) fruits.Antioxidant activities of methanol extracts and acetate ethyl fractions meat of kepel fruits calculatedprofile of malondialdehyde concentration (ng/mL) in CCl4 induced acute liver toxicity in femaleSprague Dawley rats using ELISA competitively method. All of groups induced CCl4 i.p. at 0 h, exceptuntreated and solvent control group, then vitamin C , methanol extracts and acetate ethyl fractionsp.o. once daily for 72 h. Identification of secondary metabolite was using phytochemical screeningand Thin Layer Chromatography (TLC). Liver weighed and calculated relative organ weight (ROW)of liver, then all of data analyzed using statistic tests, One Way ANOVA and Kruskall Wallis. Thisstudy showed methanol extracts can decrease MDA concentration, ALT and AST were more potent(significantly p<0.05) than acetate ethyl fractions and vitamin C. The TLC analysis identified methanolextracts have same polarity with quercetin (Rf = 0,26) and acetate ethyl fractions showed otherflavonoid class, except rutin and quercetin. ROW of acute liver toxicity in rats increased significantlyin CCl4 and vitamin C groups.

Pengaruh Pemberian Edukasi Apoteker Terhadap Tingkat Pengetahuan Masyarakat Tentang DAGUSIBU di Kabupaten Bantul Shalahuddin Al Madury; Mitsalina Fildzah Arifah; M. Fadlhil Rheza Maulana
Jurnal Indonesia Sehat Vol. 3 No. 1 (2024): JURINSE, April 2024
Publisher : SAMODRA ILMU: Lembaga Penelitian, Penerbitan, dan Jurnal Ilmiah

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Background: Medication error among the community is a major public health problem that can cause great harm to patients. Problems that are often found in the community are the level of understanding of drug use starting from obtaining, using, storing, and destruction of drugs in the correct way. Sustainable efforts are needed to improve public knowledge through the provision of information through educational media by Pharmacists as health workers who understand drugs. Purpose: This study aims to determine the effect of Pharmacist education on the level of public knowledge in Bantul Regency. Method: This type of research is pre-experimental with a one group pre-test, post-test design in one group. Analysis using univariate and bivariate using the Wilcoxon test. Result: The results showed an increase in the percentage of respondents' knowledge level in the good category after receiving educational treatment with the lecture method and assisted by leaflet media, from 27.5% to 52.5%, and a decrease in the level of knowledge is less, at the pre-test 27.5% to 15% during the post-test conducted after education was carried out. Conclusion: The provision of education materials by pharmacists has a significant effect on increasing knowledge about DAGUSIBU in the community in Bantul Regency with a p-value (0.021) <0.05.

The Antibacterial Activity of Bajakah Tampala Extracts (Spatholobus littoralis Hassk.) Mouthwash Formulation Inhibited Dental Plaque against Streptococcus mutans Rikhaturhohmah; Rospadila Dwi Adrila; Widiya Dwi Handayani; Rasyani; Ananda Alifvia Suprapto; Nofran Putra Pratama; Mitsalina Fildzah Arifah
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.15147

Dental plaque is the main cause of dental caries caused by Streptococcus mutans, with a high prevalence in Indonesia. Currently, the mouthwash market contains high levels of alcohol, which can cause long-term side effects. Tampala bajakah root (Spatholobus littoralis) is used in traditional medicine for the Dayak community in Central Kalimantan. Bajakah Tampala root has antibacterial activity produced by flavonoids and phenolic compounds. The development of herbal cosmetics can be achieved by Bajakah Tampala mouthwash formulations to prevent dental plaque caused by Streptococcus mutans infection. In this study, ultrasound-assisted extraction (UBT) and infusion (IBT) derived the active compounds of Bajakah Tampala root extract. The various concentrations of UBT (20–80%) and IBT (10%) were evaluated for antibacterial activity using the disk diffusion method. The results showed that positive control and 80% UBT have antibacterial activity higher than other extracts, with an inhibition zone of 14,01±2,70 mm. Based on these results, an effective mouthwash dosage formulation can be developed at 80% UBT. The formulation evaluation of mouthwash assessed viscosity, homogeneity, pH, and organoleptic test. The UBT mouthwash product has qualified formulation evaluation parameters. This research contributed to the innovation of herbal cosmetics by developing the potential of Indonesian medicinal plants. Keywords: Bajakah Tampala, Antibacterial activity, Mouthwash, Herbal cosmetic, Streptococcus mutans.

The Antibacterial Activity of Bajakah Tampala Extracts (Spatholobus littoralis Hassk.) Mouthwash Formulation Inhibited Dental Plaque against Streptococcus mutans Rikhaturhohmah; Rospadila Dwi Adrila; Widiya Dwi Handayani; Rasyani; Ananda Alifvia Suprapto; Nofran Putra Pratama; Mitsalina Fildzah Arifah
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.15147

Dental plaque is the main cause of dental caries caused by Streptococcus mutans, with a high prevalence in Indonesia. Currently, the mouthwash market contains high levels of alcohol, which can cause long-term side effects. Tampala bajakah root (Spatholobus littoralis) is used in traditional medicine for the Dayak community in Central Kalimantan. Bajakah Tampala root has antibacterial activity produced by flavonoids and phenolic compounds. The development of herbal cosmetics can be achieved by Bajakah Tampala mouthwash formulations to prevent dental plaque caused by Streptococcus mutans infection. In this study, ultrasound-assisted extraction (UBT) and infusion (IBT) derived the active compounds of Bajakah Tampala root extract. The various concentrations of UBT (20–80%) and IBT (10%) were evaluated for antibacterial activity using the disk diffusion method. The results showed that positive control and 80% UBT have antibacterial activity higher than other extracts, with an inhibition zone of 14,01±2,70 mm. Based on these results, an effective mouthwash dosage formulation can be developed at 80% UBT. The formulation evaluation of mouthwash assessed viscosity, homogeneity, pH, and organoleptic test. The UBT mouthwash product has qualified formulation evaluation parameters. This research contributed to the innovation of herbal cosmetics by developing the potential of Indonesian medicinal plants. Keywords: Bajakah Tampala, Antibacterial activity, Mouthwash, Herbal cosmetic, Streptococcus mutans.

Effect of Particle Size and Extraction Time on Total Flavonoid Level of Artemisia vulgaris Ethanol Extract Kurniasih, Kholif Sholehah Indra; Arifah, Mitsalina Fildzah; Setiyawati, Eka Ayu; Rahmah, Syafira Atika; Widianingrum, Lucia; Kholifah, Eva
Journal of Biotechnology and Natural Science Vol. 4 No. 2 (2024): December
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jbns.v4i2.12045

Background: Artemisia vulgaris, also referred to as Daun Baru Cina, is a herbaceous species within the Asteraceae family. Artemisia vulgaris is a traditional remedy for numerous ailments, exhibiting anti-inflammatory and antioxidant properties due to its secondary metabolites, specifically flavonoids. The extraction method is essential for extracting the desired chemical from natural sources intended for therapeutic use. The extraction process is affected by several elements, including the particle size of simplicia powder and the duration of extraction. Objective: This study aims to test the effect of differences in particle size of powdered simplicia and extraction time of Artemisia vulgaris leaves on total flavonoid levels, using 70% ethanol solvent. Researchers used a quantitative approach using a descriptive research design. In this study, a qualitative test was carried out in the form of phytochemical screening followed by a quantitative test to determine the total flavonoid levels of Artemisia vulgaris leaves. Various particle sizes (40 mesh and 80 mesh) and extraction times (12 hours and 36 hours) were used in this study. Using ultraviolet-visible spectrophotometry, the Total Flavonoid Level (TFC) of the ethanol extract of Artemisia vulgaris leaves was determined. Results: The TFC value obtained for the optimal particle size was 40 mesh, with an extraction time of 12 hours, which was 72.073 ± 1.126 mgQE / g extract. While 80 mesh, with an extraction time of 36 hours, gave a TFC value of 70.169 ± 0.480 mgQE / g extract. In addition, 70% ethanol extract of Artemisia vulgaris leaves contains secondary metabolites of phenolic alkaloids, tannins, saponins, and steroids. Conclusion: The study concludes that the quantity of simplicia powder particles and the extraction duration influence the total flavonoid concentrations in Artemisia vulgaris.

Penyuluhan Perbedaan Masa Kadaluarsa Obat (ED) dengan Obat Dapat Digunakan Setelah Dibuka (BUD) pada Masyarakat Dusun Kertan Kabupaten Bantul Shalahuddin Al Madury; Arifah , Mitsalina Fildzah; Aldian , Decky; Maulana, M. Fadlhil Rheza
JOURNAL OF PHILANTHROPY: The Journal of Community Service Vol. 3 No. 1 (2025): Journal of Philanthropy, January 2025
Publisher : Samodra Ilmu: Lembaga Penelitian, Penerbitan, dan Jurnal Ilmiah

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The proper use of drugs is a challenge in society. The level of public knowledge regarding the proper use of drugs is still low. Many people still do not understand the beyond use date (BUD) of semi-solid preparations. BUD is the limit of the drug is still safe and can be used after the packaging is opened, not the same as the Expired date (ED) listed on the drug packaging. So this can cause misunderstanding and is a new thing for the public to know the BUD of a drug preparation. The community service activity on Saturday, October 5, 2024 at 15.30 WIB took place at the Ainun Jariyah Mosque, Kertan Hamlet, Sumberagung, Jetis, Bantul Regency was attended by 31 residents. After pharmacist education was carried out through lectures, and assisted by leaflet media, there was a difference in the number of participants with a moderate pretest level, namely from 6 to 19 people. Education about ED and BUD accompanied by leaflet media can increase public knowledge as seen from the difference in pretest and posttest which shows the number of participants with an increase in correct answers during the pretest and posttest of 68%.

Sosialisasi Tanaman Obat Keluarga (TOGA) dan Pembuatan Jamu Serbuk pada Masyarakat di Padukuhan Kertan Bantul Arifah, Mitsalina Fildzah; Trinita Puspitasari; Nurul Afniatun; Fina Ummu Sayyidah Yahya; Citra Eka Runenti; Nanda Ayu Safitri
The Journal of Innovation in Community Empowerment Vol 6 No 2 (2024): Journal of Innovation in Community Empowerment (JICE)
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jice.v6i2.1351

Tanaman obat keluarga (TOGA) adalah bahan-bahan herbal yang sudah dikenal sejak lama dan dimanfaatkan Masyarakat untuk pencegahan dan pengobatan penyakit. Minimnya edukasi TOGA pada masyarakat Padukuhan Kertan khususnya ibu-ibu PKK dan Pemudi Karang Taruna pada tanaman jahe dapat digunakan sebagai apotek hidup sebagai pertolongan pertama meningkatkan kekebalan tubuh terhadap penyakit. Sosialisasi TOGA dan pembuatan jahe serbuk dilaksanakan untuk meningkatkan edukasi dan kemampuan masyarakat tentang pemanfaatan TOGA pada pembuatan jamu serbuk yang dibuat secara mandiri. Penelitian ini dilaksanakan di Padukuhan Kertan Bantul pada ibu-ibu PKK dan pemudi karang taruna dengan rentang usia 15-62 tahun. Peserta yang ikut berpartisipasi sejumah 30 orang dengan 20 anggota ibu-ibu PKK dan 10 anggota pemudi karang taruna. Hasil kuisioner dilakukan evaluasi dengan pretest dan posttest untuk mengevaluasi pengetahuan peserta. Rata-rata pengetahuan peserta tentang tanaman obat keluarga (TOGA) saat pretest sebesar 62,97% (kategori sangat paham) dan 37,03% (paham), sedangkan peningkatan pengetahuan peserta dalam posttest sebesar 66,67% (sangat paham) dan 33,33% (paham). Hasil kuisioner pengetahuan Masyarakat terhadap pembuatan jamu pada pretest sebesar 88,89% (sangat paham) dan 11,11% (paham). Peningkatan pengetahuan dan pemahaman warga terhadap Jamu pada nilai posttest sebesar 100% (sangat paham). Oleh karena itu, pengetahuan mengenai TOGA dan pembuatan jamu serbuk dapat diterapkan dalam kehidupan sehari-hari.

Pengaruh Variasi Waktu Ekstraksi terhadap Aktivitas Peredaman Radikal Bebas DPPH Ekstrak Biji Kopi Robusta Lampung Barat Arifah, Mitsalina Fildzah; Rusydan, Azka Muhammad; Sayyidah Yahya, Fina Ummu; Pratama , Nofran Putra; Saputra, Diky Permana
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i2.1454

Background: Robusta Coffee (Coffea canephora) has been cultivated in Indonesia, especially in the West Lampung area. Robusta coffee contains secondary metabolites that act as antioxidants, namely chlorogenic acid and other phenolic components. These secondary metabolites of robusta coffee bean can be obtained using the extraction method. The ultrasound-assisted extraction (UAE) is a well-known method to be more effective and lower temperature than other extraction methods. Variations in time impacted by the antioxidant activity of coffee bean extract. Research objective: To determine the effect of variation in extraction time on the free radical reduction activity of DPPH from West Lampung Robusta coffee bean extract. Research method: Robusta coffee beans were extracted by the UAE method using a 70% ethanol solvent (1:100). The variation in extraction time was 10, 20, and 30 minutes. Robusta coffee bean extract was subjected to organoleptic tests, phytochemical screening, and antioxidant activity in DPPH free radical scavenging. Research results: The yield results at 10, 20, and 30 minutes of robusta coffee bean extract were 24.04%, 35.71%, and 20.15%. The results of the organoleptic test of the extract produce a thick texture, brown color, and unique aroma. The results of the phytochemical screening of the extract contain alkaloids, phenolics, tannins, and flavonoids. The IC50 values at the time variations of 10, 20, and 30 minutes, and quercetin were 29.97 ± 2.737 ppm; 30.5 ± 1.745 ppm; 23.31 ± 4.638 ppm; and 1.42 ± 0.440 ppm respectively, which were significantly different. Conclusion: The variation in extraction time affected the free radical reduction activity of DPPH was an extraction time of 30 minutes in the most optimal DPPH free radical scavenging activity

The Effect of Extraction Time Variation on Caffeine Content in Robusta Coffee Extract using Ultrasound-Assisted Extraction Method Anggraini, Amelia Putri; Fildzah Arifah, Mitsalina; Sayyidah Yahya , Fina Ummu; Nurhasanah, Devika
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.18750

West Lampung Robusta coffee has a higher caffeine content than other types of coffee. The variations in extraction time in ultrasound-assisted extraction (UAE) produced different caffeine contents than conventional extraction methods. This study aims to determine extraction time variation (15, 30, 45) influences caffeine contents in roasted coffee beans. The organoleptic test and alkaloid test evaluated Robusta coffee qualitatively. The extract obtained was measured by measuring the % MC, yield value, and wavelength scanning. Quantitative analysis using UV-Vis Spectrophotometry determined the caffeine content with different extraction times, and then each group was assessed using SPSS software. The coffee bean powder was dark brown, had a distinctive coffee aroma, bitter taste, and smooth texture, and contained alkaloids with the Mayer, Wagner, and Dragendorff tests. The yield and % water content of extract at 30 (36.938%; 6.39%) were higher than at 15 (24.111%; 6.07%) and 45 minutes (22.170%; 6.37%). Alkaloids of the extract were investigated at a wavelength of 273 nm. Caffeine contents were 0.977 ± 0.018 mgCE/mg at the 15, 0.792 ± 0.054 mgCE/mg at the 30, and 0.979 ± 0.026 mgCE/mg at the 45 minutes in significant (P<0.05). In conclusion, the difference in extraction time impacted the caffeine content of the robusta coffee bean.

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