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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Ilmiah Farmasi e-Journal Pustaka Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) JURNAL FARMASIMED (JFM) Medfarm: Jurnal Farmasi dan Kesehatan Pharmademica: Jurnal Kefarmasian dan Gizi Farmasis: Jurnal Sains Farmasi Jurnal Kesehatan dr. Soebandi Journal of Agropharmacy
Machlaurin, Afifah
Drug Utilization Research Group, Bagian Farmasi Klinik Dan Komunitas Fakultas Farmasi Universitas Jember; Program Studi Magister Farmasi Fakultas Farmasi, Universitas Jember
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health

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Evaluasi Pengobatan pada Pasien Geriatrik Rawat Inap dengan Stroke di RS Elizabeth Situbondo Periode November 2022‒Agustus 2023 Norcahyanti, Ika; Firandi, Adelia; Mauladi, Zainol Ihsan; Machlaurin, Afifah
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.102

Abstract

Potentially Inappropriate Medicines (PIMs) cause a significant issue, particularly when dealing with elderly patients. Aging in the elderly results in a decline in physiological body functions, impacting the response to medications. Furthermore, aging leads to decreased elasticity of blood vessels, increasing the risk of cardiovascular diseases such as stroke. The management of stroke requires special attention to minimize the risk of complications and enhance recovery opportunities. This study aims to analyze patient profiles, treatment profiles, and evaluate the treatment based on the Beers Criteria 2019. It is a retrospective descriptive study using a cross-sectional research design and purposive sampling technique for sample selection. The study sample includes elderly patients diagnosed with stroke who were hospitalized at RS Elizabeth Situbondo. Patient medical record data was collected through a specifically designed Data Collection Sheet (DCS) to evaluate drug utilization in these patients. The research findings indicate that the patients are predominantly male (53.2%), aged 60-69 (62.3%), and have a Length of Stay of 1-6 days (84.4%). All patients have payment status through BPJS. The treatment profile involves the administration of medications for stroke management, with ticagrelor as the primary drug (66.2%) and citicoline as the most commonly prescribed supplementary drug (97.4%). Treatment evaluation identified 193 events of drug use that potentially met the 2019 Beers Criteria. The highest category was potentially inappropriate drugs (134 events), with pantoprazole being the most commonly used drug (71 events).
Evaluasi Penggunaan Antibiotik pada Pasien ISPA Non-pneumonia di Puskesmas Senduro Kabupaten Lumajang Tahun 2019 Pratiwi, Permata Sari; Rachmawati, Ema; Rachmawati, Sinta; Aryani, Dhita Evi; Norcahyanti, Ika; Machlaurin, Afifah; Muhammad Hilmi Afthoni
Journal of Agropharmacy Vol. 1 No. 2 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i2.1330

Abstract

Acute Respiratory Infection (ARI) is an infectious disease of the upper and lower respiratory tract. Non-pneumonic ARI is mostly caused by viral infections so symptomatic therapy can be given, but it can also be caused by bacterial infections so antibiotic therapy is needed. Unwise use of antibiotics can increase bacterial resistance, thereby increasing morbidity and mortality rates. Regular evaluations need to be carried out to reduce the unwise use of antibiotics. The evaluation method that can be used is a quantitative method (ATC/DDD) to determine trends in antibiotic use. This research was conducted on 278 outpatient non-pneumonic ARI patients at the Senduro Lumajang Community Health Center in 2019, with the aim of knowing patient characteristics, antibiotic use profile, and description of antibiotic use using the ATC/DDD method. The results showed that female patients (n=154; 55.4%), were more dominant than male (n=124; 44.6%), patients with the highest age range being 36-45 years (n=70; 25, 2%), the highest diagnosis of ARI was other acute infections of the upper respiratory tract (J06) (n=147; 52.9%), the most commonly used antibiotic was amoxicillin (n=227; 81.6%) and the most rarely used was cefadroxil (n=13; 4.7%). Based on the evaluation results using the ATC/DDD method, it shows that amoxicillin is the antibiotic with the highest DDD value of 7.5 DDD/1000 patients/day and the antibiotic levofloxacin with the lowest DDD value of 0.3 DDD/1000 patients/day.
Evaluasi Penggunaan Antibiotik pada Pasien ISPA non Pneumonia Rawat Jalan dengan pendekatan Drug Utilization 90% Rachmawati, Ema; Norcahyanti, Ika; Aryani, Dhita Evi; Machlaurin, Afifah; Kurniawan, Eka Cahya
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acute respiratory infections (ARI) are infections most commonly caused by viruses, and antibiotics are not always necessary. However, antibiotics are still frequently used needlessly in ARI patients. Unreasonably using antibiotics can affect the likelihood of adverse medication reactions, raise medical expenses, and lead to antibiotic resistance. Regular assessments are required to prevent the overuse of antibiotics. This surveillance study uses retrospective and cross-sectional data to monitor antibiotic use. We measured the amount of antibiotic use using the DDD method in combination with DU 90%. Outpatient non-pneumonia ARI patients at the Teja Health Center in the Pamekasan Regency in 2020 served as the study's sample. The study's samples consisted of 193 adult non-pneumonia ARI patients. The kind and quantity of antibiotics used were gathered from patient medical records. The daily consumption of each antibiotic was calculated in DDD/1000 inhabitants/day, then grouped into the DU 90% segment. Six types of antibiotics were used for the therapy of non-pneumonia ARI patients: amoxicillin, erythromycin, co-trimoxazole, chloramphenicol, cefadroxil, and ciprofloxacin. The most widely used antibiotic is co-trimoxazole, valued at 4.71 DDD/1000 inhabitants per day. Two antibiotics are included in the 90% DU segment: co-trimoxazole and amoxicillin. This shows that the selection of antibiotics in ARI cases is increasingly specific. However, the use of co-trimoxazole in the therapy of non-pneumonia ARI needs to be further evaluated to assess the accuracy of drug prescription. This is because co-trimoxazole is not included in one of the antibiotic choices in the therapy management guidelines.
Implementation of The Just-In-Time Method on Drug Inventory Efficiency at The Pharmacy Department of Kaliwates Hospital Jember Herjuno, Adityo; Machlaurin, Afifah; Retnaningtyas, Yuni; Khoiri, Abu; Ilma, Wilda Zidni
Jurnal Kesehatan dr. Soebandi Vol 14 No 1 (2026): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v14i1.1060

Abstract

Background: During the Covid-19 pandemic, the management of drug inventory and sypply faces a great challenges. A common problem in the management of supplies at the pharmacy installation is the accumulation of drugs that are rarely used, which causes drugs to become damaged or expired, as well as the shortage of drugs that should be available. RSU Kaliwates Jember has implemented a strategy in 2023 to optimize the drug inventory in the Pharmacy department by applying a Just-In-Time strategy in drug purchasing. This study aims to analyze the impact of the strategy in three sector: drug procurement cost, total inventory cost, and inventory day. Methods:   The analysis applied the Quacy-experimental one group pretest-posttest design. The main goal is to analyze causal relationships by comparing the results of the two tests in order to determine the impact of the treatment. This study is a one-group pretest-posttest research design by comparing the value before and after the implementation of just-In-Time strategy, value at 2022 and 2023. The data was obtained from system management at RSU Kaliwates Jember (SIMRS) for procurement cost, inventory values, an inventory days. Results:   The analysis showed that there is a significant efficiency in drug procurement cost with a p-value of 0.041. For the total inventory value, the strategy could significantly reduce the value wiyh p-value of 0.006. In addition, the strategy could shorten significantly the inventory days with p-value 0.017. Conclusions:   This study conclude that the implementation of just-in-time strategy has an impact on improving the efficiency of drug inventory management especially in the reduction of the procurement cost, inventory value and inventory days. The impact of this strategy is worth to further analyze in the other sector such us in the drug wastage due to dead stock or expire drug and drug shortage that could affect the pharmacy care.
Association Between Drug Related Problems and Outcomes of Tuberculosis Patients at Citra Husada Hospital Jember Lutvi Anggraeni; Fifteen Aprila Fajrin; Afifah Machlaurin; Irma Prasetyowati; Angga Mardro Rahardjo
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/4h3axm73

Abstract

Background: Tuberculosis (TBC) remains a major global challenge. In Indonesia, the success rate for Drug-Sensitive Pulmonary TB (DS-TBC) treatment is still below target, often linked to Adverse Drug Reaction (ADR) and Drug Related Problem (DRP). The complexity of regimens and polypharmacy increases the risk of DRPs, which are strong predictors of treatment failure. Objective: This study aimed to identify DRPs and analyze their relationship with the clinical outcomes of DS-TBC. Method: A retrospective cohort study was conducted on 281 DS-TBC patients recorded at Citra Husada Hospital Jember from January 2020 to December 2023. Data were collected from medical records and the TBC Information System (SITB). DRPs were identified using the PCNE V9.1 classification, focusing on dose inappropriateness, drug interactions, and ADR. Outcomes were categorized as successful (cured/treatment completed) or unsuccessful. Result: Data analysis included descriptive statistics, bivariate analysis using Chi-Square, and multivariate analysis using Binary Logistic regression with a significance p < 0,05. The result of this study is that patients were predominantly male (55.16%), aged 46-65 years, with a treatment completion rate of 82.21%. DRPs were found in 84.34% of patients, dominated by drug interactions (79%) and ADRs (35.23%), although the accuracy of anti-TB drug dosage was 100%. In multivariate analysis, age ≥65 years was associated with a decreased likelihood of successful treatment (aOR 0.367), while respiratory tract medication administration was associated with an increased likelihood of successful treatment (aOR 2.477). The overall relationship between DRPs and outcome was not statistically significant. Conclusion: Sociodemographic factors (age) and clinical symptom management (respiratory therapy) play the most crucial roles in determining the treatment outcome. Effective pharmaceutical intervention is suggested to mitigate the impact of DRPs on treatment failure. More aggressive clinical management is necessary for elderly patients.
Cost-Effectiveness Analysis (CEA) of Adjunctive Hyperbaric Oxygen Therapy to Standard Wound Care Alone in Diabetic Foot Ulcer (DFU) Herdian Pradana; Afifah Machlaurin; Ayik Rosita Puspaningtyas; Fifteen Aprila Fajrin; Ainur Rokhmah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8z370a41

Abstract

Background: Diabetic foot ulcer (DFU) is a chronic complication of diabetes mellitus that is associated with high treatment costs and an increased risk of amputation. Hyperbaric oxygen therapy (HBOT) has been used as an adjunctive therapy to improve wound healing, yet evidence regarding its cost-effectiveness in Indonesia remains limited. Aim: This study aimed to evaluate the cost-effectiveness of HBOT compared with standard care in patients with DFU. Methods: A retrospective observational analytic study was conducted involving 80 DFU patients treated at RS Paru Jember between January 2024 and September 2025, consisting of 37 patients receiving standard care with HBOT and 43 patients receiving standard care without HBOT. Result: Clinical outcomes assessed included wound status, pain status, duration of healing, and incidence of amputation. Cost analysis was performed from the hospital perspective using direct medical costs, and cost-effectiveness was evaluated using the Incremental Cost-Effectiveness Ratio (ICER). The results showed that the HBOT group had a significantly higher proportion of wound healing compared with the non-HBOT group (21.62% vs 4.63%) and a lower rate of wound deterioration (2.7% vs 20.93%) (p=0.001). Although the mean total treatment cost was lower in the HBOT group than in the non-HBOT group (IDR 11,737,388 vs IDR 14,177,692), the difference was not statistically significant (p=0.118). ICER analysis demonstrated negative values for all evaluated outcomes, including wound healing, pain improvement, healing within six months, and prevention of amputation, indicating cost savings. Conclusion:  HBOT as an adjunctive therapy for DFU provides better clinical outcomes with lower overall treatment costs and may be considered a cost-effective and economically favorable intervention.
Knowledge and Attitudes of Indigenous Papuan Communities Toward HIV/AIDS in Nabire District Rachmawati, Ema; Kusumaningrum, Yunita Dyah; Machlaurin, Afifah; Firandi, Adelia; Damayanti, Putri Elsa
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/2cfpmp04

Abstract

Human Immunodeficiency Virus (HIV) is a virus that attacks white blood cells and gradually weakens the immune system. Without appropriate treatment, HIV infection can progress to Acquired Immunodeficiency Syndrome (AIDS), a late stage marked by severe immune impairment. Papua is one of the provinces with the highest HIV/AIDS prevalence in Indonesia which indicating the importance of understanding community knowledge and attitudes as key elements in prevention and control efforts. This study aimed to describe the level of knowledge and attitudes toward HIV/AIDS among Indigenous Papuan communities in Nabire District. This study employed a descriptive cross-sectional design. Data were collected using a questionnaire that had been tested for validity and reliability, consisting of 23 knowledge items and 11 attitude items. A total of 300 respondents who met the inclusion criteria were included in the analysis. The findings showed that respondents’ knowledge was categorized as high (28%), moderate (32%), and low (39.67%). With regard to attitudes toward HIV/AIDS, 13% of respondents demonstrated good attitudes, 42.67% had moderate attitudes, and 43.67% showed poor attitudes. It can be concluded that the average level of knowledge among indigenous Papuan communities remains low, accompanied by less favorable attitudes toward HIV/AIDS. These findings indicate the need to strengthen more intensive, targeted, and socio-culturally appropriate educational programs to improve knowledge and promote more positive attitudes toward HIV/AIDS particularly in Nabire District.
The Role of Pharmacy Personnel in Ensuring Appropriate Diarrhea Self-Medication in an Agro-Coastal Community in Jember, Indonesia Wardhani, Firdha Aprillia; Nur Sepdianto, Bagas; Rachmawati, Ema; Pontanar, Mae Quenie; Afifah Machlaurin
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44285

Abstract

Background: Self-medication for diarrhea is a common self-care practice because diarrhea is often perceived as a mild, self-limiting condition. However, its high prevalence in Indonesia, particularly in Jember Regency, raises concerns about inappropriate medicine selection and use, including the unsupervised use of prescription-only drugs such as loperamide and antibiotics. Pharmacists and pharmacy personnel play a key role in promoting safe and rational self-medication. Method: This cross-sectional study was conducted in 15 pharmacies in Agro-Coastal Jember from August 2025 to January 2026. Using purposive sampling, 200 eligible respondents were recruited. Data were collected using a structured questionnaire and analyzed using univariate analysis and Chi-square analysis with the contingency coefficient test to assess the significance and strength of the relationship between variables. Result: Most respondents were female (67%), aged 26–35 years (46.5%), had a senior high school education (71%), and had a monthly income of < IDR 2,500,000 (86%). Loperamide was the most frequently used medication (46.36%), and more than half of the medications used were prescription-only (53.18%). The appropriateness of diarrhea self-medication remained low for both medicine selection (46.8% appropriate) and medicine use (28.2% appropriate). A significant association was found between the role of pharmacists/pharmaceutical staff and the appropriateness of diarrhea self-medication (p < 0.05), although the strength of the relationship was weak (r = 0.233 and r = 0.184). Conclusion: In conclusion, diarrhea self-medication in the Agro-Coastal Jember community was still dominated by inappropriate medication practices. Strengthening pharmacy-based counseling in community pharmacy and service quality is essential to improve the safety and rational use of medicines in diarrhea self-medication.
Co-Authors Abu Khoiri Adityo Herjuno, Adityo Agnes Jovanka Ainur Rokhmah Al Rizka, Nabila Angga Mardro Rahardjo Antonius Nugraha Widhi Pratama Antonius Nugraha Widhi Pratama Arwi, Khoiriyatul Muhlishoh Aryani, Dhita Evi Ayik Rosita Puspaningtyas1 Damayanti, Putri Elsa Dhita Evi Aryani Dian Ayu Juwita Elly Febry Taufany Ema Rachmawati Fajrin, Fifteen Aprilla Fifteen Aprila Fajrin Firandi, Adelia Fransiska Maria C. Fransiska Maria Christianty Herdian Pradana Husnun, Khoiriyah Haifa Ika Norcahyanti Ika Norcahyanti Irma Prasetyowati Kurniawan, Eka Cahya Kusumaningrum , Yunita Dyah Lutvi Anggraeni Mauladi, Zainol Ihsan Maulina Hari Pradipta Najmiatul Fitria Nguyen, Thang Nur Sepdianto, Bagas Nuraini Agustin Nurul Faridah Poerwahyuningrum, Neny Pontanar, Mae Quenie Pratiwi, Permata Sari Prihwanto Budi Subagijo Prihwanto Budi Subagio Putu Setia Pratama Rahardjo, Angga Mardro Sinta Rachmawati Sinta Rachmawati Wardhani, Firdha Aprillia Wilda Zidni Ilma, Wilda Zidni Yeni Rahmawati Negara Yuni Retnaningtyas