Ariosta Ariosta
Department Of Clinical Pathology, Faculty Of Medicine, Diponegoro University

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BLOOD PRESSURE CORRELATION WITH IN-HOSPITAL MORTALITY ST-ELEVATION MYOCARDIAL INFARCTION PATIENT CASE STUDY IN RSUP DR. KARIADI Agung Satria Winahyu; Ilham Uddin; Sefri Noventi Sofia; Ariosta Ariosta
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 4 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.025 KB) | DOI: 10.14710/dmj.v9i4.27670

Abstract

Background: Blood pressure had been suspected to correlate with in-hospital mortality on ST-Elevation Myocardial Infarct (STEMI) patients. Aim: To prove the correlation between blood pressure with short-term in-hospital mortality on STEMI patients. Methods: This study was a retrospective analytic observational qualitative study with a cohort design. The data collecting technique used STEMI patient medical records at the RSUP dr. Kariadi and took blood pressure data when the patients admitted to the hospital, after that divided into three groups, namely hypertension, normotension, and hypotension, then analyze the data on the output of patients alive or dying when they were discharged from the hospital using Fisher exact test.  Results: Hypertension (p=0,428; OR=0,355), Normotension (p = 1; OR=1,267), and Hypotension (p=0,687; OR=1,500) along with hypertension history (p=0,785; OR=1,200) was not correlated with in-hospital mortality of STEMI patient in RSUP dr. Kariadi.  Conclusion: There was no correlation between blood pressure at admission with in-hospital mortality in STEMI patients.
HUBUNGAN GULA DARAH PUASA DAN HBA1C DENGAN INDEKS MASSA TUBUH PADA PENDERITA DIABETES MELITUS TIPE 2 Nina Dorothea Budiamal; Indranilla K. Samsuria; Dwi Retnoningrum; Ariosta Ariosta
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.222 KB) | DOI: 10.14710/dmj.v9i2.27143

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Latar Belakang : Diabetes Melitus tipe 2 merupakan penyakit yang dapat  menyebabkan berbagai komplikasi yang dapat memicu terjadinya beberapa penyakit seperti hipertensi, penyakit jantung koroner, stroke. Status glikemik memiliki pengaruh terhadap IMT pada pasien dengan Diabetes Melitus tipe 2. Tujuan : Membuktikan hubungan antara GDP dan HbA1c dengan IMT pada pasien Diabetes Melitus tipe 2. Metode : Penelitian cross-sectional dengan 30 sampel berdasarkan kriteria inklusi dan eksklusi. Responden dilakukan pengukuran GDP, HbA1c, dan IMT. Analisis data dilakukan menggunakan Spearman’s sebagai uji hipotesis. Hasil : Rerata IMT subjek yaitu 24,35 ± 0,69. Sedangkan rerata untuk kadar GDP dan nilai HbA1c, yaitu 178,73 ± 11,54 mg/dl dan 7,92 ± 0,28%.Tidak didapatkan hubungan yang signifikan antara GDP dengan IMT (p=0,627) dan HbA1c dengan IMT (p=0,987). Simpulan : Tidak ada hubungan antara GDP dan HbA1c dengan IMT pada penderita Diabetes Melitus tipe 2.Kata Kunci : GDP, HbA1c, IMT, Diabetes Melitus tipe 2.
PERBANDINGAN PENGARUH PEMBERIAN EKSTRAK BAWANG PUTIH (ALLIUM SATIVUM L),KITOSAN DAN YOGURT SINBIOTIK PISANG TANDUK TERHADAP PROFIL LIPID TIKUS SPRAGUE-DAWLEY HIPERKOLESTEROLEMIA Yanuarius Alvin Pratama Budianto; Nyoman Suci Widyastiti; Ariosta Arisota
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 2 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.549 KB) | DOI: 10.14710/dmj.v7i2.20703

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Latar Belakang : Dislipidemia merupakan abnormalitas metabolisme lipid yang ditandai dengan peningkatan maupun penurunan fraksi lipid dalam serum. Berbagai penelitian terdahulu membuktikan bawang putih (Allium sativum L), kitosan dan yogurt sinbiotik pisang tanduk mempuyai efek memperbaiki profil lipid.Tujuan : Menganalisis perbandingan pengaruh pemberian ekstrak bawang putih, kitosan dan yogurt sinbiotik pisang tanduk terhadap profil lipid tikus Sprague-Dawley hiperkolesterolemia.Metode : Penelitian eksperimental dengan disain Post Test Control Group Design. Jumlah sampel 30 tikus Sprague-Dawley jantan, terbagi dalam 5 kelompok, terdiri dari kelompok kontrol normal (K1), kontrol hiperkolesterolemia (K2)dan kelompok perlakuan P1,P2,P3 yang masing-masing diberi ekstrak bawang putih, kitosan atau yogurt sinbiotik pisang tanduk. Analisis statistik yang digunakan adalah uji One Way Anova dan Post Hoc Bonferroni.Hasil : Rerata kadar kolesterol total K1,K2,P1,P2,P3 adalah 83,67 ± 3,68; 207,79 ± 5,36; 105,11 ± 3,03; 117,64 ± 4,17; 128,35 ± 3,85 mg/dL;. Rerata kadar trigliserida K1,K2,P1,P2,P3 adalah 73,68 ± 4,20;130,59 ± 3,03; 82,22 ± 1,94; 92,33 ± 3,21; 103,51 ± 3,11mg/dL;. Rerata kadar kolesterol HDL K1,K2,P1,P2,P3  adalah 89,06 ± 1,99; 25,23 ± 1,52; 74,13 ± 3,09; 62,42 ± 2,04; 56,63 ± 2,11 mg/dL;. Rerata kadar kolesterol LDL K1,K2,P1,P2,P3 adalah 24,57 ± 2,04; 77,02 ± 1,64; 35,46 ± 2,35; 45,15 ± 1,72; 56,18 ± 1,49 mg/dL.Kesimpulan : Terdapat perbedaan pengaruh pemberian ekstrak bawang putih ,kitosan dan yogurt sinbiotik pisang tanduk terhadap profil lipid tikus Sprague-Dawley  hiperkolesterolemia.Ekstrak bawang putih menunjukkan efek paling baik dalam memperbaiki profil lipid , diikuti oleh kitosan dan yogurt sinbiotik pisang tanduk.
PENGARUH EKSTRAK ETANOL DAUN ANNONA MURICATA TERHADAP KADAR MALONDIALDEHYDE (MDA) DARAH TIKUS SPRAGUE-DAWLEY YANG DIINDUKSI 7,12 DIMETHYLBENZ[Α]ANTHRACENE Blasius Adrian Budianto; Eka Yudhanto; Ariosta Ariosta
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 8, No 1 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.201 KB) | DOI: 10.14710/dmj.v8i1.23298

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Latar Belakang : Kanker payudara adalah penyakit kanker yang paling sering diderita kalangan wanita di sebagian besar negara. Kanker payudara di Indonesia menyebabkan kematian sebesar 16,6 per 100.000 penduduk. Penyebab pasti dari kanker payudara masih belum diketahui. Senyawa 7, 12-Dimethylbenz[a]anthracene (DMBA) digunakan untuk menyelidiki karsinogenesis. Pengobatan kanker berkembang terus. Berbagai penelitian yang diteliti saat ini banyak menggunakan ekstrak tumbuhan sebagai terapi suportif kanker. Salah satunya adalah daun Annona muricata atau sirsak. MDA merupakan suatu marker kerusakan oksidatif. Kadar MDA pada pasien dengan kanker payudara akan mengalami peningkatan secara signifikan. Keberhasilan terapi pada pasien kanker payudara ditunjukkan dengan penurunan kadar MDA darah Tujuan : Mengetahui pengaruh ekstrak etanol daun Annona muricata terhadap kadar MDA darah tikus Sprague Dawley yang diinduksi 7,12-Dimethylbenz[a]anthracene. Metode : Penelitian true experimental randomized post-test only with control group design pada tikus yang dibagi ke dalam dua kelompok yaitu kelompok perlakuan (P1) yang diberikan induksi DMBA dan kemudian diberikan ekstrak etanol daun sirsak melalui sonde lambung dengan dosis 200mg/KgBB/hari selama 12 hari dan kelompok kontrol (P2) yang diberikan induksi DMBA. Hasil : Rerata kadar Malondialdehyde pada kelompok P1 = 274,46±107,99 dan pada kelompok P2 = 243,21±97,41. Hasil uji normalitas data menggunakan uji Saphiro-Wilk diperoleh data berdistribusi normal untuk kedua kelompok. Hasil uji independent-samples T Test menunjukkan tidak didapatkan perbedaan bermakna dengan nilai P = 0,52. Kesimpulan : Ekstrak etanol daun Annona muricata tidak berpengaruh terhadap kadar MDA darah tikus Sprague Dawley yang diinduksi 7,12-Dimethylbenz[a]anthraceneKata kunci : Ekstrak etanol daun Annona muricata, kanker payudara, 7,12-Dimethylbenz[a]anthracene, malondialdehyde.
Correlation between Inflammatory Markers of Platelet Index and Vitamin D with Body Mass Index Grace Yuni Harviendo; Ariosta Ariosta; Meita Hendrianingtyas
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1816

Abstract

Weight loss is more of a worldwide health problem and a risk factor for chronic disease. The decrease in serum vitamin D levels in body weight leads to more low grade inflammation. This study aims to determine the relationship between the platelet index, namely MPV, P-LCR as a marker of inflammation and vitamin D with body mass index (BMI). This study was a cross-sectional study of 78 women at the Diponegoro National Hospital with overweight (BMI> 23) in July - September 2020. Data analysis was done using Pearson and Spearman tests and significant if p <0.05. Of the 78 research samples, there was a significant relationship between BMI and MPV (r = 0.404; p = 0.000); P-LCR (r = 0.425; p = 0.000) and 25 (OH) D (r = -0.231; p = 0.04). Low vitamin D levels in obesity and low-grade inflammation increase pro-inflammatory cytokines. Increased leptin levels in obesity contribute to platelet hyperreactivity. Increased platelet activity compensates for the platelets so that the MPV and P-CLR values increase. There is a moderate significant positive relationship between MPV, P-CLR and BMI and a weak significant negative relationship between 25 (OH) D and BMI.
PERBEDAAN RESPON NYERI PADA PASIEN YANG DILAKUKAN PUNKSI SUMSUM TULANG DENGAN PREMEDIKASI MIDAZOLAM DAN TANPA PREMEDIKASI Ariosta Ariosta; Imam Budiwiyono; Herniah Asti Wulanjani
Media Medika Muda Vol 1, No 3 (2016)
Publisher : Faculty of Medicine Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (662.411 KB)

Abstract

Latar belakang: Tindakan punksi sumsum tulang (PST/bone marrow puncture/BMP) memerlukan indikasi dalam menunjang diagnosis penyakit. Prosedur punksi sumsum tulang sering menggunakan premedikasi midazolam dalam mencegah sebagian nyeri. Tujuan dari penelitian ini adalah untuk menganalisa perbedaan respon nyeri pada pasien BMP dengan premedikasi midazolam dan tanpa premedikasi.Metode: Penelitian observasional analitik dengan pendekatan cross sectional. Pengambilan sampel dengan consecutive sampling pada 26 pasien yang membutuhkan tindakan punksi sumsum tulang. Penelitian dilakukan di RSUP Dr. Kariadi dan RS Telogorejo Semarang. Observasi dilakukan dengan membandingkan kelompok PST dengan premedikasi dan tanpa premedikasi midazolam. Intensitas nyeri diukur dengan Wong Baker faces pain (WBFP); respon nyeri diukur dengan mean arterial pressure (MAP), laju nadi, kadar kortisol dan kadar glukosa. Uji beda menggunakan independent t test untuk laju nadi dan kadar kortisol; dan Mann Whitney test untuk MAP dan kadar glukosa.Hasil: Terdapat perbedaan bermakna MAP (p=0,002) dan kadar kortisol (p=0,035) antara kelompok premedikasi dan tanpa premedikasi midazolam. Tidak terdapat perbedaan bermakna WBFP (p=0,468) dan laju nadi (p=0,719) antara kelompok premedikasi dan tanpa premedikasi midazolam.Simpulan: Premedikasi midazolam dalam tindakan PST dapat menurunkan respon nyeri ditandai dengan penurunan MAP kadar kortisol. Kata Kunci : respon nyeri, punksi sumsum tulang, premedikasi midazolam
Pemeriksaan Bone Mineral Density dan Pelatihan Senam Osteoporosis Sebagai Upaya Peningkatan Kewaspadaan Osteoporosis pada Penderita Talasemia Mayor Nyoman Suci Widyastiti; Edward Kurnia Setiawan Limijadi; Meita Hendrianingtyas; Ariosta Ariosta; Dwi Retnoningrum; Dwi Ngestiningsih; Yetty Movieta Nency
Journal of Dedicators Community Vol 5, No 2 (2021)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v5i2.1348

Abstract

Thalassemia major patients with routine transfusions are at risk of experiencing iron overload and bone turn over disorders which will increase the risk of osteoporosis. Community training activities with BMD examinations and osteoporosis exercise training in thalassemia major patients are expected to identify the prevalence of bone fragility in thalassemia major patients, increase the awareness of thalassemia major patients and their families to the risk of osteoporosis in thalassemia major patients and osteoporosis exercise training as an effort to prevent osteroporosis. The results of BMD on the spine showed 57.1% osteoporosis, 28.6% normal and 14.3% osteopenia. The results of BMD examination on the cervical spine showed 71.4% osteopenia, 21.4% normal and 7.2% osteoporosis. The results of BMD examination on the femur found 50% normal, 42.8% osteopenia and 7.2% osteoporosis. The bone location with the highest percentage of osteoporosis was the spine (57%), and the bone location with the highest percentage of osteopenia was the neck bone (71.4%). The high percentage of osteopenia locations in the cervical spine of thalassemia major patients with repeated transfusions should be become a concern. Based on these findings, we held education and counselling on the risk of osteoporosis in thalassemia patients with repeated transfusions, osteoporosis exercise training and distribution of osteoporosis exercise compact disk (CD) for at home osteoporosis exercise training.
Correlation between Inflammatory Markers of Platelet Index and Vitamin D with Body Mass Index Grace Yuni Harviendo; Ariosta Ariosta; Meita Hendrianingtyas
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1816

Abstract

Weight loss is more of a worldwide health problem and a risk factor for chronic disease. The decrease in serum vitamin D levels in body weight leads to more low grade inflammation. This study aims to determine the relationship between the platelet index, namely MPV, P-LCR as a marker of inflammation and vitamin D with body mass index (BMI). This study was a cross-sectional study of 78 women at the Diponegoro National Hospital with overweight (BMI> 23) in July - September 2020. Data analysis was done using Pearson and Spearman tests and significant if p <0.05. Of the 78 research samples, there was a significant relationship between BMI and MPV (r = 0.404; p = 0.000); P-LCR (r = 0.425; p = 0.000) and 25 (OH) D (r = -0.231; p = 0.04). Low vitamin D levels in obesity and low-grade inflammation increase pro-inflammatory cytokines. Increased leptin levels in obesity contribute to platelet hyperreactivity. Increased platelet activity compensates for the platelets so that the MPV and P-CLR values increase. There is a moderate significant positive relationship between MPV, P-CLR and BMI and a weak significant negative relationship between 25 (OH) D and BMI.
PERBANDINGAN KADAR GLUKOSA DARAH SETELAH MENGONSUMSI COCA-COLA REGULER DAN COCA-COLA ZERO PADA POPULASI NON-DIABETES Gabriella Carolina Hutapea; Ariosta Ariosta; Hardian Hardian
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v5i4.14450

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Latar belakang : Diabetes melitus (DM) tipe II dan obesitas merupakan penyakit metabolik yang disebabkan oleh sejumlah faktor gaya hidup diantaranya adalah aktivitas fisik, merokok, konsumsi alkohol, pola diet. Coca-cola merupakan salah satu minuman yang digemari dan mengandung tinggi karbohidrat yang diduga meningkatkan risiko obesitas dan kejadian DM tipe II. Coca cola zero merupakan solusi yang diberikan oleh coca cola untuk mengurangi peningkatan glukosa darah.Tujuan : Mengetahui perbedaan kadar glukosa darah setelah mengonsumsi 1 kaleng (330ml) coca-cola reguler dan coca-cola zero pada populasi non diabetes.Metode : Penelitian eksperimental dengan pendekatan cross sectional. Rancangan penelitian menggunakan two group Pre-test and Post-test group design (cross over). Data diambil dari mahasiswa fakultas kedokteran Universitas Diponegoro pada bulan April 2016. Analisa data menggunakan paired t-test dan uji Wilcoxon.Hasil : Subyek penelitian sebanyak 14 sampel, 6 laki-laki dan 8 perempuan.Perbandingan delta semua menggunakan uji Wilcoxon karena distribusi data tidak normal.Hasil didapatkan perbedaan bermakna (p<0,05) pada perbandingan delta GDPP 1jam-GDP (p=0,009) dan delta kadar GDPP 2jam-GDPP (p=0,005) antar kelompok coca-cola reguler dan kelompok coca-cola zero, sedangkan pada perbandingan delta GDPP 2jam-GDP antar kelompok coca-cola reguler dan kelompok coca-cola zero didapatkan perbedaan tidak bermakna (p=0,4).Kesimpulan : Didapatkan perbedaan bermakna pada kadar glukosa darah post-prandial 1 jam setelah konsumsi 1 kaleng (330ml) coca-cola reguler dan coca cola zero.
Penyuluhan Osteoporosis dalam Upaya Pencegahan Komplikasi Tulang pada Pasien Talasemia Mayor di Kabupaten Rembang dan Grobogan Widyastiti, Nyoman Suci; Retnoningrum, Dwi; Ariosta, Ariosta; Nency, Yetty Movieta; Ngestiningsih, Dwi; Partiwi, Rina; Muniroh, Muflihatul; Naviati, Elsa; Afriana, Rizky Dyas
Journal of Dedicators Community Vol 7, No 3 (2023)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v7i3.3577

Abstract

Background Osteoporosis is a complication that often occurs in thalassemia major patients. This complication is still not widely known. This community service program aims to increase the knowledge of families of major thalassemia patients in Rembang Regency and Grobogan Regency regarding the complications of osteoporosis in thalassemia patients. Methods Education about osteoporosis, risk of osteoporosis in thalassemia patients, and prevention of osteoporosis. Extension method with presentation and discussion. The activity was attended by 20 thalassemia families in the Rembang Regency and 21 families of thalassemia patients in the Grobogan Regency. Before and after counseling, pretest and posttest questionnaires were completed to measure the knowledge of families of thalassemia major patients regarding bone complications in thalassemia patients. Results and Discussion Nearly half (46.34%) of respondents did not know the risk of osteoporosis in thalassemia. After counseling, 82.93% of respondents knew the risk of osteoporosis in thalassemia, but there were still 17.07% of respondents who still did not know this risk. Conclusion There is a significant increase in family knowledge of thalassemia major patients about the risk of osteoporosis in thalassemia. Further efforts to increase knowledge are needed with written information media (leaflets) given to families of thalassemia major patients