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DOES REFLECTIVE PEDAGOGY MAKE ENVIROMENTAL LACTURER BE BETTER? Eko Yuliyanto; Fitria Fatichatul Hidayah; Enade Perdana Istyastono; Yosef Wijoyo
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2018: PROCEEDING 1ST INSELIDEA INTERNATIONAL SEMINAR ON EDUCATION AND DEVELOPMENT OF ASIA (INseIDEA)
Publisher : Universitas Muhammadiyah Semarang

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Environmental education is an aspect of education for students who are important to support life in the future. In the learning process there are several factors that influence success in learning. One of them is the ability factor of teaching from a teacher include material, method and learning media. However, there are important factors that need to be considered, namely the ability of teachers to reflect themselves during the learning process. Therefore it is necessary for the research to know the reflection of teachers in the learning process. This study aims to determine the effect of teacher reflection on student learning outcomes. The study involved as many as 15 students of English education. Data obtained in the form of student reflection data, questionnaire value of proenvironment attitudes. The data obtained were analyzed using Paired Samples T-Test. The results showed that the process of reflection that has not been optimal can’t improve the quality of learning.Keywords: pro-environment, reflection of paradigm pedagogy, lecturer, learning

ANALISIS REFLEKSI PADA PEMBELAJARAN: REVIEW REASEARCH Eko Yuliyanto; Fitria Fatichatul Hidayah; Enade Perdana Istyastono; Yosef Wijoyo
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2018: SEMINAR NASIONAL PENDIDIKAN SAINS DAN TEKNOLOGI
Publisher : Universitas Muhammadiyah Semarang

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Profesionalisme guru penting dalam menunjang proses pembelajaran di kelas. Indonesia adalah negara dengan kualitas pendidikan yang belum baik. Banyak faktor yang menyebabkan hal tersebut. Salah satu faktor adalah Sumber Daya Manusia, Guru. Seorang pendidik di sekolah dituntut memiliki 3 kompetensi wajib yaitu pedagodik, social dan professional. Pada kompetensi pedagogic menjadi kebutuhan mutlak bagi seorang guru. Untuk menjadi guru yang mampu mengajar di kelas dengan baik membutuhkan pengalaman yang cukup banyak dan waktu yang lama. Namun, jika harus demikian makan kebutuhan guru di lapangan akan sulit terpenuhi. Ada salah satu cara yang mampu untuk membantu meningkatkan kapasitas guru dalam mengajar. Alternatif tersebut berupa kemampuan refleksi diri seorang guru. Kebiasaan refleksi yang saat ini ada pada beberapa guru di Indonesia masih sedikit, salah satunya “Lesson study”, namun jumlah komunitas ini tidak begitu banyak, Oleh karena itu untuk mengetahui berbagai bentuk relfeksi guru yang ada di Indonesia diperlukan suatau penelitian untuk memetakan kondisi tersebut. Penelitian ini adalah Review Reasearch dengan objek berbagai artikel hasil penelitian di Indonesia yang meneliti tentang “refleksi” guru dalam pembelajaran. Berdasarkan hasil review artikel penelitian diperoleh banwa bentuk-bentuk refleksi yang dilakukan guru di Indonesia berupa: jurnal reflksi, refleksi wawancara, konfrensi observasi temanejawat, diskusi group, Video, Blok, dan portofolio elektronik. Kata Kunci : Refleksi, Pembelajaran

KEUNGGULAN PEMBELAJARAN REFLECTIVE PEDAGOGY PARADIGM (RPP) UNTUK PERBAIKAN PROSES PEMBELAJARAN DI PERGURUAN TINGGI Eko Yuliyanto; Fitria Fatichatul Hidayah; Enade Perdana Istyastono; Yosef Wijoyo; Titien Siwi Hartayu
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2017: Prosiding Seminar Nasional Pendidikan, Sains dan Teknologi
Publisher : Universitas Muhammadiyah Semarang

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Pendidikan di perguraun tinggi merupakan pembelajaran sangat berbeda dengan pembelajaran tingkat SMA. Namun, hal itu juga menjadi perhatiankhusus supaya proses transfer ilmu pengetahuan dari dosen ke mahasiswaberlangsung dengan baik. Tujuan penelitian ini mengetahu keunggulan RPPdalam penerapan pembelajaran di tingkat perguruan tinggi. Metode penelitianini menggunakan kajian referensi, observasi, dan wawancara. Hasil penelitianmenunjukkan bahwa pembelajaran di perguruan tinggi memerlukan perhatiankhusus terutama pada metode-metode yang digunakan. Adanya keunggulanRPP diharapkan dapat membuka pengetahuan para dosen untuk mampumelakukan pembelajaran RPP: membangu konteks, penglaman,refleksi, aksidan evaluasi, sehingga kebermaknaan belajar para mahasiswa akan tertatadengan baik dan sesuai dengan outcome yang diharapkan oleh program studi. Keywords: Reflective Pedagogy Paradigm, Keunggulan, Pembelajaran,Perguruan Tinggi

UJI IN SILICO SENYAWA COUMESTROL SEBAGAI LIGAN RESEPTOR ESTROGEN ALFA Felicia Felicia; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Breast cancer is a cancer caused by uncontrolled cell growth at breast tissue. One of the most common triggers of breast cancer is overexpression of estrogen receptor alpha (ER?). This researchs goal is to test the ability of coumestrol as the ligand of ER? with in silico method and to discover coumestrols binding pose inside the ER?s binding pocket. Coumestrols ability as ER?s ligand was tested using structure-based virtual screening (SVBS) method by Setiawati et al. (2014) that had been modified by Istyastono (2015). Results analysis was done using decision tree generated from recursive partition and regression tree method (RPART). If coumestrol is a ligand based on decision tree, it is concluded that coumestrol is active as ligand of ER?. At the end of analysis, coumestrols pose inside ER?s binding pocket was visualized using MacPyMol. From the test acknowledged that the smallest ChemPLP value of coumestrols pose was -83.1487. Coumestrol interacts with GLY420, ARG394, and GLU353 using hydrogen bonds. However, coumestrol were perceived as decoy according to decision tree. Hence, coumestrol could not be recognized as ER?s ligand by the protocol. Therefore, development of proper protocol to indentify ligand for ER? is required.

Molecular Docking Study of Caffeic Acid as Acetylcholinesterase Inhibitor Wira Waskitha, Stephanus Satria; Istyastono, Enade Perdana; Octa Riswanto , Florentinus Dika
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.7665

Abstract: Acetylcholinesterase (AChE) receptor is a receptor that has been widely used as a potential drug target for Alzheimer's disease. Caffeic acid is a phenolic compound that had been experimentally proven to be an inhibitor of AChE. In this study, 100 molecular docking simulations were performed to study the interaction of caffeic acid in inhibiting AChE. The molecular docking simulations were performed using YASARA software with an in-house developed plug-in. Redocking results showed that there were 99 out of 100 docking poses had an RMSD value of ≤ 2.000 Å, which indicated that the molecular docking procedure could be used for further processes. The molecular docking of caffeic acid showed that all docking poses had an RMSD value of ≤ 2.000 Å relative to the best pose of the first simulation, revealing that there was only one dominant docking pose in the AChE active site. Caffeic acid interacted favorably in the AChE active site with binding energy of about -8.022 kcal/mol. Its interactions were stabilized by hydrophobic and pi-anion interactions, in which some of the interactions resemble the same interaction of the native ligand. Keywords: Acetylcholinesterase, Alzheimer's disease, caffeic acid, molecular docking

PERAN EDUKASI DALAM OPTIMALISASI GERAKAN CEGAH STUNTING SEJAK DINI DI KABUPATEN GUNUNG KIDUL Pramono, Zita Dhirani; Waskitha, Stephanus Satria Wira; Chrisanti, Marcella Widya; Rekso, Putri Ayu Dharmo; Berlina, Violita Yessi; Istyastono, Enade Perdana
Jurnal Pengabdian Kesehatan Masyarakat Vol 5, No 2 (2024): November: Jurnal Pengabdian Kesehatan Masyarakat
Publisher : Program Studi Kesehatan Masyarakat Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jpkm.v5i2.27521

Stunting merupakan gangguan pertumbuhan maupun perkembangan anak akibat gizi yang buruk, kekurangan protein dan vitamin, infeksi, serta stimulasi psikosial yang kurang memadahi. Pada negara berkembang termasuk Indonesia, stunting merupakan salah satu permasalahan kesehatan anak usia balita hingga saat ini. Gunung Kidul merupakan salah satu kabupaten di Daerah Istimewa Yogyakarta yang menjadi perhatian pemerintah dalam mengupayakan penurunan angka stunting. Tujuan dari penelitian dan pengabdian kepada masyarakat ini adalah untuk memberikan edukasi kepada ibu dan ibu hamil di Desa Wonosari, Kabupaten Gunung Kidul dengan memberdayakan Tim Percepatan Penurunan Stunting Puskesmas Wonosari II. Metode pelaksanaan upaya pemberian edukasi pencegahan stunting dilakukan melalui video edukasi dan paparan materi oleh tim Puskesmas Wonosari II dan dosen Fakultas Farmasi Universitas Sanata Dharma. Pemahaman pada ibu dan ibu hamil mengenai strategi pencegahan stunting dievaluasi menggunakan nilai pre-test dan post-test. Hasil pelaksanaan kegiatan menunjukkan bahwa nilai rata-rata post-test memiliki nilai yang lebih tinggi dibandingkan pre-test pada jumlah sampel sebanyak 68 peserta ibu dan ibu hamil. Uji statistika t berpasangan (paired t-test) mengindikasikan bahwa terdapat perbedaan nilai rata-rata pre-test dan post-test dengan tingkat kepercayaan sebesar 95% yang mengindikasikan peningkatan rata-rata skor pengetahuan para ibu dan ibu hamil mengenai edukasi yang diberikan. Kesimpulan bahwa pemberian edukasi meningkatkan pemahaman dan pengetahuan ibu serta ibu hamil terkait pencegahan stunting sejak dini.Kata Kunci: Stunting; Pencegahan stunting; Edukasi.

Identifikasi Determinan Molekul Interaksi STK630921 pada Interleukin-17A Riandono, Fransiscus Deddy; Istyastono, Enade Perdana
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 No 1 (2022): J Sains Farm Klin 9(1), April 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.1.57-63.2022

Interleukin-17A (IL-17A) merupakan sitokin pro-inflamasi yang terlibat dalam patogenesis beberapa penyakit, antara lain psoriasis, rheumatoid arthritis, kanker, diabetes dan penyakit ginjal stadium akhir. Peningkatan kadar serum IL-17A memberikan petunjuk adanya keterkaitan antara IL-17A pada kejadian nefropati diabetik. Keterkaitan ini juga diperjelas dengan temuan bahwa penghambatan aktivitas IL-17A dapat menurunkan albuminuria, cedera ginjal dan menunda perkembangan nefropati diabetik. Peranan IL-17A ini menjadikannya sebagai pilihan target potensial terapi nefropati diabetik yang sejauh ini bertumpu pada pengendalian optimal sistem renin angiotensin. Penelitian ini bertujuan mengidentifikasi determinan molekul interaksi STK630921 pada IL-17A. Penelitian dilakukan dengan penambatan molekul STK630921 pada protein IL-17A, dilanjutkan dengan simulasi dinamika molekul selama 15 ns. Identifikasi determinan molekul dilakukan menggunakan bantuan perangkat lunak PyPLIF-HIPPOS terhadap hasil simulasi dinamika molekul. Penelitian ini berhasil mengidentifikasikan asam-asam amino yang berperan penting yaitu His29, Trp67, Asn27, Lys114 dan Glu95 dengan interaksi aromatik dan interaksi hidrogen sebagai jenis interaksi yang berperan pada aktivitas STK630921 pada struktur protein 4HR9.

Interaction Dynamics of Caffeine in the Human Acetylcholinesterase Binding Pocket Wiranata, Bonifacius Ivan; Istyastono, Enade Perdana
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.16533

Alzheimer’s disease (AD) cases are increasing in Indonesia, with no effective therapy due to multiple hypotheses about its causes. The cholinergic hypothesis, focusing on acetylcholinesterase (ACHE) inhibition, is a key therapeutic approach. Caffeine, a natural compound, shows a potent activity as an AChE inhibitor. This study used computational methods to investigate the interaction dynamics of caffeine with the AChE’s active site. This study performed 100 redocking simulations of donepezil to validate the docking protocol followed by 100 molecular docking simulations of caffeine. The 50-ns molecular dynamics (MD) production phase simulations of donepezil and caffeine were performed to study the interaction dynamics, such as conformational stability and binding free energies. The interaction hotspots during the simulations were identified using PyPLIF HIPPOS. Our findings reveal that caffeine interacted in the active site during the simulations and the importance of Glu202 and Phe338 in helping caffeine reside within the esteratic site of AChE.

Interaction Dynamics of Caffeine in the Human Acetylcholinesterase Binding Pocket Wiranata, Bonifacius Ivan; Istyastono, Enade Perdana
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.16533

Alzheimer’s disease (AD) cases are increasing in Indonesia, with no effective therapy due to multiple hypotheses about its causes. The cholinergic hypothesis, focusing on acetylcholinesterase (ACHE) inhibition, is a key therapeutic approach. Caffeine, a natural compound, shows a potent activity as an AChE inhibitor. This study used computational methods to investigate the interaction dynamics of caffeine with the AChE’s active site. This study performed 100 redocking simulations of donepezil to validate the docking protocol followed by 100 molecular docking simulations of caffeine. The 50-ns molecular dynamics (MD) production phase simulations of donepezil and caffeine were performed to study the interaction dynamics, such as conformational stability and binding free energies. The interaction hotspots during the simulations were identified using PyPLIF HIPPOS. Our findings reveal that caffeine interacted in the active site during the simulations and the importance of Glu202 and Phe338 in helping caffeine reside within the esteratic site of AChE.

Comparison of GPU-accelerated Molecular Dynamics Simulation Efficiency for the Acetylcholinesterase-Huprine X Complex using YASARA, GROMACS, and AMBER Wiranata, Bonifacius Ivan; Istyastono, Enade Perdana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009061

Molecular dynamics simulations are a valuable tool in identifying potential acetylcholinesterase inhibitors for Alzheimer's disease therapy. Recent advancements in hardware and software, particularly the implementation of graphics processing units (GPUs), have significantly improved the efficiency of MD simulations. This study aims to compare GPU-accelerated molecular dynamics (MD) simulations of the acetylcholinesterase-Huprine X complex using YASARA, GROMACS, and AMBER. The complex was obtained from Protein Data bank with code 1E66 and was prepared with same conditions. MD simulations were performed for 50 ns with three replicates per software. GROMACS exhibited the shortest average simulation duration (45,104 seconds), followed by AMBER (48,884 seconds) and YASARA (649,208 seconds). RMSD analysis of protein backbone and ligand movement indicated stable simulations across all platforms. Interaction analysis at 25 ns and 35 ns of YASARA’s run revealed that Huprine X maintained key aromatic interactions within the AChE binding pocket, despite undergoing a 180° rotation. YASARA proved more efficient in MD preparation and produced more precise results, while GROMACS was most efficient in simulation runtime. The study highlights the trade-offs between ease of use, simulation speed, and result consistency among these software packages for AChE-HUX MD simulations.

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