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All Journal Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Majalah Info Sains Journal of Pharmaceutical and Sciences.
Silvana L. Tumbel
Universitas Kristen Indonesia Tomohon
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Identifikasi Hidrokuinon Pada Krim Pemutih Wajah Yang Beredar Di Pasar Central Tompasobaru Jeivia Matialo; Wilmar Maarisit; Christel Sambou; Silvana Tumbel
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 5 No. 1 (2022): April 2022
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v5i1.379

Abstract

The board of trustees of medicine and food throughout Indonesia was keeping a routine check on cosmetics that ran from October 2014 to September 2015, there are 30 types of cosmetics that contain the dangerous materials of 13 types of cosmetic product and 17 types of domestic production. The harmful substances identified in such cosmetics as K3 and K10 red dye (Rhodamin B), retinoic acid, mercury and hydroquinine. Hydroquinone is a supposition or a device that ACTS to treat hyperpigmentation in the outer part of the body as skin. Hyperpigmentation is the process by which skin is exposed to such areas as pimples, scars, or brown spots from frequent exposure to sunlight. Excessive use of hydroquinone can cause ookronosis, namely the skin has nodules like sand and bluish-brown in color, people with ookronosis will feel the skin like burning and itching. This type of research is descriptive, which aims to describe and describe the presence or absence of hydroquinone in facial whitening creams. The method used for laboratory testing is qualitatively using the thin layer chromatography method. Sampling using purposive sampling method, namely sampling where the sample taken is a cream that does not have a permit from the Food and Drug Supervisory Agency. From the results of research that has been carried out on three face whitening creams circulating in the Central Tompasobaru market and do not have a permit from the Food and Drug Supervisory Agency, one of which was declared positive for containing Hydroquinone, it is shown from the results of a qualitative test using the thin layer chromatography method which has the same value. with a standard solution of hydroquinone, which is Rf = 0.84 and under UV light 254 has a blackish fluorescence.
Uji Efektitivitas Sediaan Gel Ekstrak Daun Kemangi (Ocimum basilicum L) Terhadap Penyembuhan Luka Sayatan Tikus Putih (Rattus nornvegicus) Anastasia Walukow; Douglas N. Pareta; Silvana L. Tumbel; Joke L. Tombuku; Christel N. Sambou
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.173

Abstract

Natural wealth has a variety of herbal plants, plants that are included in it efficacious as medicine. Traditional medicine, is an ingredient or herb that is usually used as traditional medicine and is used to accelerate the healing of diseases, one of the plants used to accelerate wound healing is basil leaves (Ocimum basilicum L.). This study aimed to determine the effectiveness of basil leaf gel preparations against wound healing in white rats (Rattus norvegicus). The test animals used were 15 rats. A 1 cm cut wound is made on the back of the mouse using a scalpel. The method used in this study is in the form of laboratory experiments. This study used a Complete Randomized Design (CDR) consisting of 5 treatments, including 1 negative control, 1 positive control (bioplacenton), and 3 stratified concentrations, namely 5% concentration gel, 10% concentration gel and 15% concentration gel with 3 repetitions each. The treatment is carried out for 7 days. The results of measuring wound diameter in rats based on the results showed that basil leaf extract gel concentration of 15% provided a healing effect more effective than other extracts.
Uji Efektivitas Ekstrak Daun Singkong Karet (Manihot gglaziovii) Terhadap Proses Penyembuhan Luka Sayatan Pada Tikus Putih (Rattus norvegicus) Asmuruf, Yunice; Tumbel, Silvana L.; Mongi, Jeane; Lengkey, Yessie K.; Maarisit, Wilmar; Montolalu, Friska M.; Ginting, Margaretha S.
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 7 No. 1 (2024): April 2024
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v7i1.424

Abstract

Negara Indonesia kaya akan keanekaragaman hayati yang dapat diolah menjadi berbagai macam obat yang dapat dimanfaatkan dalam semua aspek kehidupan manusia.  Salah satu tanaman yang digunakan adalah daun singkong karet yang mengandung flavonoid, saponin, dan tanin yang diketahui mempunyai aktivitas sebagai antibakteri dan juga memiliki efek dalam mengobati luka pada tikus. Penelitian ini bertujuan untuk mengetahui tingkat efektivitas ekstrak daun singkong karet (Manihot glaziovii) terhadap proses penyembuhan luka sayatan. Penelitian ini menggunakan tikus putih jantan sebanyak 15 ekor dengan membuat luka sayat di punggung tikus. Penelitian ini menggunakan bentuk ekspreimen laboratorium dengan 5 perlakuan yang terdiri dari negative control, positive control dan 3 konsentrasi bertingkat. Hasil dari penelitian ini menunjukkan bahwa ekstrak daun singkong karet konsentrasi 15 persen memberikan efek penyembuhan yang lebih efektif dibandingkan dengan ekstrak konsentrasi 5 persen dan ekstrak konsentrasi 10 persen.
Studi Aktivitas Antioksidan Dari Ekstrak Etanol Daun Benalu (Dendrophthoe pentandra (L.) Miq) Pada Tanaman Pala Besin, Cecilia S. M.; Kanter, Jabes W.; Maarisit, Wilmar; Tumbel, Silvana L.; Pareta, Douglas N.; Montolalu, Friska M.
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 7 No. 1 (2024): April 2024
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v7i1.447

Abstract

Antioksidan merupakan zat yang menghambat atau mencegah kerusakan sel akibat oksidasi dari radikal bebas. Salah satu tanaman yang berkhasiat sebagai alternatif pengobatan tradisional dan berpotensi sebagai antioksidan adalah benalu pala. Penelitian ini bertujuan untuk mengetahui apakah benalu pala memiliki aktivitas antioksidan dengan melakukan uji skrining fitokimia dan Spektrofotometer UV-Vis. Metode penelitian ini menggunakan benalu pada tanaman pala dan diekstraksi dengan etanol 95% dengan metode maserasi kemudian dipekatkan dengan rotary evaporator pada suhu 40°C untuk mencegah dekomposisi senyawa yang terdapat didalamnya. Setelah itu, dilakukan uji skrining fitokimia yang bertujuan untuk mengetahui kandungan senyawa metabolit yang ada pada sampel. Pengujian aktivitas antioksidan dilakukan secara kualitatif dengan menggunakan metode DPPH pada panjang gelombang 517 nm dan pembanding vitamin C menggunakan Spektrofotometer UV-Vis, sedangkan uji skrining fitokimia secara kuantitatif dengan uji tabung reaksi untuk mengetahui senyawa-senyawa metabot yang ada seperti alkaloid, flavonoid, saponin, taniin, triterpenoid, dan steroid. Berdasarkan hasil penelitian yang dilakukan pada uji skrining fitokimia, menunjukkan bahwa sampel memiliki senyawa metabolit seperti alkaloid, flavonoid, saponin, tanin, dan triterpenoid. Sedangkan untuk hasil uji antioksidan nilai IC50 yang diperoleh dari hasil persamaan regresi linier ialah 4,644 untuk ekstrak kasar dan nilai IC50 vitamin C sebagai pembanding 0,169. Berdasarkan hasil uji analisis yang dilakukan, dapat disimpulkan bahwa daya antioksidan yang didapatkan tergolong sangat kuat dan berpotensi menangkal radikal bebas DPPH.
Antibacterial Activity Test Of Epazote Leaf Infusion (Dysphania ambrosioides L.) Against Escherichia coli Bacteria Carolina, Saroinsong F.; Montolalu, Friska M.; Tumbel, Silvana L.; Kanter, Jabes W.; Maarisit, Wilmar; pakingki, Priska
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 7 No. 2 (2024): Oktober 2024
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v7i2.458

Abstract

The most common health problem in Indonesia is bacterial infection. Dysphania ambrosioides L., also known as epazote leaves, is an herbal plant that has antimicrobial potential. This research was conducted to see at what concentration there is antibacterial activity of epazote leaf infusion Dysphania ambrosioides L. against Escherichia coli bacteria. This laboratory experimental study used a complete randomized design (RAL) research. Antibacterial activity testing of epazote leaves was carried out using the disc paper diffusion method with concentrations of 50%, 75%, and 100%. Epazote leaves are boiled in an infusion pan for 15 minutes, until the temperature reaches 90 degrees Celsius. Ampicillin positive control 10 ?g/disc. Based on the test results of secondary metabolites of positive epazote leaf infusion there are alkaloids, flavonoids, tannins, saponins, triterpenoids, and phenolics. The results of the study showed that infusion of epazote leaves inhibited Escherichia coli bacteria by diameter inhibition. Average at a concentration of 50% = 14.04 mm, 75% = 16.92 mm, 100% = 17.94 mm, which means that there is antibacterial activity of epazote leaf infusion against Escherichia coli bacteria.
Evaluation of Ficus minahassae Fruit Extract as a Natural Agent against Propionibacterium acnes Maarisit, Abigail F.; Kojongian, Cliveno; Rondonuwu, Tesalonika; Rawung, Intan J. F.; Kalalo, Reine; Supit, Arter; Tumbel, Silvana L.; Maarisit, Wilmar
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.497

Abstract

Ficus minahassae fruit is known to contain bioactive compounds that have the potential to act as antibacterial agents. This study aims to determine the antibacterial activity of Propionibacterium acnes from F. minahassae fruit extract. F. minahassae fruit is extracted using ethanol. Antibacterial activity test using the disc diffusion method. Based on the results of the study, it was obtained that F. minahassae fruit extract was able to inhibit P. acnes bacteria at concentrations of 200, 300, 400, 500, and 600 mg/disc with inhibition zone diameters of 11.68, 13.33, 14.35, 15.47, and 17.82 mm, respectively. F. minahassae fruit extract can be developed as a raw material for drugs, especially anti-bacterial P. acnes, which causes acne.
Co-Authors Amal Ginting Amal Ginting Amal R. Ginting Anastasia Walukow Asmuruf, Yunice Besin, Cecilia S. M. Calvin Parengkuan Carolina, Saroinsong F. Christi Wuisan Dedy Whyts Mengga Deo Tampongangoy Dian K. Ta’au Douglas N. Pareta Einstein Karundeng Eunike Dareda Florendo F. Tuegeh Friska Mery Montolalu Gideon A. R. Tiwow Ginting, Margaretha S. Hanna M. Rumagit, Hanna M. Hariawani Bauda Hariyadi Hariyadi Haryadi Haryadi Jabes Wolter Kanter Jeane Mongi Jeivia Matialo Jessica I Mampouw Jessy Lintongan Junita Dompas Kalalo, Reine Karauwan, Ferdy Kojongian, Cliveno Lengkey, Yessie Maarisit, Abigail F. Marlein M.C. Laloan Meifi Kaparang Molina W.O.C Akely Nerni Potolangi Olvie Datu Olvie S. Datu Paat, Vlagia Indira Pakingki, Priska Rafika Madonsa Rahmat S. Santoso Randi Tampa’i Rawung, Intan J. F. Rivaldy Lobot Rondonuwu, Tesalonika Royke R. Palandi Sambou, Christel N. Sartika Pendong Sonny Untu Supit, Arter Swingly Fidelik Manengkey Tiara Misericordia Lasut Tombuku, Joke Luis Tulandi, Selvana Stien Wenny Tilaar Widya Astuti Wilmar Maarisit Yohana I. C. Widodo