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All Journal Nurse Media Journal of Nursing The Indonesian Journal of Public Health Sari Pediatri The Journal of Educational Development Paediatrica Indonesiana Belitung Nursing Journal Jurnal Gizi Klinik Indonesia Journal of Community Empowerment for Health Berita Kedokteran Masyarakat

Elisabeth Siti Herini

Department Of Child Health, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/ Dr. Sardjito Hospital, Yogyakarta, Central Java

Author-ID : 3093796

Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Nursing Public Health

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Potentially predictive factors for hearing function improvement in pediatric cytomegalovirus infection therapy Agung Triono; Elisabeth Siti Herini; Braghmandita Widya; Dian Kesumapramudya Nurputra
Paediatrica Indonesiana Vol 61 No 5 (2021): September 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.5.2021.235-9

Background Symptomatic congenital cytomegalovirus (CMV) infection has an impact mainly on neurological sequelae, including sensorineural deafness. Because of the long-term impact, early treatment of CMV infection is mandatory. However, predictive factors for hearing function improvement in CMV infection therapy remain unexamined. Objective To evaluate potential predictive factors for hearing improvement in pediatric CMV infection therapy. Methods All medical record data of patients aged 0-6 years with CMV infection who completed a 6-week course of ganciclovir therapy or a combination of a 4-week course of ganciclovir and a 2-week course valganciclovir from January 2013 to December 2017 were collected. Age at onset of therapy, gender, gestational age, nutritional status, multi-organ involvement, and neurological symptoms were studied as potential predictive factors of hearing improvement in CMV therapy. The effectiveness of CMV infection therapy on improving hearing function was measured with the brainstem evoked response audiometry (BERA) test. Results BERA tests proportion in the right, left, and best ear showed significant improvement after therapy. All variables analyzed were not statistically significant as predictive factors for hearing improvement in CMV infection therapy. Conclusion Ganciclovir/valganciclovir therapy in CMV infection patients accounted for the improvement of hearing impairment. However, none of the assessed factors were considered predictive for improving hearing function in CMV infection therapy.

CAREGIVERS’ EXPERIENCE IN MEETING SELF-CARE NEEDS OF ADOLESCENTS WITH AUTISM SPECTRUM DISORDER: A QUALITATIVE STUDY Lilis Lestari; Elisabeth Siti Herini; Indria Laksmi Gamayanti
Belitung Nursing Journal Vol. 3 No. 4 (2017): July - August
Publisher : Belitung Raya Foundation, Indonesia

Background: Autism spectrum disorder is a complex developmental disorder, which increased rapidly than other developmental disorders in the world. This complex disorder affects a child’s self-autonomy, which has become a challenge for their parents or caregivers. Objective: This study is to explore main caregivers’ experience to meet self-care needs of adolescents with autism spectrum disorder in Pontianak, West Borneo, Indonesia. Methods: This study employed a qualitative design with semi-structured in-depth interviews. Seven main caregivers who are living together and taking care of the adolescents with autism spectrum were selected using a purposive sampling. Triangulation was conducted to ensure the trustworthiness of this study, including interviews, observations of self-care activities, documents such as photos, learning reports, and field notes. Participants’ statements were recorded using a voice recorder, and then transcribed, coded, interpreted, and categorized to form main themes and sub-themes. Results: The study identified three main themes: 1) autonomy in self-care, 2) care effort, 3) feelings, supports, and expectations. These findings emphasize the potentials of the children with autism to be autonomous in their daily self-care. Conclusions: Adolescents with autism spectrum disorder can potentially meet the needs of their daily care independently. This article has been corrected with a separate erratum: https://doi.org/10.33546/bnj.1146

Pengetahuan dan sikap orang tua hubungannya dengan pola konsumsi dan status gizi anak autis Maria Martiani; Elisabeth Siti Herini; Martalena Purba
Jurnal Gizi Klinik Indonesia Vol 8, No 3 (2012): Januari
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18209

Background: The prevalence of autistic spectrum disorder (ASD) has increased in recent years. In 1993 the prevalence of ASD was 2-4 cases per 10.000 children. The number increased significantly to 152 cases per 10.000 children in 2003 (0.15-0.2%). In addition to diet, nutritional status can be influenced by parent’s knowledge and attitudess toward children with autism. Improving parent’s knowledge and attitudess about autism can be an effective way to manage children with autism.Objective: To examine the relationship between parent’s knowledge and attitudes toward autism with dietary pattern and nutritional status of autistic children in SLBN Semarang.Methods: This was an observational study with cross sectional design. The subjects were students with autism who attended SLBN Semarang and their parents. A questionaire was used to collect the information on parent’s knowledge and attitudes toward autism, Food Frequency Questionnaire (FFQ) was used to obtain the data on gluten and casein consumption, whereas the data on nutritional status were measured by weight and height of the children. Chi square and Fisher Exact test were used to analyze the data.Result: As many as 55.3% of parents have good knowledge and 65.8% have a possitive attitudes toward autism. Fifty percent of children presented with good consumption pattern of gluten, 65% exhibited good consumption pattern of casein and 55.3% of autistic children had good consumption pattern of both gluten and casein. Almost half (47.4%) of the children were undernourished. There were no association found between parent’s knowledge and gluten and casein consumption (p>0.05); parent’s knowledge and nutritional status (p>0.05); and parent’s attitudes and nutritional status (p>0.05). Only parent’s attitudes towards autism was found to be associated with casein and gluten consumption pattern (p<0.05).Conclusion: There was a significant association between parent’s attitudes and consumption of gluten and casein in children with autism.

ASI sebagai faktor protektif terhadap autisme Kornelius Dandung Bawono; Elisabeth Siti Herini; Setya Wandita
Jurnal Gizi Klinik Indonesia Vol 8, No 4 (2012): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18213

Background: The prevalence of autism has risen in the last decades. Risk factors of autism remain controversial and were thought to be multifactorial. One hypothesis stated that it may be caused by leaky gut theory and long chain polyunsaturated fatty acid defi ciency. Optimal duration of breastfeeding has been proven to reduce risk of gastrointestinal infection and improve child’s cognitive ability.Objective: To study the protective effect of optimal duration of breastfeeding to reduce the risk of autism. Method: A matching case-control study was conducted in Yogyakarta and Magelang during 2008. Inclusion criteria of case group were all children with autism (diagnosed based on DSM-IV TR criteria), aged 3-10 years. Autistic children with distinct genetic disorder were excluded. Control group was matched on gender, age, and their residence. Breastfeeding pattern and other related information were obtained by direct interview. McNemar test, conditional multivariate logistic regression, and Maentel-Haenszel test were used to fi nd factors that are signifi cantly associated with autism.Result: There were 52 children with autism and 104 control subjects. The mean age was 5 years old. The analysis revealed that breastfeeding duration for less than 6 months was a signifi cant risk factor for autism (ORMH=2,05; RK 95%:1,03-5,01), as well as history of abnormal birth weight (OR=3,36; RK 95%:1,37-8,44). There was dose-effect gradient as breastfeeding duration affected risk of autism. There was no differences on the duration of exclusive breastfeeding between the two groups. Conclusion: Breastfeeding duration of less than 6 months was a signifi cant risk factor for autism.

Kebutuhan dan perawatan anak penyandang cerebral palsy yang mengalami drooling: studi eksplorasi Andri Kenti Gayatina; Fitri Haryanti; Elisabeth Siti Herini
Berita Kedokteran Masyarakat (BKM) Vol 34, No 9 (2018)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Needs and care for cerebral palsy children with drooling: an exploratory study Purpose: To explore the needs and care and expectations of parents of children with disabilities that improve saliva.Methods: A qualitative research with a phenomenology conducted at YPAC Semarang in September 2016. Data were collected using in-depth interviews with 6 maternal participants who were selected through purposive sampling and 1 doctor improving medical and 1 teacher as a triangulation participant. Data analysis was performed according to Collaizi's steps.Results: This study produced ten themes, namely: the need to deal with saliva; overcoming feelings of sadness, shame, brokenness, low self-esteem, hurt, sensitive, offended when the child is humiliated, can not bear, feelings of rejection, not accept, afraid and violate themselves; Overcoming the shame of children; Budget for pediatric therapy; strength, enthusiasm, gratitude, patience and endeavor; accepted by the community and considered by the government; Environmental modification; efforts to overcome saliva; poor understanding of mothers; expectation of the mother towards the foundation and the government regarding health services, education, and children's independence.Conclusions: Optimizing the fulfillment of needs and care for CP children who increase the saliva of class IV and V by overcoming saliva using a saliva absorber and prolonging treatment.

Predictive factors of advanced chronic kidney disease in children with congenital anomalies of kidney and urinary tract Dea Puspitarini; Elisabeth Siti Herini; Cahya Dewi Satria; Kristia Hermawan
Paediatrica Indonesiana Vol 63 No 2 (2023): March 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.2.2023.96-101

Background Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease (CKD) in children. Delayed diagnosis of CAKUT due to lack of universal screening (such as prenatal ultrasound screening or postnatal ultrasound screening in neonates with risk of CAKUT) has led to more cases of advanced CKD in children. CKD has high morbidity and mortality, and early detection is required to prevent the progression of CKD. Objective To determine the factors that predict the development of advanced CKD in children with CAKUT. Methods This retrospective cohort study included children with CAKUT at Dr. Sardjito Hospital, Yogyakarta, Indonesia from January 2016 to February 2021. Patients who were diagnosed with CAKUT were followed up to 5 years or until the onset of advanced CKD. Advanced CKD was defined as a decreased estimated glomerular filtration rate (eGFR) of less than 30mL/min/1.73m2 based on the revised Schwartz formula. CKD progression-free survival was determined with Kaplan-Meier and Cox regression analyses. Results Among 62 subjects with CAKUT, 7 (11.3%) subjects progressed to advanced CKD. The mean time of advanced CKD progression was 52.2 (95%CI 46.9 to 57.5) months. The overall incidence rate was 22 per 1,000 person-years. Based on Kaplan-Meier analysis, children with eGFR <60 mL/min/1.73m2 at the time of diagnosis had more rapid progression to advanced CKD than patients with eGFR ?60 mL/min/1.73m2 [40.2 (95%CI 33.4 to 46.6) months vs. 58.2 95%CI 46.9 to 57.5) months; P=0.02, respectively]. Conclusion Reduced eGFR at the time of diagnosis showed rapid progression to advanced CKD.

Studi Prospektif pada Anak dengan Manifestasi Neurologi yang Terinfeksi SARS-CoV-2 di Rumah Sakit Umum Pusat Dr. Sardjito, Yogyakarta Kristy Iskandar; Agung Triono; Alexandra Widita Swipratami; Yunika Puspa Dewi; Marissa Leviani Hadiyanto; Ignatia Rosalia Kirana; Salsabilla Hasna Mutiara Rizki; Elisabeth Siti Herini
Sari Pediatri Vol 25, No 1 (2023)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.1.2023.1-6

Latar belakang. Infeksi virus SARS-CoV-2 dilaporkan menyerang anak-anak dengan prevalensi 1-5% kasus di dunia. Manifestasi neurologis dapat terjadi pada fase akut maupun subakut infeksi SARS-CoV-2. Gejala neurologi telah ditemukan pada 9,2% pasien anak dengan COVID-19 dan berhubungan dengan perburukan kualitas hidup serta prognosis pasien. Tujuan. Penelitian ini bertujuan untuk mendeskripsikan kejadian infeksi SARS-COV-2 pada anak dengan manifestasi neurologi di Rumah Sakit Umum Pusat Dr. Sardjito pada tahun 2021.Metode. Penelitian deskriptif prospektif ini mengambil subjek pasien berusia 0-18 tahun dengan manifestasi neurologi yang dirawat di Rumah Sakit Umum Pusat Dr. Sardjito pada Januari 2021 sampai Januari 2022. Pemeriksaan konfirmasi SARS-CoV-2 dilakukan dengan swab tenggorokan dan cairan serebrospinal yang dianalisis melalui polymerase chain reaction dan/atau antibodi Immunoglobulin G dan M serum.Hasil. Infeksi SARS-CoV-2 ditemukan pada 45,5% pasien ensefalitis/ensefalopati, 30,3% pasien status epileptikus, 21,2% pasien epilepsi, 21,2% pasien gangguan neuromuskular, dan 12,1% pasien stroke. Delapan belas pasien (54,5%) memenuhi kriteria MIS-C. Tidak ditemukan hubungan signifikan antara luaran pasien dengan insidensi infeksi SARS-CoV-2 (p=0,4).Kesimpulan. Infeksi SARS-CoV-2 positif ditemukan cukup tinggi pada pasien dengan manifestasi neurologi. Kejadian multisystem inflammatory syndrome meningkat pada pasien anak dengan manifestasi neurologi yang terinfeksi SARS-CoV-2 sehingga memerlukan pengawasan.

Increasing the Health-Related Quality of Life in Children with Congenital Rubella Syndrome: A Mixed-methods Study Elisabeth Siti Herini; Agung Triono; Kristy Iskandar; Ashadi Prasetyo; Albaaza Nuady; Marissa Leviani Hadiyanto; Kania Diantika; Veronica Wulan Wijayanti; Avianti Pramastuti
Journal of Community Empowerment for Health Vol 6, No 2 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.80029

Introduction: Rubella infection during the first trimester of pregnancy is a significant cause of fetal malformation syndrome, or Congenital Rubella Syndrome (CRS), which affects the children’s quality of life (QoL). A Community Engagement Program was arranged collaboratively to increase the QoL of children with CRS and enhance parents’ skills and knowledge to better care for their children with CRS. Methods: A mixed-method descriptive study was conducted from April to October 2022 at Dr. Sardjito General Hospital. Sample recruitment used the purposive sampling method, which had been clinically and serologically diagnosed with CRS. Children’s QoL data were analyzed with a cross-sectional study design. The tools used were the Pediatric Quality of Life Inventory (PedsQL)TM 4.0 Generic Core Scales and SPSS version 26 to analyze paired T-tests. A focus group discussion (FGD) was used for qualitative thematic analysis. Results: We involved ten members willing to participate voluntarily in the PedsQL assessment and FGD. The result was an increase in patients’ QoL in the Physical Function domain that was statistically significant: pre-test and post-test physical health summary [490 (±261) vs. 510 (±251); p=0.022]. While social, emotional, and school functions increased were not statistically significant. From the FGD, the parents had diverse experiences and understanding of CRS-supporting examinations and treatments needed. Parents felt the children’s growth and development, as social and school functions were the common burdens. In order to help CRS prevention, the parents suggested a more comprehensive premarital program and antenatal care. Conclusions: The Community Engagement Program helps to increase the patient’s QoL in the Physical Function domain. Comprehensive multidiscipline management is needed to support children’s growth, social and educational functions. Periodic evaluations are required to monitor the QoL of children with CRS.

Predictors for seizure relapse in children with epilepsy after antiepileptic drug withdrawal: case-control study Triono, Agung; Herini, Elisabeth Siti; Mangunatmaja, Irawan
Paediatrica Indonesiana Vol. 64 No. 2 (2024): March 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.2.2024.120-5

Background Epilepsy is defined as a neurologic condition caused by a pathological brain condition. Epilepsy patients who have stopped treatment and are seizure-free for two years are considered to have achieved complete remission. Relapse occurs when seizures return after anti-epileptic drug (AED) withdrawal. Several studies reported that frequent seizures, prolonged duration to control seizures, number of AEDs consumed, and abnormal electroencephalography (EEG) found during AEDs tapered, were reported as predictors of relapse. Methods This retrospective, case-control study was carried out from 2012 – 2016 using multisite medical record evaluation, followed by interviews and EEG examinations. The case group included children with epilepsy who had seizure relapse, while the control group included children with complete remission of epilepsy. Bivariate and multivariate analyses were performed to identify predictors of relapse. Results Relapse predictors in bivariate analysis were symptomatic etiology epilepsy (OR 5.000; 95%CI 2.345 to 10.660; P<0.001), time to seizure control ?1 year (OR 3.689; 95%CI 1.493 to 9.116; P=0.003), and worsened EEG evolution at pre-withdrawal compared to EEG at the time of diagnosis (OR 2.310; 95%CI 1.132 to 4.717; P=0.021). Statistically significant relapse predictors in multivariate analysis were symptomatic etiology epilepsy (OR 4.384; 95%CI 1.985 to 9.681; P<0.001) and slow (?1 year) time to seizure control (OR 4.355; 95%CI 1.753 to 10.817; P 0.002). Conclusion Symptomatic etiology epilepsy and time to seizure control ?1 year are independent predictive factors for seizure relapse in children with epilepsy. Therefore, children with these conditions require a longer period and careful, gradual dose reduction before antiepileptic drugs withdrawal.

ENHANCING KNOWLEDGE AND AWARENESS FOR MEASLES AND RUBELLA ELIMINATION TO PREVENT CONGENITAL RUBELLA SYNDROME IN KULON PROGO AND GUNUNGKIDUL REGENCIES Herini, Elisabeth Siti; Triono, Agung; Iskandar, Kristy; Indrawanti, Ratni; Sitaresmi, Mei Neni; Nuady, Albaaza; Prasetyo, Ashadi; Paramastuti, Avianti; Nugrahanto, Andika Priamas; Mooiindie, Khansadhia Hasmaradana; Damroni, Rais Aliffandy; Timoti, Joshua
The Indonesian Journal of Public Health Vol. 19 No. 3 (2024): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v19i3.2024.442-452

Introduction: Measles-Rubella (MR) Vaccination coverage is important in eliminating Congenital Rubella Syndrome (CRS). In 2023, Kulon Progo and Gunungkidul Regencies recorded 98.59% and 97.63%, respectively. We conducted campaign activities, introduced the Measles-Rubella (MR) vaccine, and implemented educational efforts crucial for controlling measles, rubella and CRS. A collaborative educational program was organized to improve the quality of promotive and preventive education provided to health workers and elementary teachers. Aims: To enhance the knowledge of health workers and elementary teachers regarding measles, rubella, CRS and elimination strategies in Kulon Progo and Gunungkidul Regency. Methods: This study employed a quasi-experimental, non-randomized design with no control group. The participants were selected from all primary health care centers and selected elementary schools in Kulon Progo and Gunungkidul Regency. Before and after a multi-modal educational program, knowledge of participants was measured using questionnaire and analyzed using Wilcoxon signed-rank test. Results: We included 72 health workers and 8 elementary teachers in Kulon Progo and Gunungkidul Regency. The results indicated an increase in knowledge among health workers regarding these topics. However, elementary teachers did not demonstrate statistically significant improvements in knowledge level, likely due to the small number of participants and a general lack of knowledge about these subjects among teachers. Conclusion: Multi-modal intervention enhanced the knowledge of health workers and elementary teachers about measles, rubella, CRS, elimination strategies of these diseases in two regencies of the Special Region of Yogyakarta. Therefore, it is essential that public health authorities should prioritize continuous and accessible education programs for them

Co-Authors Abdul Wahab Adeta Stefianti Isnoor Agung Triono Agung Triono Agung Triono Agung Triono, Agung Albaaza Nuady Alexander Kurniadi Alexandra Widita Swipratami Alifiani Hikmah Putranti Andri Kenti Gayatina Ashadi Prasetyo Avianti Pramastuti Bawono, Kornelius Dandung Braghmandita Widya Braghmandita Widya Indraswari Cahya Dewi Satria Damroni, Rais Aliffandy Dea Puspitarini Diantika, Kania Dwi Yuwono Puji Sugiharto, Dwi Yuwono Puji Fitri Haryanti Hadiyanto, Marissa Leviani Ignatia Rosalia Kirana Indria Laksmi Gamayanti Irawan Mangunatmadja Iskandar, Kristy Kania Diantika Kornelius Dandung Bawono Kristia Hermawan Kristy Iskandar Lestari, Lilis Mangunatmaja, Irawan Maria Martiani Marissa Leviani Hadiyanto Marissa Leviani Hadiyanto Martalena Purba Martiani, Maria Maulina Handayani Mei Neni Sitaresmi Melina Dian Kusumadewi Mooiindie, Khansadhia Hasmaradana Muriana Novariani Nugrahanto, Andika Priamas Nurputra, Dian Kesumapramudya Paramastuti, Avianti Prasetyo, Ashadi Purba, Martalena Ratni Indrawanti Salsabilla Hasna Mutiara Rizki Sari Wardhani Satoshi Takada Setya Wandita Setya Wandita, Setya Sri Hartini Suryono Yudha Patria Timoti, Joshua Totok Sumaryanto Florentinus, Totok Sumaryanto Veronica Wulan Wijayanti Wahyu Damayanti Warantika Rikma Yuniarini Wijayanti, Veronica Wulan Yunika Puspa Dewi Yusmiyati Yusmiyati

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