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All Journal Journal of Food and Pharmaceutical Science PROSIDING SEMINAR NASIONAL Jurnal Ilmiah Farmasi Journal of Mathematical and Fundamental Sciences Jurnal Riset Kimia JPS Unimus Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Unnes Science Education Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Kesehatan Masyarakat Jurnal Farmasi Sains dan Praktis Prosiding Seminar Nasional Universitas Ma Chung Jurnal Manusia dan Lingkungan Journal of Food and Pharmaceutical Sciences Journal of Pharmascience Journal of Pharmaceutical Sciences and Community

Enade Perdana Istyastono

Department Of Pharmacy, Faculty Of Medicine And Health Sciences, Atma Jaya Catholic University Of Indonesia, Jalan Pluit Raya 2, Jakarta 14440, Indonesia

Author-ID : 290147

Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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UJI IN SILICO SENYAWA EMODIN SEBAGAI LIGAN PADA RESEPTOR ESTROGEN ALFA Liliana Liliana; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Breast cancer is a disease with abnormal cell proliferation at breast tissue that can invade the surrounding tissue and spread to another organ. Based on WHO (2014) at 2012, there are 48,998 breast cancer cases on women in Indonesia with 19,730 death cases. In breast cancer, overexpression estrogen receptor alpha (ER-?) usually observed. Hence ER-? became the focus of prevention and therapy for breast cancer. In vitro study of emodin shows IC50 2.7 M and Ki 0.77 M on ER-?. In silico research using docking protocol and post docking analysis protocol shown that emodin was not an active ligand on ER-?. The outcome shown as ChemPLP score with average -75.292 and PLIF bitstring. Emodin binds with LEU346, LEU387, and ARG394 residue. Currently, the protocol that used in this research has yet identified marginal compound like emodin as an active ligand on ER-?.

MOLECULAR DYNAMICS STUDIES OF FULL HUMAN MATRIX METALLOPROTEINASE 9 LIGANDED WITH N-HYDROXY-2-[(4-PHENYLPHENYL) SULFONYL-PROPAN-2-YLOXYAMINO] ACETAMIDE Roy Gunawan Wicaksono; Maywan Hariono; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

The research presented in this article aimed to provide a full quarternary structure of human matrix metalloproteinase 9 (MMP9) enzyme with a ligand in the catalytic site for structure-based virtual screening. The enzyme plays an important role in wound healing of diabetic foot ulcer. By employing the primary structure of the enzyme obtained from UniProt database (UniProt:P14780), the theoretical structure of full apoenzyme of the human MMP9 (PDB:1LKG), the crystal structures of the catalytic domain (PDB:4H3X) and the hemopexin domain (PDB:1ITV) of the human MMP9, homology modeling studies have been performed. The ligand N-2-(biphenyl-4-yl-sulfonyl)-N-2-(isopropyloxy)-acetohydroxamic acid (CC27) or N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide (IUPAC version) from PDB:4H3X was embedded in the catalytic site of the enzyme. The modeling made use of the modules of homology modeling in YASARA structure. Subsequently, molecular dynamics (MD) simulations in YASARA structure were performed to examine the stability of the enzyme. The homology model was found stable after 5.05 ns and the lowest energy of the model was found at the 6.40 ns of the MD production run. This lowest energy snapshot was then energetically minimized and analyzed for its applicability for virtual screening. This optimized model was then stored in Mendeley Data (DOI: 10.17632/4gsb4p75gz.1).

METODE PEMANASAN DAN SONIKASI MENGHASILKAN NANOLIPOSOM DARI FOSFOLIPID LESITIN KEDELAI (SOY LECITHIN) Rini Dwiastuti; Sri Noegrohati; Enade Perdana Istyastono; Marchaban Marchaban
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

Liposomes in topical drug delivery preparation is developed because having a good penetration through the skin. The lecithin which is often used in liposome formulations is soy lecithin. Heating and sonication methods can be done to reduce the size of the particles. This study aims to produce nanoliposom dosage formulations of soy lecithin phospholipids by using a combination of heating and sonication methods to generate liposomes with size 150nm . The methods of nanoliposomes preparation in this study using a combination of heating 60?C and sonication methods for about 30 minutes in the manufacturing process . The results showed that the preparation of nanoliposomes formulation from soy lecithin can be done by using a combination of heating 60?C and sonication methods for about 30 minutes.

ANALISIS KUANTITATIF ISOFLAVON TEMPE SECARA CEPAT DAN SEDERHANA MENGGUNAKAN METODE KROMATOGRAFI LAPIS TIPIS- DENSITOMETRI Agustina Setiawati; Sri Hartati Yuliani; Enade Perdana Istyastono; Michael Raharja Gani; Evy Fenny Veronica; Dina Christin Ayuning Putri; Reza Eka Putra; David Chandra Putra; Agnes Mutiara Kurniawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Rapid and simple quantitative analysis isoflavones tempe using densitometric TLChas been done. The mobile phase of the system was chloroform: methanol: ethylacetate (45: 5:0.75). Thin layer chromatography was performed on aluminium TLC plates.Ascending distanceof 1 ?L sample was performanced 10 cm. Then the plate was scanned at 261 nm. A linearrelationship obtained at 0.08 - 2 ?g/spot with r= 0.9986. The LOD and LOQ of isoflavone were0.014 ?g/spot and 0.048 ?g/spot. Genistein contained in tempe was 0.151 0.005 % b/b.

EKSPLORASI SIFAT FISIKOKIMIA 2-BENZILIDEN-SIKLOHEKSANA-1,3- DION BERDASAR PERHITUNGAN KIMIA KUANTUM SEMIEMPIRIK Enade Perdana Istyastono
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTAromatic cyclic endione has been predicted qualitatively as anticancer agent. 2-Benzylidenecylclohexane-1,3-dione is the simplest aromatic cyclic endione compound. Physicochemistryproperties of 2-benzylidene-cylclohexane-1,3-dione have been explored. The properties wereexplored by semiempirical quantum-chemical calculations using the computational chemistryapproach. Vibrations spectrum of 2-benzylidene-cylclohexane-1,3-dione has been used todetermine the best semiempirical method. The AM1 semiempirical method was found to be themost appropriate method to describe the structure of 2-benzylidene-cylclohexane-1,3-dione andexplore the physicochemistry properties.Keywords : anticancer, physicochemistry, semiempirical quantum-chemical calculation, 2-benzylidene-cylclohexane-1,3-dione.

Pembuatan Protokol Penapisan Virtual Berbasis Stuktur (pvbs) untuk Identifikasi Ligan Inhibitor Reseptor Platelet-Activating Factor (PAF-r) sebagai Target Terapeutik Asma menggunakan YASARA Gerry Nugraha; Enade Perdana Istyastono
Jurnal Riset Kimia Vol. 11 No. 1 (2020): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v11i1.346

Platelet-activating factor receptors (PAF-r) is known as one of the receptors that affect asthma, while the Y-21480 ligand is reported as an effective, specific, and active PAF-r antagonist for asthma patients. Research in building structure-based virtual screening protocol (SBVS) for identification of PAF-r ligand inhibitors has been performed, the receptor crystal structure was obtained from the Protein Data Bank (PDB ID: 5zkp), while the ligand used as a leading compound is Y-24180, obtained from U.S. National Library of Medicine. Interactions between ligands and receptors are observed through molecular dynamics simulations using the YASARA program at intervals up to 20 nanoseconds, ligand-receptor binding stability occurs after a time interval of 2 nanoseconds, the lowest ligand-receptor binding energy occurs at a time interval of 1,401 picoseconds. Internal validation by re-docking 1,000 times the ligand to receptor resulted in a value of Root Mean Square Deviation (RMSD) of 0.6037 Ã…,Â confirmed that SBVS protocol was accurately able to reproduce the Y-24180 ligand pose on the 5zkp crystal structure,Â the protocol can be used as a new approach for investigation or design of compounds that have therapeutic potential as anti-asthma.

Reflective Pedagogy: Case Study of Organic Chemistry at the University of Muhammadiyah Semarang Eko Yuliyanto; Fitria Fatichatul Hidayah; Enade Perdana Istyastono; Yosef Wijoyo; Titien Siwi Hartayu
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2017: Proceeding 3rd ISET 2017 | International Seminar on Educational Technology 3rd 2017
Publisher : Universitas Muhammadiyah Semarang

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The development of the modern age is a lot of changes in education is the paradigm of teacher-centered learninginto student-centered learning which has a very important role in maximizing its competence in classroom management. One of the lessons in chemistry education that has problems is organic chemistry courses. Based onthe reflections applied to teachers and students "What has been gained from the learning process?", "What is thevalue obtained while the process is underway?" And "What will be done next (implementation)?". The results arestill very unsatisfactory, this is due to the limited ability of lecturers in the learning process. Associated with these conditions, then of course required intensive changes and planned for comprehensive improvement associated with the input to be generated. Efforts to be made is to improve the paradigm of learning. The selected learning paradigm is Reflective Pedagogy Paradigm (PPR). Reflective Pedagogy Paradigm was chosen because based on the results of research can improve the performance of lecturers in teaching, improve the readiness of lecturers in teaching, and make students able to reflect the learning process, and students become more active. The research was conducted following a workshop with lecturers who have implemented Reflective Pedagogy at Sanata Dharma University Yogyakarta. Stages in Reflective Pedagogy are context, experience, reflection, action and evaluation. It is expected by the end of two meetings. To be able to apply PPR, a lecturer needs to be equipped with special training on PPR-based teaching strategies as well asreflection skills (ICAJE, 1993, Gwaza et al., 2010; Schaub-de Jong dkk.2011; Wijoyo et al., 2016). Based on the results of the teacher reflection, it is increasingly realized that the preparation of learningis very important, and it is realized. While based on the results of reflection students stated that the purpose oflearning is clear, the material relevant to the profession of students, and understanding of the material becomeseasier, and the moral values for students. This case study is also in line with previous research that John Dewey(1933), He argued that learning from experience is enriched by reflecting on experience and Donald A. Schön (1987) theorized that reflective practice represents an important factor to improve professional activity. Jack Mezirow, (1991, 2000) gives reflection a central role in learning because through it we become aware of the ways in which we interpret reality and give meaning to actions and behavior. Writing-to-learn tasks should encourage students to conceptualize writing in a way that emphasizes exploration, expressive inquiry, discovery, problem-solving, decision making and knowledge construction.Key Word: Reflective Pedagogy Paradigm, case study, Organic Subject

DOES REFLECTIVE PEDAGOGY MAKE ENVIROMENTAL LACTURER BE BETTER? Eko Yuliyanto; Fitria Fatichatul Hidayah; Enade Perdana Istyastono; Yosef Wijoyo
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2018: PROCEEDING 1ST INSELIDEA INTERNATIONAL SEMINAR ON EDUCATION AND DEVELOPMENT OF ASIA (INseIDEA)
Publisher : Universitas Muhammadiyah Semarang

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Environmental education is an aspect of education for students who are important to support life in the future. In the learning process there are several factors that influence success in learning. One of them is the ability factor of teaching from a teacher include material, method and learning media. However, there are important factors that need to be considered, namely the ability of teachers to reflect themselves during the learning process. Therefore it is necessary for the research to know the reflection of teachers in the learning process. This study aims to determine the effect of teacher reflection on student learning outcomes. The study involved as many as 15 students of English education. Data obtained in the form of student reflection data, questionnaire value of proenvironment attitudes. The data obtained were analyzed using Paired Samples T-Test. The results showed that the process of reflection that has not been optimal can’t improve the quality of learning.Keywords: pro-environment, reflection of paradigm pedagogy, lecturer, learning

ANALISIS REFLEKSI PADA PEMBELAJARAN: REVIEW REASEARCH Eko Yuliyanto; Fitria Fatichatul Hidayah; Enade Perdana Istyastono; Yosef Wijoyo
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2018: SEMINAR NASIONAL PENDIDIKAN SAINS DAN TEKNOLOGI
Publisher : Universitas Muhammadiyah Semarang

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Profesionalisme guru penting dalam menunjang proses pembelajaran di kelas. Indonesia adalah negara dengan kualitas pendidikan yang belum baik. Banyak faktor yang menyebabkan hal tersebut. Salah satu faktor adalah Sumber Daya Manusia, Guru. Seorang pendidik di sekolah dituntut memiliki 3 kompetensi wajib yaitu pedagodik, social dan professional. Pada kompetensi pedagogic menjadi kebutuhan mutlak bagi seorang guru. Untuk menjadi guru yang mampu mengajar di kelas dengan baik membutuhkan pengalaman yang cukup banyak dan waktu yang lama. Namun, jika harus demikian makan kebutuhan guru di lapangan akan sulit terpenuhi. Ada salah satu cara yang mampu untuk membantu meningkatkan kapasitas guru dalam mengajar. Alternatif tersebut berupa kemampuan refleksi diri seorang guru. Kebiasaan refleksi yang saat ini ada pada beberapa guru di Indonesia masih sedikit, salah satunya “Lesson study”, namun jumlah komunitas ini tidak begitu banyak, Oleh karena itu untuk mengetahui berbagai bentuk relfeksi guru yang ada di Indonesia diperlukan suatau penelitian untuk memetakan kondisi tersebut. Penelitian ini adalah Review Reasearch dengan objek berbagai artikel hasil penelitian di Indonesia yang meneliti tentang “refleksi” guru dalam pembelajaran. Berdasarkan hasil review artikel penelitian diperoleh banwa bentuk-bentuk refleksi yang dilakukan guru di Indonesia berupa: jurnal reflksi, refleksi wawancara, konfrensi observasi temanejawat, diskusi group, Video, Blok, dan portofolio elektronik. Kata Kunci : Refleksi, Pembelajaran

KEUNGGULAN PEMBELAJARAN REFLECTIVE PEDAGOGY PARADIGM (RPP) UNTUK PERBAIKAN PROSES PEMBELAJARAN DI PERGURUAN TINGGI Eko Yuliyanto; Fitria Fatichatul Hidayah; Enade Perdana Istyastono; Yosef Wijoyo; Titien Siwi Hartayu
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2017: Prosiding Seminar Nasional Pendidikan, Sains dan Teknologi
Publisher : Universitas Muhammadiyah Semarang

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Pendidikan di perguraun tinggi merupakan pembelajaran sangat berbeda dengan pembelajaran tingkat SMA. Namun, hal itu juga menjadi perhatiankhusus supaya proses transfer ilmu pengetahuan dari dosen ke mahasiswaberlangsung dengan baik. Tujuan penelitian ini mengetahu keunggulan RPPdalam penerapan pembelajaran di tingkat perguruan tinggi. Metode penelitianini menggunakan kajian referensi, observasi, dan wawancara. Hasil penelitianmenunjukkan bahwa pembelajaran di perguruan tinggi memerlukan perhatiankhusus terutama pada metode-metode yang digunakan. Adanya keunggulanRPP diharapkan dapat membuka pengetahuan para dosen untuk mampumelakukan pembelajaran RPP: membangu konteks, penglaman,refleksi, aksidan evaluasi, sehingga kebermaknaan belajar para mahasiswa akan tertatadengan baik dan sesuai dengan outcome yang diharapkan oleh program studi. Keywords: Reflective Pedagogy Paradigm, Keunggulan, Pembelajaran,Perguruan Tinggi

Co-Authors ., Jumina Abdul Mutholib Aditya Asyhar Agnes Mutiara Kurniawan Agnes Nora Iska Harnita Agnes Nora Iska Harnita Agung Endro Nugroho Agustina Setiawati Akhmad Darmawan Andreas Asdi Utama ARGUN WIDARSA ARIEF NURROCHMAD As'ari Nawawi Berlina, Violita Yessi Bonifacius Ivan Wiranata Bonifacius Ivan Wiranata Bonifacius Ivan Wiranata Chrisanti, Marcella Widya Chrisologus Ivan Prasetyo David Chandra Putra Dewi Setyaningsih Dina Christin Ayuning Putri Dita Maria Virginia Eko Yuliyanto Eko Yuliyanto, Eko Esti Mumpuni Evy Fenny Veronica Fajar Agung Dwi Hartanto Fajar Ira Juwita Farach Khanifah Felicia Felicia Felicia Fraulein Setiawan Fitria Fatichatul Hidayah Fitria Fatichatul Hidayah Fitria Fatichatul Hidayah Florentinus D.O. Riswanto Florentinus Dika Octa Riswanto Florentinus Dika Octa Riswanto Florentinus Dika Octa Riswanto Florentinus Dika Octa Riswanto Fransiscus Deddy Riandono Fransiska Kurniawan Gani, Michael Gatot Nugroho Susanto Gerry Nugraha Glory Ivana Ardine Harno Dwi Pranowo Harno Dwi Pranowo Harno Dwi Pranowo Herluin Sekar Krisantia I Gusti Ayu Intan Puspita Dewi Ignasius Widya Parahita Putranto Ignatius Yulius Kristio Budiasmoro Iqmal Tahir Iwan J. P. de Esch Jeffry Julianus Julyus Jason Mark Jutti Levita Liana Roh Widiyani Liliana Liliana Lukman Hakim Marchaban Marchaban Marchaban Marchaban Marchaban Marchaban Maria Ludya Pulung Maywan Hariono Maywan Hariono Michael Raharja Gani Michael Raharja Gani Michael Raharja Gani Michael Resta Surya Yanuar Muhamad Hanafi MUHAMMAD RADIFAR Muhammad Radifar Muhammad Radifar Muhammad Radifar Natalia Kristina Nugraha, Gerry Nunung Priyatni Nunung Yuniarti Nunung Yuniarti Nunung Yuniarti Nunung Yuniarti Nunung Yuniarti Nunung Yuniarti Nunung Yuniarti Octa Riswanto , Florentinus Dika OISAN OISAN Oka, Mitsue Perdana Adhi Nugroho Pramono, Zita Dhirani Primana, Mala Hikmawan Pudjono Pudjono Radite Yogaswara Rekso, Putri Ayu Dharmo reza eka putra Riandono, Fransiscus Deddy Rini Dwiastuti Rizna Triana Dewi Roy Gunawan Wicaksono Rr. Sri Untari Siwi S.M.P Sardjiman Sardjiman Slamet Ibrahim - Sri Hartati Yuliani Sri Noegrohati Sri Noegrohati St. Layli Prasojo Stefanus Layli Prasojo Stephanus Satria Wira Waskitha Sudibyo Martono Sudibyo Martono Sudibyo Martono Sudibyo Martono Sudibyo Martono Supardjan . Supardjan . Supardjan A. Margono Supardjan A. Margono Supardjan A.M Supardjan A.M. Supardjan AM Tasia Amelia Titien Siwi Hartayu Umar Anggara Jenie Vivitri Dewi Prasasty Waskitha, Stephanus Satria Wira Widayati, Aris Windah, Axl Laurens Lukas Wira Waskitha, Stephanus Satria Wiranata, Bonifacius Ivan YANTI SUSILAWATI Yohanes Eko Adi Prasetyanto Yosef Wijoyo Yosef Wijoyo Yosef Wijoyo, Yosef Yosi Bayu Murti Yulia Anita YUMI RAHMADANI Yuniarti, Nunung Zullies Ikawati Zullies Ikawati

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