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Machlaurin, Afifah
Drug Utilization Research Group, Bagian Farmasi Klinik Dan Komunitas Fakultas Farmasi Universitas Jember; Program Studi Magister Farmasi Fakultas Farmasi, Universitas Jember
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health

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Evaluasi Pengobatan pada Pasien Geriatrik Rawat Inap dengan Stroke di RS Elizabeth Situbondo Periode November 2022‒Agustus 2023 Norcahyanti, Ika; Firandi, Adelia; Mauladi, Zainol Ihsan; Machlaurin, Afifah
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.102

Abstract

Potentially Inappropriate Medicines (PIMs) cause a significant issue, particularly when dealing with elderly patients. Aging in the elderly results in a decline in physiological body functions, impacting the response to medications. Furthermore, aging leads to decreased elasticity of blood vessels, increasing the risk of cardiovascular diseases such as stroke. The management of stroke requires special attention to minimize the risk of complications and enhance recovery opportunities. This study aims to analyze patient profiles, treatment profiles, and evaluate the treatment based on the Beers Criteria 2019. It is a retrospective descriptive study using a cross-sectional research design and purposive sampling technique for sample selection. The study sample includes elderly patients diagnosed with stroke who were hospitalized at RS Elizabeth Situbondo. Patient medical record data was collected through a specifically designed Data Collection Sheet (DCS) to evaluate drug utilization in these patients. The research findings indicate that the patients are predominantly male (53.2%), aged 60-69 (62.3%), and have a Length of Stay of 1-6 days (84.4%). All patients have payment status through BPJS. The treatment profile involves the administration of medications for stroke management, with ticagrelor as the primary drug (66.2%) and citicoline as the most commonly prescribed supplementary drug (97.4%). Treatment evaluation identified 193 events of drug use that potentially met the 2019 Beers Criteria. The highest category was potentially inappropriate drugs (134 events), with pantoprazole being the most commonly used drug (71 events).
Evaluasi Penggunaan Antibiotik pada Pasien ISPA Non-pneumonia di Puskesmas Senduro Kabupaten Lumajang Tahun 2019 Pratiwi, Permata Sari; Rachmawati, Ema; Rachmawati, Sinta; Aryani, Dhita Evi; Norcahyanti, Ika; Machlaurin, Afifah; Muhammad Hilmi Afthoni
Journal of Agropharmacy Vol. 1 No. 2 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i2.1330

Abstract

Acute Respiratory Infection (ARI) is an infectious disease of the upper and lower respiratory tract. Non-pneumonic ARI is mostly caused by viral infections so symptomatic therapy can be given, but it can also be caused by bacterial infections so antibiotic therapy is needed. Unwise use of antibiotics can increase bacterial resistance, thereby increasing morbidity and mortality rates. Regular evaluations need to be carried out to reduce the unwise use of antibiotics. The evaluation method that can be used is a quantitative method (ATC/DDD) to determine trends in antibiotic use. This research was conducted on 278 outpatient non-pneumonic ARI patients at the Senduro Lumajang Community Health Center in 2019, with the aim of knowing patient characteristics, antibiotic use profile, and description of antibiotic use using the ATC/DDD method. The results showed that female patients (n=154; 55.4%), were more dominant than male (n=124; 44.6%), patients with the highest age range being 36-45 years (n=70; 25, 2%), the highest diagnosis of ARI was other acute infections of the upper respiratory tract (J06) (n=147; 52.9%), the most commonly used antibiotic was amoxicillin (n=227; 81.6%) and the most rarely used was cefadroxil (n=13; 4.7%). Based on the evaluation results using the ATC/DDD method, it shows that amoxicillin is the antibiotic with the highest DDD value of 7.5 DDD/1000 patients/day and the antibiotic levofloxacin with the lowest DDD value of 0.3 DDD/1000 patients/day.
Evaluasi Penggunaan Antibiotik pada Pasien ISPA non Pneumonia Rawat Jalan dengan pendekatan Drug Utilization 90% Rachmawati, Ema; Norcahyanti, Ika; Aryani, Dhita Evi; Machlaurin, Afifah; Kurniawan, Eka Cahya
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acute respiratory infections (ARI) are infections most commonly caused by viruses, and antibiotics are not always necessary. However, antibiotics are still frequently used needlessly in ARI patients. Unreasonably using antibiotics can affect the likelihood of adverse medication reactions, raise medical expenses, and lead to antibiotic resistance. Regular assessments are required to prevent the overuse of antibiotics. This surveillance study uses retrospective and cross-sectional data to monitor antibiotic use. We measured the amount of antibiotic use using the DDD method in combination with DU 90%. Outpatient non-pneumonia ARI patients at the Teja Health Center in the Pamekasan Regency in 2020 served as the study's sample. The study's samples consisted of 193 adult non-pneumonia ARI patients. The kind and quantity of antibiotics used were gathered from patient medical records. The daily consumption of each antibiotic was calculated in DDD/1000 inhabitants/day, then grouped into the DU 90% segment. Six types of antibiotics were used for the therapy of non-pneumonia ARI patients: amoxicillin, erythromycin, co-trimoxazole, chloramphenicol, cefadroxil, and ciprofloxacin. The most widely used antibiotic is co-trimoxazole, valued at 4.71 DDD/1000 inhabitants per day. Two antibiotics are included in the 90% DU segment: co-trimoxazole and amoxicillin. This shows that the selection of antibiotics in ARI cases is increasingly specific. However, the use of co-trimoxazole in the therapy of non-pneumonia ARI needs to be further evaluated to assess the accuracy of drug prescription. This is because co-trimoxazole is not included in one of the antibiotic choices in the therapy management guidelines.
Co-Authors Agnes Jovanka Al Rizka, Nabila Antonius Nugraha Widhi Pratama Antonius Nugraha Widhi Pratama Arwi, Khoiriyatul Muhlishoh Aryani, Dhita Evi Dhita Evi Aryani Dian Ayu Juwita Elly Febry Taufany Ema Rachmawati Fajrin, Fifteen Aprilla Firandi, Adelia Fransiska Maria C. Fransiska Maria Christianty Husnun, Khoiriyah Haifa Ika Norcahyanti Ika Norcahyanti Irma Prasetyowati Kurniawan, Eka Cahya Mauladi, Zainol Ihsan Maulina Hari Pradipta Najmiatul Fitria Nguyen, Thang Nuraini Agustin Nurul Faridah Poerwahyuningrum, Neny Pratiwi, Permata Sari Prihwanto Budi Subagijo Prihwanto Budi Subagio Putu Setia Pratama Rahardjo, Angga Mardro Sinta Rachmawati Sinta Rachmawati Yeni Rahmawati Negara