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Journal : e-Journal Pustaka Kesehatan

Efek Pati Resisten Singkong (Manihot esculenta Crantz) terhadap Indeks HOMA-IR dan HOMA-B Tikus Model Diabetes Maria Ulfa; Elly Nurus Sakinah; Yohanes Sudarmanto; Jauhar Firdaus
Pustaka Kesehatan Vol 7 No 1 (2019): Volume 7 No. 1, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i1.17586

Abstract

Insulin resistance is a condition in which target organs fail to respond normally to insulin. Cassava contains 9,69 percent starch that resist to digestive enzyme in intestine and has been shown to increase insulin sensitivity and enhance β cell function. The aim of this study was to analyze the difference effect of native cassava starch and cassava resistant starch consumption on insulin resistance and β cell function indexes. This study was quasy experimental research with post-test only control group design using 16 male wistar strain rats divided into four groups: K1 (normal rats with standard diet), K2 (diabetic rats with standard diet), P1 (diabetic rats with native cassava starch diet) and P2 (diabetic rats with cassava resistant starch diet). The rats were fed with high fat diet and injected with low-dose streptozotocin to mimic the patogenesis of type 2 diabetes. The rats were then fed with assigned diet for 28 days. The data collection was obtained from laboratory examination of fasting plasma glucose and fasting plasma insulin to determine HOMA-IR and HOMA-B indexes. Post Hoc analysis showed no difference in both indexes between native cassava starch and cassava resistant starch fed groups (p>0,05).
Pengaruh Hemodialisis terhadap Fungsi Diastolik Ventrikel Kiri pada Pasien Penyakit Ginjal Kronik Stadium V Rifqi Rahadian; Yuli Hermansyah; Yohanes Sudarmanto; Suryono Suryono
Pustaka Kesehatan Vol 7 No 1 (2019): Volume 7 No. 1, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i1.17584

Abstract

Stage V chronic kidney disease (CKD) patients need renal replacement therapy. Hemodialysis is main choice for renal replacement therapy and correlates with changes of left ventricular function. Left ventricular diastolic function is one parameter of left ventricular function. The aim of this study was to analyze the effect of hemodialysis towards left ventricular diastolic function in stage V CKD patients at RSD dr. Soebandi Jember. This study included 30 patients (17 female, age 48,20±8,02 years) and underwent echocardiography 30 min before and after a hemodialysis session. Sample characteristics were divided into sex, age, duration of hemodialysis, blood pressure before and after hemodialysis. Diastolic function was measured with E/E’ ratio. Diastolic function criteria of 16 samples (53,5%) were normal (E/E’ ratio <10) after doing a hemodialysis session. Mean ratio E/E’ was significantly reduced (13,09±4,55 vs 11,6±5,04, p<0,05). In conclusion, hemodialysis could increase left ventricular diastolic function in stage V CKD patients at RSD dr. Soebandi Jember.