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All Journal Pharmaciana: Jurnal Kefarmasian Biology, Medicine, & Natural Product Chemistry CERATA Jurnal Ilmu Farmasi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Sains dan Praktis Urecol Journal. Part C: Health Sciences Prosiding University Research Colloquium Borobudur Pharmacy Review CERATA Journal of Tropical Pharmacy and Chemistry
Heni Lutfiyati
Universitas Muhammadiyah Magelang, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Veterinary

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GAMBARAN PENGGUNAAN OBAT DAN TINGKAT KONTROL ASMA PADA PASIEN ASMA DEWASA RAWAT JALAN DI BKPM MAGELANG PERIODE FEBUARI-MARET 2016 whiliani indra astuti; Widarika Hapsari; Heni Lutfiyati
Jurnal Farmasi Sains dan Praktis Vol 4 No 1 (2018)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v4i1.2588

Abstract

Asma merupakan penyakit inflamasi kronik saluran pernapasan. Saat ini diperkirakan sekitar 100-150 juta penduduk di dunia menderita asma, jumlah ini diperkirakan akan terus bertambah hingga mencapai 180.000 orang setiap tahunnya. Tingginya prevalensi asma yang terjadi, maka dibutuhkan perhatian khusus dalam penggunaan obat untuk meningkatkan tingkat kontrol asma pada pasien asma. Penelitian ini bertujuan untuk mengetahui penggunaan obat dan tingkat kontrol asma pada pasien asma rawat jalan di Balai Kesehatan Paru Masyarakat Magelang.Penelitian ini merupakan penelitian deskriptif, pengambilan data dilakukan dengan resep pasien asma secara prospektif dan dilakukan pendekatan non eksperimental dengan pengamatan secara tidak langsung menggunakan kuesioner ACT untuk mengetahui tingkat kontrol asma. Sampel dalam penelitian ini berjumlah 46 responden, pengambilan sampel menggunakan tehnik purposive sampling. Hasil penelitian disajikan dalam bentuk tabel disertai pembahasan. Pasien asma yang paling banyak yaitu perempuan berjumlah 30 orang (65%), sedangkan laki-laki berjumlah 16 orang (35%). Distribusi pasien asma terbanyak pada kelompok umur 42-47 tahun (24%) dan umur 48-53 tahun (20%). jenis obat yang banyak digunakan di BKPM Magelang untuk pengobatan asma yaitu obat agonis β2 adrenergik (47,41%). Pasien asma yang tidak terkontrol sebanyak 24 orang (52%), dan yang terkontrol sebagian sebanyak 22 orang (48%).
Wuluh Starfruit (Averrhoa Bilimbi) Extract Gel For Recurrent Aftosa Stomatitis Umaimatun Nakhil; Isabella Meliawati Sikumbang; Nugrahani Hendra Putri; Heni Lutfiyati
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.2713

Abstract

The purpose of this study was to test the antibacterial activity of the gel extract of Wuluh starfruit (Averrhoa bilimbi L.). So that it can provide a representation of the use of starfruit in medicine and as an enrichment of insight. Averrhoa bilimbi L contains flavonoids, tannins and saponins which have antibacterial properties. The stages that have been carried out include identification and determination of the starfruit fruit plant, then the simplicia powder of starfruit is extracted using 70% ethanol by maceration which is then carried out evaporation on the waterbath to obtain thick extract. Then made the gel preparation with a concentration of b / v 40%, 45% and 50%. Evaluation of stability physical gel includes organoleptic test, homogeneity, pH, viscosity and spreading ability. The result showed that the three formulas were thick, brown with a characteristics smell of starfruit, homogeny, pH 5, viscosity 190-260 dPas and the spreadability test was 2,5-4,2 cm. Then a bacterial suspension was made by being immersed for 24 hours at 37 ℃. Then tested by dividing into 5 treatment groups, with positive controls Amoxicillin and negative control gel basis. The results showed that the average inhibition zone for each treatment was positive control 4.66 cm, negative control 0 cm, gel 40% 1.77 cm, gel 45% 1.93 cm, and gel 50% 2.67 cm. From the average inhibitory zone it can be seen that gel wuluh starfruit extract has antibacterial activity.
Psychological and Environmental Support: An Important Complement to Controlled Antiretroviral Therapy for HIV Patients Setiyo Budi Santoso; Heni Lutfiyati; Ulfahishofi Hanifah Afifi; Shellyta Ratnafuri
Urecol Journal. Part C: Health Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.447 KB) | DOI: 10.53017/ujhs.13

Abstract

This article presents a quality of life profile for HIV patients who have undergone controlled antiretroviral therapy. Specifically, researchers reviewed the unique needs of research subjects for psychological and environmental support. The research took place at the Regional General Hospital KRT Setjonegoro Wonosobo, involving 68 research subjects. All study subjects were HIV patients undergoing controlled antiretroviral therapy (outpatient) with a duration of more than six months and were aged more than 15 years. Investigation of the quality of life profile used the Indonesian version of the WHOQOL-HIV Bref questionnaire. The results showed that HIV patients who underwent controlled therapy had a higher quality of life score than general HIV patients. Antiretroviral treatment has helped them have physical qualities, independence, spiritual side, and social abilities in living life. Even so, they need psychological intervention and environmental support to have consistent quality of themselves. Health workers involved in managing HIV patients need to provide professional interventions to improve their ability to concentrate and ensure that they are always comfortable with their physical condition. Further, there is a need for cooperation by relationships (family, friends, community) and health workers to ensure that HIV patients do not experience financial difficulties, enjoy time in a relaxed manner, and feel safe as part of the environment society in general.
Efek Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Binahong Terhadap Penyembuhan Luka Fase Proliferasi Pada Mencit Diabetik Eka Sakti Wahyuningtyas; N Nasruddin; Heni Setyowati Esti Rahayu; Heni Lutfiyati; Isabella Meliawati Sikumbang; Laela Hayu Nurani; Arum Kartikadewi; Nia Salsabila; Gela Setya Ayu Putri; Putri Kurniasiwi; Devi Kemala Dewi
Prosiding University Research Colloquium Proceeding of The 12th University Research Colloquium 2020: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.287 KB)

Abstract

Plasma medicine is a relatively new and multidisciplinary studyinvolving the study of plasma science, biomedicine, pharmacy, andother health sciences to utilizing plasma for medical therapy. Plasmais the fourth substance, after solids, liquids, and gases. Plasma canproduce biological molecules of Reactive Oxygen and NitrogenSpecies (RON) which, if controlled in the right dose, can bebeneficial for health. This animal study examines the effect ofcombinative treatment of medicine plasma and binahong leaf extracton proliferation phase wound healing in a diabetic test model. Thestudy used Balb mice 7-8 years old which were induced by STZ withacute wounds which were divided into 4 groups, namely the woundgroup of diabetic mice without treatment (C), the group of diabeticmice with the treatment of binahong leaf extract (B), the group ofcombined treatment wounds plasma jet (P) and the wound group ofdiabetic mice treated with a combination of plasma and, binahongleaf extract (PB). Binahong leaf extract concentration 1% in DMSOsolvent. The jet type medicine plasma treatment was carried outevery day from day 0 to day 6. Macroscopic observation of thewound was carried out every day from day 0 to day 7. On day 7 itappears that the size of the wound area for P is much smaller thanfor C, B, and PB. The size of area B and PB is relatively the same,but smaller than C. The results of this study indicate that thebinahong leaf extract tends to inhibit the performance of medicineplasma in accelerating the healing of the proliferation phase.
Selain Terapi Antiretroviral Secara Terkontrol, Pasien HIV Juga Memerlukan Dukungan Psikologis dan Lingkungan Setiyo Budi Santoso; Heni Lutfiyati; Ulfahishofi Hanifah Afifi; Shellyta Ratnafuri
Prosiding University Research Colloquium Proceeding of The 13th University Research Colloquium 2021: Kesehatan dan MIPA
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.811 KB)

Abstract

Artikel ini menyajikan profil kualitas hidup pasien HIV yang telah menjalani terapi secara terkontrol. Secara spesifik, peneliti mengulas kebutuhan khusus subyek penelitian terhadap dukungan psikologis dan lingkungan. Penelitian berlangsung di Rumah Sakit Umum Daerah KRT Setjonegoro Wonosobo dengan melibatkan 68 subyek penelitian. Seluruh subyek penelitian merupakan pasien HIV yang sedang menjalani terapi antiretroviral (rawat jalan) secara terkontrol dengan durasi lebih dari 6 bulan, dan berusia lebih dari 15 tahun. Investigasi profil kualitas hidup menggunakan kuesioner WHOQOL-HIV Bref versi Bahasa Indonesia. Hasil penelitian menunjukkan bahwa pasien HIV yang menjalani terapi secara terkontrol memiliki nilai kualitas hidup yang lebih baik dari pasien HIV umum. Terapi antiretroviral telah membantu mereka memiliki kualitas fisik, tingkat kemandirian, sisi spiritual dan kemampuan sosial dalam menjalani hidup. Meski begitu, mereka memerlukan intervensi psikologis dan dukungan lingkungan agar memiliki kualitas diri yang merata. Tenaga kesehatan yang terlibat dalam pengelolaan pasien HIV, perlu memberikan intervensi profesional untuk meningkatkan kemampuan mereka dalam berkonsentrasi, serta memastikan mereka senantiasa nyaman dengan kondisi fisiknya. Lebih dari itu, perlu gotong royong pula oleh relasi (keluarga, teman, komunitas) dan tenaga kesehatan dalam menjamin pasien HIV tidak mengalami kesulitan finansial, mampu menikmati waktu secara rileks, dan merasa aman sebagai bagian dari lingkungan sebagaimana masyarakat secara umum.
Evaluasi rasionalitas penggunaan antibiotik profilaksis pada pasien fraktur terbuka di instalasi rawat inap bedah tahun 2019 Lilik Kurniati; Widarika Santi Hapsari; Fitriana Yuliastuti; Heni Lutfiyati
Borobudur Pharmacy Review Vol 1 No 1 (2021): January-June
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/bphr.v1i1.4862

Abstract

Antibiotik profilaksis merupakan antibiotik yang digunakan untuk mengatasi pasien yang mempunyai peluang besar terkena infeksi yang dapat menimbulkan dampak buruk bagi pasien dan dapat digunakan juga untuk pasien yang belum terkena infeksi. Pembedahan fraktur terbuka dengan jenis operasi merupakan pilihan untuk penggunaan antibiotik profilaksis. Tujuaan dalam penelitian ini adalah untuk mengetahui rasionalitas penggunaan antibiotik profilaksis pada pasien tulang fraktur terbuka di instalasi rawat inap bedah orthopaedi di RS X Magelang tahun 2019. Metode dalam melakukan penelitian ini adalah penelitian non-eksperimental dengan pengambilan data secara retrosprektif pada populasi pasien yang menjalani bedah orthopedi patah tulang fraktur terbuka dan menggunakan antibiotik profilaksis. Data dianalisis secara deskriptif dengan parameter tepat indikasi, tepat pasien, tepat obat, tepat dosis, tepat waktu pemberian dan efek samping. Hasil analisis evaluasi rasionalitas ketepatan penggunaan antibiotik profilaksis pada fraktur terbuka berdasarkan Role of Prophylactic Antibiotics in Orthopaedics : Current Concpet (2017), Pedoman Umum Penggunaan Antibiotik (Peraturan Menteri Kesehatan Republik Indonesia Nomor 2406/Menkes/Per/Xii/2011), Pharmacotherapy Handbook Ninth Edition, IONI(2017), Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery dan WHO (2016) bahwa tepat indikasi 3,57 %, tepat obat 3,57%, tepat pasien 3,57 %, tepat dosis 85,72%, tepat waktu pemberian 96,42%, wapada efek samping 100%.
The Weight Performance Stability of Mice on Modeling Obesity-Associated Hyperglycemia Induced by Dextrose Monohydrate Deksa Yudha Syach Putra; Setiyo Budi Santoso; Heni Lutfiyati
Biology, Medicine, & Natural Product Chemistry Vol 11, No 2 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.112.169-173

Abstract

Previously, streptozotocin and alloxan were employed to imitate hyperglycemia in mice. High doses of sucrose were also induced as an alternative. Due to body mass index has been associated with hyperglycemia, the evidence of weight body index in various induction alternate kinds, however, have not been fully reported. Here-in, we report on the weight performance stability of mice body weight induced by dextrose, streptozotocin, and alloxan. To begin, all mice were divided into six groups of five, with one reserve in each. Following seven days of acclimatization, the mice were induced for nine days of hyperglycemia modeling; alloxan (Groups A and D), streptozotocin (Group B and E), dextrose monohydrate (Groups C and F). On preclinical research animals modelling related to obesity-associated hyperglycemia in mice, dextrose monohydrate induction was most successful than streptozocotin and alloxan induction, which performed best during the induction period (31% weight growth) and after metformin intervention (36% weight growth). Overall, dextrose monohydrate is most suitable to be used for modeling type 2 diabetes mellitus test animals rather than alloxan and streptozocotin.
Psychological and Environmental Support: An Important Complement to Controlled Antiretroviral Therapy for HIV Patients Setiyo Budi Santoso; Heni Lutfiyati; Ulfahishofi Hanifah Afifi; Shellyta Ratnafuri
Urecol Journal. Part C: Health Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujhs.13

Abstract

This article presents a quality of life profile for HIV patients who have undergone controlled antiretroviral therapy. Specifically, researchers reviewed the unique needs of research subjects for psychological and environmental support. The research took place at the Regional General Hospital KRT Setjonegoro Wonosobo, involving 68 research subjects. All study subjects were HIV patients undergoing controlled antiretroviral therapy (outpatient) with a duration of more than six months and were aged more than 15 years. Investigation of the quality of life profile used the Indonesian version of the WHOQOL-HIV Bref questionnaire. The results showed that HIV patients who underwent controlled therapy had a higher quality of life score than general HIV patients. Antiretroviral treatment has helped them have physical qualities, independence, spiritual side, and social abilities in living life. Even so, they need psychological intervention and environmental support to have consistent quality of themselves. Health workers involved in managing HIV patients need to provide professional interventions to improve their ability to concentrate and ensure that they are always comfortable with their physical condition. Further, there is a need for cooperation by relationships (family, friends, community) and health workers to ensure that HIV patients do not experience financial difficulties, enjoy time in a relaxed manner, and feel safe as part of the environment society in general.
Kesiapan Apoteker dalam Memberikan Layanan Medication Therapy Management Heni Lutfiyati; Prasojo Pribadi; Setiyo Budi Santoso
CERATA Jurnal Ilmu Farmasi Vol 10 No 1 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v10i1.74

Abstract

Optimizing the implementation of the referral program is one of BPJS 'top programs. BPJS Health implements a referral program based on Medication Therapy Management. Medication therapy management interventions can reduce the frequency of drug-related problems, including non-compliance, and reduce health care costs. The purpose of this study was to evaluate the readiness of pharmacists in providing medication therapy management services This research uses a descriptive method by using a questionnaire as an instrument for data retrieval. The sampling technique is convenience sampling. The population is pharmacists who practice pharmaceutical services and are willing to fill out questionnaires. The result most pharmacists feel they have enough clinical knowledge and experience to provide MTM services. There are still many pharmacist workplaces (Puskesmas, Pharmacies and hospitals) that have not yet prepared to provide MTM services. Pharmacists think they have a desire to provide MTM services and have sufficient access to information in designing appropriate MTM services and pharmacists should be involved in providing MTM services. The obstacles faced by pharmacists in providing MTM services are insufficient time, insufficient human resources, limited space, limited information regarding MTM services, and the costs needed to implement MTM. Pharmacists are willing to provide Medication Therapy Management services but many obstacles remain. Training is needed so that pharmacists become more confident in providing clinical services
Antidiabetic Activities of Broccoli Extracts (Brassica oleracea L.var italica) on Mice Induced Streptozotocin-Nicotinamide Heni Lutfiyati; Fitriana Yuliastuti; Imron Wahyu Hidayat; Prasojo Pribadi; Sodiq Kamal
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 4 (2018): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i3.203

Abstract

Several plant species have been used for the treatment of diabetes. Research on plants that can be used to treat diabetes such as Cinnamomum cassia and Cinnamomum zeylanicum, Piper sarmentosum Roxb, Nelumbo nucifera, Ceiba petandra Memecylon malabaricum. Broccoli (Brassica oleracea L var italics) is a flower of vegetables like cabbage plants. Broccoli juice is made capable of direct and indirect effects on the reduction of blood LDL; the indirect effect is by repairing pancreatic beta cells and increasing insulin sensitivity. The purpose of this study was to determine whether broccoli has activity as antidiabetic. The subjects consisted of 15 mice induced with nicotinamide 70 mg/kg BW and Stz 150 mg/kg BW. Diabetic mice were divided into the positive control group (glibenclamide), negative control group (CMC Na) and three treatment groups. The test material is broccoli extract dose 75 mg / kg BW, 150 mg /kg BW and 300 mg/kg BW given peroral for 14 days. Anova test results showed that there was a significant difference in the average percentage of decreased blood glucose levels in all treatments. The result of Post Hock Tukey HSD test with a 95% confidence level showed a significant difference in the negative control group compared with positive control group and extract 300mg / kg BW. This shows that positive control group and extracts 300mg / kg body weight have an activity to decrease blood glucose level.
Co-Authors Arrum Khotimah Arum Kartikadewi Chairun Wiedyaningsih Deksa Yudha Syach Putra Devi Kemala Dewi dianita prastika Dimas Ariandi Candra Putra Eka Sakti Wahyuningtyas Fitriana Yuliastuti Gela Setya Ayu Putri Heni Setyowati Esti Rahayu Imron Wahyu Hidayat Imron Wahyu Hidayat Isabella Meliawati Sikumbang Isabella Meliawati Sikumbang Laela Hayu Nurani Lilik Kurniati N Nasruddin Nia Salsabila Nugrahani Hendra Putri Prasojo Pribadi Puspita Dianita Puspita Septie Dianita Putra, Dimas Ariandi Candra Putri Kurniasiwi Reni Chandra Kirana Septi Wardani Setiyo Budi Santoso Shellyta Ratnafuri Shellyta Ratnafuri Sodiq Kamal Tiara Mega Kusuma Ulfahishofi Hanifah Afifi Ulfahishofi Hanifah Afifi Umaimatun Nakhil whiliani indra astuti Widarika Hapsari Widarika Santi Hapsari ZULLIES IKAWATI