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All Journal Biospecies Biotika: Jurnal Ilmiah Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biogenesis: Jurnal Ilmiah Biologi Prosiding Seminar Biologi Biology, Medicine, & Natural Product Chemistry Bioeksperimen: Jurnal Penelitian Biologi Pro-Life Edumatsains Jurnal Biodjati BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Jurnal Pembelajaran dan Biologi Nukleus Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Sciscitatio : Journal for Biological Science Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Dwi Aditiyarini
Department Of Biology, Faculty Of Biotechnology, Universitas Kristen Duta Wacana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Physics Public Health

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Antibacterial Activity of Scurrula ferruginea (Roxb. Ex Jack) Leaves Extract Against Staphylococcus aureus and Escherichia coli Dwi Aditiyarini; Nita Sonia Sipayung; Vinsa Cantya Prakasita
Jurnal Biodjati Vol 9 No 1 (2024): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v9i1.30445

Abstract

The mistletoe (Scurrula ferruginea) is a parasitic plant obtaining nutrients and water from host plants at Nglinggo tea plantation, Kulon Progo, Yogyakarta. Despite the numerous benefits of Scurrula ferruginea leaf, substantiation regarding its pharmacological activity is still lacking. Therefore, this research aimed to identify Scurrula ferruginea species and obtain secondary metabolites with antibacterial activity. The experiment was carried out by extracting Scurrula ferruginea leaf using maceration methods with 96% ethanol, followed by qualitatively and quantitatively phytochemical screening, inhibitory zone test, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) test. Several compounds, such as flavonoids, tannins, phenols, saponins, alkaloids, terpenoids, and steroids, were identified in the mistletoe extract. The results showed total flavonoid, phenolic, and tannin levels were 7.41 ± 0.38 mg QE/mg, 1672 ± 50.99 mg GAE/g, and 1.43 ± 0.15 mg TAE/g, respectively. Scurrula ferruginea leaf ethanolic extract showed the potential to form an inhibition zone against S. aureus in the moderate category at 525 mg/mL, but no significant activity was observed against E. coli. The MIC results of Scurrula ferruginea leaf ethanolic extract against S. aureus were 0.6%, and the MBC was at 2.4%. Furthermore, the MIC value against E. coli was 14%, and the MBC value was 28%. Based on these results, it could be concluded that Scurrula ferruginea leaf ethanolic extract showed high effectiveness in inhibiting and killing S. aureus bacteria compared to E. coli, with MIC and MBC values of 0.6% and 2.4%, respectively
Antidiabetic Potential of Ethanol Extract from Moringa oleifera Leaves in Streptozotocin-Nicotinamide-Induced Female Mus musculus Vinsa Cantya Prakasita; Nadya Aprina Theodora; Enjelin Anjung Susilowati; Dwi Aditiyarini; Aniek Prasetyaningsih
Jurnal Biodjati Vol 9 No 1 (2024): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v9i1.30699

Abstract

Type 2 diabetes mellitus (DM) is a chronic metabolic dis­order characterized by elevated blood glucose levels due to insulin resistance. Type 2 diabetes is considerably more prevalent than oth­er forms (85–90%). The risk of type 2 diabetes is higher in women (53.2%). There is an urgent requirement for better and more afforda­ble treatment options considering DM therapy is expensive and may have adverse health effects. The study's objective is to examine how acute toxicity, blood glucose levels, and body weight are affected by Moringa leaf ethanol extract (MLEE). Maceration was employed to eliminate the leaves of the moringa plant. Phytochemical screening was completed to assess the total flavonoid content and screen for alkaloids, flavonoids, phenolics, saponins, and tannins. Acute toxicity testing was performed following OECD guideline 423. Clinical symp­toms of acute toxicity were observed every 30 minutes for the first 24 hours post-treatment, followed by observations every 24 hours up to 14 days. The estimated LD50 range was determined. Streptozotocin/ nicotinamide-induced female Mus musculus was administered to eval­uate the antidiabetic potential of MLEE. Six groups of mice were uti­lized, which included a healthy control group (aquades not induced), a negative control group (induced aquades), a positive control group (induced glimepiride 0.8 mg/kg BW), and three treatment groups with varying dosages of MLEE (induced; 0, 100, and 150 mg/kg BW). A semi-auto chemical analyzer was employed on days 0 through 31 to determine blood glucose levels. An analytical digital balance was utilized to calculate the body weight. With a total flavonoid concen­tration of 20.75%, MLEE incorporated alkaloids, flavonoids, pheno­lics, saponins, and tannins. MLEE demonstrated a significant effect in lowering blood glucose levels at a dose of 100 mg/kg BW (P<0.05). A significant positive correlation has been identified between body weight and blood glucose levels (P<0.05).
Effect of Plant Growth Regulators (PGRs) on Biomass and Flavonoid Production of Talinum paniculatum Callus Culture Sarah Mega Pratenna Kaban; Ratih Restiani; Dwi Aditiyarini
Jurnal Biodjati Vol 9 No 1 (2024): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v9i1.33788

Abstract

Talinum paniculatum Jacq (Gaertn), locally known as Javanese Ginseng, is an essential medicinal plant characterized by high flavonoid content with antioxidant and antimicrobial activities. Compared to other natural sources, a larger number of T. paniculatum leaves is required to obtain high amounts of flavonoid for drug development. In this context, in vitro culture can be used to increase flavonoid production in a controlled condition without reducing plant population. The concentration of Plant Growth Regulators (PGRs) is capable of influencing biomass and flavonoid accumulation in callus culture from several species. Despite these benefits, there is limited information about the optimal concentration of PGRs for flavonoid production from T. paniculatum callus culture. Therefore, this study aimed to investigate the optimum concentration of 2,4-D and kinetin for callus growth, as well as flavonoid production from T. paniculatum. The investigation was carried out using a completely randomized design (CRD), where young leaves explants were cultured on MS media supplemented with various concentrations of 2,4-D (0, 0.5, 1, 2) mg/L and kinetin (0, 0.5, 1, 2) mg/L for callus and flavonoid production. The results showed that the highest callus biomass of 0.105 g was produced from MS medium with 2 mg/L of 2,4-D and 1 mg/L of kinetin. Meanwhile, the highest total flavonoid content of 25.66 mg QE/g DW was produced from media supplemented with 1 mg/Lof 2,4-D and 2 mg/L of kinetin. These results showed that different combinations of 2,4-D and kinetin were required to increase biomass and flavonoid production. In conclusion, this study provided valuable information for the development of bioactive compounds through in vitro culture.
Cadmium Accumulation and Tolerance of Talinum paniculatum Callus Culture Miranda Gardha Viorenta; Ratih Restiani; Dwi Aditiyarini
Jurnal Biodjati Vol 10 No 1 (2025): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v10i1.38255

Abstract

The increasing use of inorganic fertilizers is one of the main factors contributing to increased Cadmium (Cd) pollution in the environment. Phytoremediation is one of the strategies that can be used to address the problem of Cd pollution in the environment. The selection of Cadmium-tolerant plants can be conducted using an in vitro culture. Talinum paniculatum as an ornamental plant is potentially used as a phytoremediation agent, but limited information is available regarding its accumulation ability and tolerance to cadmium stress. Therefore, this study aims to determine the accumulation ability and tolerance of T. paniculatum callus to cadmium at various concentrations. This study used a completely randomized design (CRD) with six replications of Cd concentration treatment (0, 5, 10, and 20 ppm). Accumulation and tolerance of callus to Cd were assessed based on callus biomass, callus color, tolerance index, heavy metal concentration in callus and media, and Bioconcentration Factor value. An increase in Cd concentration showed a change in callus color from yellowish green to blackish. In addition, there was no significant difference in dry weight (0.078-0.086 g) and tolerance index (102.631%-113.158%) of callus. However, increasing Cd concentration showed significant differences in callus Cd accumulation from media (5-20 ppm) and Bioconcentration Factor (BCF) ratio (1.282-5.701), indicating the ability of T. paniculatum as an accumulator plant. This study's results support phytoremediation efforts against heavy metal pollution, including cadmium.
Co-Authors Anggel Christia Dolonseda Aniek Prasetyaningsih Aniek Prasetyaningsih Aniek Prasetyaningsih Anjarsari, Lusiana Dian Annabelle Marie Inggrid Ariestanti, Catarina Aprilia Astrid Helena Centaury Harjani Christini Bernaindah Nadapdap Dena, Amelia Dolonseda, Anggel Christia Enjelin Anjung Susilowati Evieyana Evieyana Feblicya Palimbunga Guntoro Guruh Prihatmo Haryono, Sevien Elamaria Heralius Dwiki Anggoro Inggrid, Annabelle Marie Jade Septhimoranie Justina, Fayola Kania Apenta Olisvelos Maria Grasela Kase Marsauli Manalu Matthew Linardi Minarsih Maria Sambo Miranda Gardha Viorenta Nadya Aprina Theodora Nathania, Yohana Elsa Nita Sonia Sipayung Prihatmo, Guruh Ratih Restiani Ratih Restiani Regina Asteria Riyanto Rizki Wijaya Sarah Mega Pratenna Kaban Sari, Devina Puspita Septhimoranie, Jade Tangnga Layuk, Rhamatya Tiffany, Yollanda Vinsa Cantya Prakasita Vinsa Cantya Prakasita Vinsa Cantya Prakasita