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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Indonesian Journal of Chemistry JFIOnline Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Sciences and Research (PSR)
Raditya Iswandana
Fakultas Farmasi Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Medicine & Pharmacology Public Health Other

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Advancing Herbal Medicine: The Role of Nanosomal Technology in Treating Skin Diseases Aswan, Pedro Anugerah; Maggadani, Baitha Palanggatan; Fachri, Wilzar; Iswandana, Raditya
Pharmaceutical Sciences and Research Vol. 12, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Herbal medicine has become popular worldwide, especially in developing countries, with around 80% of the population opting for herbal treatments. The perceived benefits of natural remedies, such as affordability and fewer side effects, drive this trend. Herbal therapies effectively manage skin diseases, infections, and common ailments. However, the absorption of bioactive compounds in herbal extracts is often limited. Recent developments in nano-based herbal delivery systems, like nanosomal, show promise in enhancing the efficacy of herbal remedies for topical applications, providing improved solubility, stability, and skin penetration. This review describes various nanosomal studies developed and successfully used to enhance the topical delivery of natural compounds, including liposomes, ethosomes, transfersomes, transethosomes, phytosomes, and niosomes.
Simultaneous HPLC Analysis of Asiaticoside and α-Mangostin in Nanoethosomal Carriers Aswan, Pedro Anugerah; Maggadani, Baitha Palanggatan; Fachri, Wilzar; Iswandana, Raditya
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.111150

Abstract

The development of robust analytical methods is essential for quality control of nanoethosomal formulations containing asiaticoside and α-mangostin, bioactive compounds with anti-inflammatory and antioxidant properties. Simultaneous quantification within nanocarriers is challenging and requires validated techniques. This study established a precise HPLC method, in accordance with ICH Q2(R2) guidelines, for the concurrent determination of both compounds. The technique demonstrated excellent linearity (R2 > 0.999), precision (%RSD < 2%), and accuracy (95–105% recovery). The nanoethosomal system also achieved high encapsulation efficiencies of 94.76% for asiaticoside and 99.27% for α-mangostin. This validated method provides a reliable tool for standardizing these complex nano-formulations, supporting their further development and clinical translation.
Development of Gingerol-Loaded Nanostructured Lipid Carriers Using a Two-Step Method Sagala, Reynelda Juliani; Iswandana, Raditya; Louisa, Melva; Surini, Silvia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.51-59

Abstract

Ginger (Zingiber officinale) is well known for its beneficial effects on health, and it use as a culinary spice, mainly due to the presence of bioactive compounds such as 6-,8-, and 10-gingerol. Although 6-gingerol exhibits remarkable therapeutic potential, its clinical application is constrained by poor bioavailability and rapid metabolic degradation. Nanotechnology-based drug delivery systems have been widely explored to overcome these limitations by improving the stability, solubility, and bioavailability of bioactive compounds. Among these systems, nanostructured lipid carriers (NLCs) have attracted considerable to facilitate high drug-loading, enhanced stability, and controlled drug release. To address these issues, this study focused on formulating and characterizing gingerol using nanostructured lipid carriers. Gingerol-loaded NLCs were produced using a two-step process of high-shear homogenization followed by ultrasonication. Different total lipid contents were tested, specifically 5%, 8%, 10%, and 15%. Characterization of the resulting NLCs included particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, in vitro release of gingerol, and stability over 30 days. The findings revealed that the NLC formulation with a total lipid content of 5% yielded the smallest average particle size of 208.32 ± 3.20 nm, alongside the lowest PDI of 0.231 ± 0.014, and the zeta potential measured at -25.90 ± 1.38 mV. The entrapment efficiency for this optimal total lipid was noted to be 70.65 ± 0.75%. Furthermore, stability testing conducted over a designated period demonstrated that the gingerol-loaded NLC formulation with a 5% lipid content maintained its integrity, exhibiting no significant degradation or alteration in properties. The results of this study highlight the critical role of the total lipid content in influencing the characteristics of NLC formulations achieved at 5% total lipid content, which not only improved the properties of gingerol delivery but also presented a potential approach for improving the delivery of compounds with low water solubility such as gingerol.
Co-Authors AA Sudharmawan, AA Abdul Munim Anjasmara, Gede Anom Aswan, Pedro Anugerah Aziz, Fiq'rah Lestari Baitha Palanggatan Maggadani, Baitha Palanggatan Catur Jatmika, Catur Effionora Anwar Erny Sagita, Erny Fachri, Wilzar Fadlina Chany Saputri gunawan, maxius Hartrianti, Pietradewi Kurnia Sari Setio Putri, Kurnia Sari Setio Larasati, Sekar Arum Lestari, Indah Dewi Lukmanto, Donny Mahdi Jufri Melva Louisa Mu'nim, Abdul Putri, Fathia Amalia RAYHAN AKBAR Sagala, Reynelda Juliani Sihombing, Lidya KM Silvia Surini Tiara Aninditha Widiani Batubara, Risa Winata, Ronaldo Ongki