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All Journal Jurnal Farmasi Udayana Pendas : Jurnah Ilmiah Pendidikan Dasar JFL : Jurnal Farmasi Lampung PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kolaboratif Sains
Retno Wahyuningrum
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Tinjauan Literatur: Peran Sentral Distribusi Ukuran Partikel (DAP) Dalam Memodulasi Kualitas Fisik, Kinerja Pelepasan Obat, Dan Farmakokinetik Sediaan Tablet: Literature review: the central role of particle size distribution (DAP) in modulating physical quality, drug release performance, and pharmacokinetics of tablet preparations Ines Septiani Pratiwi; Ika Lismayani Ilyas; Retno Wahyuningrum; Nur Hafshah Mardhiyyah; Sri Agustini; Dian Sridevi; Sitti Rafifah. R.; Nurul Izzah; Jeslianti Samenna; Vivi Wulandari; Amelia Putri; Melisa Tahang; Nur Elisa
Jurnal Kolaboratif Sains Vol. 8 No. 12: Desember 2025
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v8i12.9569

Abstract

Penelitian ini menganalisis pengaruh ukuran partikel secara komprehensif mensintesis temuan-temuan dari studi kritis dalam formulasi farmasi padat, dengan fokus pada peran fundamental Critical Material Attributes (CMA), khususnya distribusi ukuran partikel (DAP) dan morfologi dalam memengaruhi kualitas fisik, kinerja pelepasan obat, dan farmakokinetik sediaan tablet. Hasil studi menunjukkan bahwa DAP merupakan faktor determinan dalam modulasi disolusi, di mana pengurangan ukuran partikel Metronidazol (melalui penggilingan) secara langsung meningkatkan laju disolusinya. Dampak ini meluas ke sistem pelepasan terkontrol; laju pelepasan Karvedilol dari tablet matriks yang diproduksi melalui roller compaction sangat dipengaruhi oleh DAP granul, di mana kecepatan roll yang lebih lambat dan DAP yang lebih besar cenderung memperlambat pelepasan. Secara biofarmasi, ukuran partikel serbuk tablet Oksikodon Extended-Release Abuse-Deterrent (ER-AD) yang digiling terbukti menjadi penentu farmakokinetik (PK) setelah insuflasi nasal, di mana partikel yang lebih halus meningkatkan konsentrasi plasma puncak (Cmax) dan paparan sistemik total. Selain itu, pada mini-tablet, DAP eksipien meskipun memiliki efek terbatas pada sifat fisik umum, namun menunjukkan pengaruh signifikan terhadap nilai kekuatan hancur (crushing strength). Untuk memfasilitasi pengendalian mutu ini, studi menunjukkan bahwa teknik in-situ seperti pencitraan hiperspektral Raman berbasis fiber-array adalah alat yang efektif dan selektif secara kimiawi untuk memantau ukuran, bentuk, dan distribusi API dalam matriks tablet. Oleh karena itu, dapat disimpulkan bahwa pengendalian yang ketat terhadap DAP dan CMA adalah prasyarat penting untuk memastikan kualitas fisik dan performa terapeutik yang konsisten pada berbagai jenis formulasi tablet.
REVIEW ARTICLE: METODE UJI TEGANGAN PERMUKAAN DALAM ZAT CAIR Ika Lismayani Ilyas; Retno Wahyuningrum; Ines Septiani Pratiwi; Riska Asmayanti; Murni; Nur Nisawati; Hasyim Asyari; Aulia Alfia; Putri Astin; Arianto; Nopianti Sa’dan; Hikma; Regina Tri Olivia Marundu; Resky Rahayu Ningsih
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 04 (2025): Volume 10 No. 04 Desember 2025
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i04.39398

Abstract

Surface tension is an important physicochemical property that plays a major role in determining the interfacial behavior of a liquid in various scientific and industrial applications. Accurate surface tension measurement is required to understand liquid interactions, optimize formulation processes, and predict the stability of dispersed systems such as emulsions. This review article examines and compares several commonly used methods in surface tension measurement, namely the capillary rise method, the Du Noüy ring method, the drop and drop–weight/volume comparison method, the maximum bubble pressure method (MBPM), and micro-droplet measurement using Atomic Force Microscopy (AFM). Each method is analyzed based on its working principle, level of accuracy, advantages, limitations, and suitability for various types of liquids. The results of the review show that classical methods such as Du Noüy and the stalagmometer remain relevant because they are practical and easy to use, while modern methods such as AFM offer high sensitivity for micro-droplet samples. Overall, selecting the appropriate measurement method must consider sample characteristics, instrument availability, and analytical objectives. This review is expected to serve as a comprehensive reference for researchers, students, and industry practitioners in determining the most suitable technique for surface tension measurement.
Co-Authors A. Ayuni Waris Amelia Putri Anjar Mahardian Kusuma Apri Yudis Fitriana Arabiah Ari Kurniawan Arianto Aulia Alfia Aura Nabila. A Binar Asrining Dhiani Dewi Sartika Dian Sridevi Diva Adhiesti Aulia Elis Yuliya Sandi Fitri Sani Genatrika E Hasyim Asyari Herawati Herlinda Firdaus Hikma Ika Lismayani Ilyas Ika Yuni Astuti Indri. R Ines Septiani Pratiwi Isni Sri Wahyuni Jeslianti Samenna Kevin Gilberth Roganda Putra Melisa Tahang Milka Verawati Mufti Kharismawati Murni Muslim Sukri Ni Luh Gede Sartika Nidaul Husna Nopianti Sa’dan Nur Aini Syafira Nur Elisa Nur Hafshah Mardhiyyah Nur Nisawati Nurul Izzah Pahalawati IN Pri Iswati Utami Putri Astin Putri Ramadhani Salsabila Regina Tri Olivia Marundu Resky Rahayu Ningsih Rina Purnama Sari Riska Asmayanti Sasmita Sasmita Selvia Susantri Kaley Sitti Rafifah. R. Sri Agustini Sudarso Sudarso Try Widyati Vivi Wulandari Wiranti Sri Rahayu Wiwi Wulan Sari