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All Journal Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Science Midwifery Jurnal Kebidanan Khatulistiwa Journal of Applied Nursing and Health
Sofie R. Krisnadi
Departemen Obstetri Dan Ginekologi Fakultas Kedokteran Universitas Padjadjaran-Rumah Sakit Dr. Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Pregnant Human Myometrial 1-41 Cell Viability Test on Vitamin D Administration Aziz, Muhammad Alamsyah; Krisnadi, Sofie Rifayani; Handono, Budi; Setiabudiawan, Budi
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2750

Abstract

Background: Preterm labor is one of the universal causes of perinatal mortality worldwide. One of the causes of preterm labor is uterine muscle integrity problems. Some mechanistic studies show insight into vitamin D activity’s possible role in the injured muscle. This study aimed to determine whether vitamin D can increase muscle cell viability.Methods: This experimental research used human smooth muscle uterine myometrium cell line pregnant human myometrial (PHM) 1-41. The cells were cultured for 24 hours in hypoxia condition, then incubated with several doses of vitamin D. The PHM1-41 cell viability was measured using spectrophotometry. Data analysis was conducted using IBM SPSS 24.0. A p-value <0.05 was considered statistically significant. Results: The result showed that the minimum level of muscle cell viability after vitamin D incubation was with 300 nM administration, and the maximum level was after 10nM (88.57%+4.48 and 96.21%+2.13 respectively).Conclusions: Vitamin D at a specific dose can improve cell availability. The optimal dose to improve cell viability is 10 nM. 
Risk factors influencing the incidence of perineal rupture in normal delivery Darlina, Darlina; Hakim, Dzulfikar Djalil Lukman; Mose, Johanes C.; Sukarsa, Mochamad Rizkar Arev; Krisnadi, Sofie Rifayani; Susiarno, Hadi
Science Midwifery Vol 13 No 3 (2025): August: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i3.2010

Abstract

Perineal rupture is a common complication during vaginal delivery and can lead to long-term health consequences for the mother. This study aims to identify the risk factors associated with perineal rupture in normal vaginal delivery. A scoping review was conducted by analyzing relevant literature from 2020 to 2024. The results indicate that major risk factors for perineal rupture include birth weight, parity, duration of the second stage of labor, and the use of obstetric instruments. Additionally, pregnancy exercise and perineal massage were found to be effective in reducing the incidence of perineal rupture, particularly in primiparous women. Proper management of labor, including monitoring fetal weight and employing appropriate medical techniques, plays a significant role in minimizing the risk of perineal rupture. This study recommends the implementation of evidence-based preventive measures to reduce the prevalence of perineal rupture and its long-term impacts on maternal health.
PENGARUH PIJAT OKSITOSIN DALAM MENURUNKAN KECEMASAN IBU NIFAS PRIMIPARA DI KOTA DEPOK Yuniartis, Putri; Krisnadi, Sofie Rifayani; Zulvayanti, Zulvayanti; Irianti, Setyorini; Sapiie, Tuti Wahmurti A.
Jurnal Kebidanan Khatulistiwa Vol 11, No 2 (2025): Jurnal Kebidanan Khatulistiwa
Publisher : Poltekkes Kemenkes Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jkk.v11i2.1874

Abstract

Latar Belakang: Ibu nifas primipara rentan mengalami kecemasan akibat perubahan fisiologis, psikologis, dan adaptasi terhadap peran baru yang apabila tidak ditangani dapat menghambat pemulihan serta memengaruhi kualitas interaksi dengan bayi. Pijat oksitosin dapat merangsang hormon oksitosin untuk memberikan efek relaksasi, meningkatkan kenyamanan, dan memperkuat ikatan emosional antara ibu dan bayi. Tujuan: Penelitian ini bertujuan untuk menganalisis pengaruh pijat oksitosin terhadap kecemasan ibu nifas primipara di Kota Depok. Metode: Penelitian ini adalah penelitian kuantitatif dengan rancangan Randomized Controlled Trial (RCT). Subjek penelitian ibu nifas primipara yang memenuhi kriteria inklusi sejumlah 32 orang dengan teknik pengambilan sampel Consecutive sampling dan dilakukan alokasi randomisasi untuk menentukan kelompok intervensi (diberikan pijat oksitosin) dan kelompok kontrol (tidak diberikan pijat oksitosin). Pengukuran kecemasan menggunakan kuesioner Zung’s Self-Rating Anxiety Scale. Analisis data menggunakan uji Wilcoxon dan uji Mann Whitney. Hasil: Terdapat perbedaan yang bermakna antara skor kecemasan sebelum dan sesudah intervensi dengan nilai p 0.000 (p<0.05) juga terdapat perbedaan yang bermakna antara penurunan skor kecemasan pada kelompok intervensi dan kelompok kontrol dengan nilai p 0.000 (p<0.05). Kesimpulan: Pijat oksitosin berpengaruh signifikan terhadap penurunan skor kecemasan pada ibu nifas primipara di Kota Depok.
The Comparative Effects of Hatha Yoga and Prenatal Exercise on Physiological and Psychological Outcomes in Primigravid Women: A Randomized Controlled Trial Fernandez, Veronica; Lesmana, Ronny; Krisnadi, Sofie R.; Susiarno, Hadi; Iskandar, Shelly; Tarawan, Vita Muniarti
Journal of Applied Nursing and Health Vol. 7 No. 3 (2025): Journal of Applied Nursing and Health
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/janh.v7i3.445

Abstract

Background: Primigravid women are prone to stress due to physical and psychological changes during pregnancy, which can lead to hypertension, preeclampsia, preterm birth, fetal growth restriction, and postpartum depression. While non-pharmacological interventions like hatha yoga and prenatal exercise are used to reduce stress, comparative evidence—especially on oxygen saturation (SpO₂)—is limited. This study analyzes the effects of hatha yoga and prenatal exercise on stress, blood pressure, and SpO₂ among primigravid women, and compares both interventions across these outcomes. Methods: This randomized controlled trial (RCT) followed the CONSORT 2010 guidelines. Forty-eight eligible primigravid women were selected using a probability sampling technique, specifically the simple random sampling method. Random numbers were generated using Microsoft Excel to determine participant selection from the maternal cohort register. Inclusion criteria were a normal singleton pregnancy at 24–28 weeks of gestation, maternal age 20–35 years, and normal Body Mass Index (BMI) (18.5–24.9 kg/m²). Exclusion criteria included regular exercise more than twice a week, abnormal fetal heart rate, and scheduled elective cesarean delivery. Participants were randomly assigned to either a hatha yoga group or a prenatal exercise group (24 each). Both interventions were conducted twice weekly for four weeks. Data were analyzed using the Wilcoxon and Mann–Whitney tests. Results: Data were analyzed using the Wilcoxon and Mann-Whitney tests. Median stress scores decreased from 22 to 12 in the hatha yoga group and from 22 to 17 in the prenatal exercise group (p < 0.001). Median SpO₂ increased from 96.88% to 98.38% and from 96.81% to 97.00%, respectively (p = 0.002). Median systolic pressure changed from 120.06 to 121.31 mmHg and 118.75 to 117.44 mmHg (p = 0.009), while diastolic pressure showed no significant difference (p = 0.076). Overall, hatha yoga showed greater improvements in stress, SpO₂, and blood pressure stability than prenatal exercise. Conclusion: Hatha yoga proved more effective than prenatal exercise in reducing stress, increasing SpO2, and stabilizing systolic blood pressure among primigravid women, although no significant difference was found in diastolic pressure. These findings strengthen the evidence supporting yoga as a safe, non-pharmacological approach to enhance maternal physiological and psychological well-being during pregnancy.
Co-Authors Akbar Rahmat Akhmad Yogi Pramatirta, Akhmad Yogi Anita D. Anwar Anita Deborah Anwar Astri Novianti Aziz, Muhammad Alamsyah Benny Hasan Purwara Budi Handono Budi Setiabudiawan Darlina Darlina Dini Pusianawati Donel S Edwin Armawan Fernandez, Veronica Firman Fuad Wirakusumah Hadyana Sukandar Hakim, Dzulfikar Djalil Lukman Hartanto Bayuaji Herman Susanto Johanes C. Mose Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Lucky Saputra M. Rizkar Arev Sukarsa MARINGAN DIAPARI LUMBAN TOBING Maya Savira Meice Fitrina Mira Dyani Dewi R. M. Sonny Sasotya Rachmat Zulkarnain Ronny Lesmana S. Meliala, Yan O'Neil Santi Maria Burhanuddin Sapiie, Tuti Wahmurti A. Setyorini Irianti Shelly Iskandar Supriadi Gandamihardja Susiarno, Hadi Tri Hanggono Achmad Udin Sabarudin Vita Muniarti Tarawan Yudi Mulyana Hidayat Yuniartis, Putri Zulvayanti Zulvayanti