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All Journal Microbiology Indonesia Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Respirasi (JR) Ina Kidney Biomolecular and Health Science Journal Majalah Biomorfologi (Biomorphology Journal) Narra J Personifikasi: Jurnal Ilmu Psikologi Journal of Indonesia Vascular Access
MOCHAMMAD THAHA
Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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8-Hydroxydeoxyguanosine Urine and Total Nitric Oxide Serum in Chronic Kidney Disease Putri Aliya Ahadini; Mochammad Thaha; Arifa Mustika
Folia Medica Indonesiana Vol. 58 No. 2 (2022): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (614.229 KB) | DOI: 10.20473/fmi.v58i2.31814

Abstract

Highlights: Oxidative markers 8-Hydroxydeoxyguanosine and Nitric Oxide was found high in hemodialysis and non-hemodialysis chronic kidney disease patients. There is no correlation between 8-Hydroxydeoxyguanosine and Nitric Oxide in hemodialysis and non-hemodialysis chronic kidney disease patients.   Abstract: Oxidative stress is essential to chronic kidney disease (CKD). Several markers include 8-Hydroxydeoxyguanosine (8-OHdG) and Nitric Oxide (NO). Reactive oxygen species (ROS) and Reactive Nitrogen Species (RNS) increased in CKD and had a role in renal impairment progressivity. There are some controversies regarding oxidative markers in CKD patients in several studies. This study aimed to understand oxidative markers 8-OHdG and NO and explained the correlation of both markers in hemodialysis and non-hemodialysis CKD patients. Twenty hemodialysis patients and forty-nine non-hemodialysis patients were enrolled in this cross-sectional study. Urine patients were collected to measure 8-OHdG using the enzyme-linked immunoassay (ELISA) method, and NO was measured from serum patients using the Griss Saltzman method. Based on Bivariate Pearson analysis, there was no significant correlation between 8-OHdG urine and total NO serum in the hemodialysis group (p= 0,510, p>0.05) and in the non-hemodialysis group (p= 0.801, p>0,05). In this study, DNA oxidative marker, 8-OHdG, was not correlated with NO in CKD patients.
The Prevalence and Subtype Distribution of Hepatitis C Virus Infection among Hemodialysis Patients in a Private Hospital in Surabaya, Indonesia MOCHAMAD AMIN; JUNIASTUTI .; TAKAKO UTSUMI; YOSHIHIKO YANO; MOCHAMAD YUSUF; MOCHAMMAD THAHA; PRIYO BUDI PURWONO; RETNO HANDAJANI; SOETJIPTO .; HAK HOTTA; YOSHITAKE HAYASHI; MARIA INGE LUSIDA
Microbiology Indonesia Vol. 6 No. 4 (2012): December 2012
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (837.539 KB) | DOI: 10.5454/mi.6.4.5

Abstract

The prevalence of hepatitis C virus (HCV) infection has been as high as approximately 80% in patients with maintenance hemodialysis in public hospitals in Indonesia. However, the prevalence in private hospitals has not been examined yet. The aim of  this study was  to  investigate  the prevalence of anti-HCV antibody and  the subtype distribution in patients with hemodialysis in a private hospital in Surabaya, Indonesia. Sera were obtained from 41 hemodialysis patients in a private hospital in Surabaya. The positive prevalence of anti-HCV antibody was carried out by  the enzyme-linked  immunosorbent assay (ELISA). Anti-HCV-positive sera were subjected  to  reverse transcription-PCR (RT-PCR) to detect HCV RNA and then direct sequencing. The HCV subtype was examined by phylogenetic analysis. Twenty five patients (61%) out of 41 were positive for anti-HCV antibody, and HCV-RNA was detected in 19 patients. The positive prevalence of anti-HCV antibody was 7.7% (one out of 13 patients) among patients who had undergone hemodialysis  for  less  than one year, whereas  it was 85.7%  (24 out of  28  patients)  among  patients who  had  undergone  hemodialysis  for  over  one  year.  Phylogenetic  analysis revealed HCV-1a  (52.6%) was  the most common  subtype,  followed by 1b  (15.8%), 1c  (15.8%), 2a  (5.3%), and 3k (5.3%). In conclusion,  the prevalence of HCV  infection among hemodialysis patients  in a private hospital was as high as  that  in general hospitals. The predominant subtype was HCV-1a, which  is  in accordance with  the previous studies  in general hospitals  in Surabaya,  Indonesia.
Providing Intradialytic Parenteral Nutrition Therapy Does Not Improve Anthropometric Status in Hemodialysis Patients with Malnutrition Suryantoro, Satriyo Dwi; Tjempakasari, Artaria; Nurwidda, Arvi Dian Prasetia; Widodo, Widodo; Thaha, Mochammad; Mardiana, Nunuk
Indonesian Journal of Kidney and Hypertension Vol 1 No 1 (2024): Volume 1 No. 1, April 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i1.123

Abstract

Background: Malnutrition is prevalent in hemodialysis patients and significantly impacts prognosis. It can result from reduced food intake and protein loss during hemodialysis. Nutritional status is determined through anthropometric examinations, which include upper arm circumference (UAC), body mass index (BMI), hand grip strength, bicep, and tricep fold thickness. Laboratory examinations like total cholesterol and Malnutrition Inflammation Score (MIS) or Subjective Global Assessment (SGA) are also used. Intradialytic Parenteral Nutrition (IDPN) is expected to maintain or improve the nutritional status of hemodialysis patients. Objective: This research examines the impact of parenteral nutrition therapy on the anthropometric status of malnourished hemodialysis patients. Methods: This cross-sectional study, a sub-analysis of a larger nutritional therapy study, involved 24 hemodialysis patients experiencing malnutrition based on SGA B and C criteria with 1-10 years of hemodialysis. IDPN therapy was provided, and anthropometric measurements and total cholesterol were taken at baseline and three months after nutritional therapy. Data processing used comparative statistical analysis. Results: The mean age was 45.33 years, with 14 males and 10 females. After 3 months, there were no significant differences in UAC (mean difference = 0.13; p = 0.69), BMI (mean difference = 0.13; p = 0.50), hand grip strength (mean difference = -0.96; p = 0.282), biceps skinfold thickness (mean difference = 0.13; p = 0.69) and triceps (mean difference = 0.59; p = 0.134) or total cholesterol (mean difference = -1.5; p = 0.71). Conclusion: IDPN therapy for 3 months did not improve the anthropometric status of hemodialysis patients with malnutrition.
ACTI ON OF N- ACETYLCYSTEI NE ON ASYMMETRI C DIMETHYLARGININE AND ALBUMINURIA IN STAGE 1-4 NONDIABETIC CHRONIC KIDNEY DISEASE PATIENTS THAHA, MOCHAMMAD; Widodo, Widodo; Yogiantoro, Moh.; NILAMSARI, WENNY PUTRI; YUSUF, MOCHAMAD; Tomino, Yasuhiko
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 3 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (671.052 KB) | DOI: 10.20473/ijtid.v1i3.2198

Abstract

Background: Uremic patients are in a pro-oxidant state and show an increased level of asymmetric dimethylarginine (ADMA), which is due to increased PRMT1 activity and reduced dimethylarginine dimethylaminohydrolase (DDAH) as degradation enzymes. Reactive oxidant species may play an important role in increasing the action of PRMT1 and in inhibiting the action of DDAH. Albuminuria and ADMA are closely correlated with progression of cardiovascular disease in chronic kidney disease (CKD) patients as well as indicators for decreasing renal function. Although ACEIs and/or ARBs reduced albuminuria in CKD patients, the results are still conflicting. Several factors in these patients may play important roles in the mechanism of albuminuria such as oxidative stress. The antioxidant N-acetylcysteine may prove to have beneficial therapeutic effect, because it can reduce oxidative stress as shown by evidence in humans, and subsequently increase ADMA. The objective of the present study is to explore the contribution of the antioxidant N-acetylcysteine (NAC) to the decrease of ADMA and albuminuria in non-diabetic CKD patients. Material and Methods: Patients with non-DM CKD stage 1–4 with albuminuria were randomized to receive ACEI and/or ARB alone (control group) or with antioxidant NAC 600 mg orally twice a day (treatment group). Observations were performed for 3 months to measure ADMA and albuminuria before and after-treatment. 80 patients in total 40 in the control group and 40 in the treatment group were used. Results: After oral treatment with NAC, the plasma level of ADMA in the treatment group increased from 0.604 µmol/l to 0.689 µmol/l, whereas ADMA level in the control group exhibited a higher increase from 0.561 µmol/l to 0.743 µmol/l. The increases in these groups were significantly different (p < 0.02). Moreover, the level of albuminuria was reduced from 148.12 µg/mg • cr to 132.7 µg/mg • cr in the treatment group, and from 75.25 µg/mg • cr to 71.85 µg/mg • cr in the control group. The difference was significant (p < 0.001). Conclusion: The anti-oxidant N-acetylcysteine can be used as adjuvant therapy to inhibit the progression of CKD in patients by decreasing the ADMA level and albuminuria.
Efficacy of angiotensin receptor neprilysin inhibitor in hypertension management: A systematic review and meta-analysis of clinical trials Ramadhan, Roy N.; Rampengan, Derren DCH.; Puling, Imke MDR.; Willyanto, Sebastian E.; Tjandra, Kevin C.; Thaha, Mochammad; Multazam, Chaq ECZ.; Suryantoro, Satriyo
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1247

Abstract

Dysregulation of renin-angiotensin-aldosterone system (RAAS) often leads to hypertension and severe cardiorenal complications. Although RAAS-targeted therapies have proven effective, it remains yet optimal in reducing cardiovascular events. The aim of this study was to evaluate the efficacy and safety of angiotensin receptor neprilysin inhibitor (ARNI) compared to control in patients with hypertension. The primary outcomes were systolic and diastolic blood pressure (BP) control, along with the incidence of adverse events. A systematic review and meta-analysis was conducted according following PRISMA guidelines. A comprehensive literature search was performed across five databases: PubMed, ScienceDirect, EBSCO, Cochrane, and ProQuest, with studies identified up until 3 October 2024. The study included nine clinical trials that met the predefined eligibility criteria: (1) randomized clinical trials; (2) adult patients diagnosed with hypertension; and (3) comparison of ARNI versus control, reporting either BP control or adverse events. Quality appraisal using RoB 2.0 revealed that eight studies had a low risk of bias, and one had a high risk of bias. The pooled analysis demonstrated that ARNI is significantly more efficacious in achieving targeted systolic BP as compared to the control group (OR: 1.80; 95%CI: 1.41-2.30; p<0.001; I²=0%), and there was no statistical difference for the efficacy on diastolic BP compared to control (OR: 0.92; 95%CI: 0.75–1.13; p=0.45; I²=75%). The incidence of adverse events was not associated with ARNI (OR: 1.07; 95%CI: 0.90–1.27; p=0.46; I²=72%). In conclusion, ARNI demonstrated a favorable outcome only in systolic BP, but in diastolic BP which could be associated with inadequate duration of observation. Further studies are warranted to assess BP-lowering effect and safety profile of ARNI in a longer observation time.
Correlation Between Intraoperative Blood Vessel Diameter and Technical Success Rate of AV Shunt Surgery in Dr. Soetomo Hospital Surabaya Saphira, Diva; Soebroto, Heroe; Thaha, Mochammad; Hakim, Arief Rakhman; Widipriyatama, Gabriel Rio
Journal of Indonesia Vascular Access Vol. 3 No. 2 (2023): (Available online: 1 December 2023)
Publisher : Indonesian Vascular Access Association (IVAA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jinava.v3i2.45

Abstract

Introduction: An arteriovenous (AV) shunt is an anastomosis between vein and artery made in a surgical procedure as vascular access for patients with end-stage renal disease that are projected to undergo hemodialysis. Unfortunately, AV shunt failure remains a significant clinical problem for hemodialysis patients. In general, the cause of most early AV shunt failure is still unknown, but the quality of the blood vessels is suspected as a factor. This study aimed to determine the correlation between blood vessel diameter and the success of AV shunt surgery. Methods: This study is a cross sectional study that uses a descriptive-analytic design. The samples were obtained from the patient’s medical records with the total sampling technique of all patients who have undergone AV shunt surgery from January 2019 – December 2020 at Dr. Soetomo General Hospital which matches the inclusion and exclusion criteria. Results: Patients’ blood vessel diameter measurement is divided into four categories which are <2 mm, 2 - <4 mm, 4 - <6 mm, and ≥6 mm. From a total of 62 patients, the highest successful surgery rate is carried out in patients with a vein diameter of 2 - <4 mm (77.59%) and artery diameter of 2 - <4 mm (63.79%). The results of the Chi-Square analysis found no significant correlation between vein diameter (p=0.769) or artery diameter (p=0.922) and the success of AV shunt surgery at Dr. Soetomo Hospital, Surabaya 2019-2020. Conclusions: In conclusion, this study did not find a correlation between the intraoperative blood vessel diameter and the technical success of AV shunt surgery.
Peran Resiliensi, Positive Social Relationships, dan Health Belief terhadap Kesejahteraan Emosi Pasien Hemodialisis Istiqomah, Nur; Hadjam, M. Noor Rochman; Yuniarti, Kwartarini Wahyu; Paramastri, Ira; Thaha, Mochammad
Personifikasi: Jurnal Ilmu Psikologi Vol 13, No 1 (2022)
Publisher : Universitas Trunojoyo Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21107/personifikasi.v13i1.13958

Abstract

Individu didiagnosis dengan penyakit ginjal stadium akhir dan harus menjalani perawatan hemodialisis memiliki implikasi bahwa menjadi tergantung pada pengobatan seumur hidup. Sejumlah studi melaporkan pasien hemodialisis mengalami beban simtom dan terganggunya well-being akibat penyakit maupun perawatan hemodialisis. Penelitian ini bertujuan untuk menguji peran resiliensi, positive social relationships, dan health belief terhadap emotional well-being pasien hemodialisis. Subjek penelitian yaitu pasien penyakit ginjal stadium akhir yang menjalani hemodialisis secara rutin di Instalasi Hemodialisis RSU Dr. Soetomo, Surabaya yang dipilih melalui purposive sampling, artinya dipilih berdasarkan pertimbangan kriteria tertentu dan kesediaan berpartisipasi. Penelitian ini melibatkan pasien hemodialisis sejumlah 55 orang terdiri dari 34 laki-laki dan 21 perempuan, berusia 26 – 60 tahun. Menggunakan metode kuantitatif dengan melakukan survei, pengumpulan data dilakukan menggunakan lima Skala yakni Scale of Positive and Negative Experience (SPANE) dan Satisfaction with Life Scale (SWLS), 10-Item Connor-Davidson Resilience Scale (10-Item CD-RISC), Medical Outcomes Study Social Support Survey (MOS-SSS), dan Skala Health Belief. Analisis data dilakukan dengan analisis statistik uji regresi ganda. Hasil uji regresi ganda menunjukkan bahwa hipotesis ditolak, artinya resiliensi, positive social relationships, dan health belief secara simultan tidak dapat memprediksi emotional well-being pasien hemodialisis (F sama dengan 2,363, p lebih besar dari 0,05). Secara parsial, berdasarkan nilai t diketahui hanya resiliensi memberi kontribusi signifikan terhadap emotional well-being (t sama dengan 2,342, p lebih kecil dari 0,05), sementara positive social relationships dan health belief masing-masing memberi kontribusi tidak signifikan terhadap emotional well-being. Penelitian berikutnya diharapkan dapat membantu meningkatkan coping resources yakni resiliensi yang bermanfaat mendorong perkembangan emosi positif, serta dapat membantu memberi edukasi terkait penyakit ginjal dan hemodialisis sehingga pasien memiliki pemahaman, respon permasalahan, dan belief yang lebih positif.
Co-Authors Aditia Wardana Alisia Y Putri, Alisia Y Arifa Mustika Artaria Tjempakasari, Artaria Berliana Hamidah Budi Susetyo Pikir Budiono Budiono Cahyo Wibisono Nugroho chandra irwanadi David Setyo Budi Dinda Dwi Purwati Djoko Santoso Eka Arum Cahyaning Putri Haerani Rasyid Haerani Rasyid HAK HOTTA Hakim, Arief Rakhman Hendri Susilo I Gde Raka Widiana Ika Nindya Kadariswantiningsih Ira Paramastri Juniastuti Juniastuti Kwartarini Wahyu Yuniarti Laurentius Andre Lukman Hakim M. Amin M. Noor Rochman Hadjam MARIA INGE LUSIDA Maulana Antiyan Empitu Maulana Muhtadin Suryansyah Maulana Muhtadin Suryansyah Maulana Muhtadin Suryansyah MOCHAMAD AMIN Mochamad Yusuf Alsagaff Mochammad Amin Mochammad Yusuf Alsagaff Mochammad Yusuf, Mochammad Moh. Yogiantoro, Moh. Mohammad Yusuf Alsagaff Mohammad Yusuf Alsagaff Multazam, Chaq ECZ. Mutiara Rizki Haryati Nunuk Mardiana, Nunuk Nur Istiqomah Nurina Hasanatuludhhiyah Nurwidda, Arvi Dian Prasetia Pakpahan, Cennikon Pranawa Pranawa Priyo Budi Purwono Puling, Imke MDR. Putri Aliya Ahadini Ramadhan, Roy N. Rampengan, Derren DCH. Retno Handajani Rieza Rizqi Alda Rieza Rizqi Alda Rosyid, Alfian Nur Saphira, Diva Sharifa Audi Salsabila Soebroto, Heroe SOETJIPTO . Suryantoro, Satriyo Suryantoro, Satriyo Dwi TAKAKO UTSUMI Tjandra, Kevin C. Tri Asih Imroati Wenny P Nilamsari, Wenny P WENNY PUTRI NILAMSARI, WENNY PUTRI Widipriyatama, Gabriel Rio Widodo Widodo Widodo Widodo Willyanto, Sebastian E. Wungu, Citrawati Dyah Kencono Yasuhiko Tomino, Yasuhiko Yetti Hernaningsih YOSHIHIKO YANO YOSHITAKE HAYASHI Yusuke Suzuki Yusuke Suzuki Yusuke Suzuki Zaky El Hakim Zaky El Hakim Zaky Firmawan El-Hakim