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All Journal Prosiding Seminar Nasional MIPA Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JFIOnline Jurnal Respirasi (JR) Journal of Health Sciences and Medicine Jurnal Ilmiah Medicamento Jurnal Cahaya Mandalika Hang Tuah Medical Journal Journal of Public Health and Pharmacy
Ni Made Ary Sarasmita
Program Studi Farmasi Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Udayana
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Challenging Treatment of Drug-Resistant Tuberculosis during Pregnancy: A Case Report Ni Luh Putu Eka Arisanti; Ni Putu Ayu Widiasari; Ni Wayan Candrawati; Ida Ayu Jasminarti Dwi Kusumawardani; Ida Bagus Ngurah Rai; Made Ary Sarasmita
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.221 KB) | DOI: 10.20473/jr.v8-I.3.2022.153-160

Abstract

Introduction: Globally, drug-resistant tuberculosis (TB) still has a high number of cases. Pregnant women are one of the high-risk populations for TB infection, especially multidrug resistance (MDR)/Rifampicin resistance (RR) TB. Physiological differences in pregnant women and the safety of the fetus make drug resistance TB treatment challenging. Case: A 20-year-old woman was 22 weeks pregnant while undergoing the third month of the late phase for short-regimen. Thus, Kanamycin was one of her early phase treatment combinations during the first trimester of pregnancy. After we consulted with other departments, especially the obstetric department, we decided not to change her regimen. Her chief complaint before treatment was cough with white sputum and fluctuated shortness of breath for two months. The patient only experienced minor side effects in the early treatment phase. The patient was cured of MDR TB on 8 October 2020 at 34 weeks of gestation. Her baby was born on 10 November 2020 at 37 weeks without congenital abnormality. Observation for her baby continued by the pediatric department. The last follow-up of her baby in the middle of 2022 found no abnormality in the child’s growth and development. Conclusion: Drug-resistant TB therapy in pregnant women requires the collaboration of a multidisciplinary team to consider the benefits and risks of the therapy based on gestational age and disease severity.
Integration of genomic databases and bioinformatic approach to identify genomic variants for sjogren’s syndrome on multiple continents Anisa Nova Puspitaningrum; Dyah Aryani Perwitasari; Wirawan Adikusuma; Gina Noor Djalilah; Haafizah Dania; Rita Maliza; Imaniar Noor Faridah; Made Ary Sarasmita; Melodia Rezadhini; Rocky Cheung; Lalu Muhammad Irham
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1210.726 KB) | DOI: 10.12928/mf.v19i2.23706

Abstract

An autoimmune disorder is an abnormality that causes a disease. It is caused by a weakened immune system. One of the autoimmune diseases is Sjogren’s syndrome, which affects the salivary and lacrimal glands and causes dry mouth, dry eyes, and dry skin. Sjogren’s syndrome influences humans of every age, with the symptoms occurring at the age of 45–55 years and rarely in children. One of the factors causing Sjogren’s syndrome is genetic disorders. To identify genes that can influence Sjogren’s syndrome in this study, we used several databases, including GWAS Catalog, HaploReg Version 4.1, GTEX portal, and Ensembl, particularly to identify the gene expression profiles of TNIP1, TNFAIP3, and IRF5 and the quantitative properties of locus’ expression. This research showed that the missense variants and splice donor rs2233290, rs2230926, and rs2004640 influenced the susceptibility of autoimmune diseases, especially Sjogren’s syndrome, in the fibroblast tissue, sigmoid tissue, sigmoid colon, skin, esophagus, and adrenal glands. The allele frequency of each variant was then assessed in African, American, European, and Asian populations. Our data showed that TNIP1, TNFAIP3, and IRF5 genes in African and American populations had higher frequencies than in the Asian population. This implies that the last of the aforementioned populations might be relatively susceptible to the autoimmune disease Sjogren’s syndrome.
Efficacy and Safety of Cannabidiol for Anxiety: A Bibliometric Analysis and Systematic Review Fajaryani, Putu Ayu Putri; I Made Agus Gelgel Wirasuta; Pande Made Nova Armita Sari; Dyah Kanya Wati; Putu Indah Budi Apsari; Made Ary Sarasmita
Journal of Public Health and Pharmacy Vol. 5 No. 3 (2025): November 2025
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v5i3.6807

Abstract

Introduction: A non-psychoactive substance present in the cannabis plant, cannabidiol (CBD), seems to have potential as an anxiolytic agent. This study systematically reviews the efficacy, safety, dosage, mechanisms, and adverse effects of CBD in treating anxiety. Methods: The PRISMA guideline was used to conduct the review. Results: A total of 64 articles were included in the study. It showed that CBD works at the endocannabinoid receptors CB1 and 5-HT1A, which regulate mood and reduce anxiety. In animal models, a range dosage of 5 – 10 mg/kg showed a significant anxiolytic effect in behavioral tests, while in humans, 300 mg/day was proven to be effective in treating various types of anxiety disorders. However, individual responses to CBD showed varying results, and demographic characteristics affect the efficacy of animal and human studies. CBD was also considered safer to be used in the short term compared to diazepam, although the long-term effect remains lacking evidence Conclusion: This study concludes that CBD has potential as an alternative choice for anxiety. Further research is needed in larger populations with rigorous study design and longer study durations to evaluate its effectiveness and ensure its safety. Recommendations for Future Research: It is hoped that future research can examine the effects of fly resistance and killing on non-target organisms and control environmental conditions.
Integration of genomic databases and bioinformatic approach to identify genomic variants for sjogren’s syndrome on multiple continents Puspitaningrum, Anisa Nova; Perwitasari, Dyah Aryani; Adikusuma, Wirawan; Djalilah, Gina Noor; Dania, Haafizah; Maliza, Rita; Faridah, Imaniar Noor; Sarasmita, Made Ary; Rezadhini, Melodia; Cheung, Rocky; Irham, Lalu Muhammad
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.23706

Abstract

An autoimmune disorder is an abnormality that causes a disease. It is caused by a weakened immune system. One of the autoimmune diseases is Sjogren’s syndrome, which affects the salivary and lacrimal glands and causes dry mouth, dry eyes, and dry skin. Sjogren’s syndrome influences humans of every age, with the symptoms occurring at the age of 45–55 years and rarely in children. One of the factors causing Sjogren’s syndrome is genetic disorders. To identify genes that can influence Sjogren’s syndrome in this study, we used several databases, including GWAS Catalog, HaploReg Version 4.1, GTEX portal, and Ensembl, particularly to identify the gene expression profiles of TNIP1, TNFAIP3, and IRF5 and the quantitative properties of locus’ expression. This research showed that the missense variants and splice donor rs2233290, rs2230926, and rs2004640 influenced the susceptibility of autoimmune diseases, especially Sjogren’s syndrome, in the fibroblast tissue, sigmoid tissue, sigmoid colon, skin, esophagus, and adrenal glands. The allele frequency of each variant was then assessed in African, American, European, and Asian populations. Our data showed that TNIP1, TNFAIP3, and IRF5 genes in African and American populations had higher frequencies than in the Asian population. This implies that the last of the aforementioned populations might be relatively susceptible to the autoimmune disease Sjogren’s syndrome.
TINJAUAN SISTEMATIS: PENGARUH TOCILIZUMAB TERHADAP FUNGSI LIPOPROTEIN PADA PASIEN RHEUMATOID ARTRITIS DENGAN RESIKO KARDIOVASKULAR Ni Wayan, Antika Sri Devi; I Nyoman Arya Nugraha Wicaksana; Made Ary Sarasmita; Eka Indra Setyawan
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 6 No. 3 (2025)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v6i3.4375

Abstract

Rheumatoid arthritis (RA) merupakan penyakit autoimun yang dapat meningkatkan risiko kardiovaskular dan pengobatan dengan Tocilizumab telah menunjukkan potensi dalam memodulasi fungsi lipoprotein. Penelitian ini bertujuan untuk mengevaluasi pengaruh Tocilizumab terhadap fungsi lipoprotein pada pasien RA dengan risiko kardiovaskular. Tinjauan sistematis ini dilakukan dengan mengikuti pedoman pelaporan sistematis untuk tinjauan dan meta-analisis (PRISMA). Proses penelitian meliputi identifikasi, seleksi, dan analisis data dari berbagai studi yang relevan. Hasil analisis menunjukkan bahwa Tocilizumab dapat berkontribusi dalam perbaikan profil lipoprotein dan mengurangi parameter inflamasi pada pasien RA yang berpotensi menurunkan risiko kardiovaskular. Tocilizumab menunjukkan efek positif terhadap fungsi lipoprotein pada pasien dengan rheumatoid arthritis yang berisiko kardiovaskular. Temuan ini mendukung penggunaan Tocilizumab sebagai terapi yang tidak hanya mengatasi gejala RA, tetapi juga berkontribusi pada pengelolaan risiko kardiovaskular. Penelitian lebih lanjut diperlukan untuk memahami mekanisme yang mendasari efek ini dan untuk mengeksplorasi implikasi klinisnya.
Co-Authors A.A.R Karsana A.H Jaya Anisa Nova Puspitaningrum Cahyadi, Maria Fiani Cahyadi, Maria Fiani Cheung, Rocky Cia Intania Warnaya Dewantara Putra, I Gusti Ngurah Agung Dyah Aryani Perwitasari Dyah Kanya Wati Eka Indra Setyawan Eka Indra Setyawan Fajaryani, Putu Ayu Putri Gina Noor Djalilah Haafizah Dania Haafizah Dania Hendra Jaya A. I Dewa Agung Ayu Divacandraningrat I GUSTI A. A. E. AMANDARI I Gusti Ayu Artini Ekajaya Amandari I Gusti Ngurah Agung Dewantara Putra I Made Agus Gelgel Wirasuta i made suardhika I Nyoman Arya Nugraha Wicaksana I Wayan Karta I Wayan Karta I. G. A. A. E. AMANDARI Ida Ayu Jasminarti Dwi Kusumawardani Ida Ayu Sintya Deviyanthi Ida Bagus Ngurah Rai Imaniar Noor Faridah Imaniar Noor Faridah Kadek Nadia Marta Dewi Kosasih, Diah Ayu Nirmala Kosasih, Diah Ayu Nirmala Lalu Muhammad Irham Larasaty, Luh Putu Febryana Lestari, N. K. S. Luh Putu Ayu Meryta Luh Putu Febriana Larasanty Luh Putu Febryana Larasanty Luh Putu Febryana Larasaty M. W.KRISNAYANTI MADE WINDA KRISNAYANTI Made Winda Krisnayanti Maliza, Rita Maria Fiani Cahyadi Melodia Rezadhini N. K. S. Lestari N. M. R. A. M Samba N. N. F. Sukarmini N. P. U. S. DEWI N.N.S.M. Arwanawati Ni Luh Putu Eka Arisanti Ni Made Ayu Wistari Ni Made Rai Sudarni Ni Nyoman Abigail Triastuti Ni Nyoman Della Yanti Ni Putu Ayu Widiasari Ni Putu Linda Laksmiani NI PUTU U. S. DEWI Ni Putu Uma Sari Dewi Ni Wayan Candrawati Ni Wayan Wirayanti Ni Wayan, Antika Sri Devi P.B.P.P. Budiartha P.C.I. Warnaya Pande Made Nova Armita Sari, Pande Made Nova Puspitaningrum, Anisa Nova Putu Indah Budi Apsari Rezadhini, Melodia Rocky Cheung Samba, N. M. R. A. M Sari, Ni Putu Latsartika Sari, Ni Putu Latsartika Sudarni, Ni Made Rai Sudarni, Ni Made Rai Sukarmini, N. N. F. Wayan Risma Iswari Wirawan Adikusuma Wistari, Ni Made Ayu Wistari, Ni Made Ayu