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All Journal Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Indonesian Journal of Rheumatology Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Nurse and Health: Jurnal Keperawatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ners Indonesian Journal of Anesthesiology and Reanimation (IJAR) Majalah Biomorfologi (Biomorphology Journal) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Journal of Clinical Microbiology and Infectious Diseases
Betty Agustina Tambunan
Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Examining convalescent plasma transfusion in severe COVID-19 patients, recent research highlights the significance of S-RBD antibodies and IL-10 levels Etnawati Putri, Aditea; Agustina Tambunan, Betty; Pujo Semedi, Bambang; Mohd Yusoff , Narazah; Salmah Bt Noordin, Siti
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 3 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i3.50859

Abstract

Convalescent plasma (CP) may be an option for people with severe COVID-19. However, its efficiency remains unknown. A study was done to determine whether the levels of Anti-SARS-CoV-2 Spike Receptor-Binding Domain (S-RBD) antibodies and IL-10 in COVID-19 patients who had CP transfusion were related to their survival status. The observational cohort study included 40 patients with severe COVID-19 who were followed for 28 days after receiving a CP transfusion. Antibody and IL-10 levels were assessed on Day 1 before to CP transfusion and on Days 1, 2, and 7 following CP transfusion. Twenty six (65%) of the 40 patients survived. Anti-SARS-CoV-2 S-RBD antibody levels were observed to be significantly higher on Days 1, 2, and 7 following CP transfusion (p-value 0.05). Furthermore, IL-10 levels dropped significantly on Days 2 and 7 (p-value 0.05). However, neither the CT value nor the patients' survival status were linked to greater antibody levels or changes in IL-10 levels. According to the findings, CP transfusion can greatly enhance anti-SARS-CoV-2 S-RBD antibody levels while drastically decreasing IL-10 levels. These findings may have therapeutic implications for the use of CP as a COVID-19 therapy option. More research is needed to determine its efficacy in enhancing the survival rate of COVID-19 patients with severe symptoms.
The effect of low-electrical voltage as a method to eradicate Acinetobacter baumannii bacteria Putri, Naomi Lesmana; Koendhori, Eko Budi; Susilo, Imam; Tambunan, Betty Agustina
Journal of Clinical Microbiology and Infectious Diseases Vol. 3 No. 2 (2023): Available online: December 2023
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v3i2.20

Abstract

Introduction: Acinetobacter baumannii is one of the bacteria in critical priority according to WHO in 2017 and one of the causes of nosocomial infections in the world. These bacteria usually become resistant to antibiotics (Multi Drug Resistant Organism, MDRO), infect the bloodstream, and cause pneumonia. This study aimed to examine the effect of low-voltage electricity as a method to kill Acinetobacter baumannii by using a different electric current. Methods: This study is experimental research in the Microbiology Laboratory of RSAB Harapan Kita. Experiments were carried out using a solution of Acinetobacter baumannii non-MDRO and MDRO bacteria with a parallel design device opposite to the GPS 3030D power supply with a power of 90 W. Each tube was fitted with a 12 cm stainless steel rod conductor with a diameter of 3 mm and delivered amperage 1 mA, 2 mA, 5 mA, and 10 mA and 0.5V with each amperage performed 5 times and measured using DensiCHEK. Result: From 20 Acinetobacter baumannii non-MDRO experiments and 20 MDRO experiments, it was found that from 1 mA, 2 mA, 5 mA, and 10 mA with monitoring time of 30 minutes, 2 hours, and 4 hours, the results of bacterial eradication by DC stimulation with 5 mA and the most optimal time is 30 minutes according to what has been applied. Conclusion: Using an electric current of 5 mA and a duration of 30 minutes can reduce Acinetobacter baumannii MDRO and non-MDRO bacteria with more optimal results in the non-MDRO group.
Omega-3 Polyunsaturate Fatty Acid Supplementation Potential to Improve Activity Components of Rheumatoid Arthritis: A Systematic Review Hidayat, Nadia; Awalia, Awalia; Tambunan, Betty Agustina; Novida, Hermina
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.32613

Abstract

Introduction: Rheumatoid arthritis (RA) is a chronic disease that causes deformity in most productive age and can lead to death as disease activity increases. Omega-3 polyunsaturated fatty acids have the potential to complement available therapies in reducing disease activity. Currently, the effect of omega-3 PUFAs on disease activity components is still unclear. The current systematic reviews determine the effect of omega-3 PUFAs' supplementation on the components of RA disease activity. Methods: This research is guided by the PRISMA guidelines systematically. Literature was searched in the databases: PubMed, MDPI, and Clinicaltrials.gov. The inclusion criteria used were: giving omega-3 PUFAs, free full-text, RCT, in English or Indonesian, assessing disease activity and its components; while the exclusion criteria were: unpublished, comparisons were inappropriate. Assessment of literature quality with the Cochrane Collaboration's tool. The study included six studies from 1994 to 2017. Results: The effect of omega-3 PUFAs is diversity in changes of disease activity in 4 of 5 studies. There are significant reductions in the number of joint pains in the literature by daily doses above 2.9 grams or at lower doses taking longer; and swollen joints in 2 studies that were only affected in doses above 2.9 grams. There are significant reductions in pain severity in the studies. Change increases with higher doses. There are variable LED and CRP changes. Conclusion: Depending on their dose and administration duration, omega-3 PUFAs can directly and indirectly affect disease activity through the influence of most of its components, namely: the number of joints affected and the degree of pain.
Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum Disorder Verna Biutifasari; Ni Komang Sri Dewi Untari; Pramita Anindya Nugraheni; Ronald Pratama Adiwinoto; Djatiwidodo Edi Pratiknya; Vendra Setiawan; Hartono Kahar; Betty Agustina Tambunan
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3358

Abstract

BACKGROUND: Neuroinflammation and immune dysregulation are frequently viewed as contributing factors of autism spectrum disorder (ASD). Brain-derived neurotrophic factor (BDNF) is involved in the maintenance of neuron viability, as well as in neuron differentiation. Meanwhile, Systemic Immune-Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI) are basic hematological indices used to assess inflammation and immune status. Hyperbaric oxygen (HBO) is known to enhance cerebral blood flow and reduce inflammation, however, not many studies have observed the its effect on BDNF level, SII, and SIRI in ASD subjects; therefore, this study was performed.METHODS: Fifteen ASD subjects were involved in this study and received HBO therapy 10 times within a 2-week period. The HBO therapy was performed by letting the subjects got into an isolated chamber filled with 100% oxygen and 1.3 ATA pressure for 60 minutes. Pre- and post-therapy blood samples were taken from subjects. BDNF level was measured with Enzyme Linked Immunosorbent Assay (ELISA), while neutrophils, monocytes, lymphocytes and platelets were measured by hematology analyzer for the calculation of SII and SIRI.RESULTS: Post-therapy BDNF level was higher than pre-therapy (1.84 ng/mL vs. 1.46 ng/mL; p=0.039). The increased in BDNF suggested reduced neuroinflammation and enhanced connections between neurons. Both post-therapy SII (672.4 vs. 359.4; p=0.005) and SIRI (1.3 vs. 0.7; p=0.009) were significantly lower than pre-therapy indexes. Decreased in SII and SIRI signified a reduction in neuroinflammation.CONCLUSION: HBO therapy increases BDNF level, also decreases SII and SIRI in ASD subjects. These results suggest that HBO has an effect on neuroinflammation, specifically in ameliorating inflammation.KEYWORDS: autism spectrum disorder, BDNF, SII, SIRI, hyperbaric oxygen therapy
Blood Transfusion Practices at The Intensive Observation Unit (Ruang Observasi Intensif/ROI) of Dr. Soetomo General Academic Hospital Surabaya Almira Saskia Sabila; Maulydia; Betty Agustina Tambunan; Edward Kusuma
Indonesian Journal of Anesthesiology and Reanimation Vol. 5 No. 1 (2023): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijar.V5I12023.1-10

Abstract

Introduction: Blood transfusion is the process of transferring blood or its components, such as red blood cells, plasma, and platelets, from donor to recipient. The major reason for blood transfusion is anemia and bleeding, frequently seen in critically ill trauma patients in Intensive Observation Unit (Ruang Observasi Intensif/ROI). One of the most prevalent causes of potentially preventable death in trauma patients is uncontrolled bleeding. In addition to controlling the bleeding by surgical or interventional procedures, blood transfusion is carried out to maintain oxygenation to tissue, preventing organ dysfunction due to hypoxia. Objective: This study aimed to determine the profile of blood transfusion carried out on the patients in the ROI of Dr. Soetomo General Academic Hospital. Methods: This retrospective descriptive study was conducted using medical records involving 258 patients who met the inclusion criteria. Results: The result showed that the majority of patients were female, aged 26-35 years, had blood type O, and Rhesus (Rh)-positive, accounting for 55.04%, 26.36%, 39.53%, and 100%, respectively. The most common indication for transfusion was anemia, with a percentage of 69.10%, particularly severe anemia, accounting for 48.45%. Furthermore, 57.36% of patients were from the surgery department, and 36.05% stayed in ROI for 2-3 days. The most common blood component and unit transfused was packed red blood cells (PRC), with a percentage of 57.50% and 439 units at 47.82%. Most of the transfusions, with a percentage of 37.80%, were carried out within 3-4 hours. Some patients were experiencing pruritus, febrile, urticaria, and chills, accounting for 0.39%, 0.39%, 0.39%, and 0.39%, respectively. Conclusion: Understanding transfusion practices, including blood type distribution, can prevent blood shortage, estimate the need for blood among ROI patients in Dr. Soetomo General Academic Hospital, and further ensure that all transfusions are ABO and Rh compatible.
Complement Profile, Ana Test, And Anti-Dsdna in Systemic Lupus Erythematosus (Sle) Patients Treated At Dr. Soetomo General Hospital Surabaya 2022–2023 Reisya Fadhilah Noor Hafizhah; Yuliasih Yuliasih; Betty Agustina Tambunan; Lita Diah Rahmawati
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52851

Abstract

The complement system is an important part of the innate immune system, consisting of several proteins that play a role in defending the body against infection, tissue repair, and immune complex clearance. Components C3 and C4 are major parts of this system that can describe immune response activity in autoimmune diseases such as systemic lupus erythematosus (SLE). This study aims to determine the complement levels (C3 and C4), ANA test results, and anti-dsDNA levels in patients with systemic lupus erythematosus (SLE) treated at the Dr. Soetomo General Hospital in Surabaya during the period 2022–2023. This study used a retrospective descriptive design with secondary data from the medical records of SLE patients treated at Dr. Soetomo General Hospital in Surabaya. The variables analyzed included patient characteristics (age, gender, occupation), C3 and C4 complement levels, ANA test results, and anti-dsDNA levels. The results showed that out of 1,978 SLE patient data, 274 patients met the inclusion criteria for the study. Most patients were female (81%) with the highest age range being 15–19 years (28.1%). Complement level tests showed that 57.6% of patients had below-normal C3 levels, while 51.1% of patients had normal C4 levels. Positive ANA test results were found in 52.6% of patients, while 26.6% of patients showed positive anti-dsDNA levels. Spearman's correlation analysis showed a significant negative correlation between anti-dsDNA levels and C3 levels (r = –0.498; p < 0.001) and C4 levels (r = –0.561; p < 0.001), meaning that an increase in anti-dsDNA levels was followed by a decrease in complement levels. The majority of SLE patients at Dr. Soetomo General Hospital in Surabaya were women of childbearing age. Most patients showed decreased complement levels and increased anti-dsDNA levels, which correlated with disease activity.
Co-Authors Aditea Etnawati Putri Almira Saskia Sabila Anindya Widyasari Arifoel Hajat Aryati Aryati Awalia Awalia Awalia Awalia Awalia, Awalia Biutifasari, Verna Caesaroy Afif Wibowo Citra Novita Desak Nyoman Surya Suameitria Dewi Devi Rahmadhona Djatiwidodo Edi Pratiknya Dwi Ajeng Roosanti Eko Budi Koendhori, Eko Budi Endang Retnowati Ersa Bayung Maulidan Faizatuz Azzahrah Syamsudi Francisca Srioetami Tanoerahardjo Fransiska Sri Oetami Hadid, Tsabita Hardiono Hardiono Hardiono Hardiono Harida Zahraini Hartono Kahar, Hartono Hermina Novida, Hermina Hidayat, Nadia I. Komang Parwata IGAA. Putri Sri Rejeki Imam Susilo Istiana Hairiah Abas John Wiwin Jusak Nugraha Kintan Putri Kusuma, Edward Putra Lita Diah Rahmawati Mario Mario Maulydia Miftahul Ilmiah Mirna Rahmafindari Mohd Yusoff , Narazah Muhammad Faris, Muhammad Nadia Hidayat Ni Komang Sri Dewi Untari Ni Made Rindra Hermawathi Notopuro, Paulus Budiono Oetami, Fransisca Sri Pramita Anindya Nugraheni Putri, Naomi Lesmana Rahma Indah Pratiwi Reisya Fadhilah Noor Hafizhah Ronald Pratama Adiwinoto Salmah Bt Noordin, Siti Semedi, Bambang Pujo Siti Nurul Hapsari Soedarsono Soedarsono Soeprapto Maat Sri Rejeki Wulandari Tanzilia, May Fanny Tedja, I G.A. Wiradari Tigor Pandapotan Sianturi Vendra Setiawan Vicky S. Budipramana Willy Sandhika Windu Nafika Yulia Nadar Indrasari Yuliasih Yuliasih