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All Journal Majalah Ilmiah Peternakan Media Akademika Al-Jami'ah: Journal of Islamic Studies Jurnal Fitofarmaka Indonesia Tadbir : Jurnal Studi Manajemen Pendidikan Jurnal Kolaboratif Sains Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Jurnal Kesehatan Tambusai Dinamika Lingkungan Indonesia MPSJ
ABD. MALIK
Dosen IAIN Sulthan Thaha Saifuddin Jambi
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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In Silico Screening Inhibitors Histamine H2 Chemical Compounds in Licorice Plants (Glycyrrhiza glabra L.) Using Autodock Vina Najib, Ahmad; Malik, Abd.; Sumartono, Sumartono
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1100

Abstract

The inquiry about on in silico screening of chemical compounds of Histamine H2 of Liquorice (Glycyrrhiza glabra L.), aimed to get the potential bioactive compounds found in plants The Liquorice (Glycyrrhiza glabra L.) as a potential inhibitor Histamine H2 with a screening in silico by Autodock Vina Docking process is carried out on enzyme Histamine H2 as receptors and 105 chemical compounds in plants Liquorice (Glycyrrhiza glabra L.) as ligands using Autodock Vina program. ∆Gbind value and lowest RMSD of each compound that has been in the docking taken the value of the free energy change (∆G) as a result of docking. Docking results showed that of the 105 chemical compounds of plant Liquorice (Glycyrrhiza glabra L.)  are all potential as inhibitors Histamine H2  with free energy change (∆G) most low at Glabrene amounted to -9.6 kcal/mol, and the highest Isotachioside amounted to -4.5 kcal/mol.
Antioxidant Activity Test of Sappan (Caesalpinia sappan L.) and Chinese Teak (Senna alexandrina) Extract Combination Using DPPH (1,1 Diphenyl 2 Picrylhydrazyl) Free Radicals Scavenging Method Anisa, Rianti; Naid, Tadjuddin; Malik, Abd.; Nisaa, Nur Rezky Khairun
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1103

Abstract

Sappan (Caesalpinia sappan L.) is applied as food and traditional medicine. Chinese teak (Senna alexandrina) is a plant from the tropics that can be developed as an antioxidant. This study was conducted to determine the antioxidant activity of the combination of Sappan and Chinese Teak by the DPPH (1,1 Diphenyl 2 Picrylhydrazyl) Free Radical Scavenging method. The extraction method used was maceration with Ethanol 96% as solvent. Determination of antioxidant levels was done quantitatively using the UV-Vis Spectrophotometer instrument at a wavelength of 514 nm. From the results of the study, the regression value obtained for the comparison of Quercetin is y = 3.1303x + 0.2292 with R2 = 0.9974 and IC50 value of 15.899 μg/mL. For the antioxidant activity of Sappan, the regression value y=0.5769x + 18.543 with R2=0.9969 and IC50 value of 54.53 μg/mL, Chinese Teak obtained regression value y=0.1421x + 17.506 with R2=0.9989 and IC50 value of 228.67 μg/mL, and for the combination obtained regression value y=0.4304x + 36.622 with R2=0.9954 and IC50 value of 40.38 μg/mL. The results of this study indicate that the combination of Sappan and Chinese Teak extracts has a very strong antioxidant effect (<50 μg/mL).
Co-Authors AAM GUNAWAN Agus Budianto Ahmad Najib Ahmad, Aktsar Roskiana Ainina, Adiva Nur Al Arobi, Achmad Syuro Anisa, Rianti Arrozak, Muhammad As’ad, A Azizi, Pedja Rifki Cahyanto, Bagus Fadhilah, Putri Nur Fadliyah, Nurfadhilah Fauzan, Muh. Alif Noor Fitria, Rhizma Nur Harti Widiastuti Hasnaeni hasnaeni, Hasnaeni Hatim Gazali HM, Nur Rahmah Hutagalung, Maruli Kusdarini, Esthi Lomba, Sepriyaco Masrukhin Masrukhin Matompo, Osgar S. Mutmainah, Syifa Nadya, Alifah Rifa Nisaa, Nur Rezky Khairun Rahayu, Sitti Dian Risda Waris, Risda Sodiah, S SUDARMAJI SUDARMAJI Sumartono Sumartono Tadjuddin Naid Utamakno, Lakon Virsa Handayani Yulandra, Novita