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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Global Medical and Health Communication The Indonesian Biomedical Journal Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Gizi Klinik Indonesia Jurnal Kedokteran dan Kesehatan

Mukhyarjon

Universitas Riau

Author-ID : 3192977

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Peningkatan Rasionalitas Penggunaan Antibiotik Pasca Implementasi Kebijakan Penggunaan Antimikroba di RSUD Arifin Achmad Pekanbaru Rosdiana, Dani; Anggraini, Dewi; Balmas, Mukhyarjon; Effendi, Dasril; Bet, Anwar
Jurnal Kedokteran Brawijaya Vol 30, No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2018.030.01.7

Ancaman global permasalahan resistensi antibiotik membutuhkan strategi pencegahan yang mencakup penggunaan antibiotik secara bijak melalui pengawasan penggunaan antimikroba. Penggunaan antibiotik harus memenuhi beberapa kriteria seperti indikasi, dosis, lama pemakaian, jarak pemberian yang tepat, serta aman dan terjangkau bagi masyarakat, dan juga memenuhi pola mikroba dan kultur. Pada penelitian ini dilakukan analisis rasionalitas penggunaan antibiotik di Bangsal Kenanga RSUD Arifin Achmad Pekanbaru setelah implementasi kebijakan penggunaan antimikroba pada periode Maret hingga Agustus 2016. Terdapat 252 penggunaan antibiotik yang terbagi menjadi dua kelompok, yaitu pre-implementasi sebanyak 92 dan pasca-implementasi sebanyak 160 penggunaan antibiotik. Rasionalitas penggunaan antibiotik dinilai dengan metode Gyssens yang dilakukan oleh tim pengkaji. Penggunaan antibiotik rasional meningkat sebanyak 15,1%, penggunaan antibiotik tanpa indikasi menurun sebanyak 10,9% dan terdapat peningkatan pemeriksaan kultur sebanyak 57,7%. Berdasarkan uji statistik, terdapat peningkatan bermakna rasionalitas penggunaan antibiotik setelah implementasi pedoman penggunaan antibiotik (33,7% vs 48,8%, p=0,020), dan penurunan penggunaan antibiotik tanpa indikasi (27,2% vs 16,3%, p=0,038). Penerapan kebijakan penggunaan antimikroba efektif meningkatkan rasionalitas penggunaan antibiotik. Program ini dapat diperluas di bangsal lain sehingga rasionalitas penggunaan antibiotik merata di seluruh rumah sakit.

Gambaran Status Gizi Pasien Diabetes Melitus Tipe 2 Berdasarkan Antropometri Mukhyarjon, Mukhyarjon; Pardede, Imelda Tresia; Putri, Wulan Amelia
Jurnal Ilmu Kedokteran Vol 15, No 1 (2021): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v15i1.2021.41-47

Nutritional status is an expression of a state of balance between intake of nutrient and their requirements. Diabetes mellitus is one of the comorbid diseases of obesity due to insulin resistance. This has a negative impact on the tissue causing complications, especially central obesity because it is more resistant to the effects of insulin than adipocytes in other areas. This study aims to describe the nutritional status of people with type 2 diabetes based on anthropometry. This research was a descriptive study with a cross sectional approach using purposive sampling method on 62 respondents. The data collected were anthropometric examinations, HbA1c, and questionnaires. Result of this study showed that most subjects were aged between 45-65 years (64,5%), mostly female (54,8%). Most subject (75,8%) being diabetic â‰¤5 years and as many as 61,3% had HbA1c levels â‰¥7%. The most prevalent diabetic drag used was metformin (69,4%). From the anthropometric examination, it was found that the most nutritional status was obesity (54.85%), with the most age> 45 years (56.9%), male gender (57.1%), onset from type 2 diabetes >65 years ( 66,7%), HbA1c levels â‰¥7% (55.3%) and use of insulin with a percentage of 71,4%. As many as 72,6% subject had central obesity.

Gambaran Status Gizi Pasien Diabetes Melitus Tipe 2 Berdasarkan Antropometri Mukhyarjon Mukhyarjon; Imelda Tresia Pardede; wulan amelia putri
Jurnal Ilmu Kedokteran Vol 15, No 1 (2021): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v15i1.2021.41-47

Nutritional status is an expression of a state of balance between intake of nutrient and their requirements. Diabetes mellitus is one of the comorbid diseases of obesity due to insulin resistance. This has a negative impact on the tissue causing complications, especially central obesity because it is more resistant to the effects of insulin than adipocytes in other areas. This study aims to describe the nutritional status of people with type 2 diabetes based on anthropometry. This research was a descriptive study with a cross sectional approach using purposive sampling method on 62 respondents. The data collected were anthropometric examinations, HbA1c, and questionnaires. Result of this study showed that most subjects were aged between 45-65 years (64,5%), mostly female (54,8%). Most subject (75,8%) being diabetic ≤5 years and as many as 61,3% had HbA1c levels ≥7%. The most prevalent diabetic drag used was metformin (69,4%). From the anthropometric examination, it was found that the most nutritional status was obesity (54.85%), with the most age> 45 years (56.9%), male gender (57.1%), onset from type 2 diabetes >65 years ( 66,7%), HbA1c levels ≥7% (55.3%) and use of insulin with a percentage of 71,4%. As many as 72,6% subject had central obesity.

Gambaran Pemakaian Antibiotika Setelah Implementasi Pedoman Pemakaian Antibiotika di Bangsal Kenanga RSUD Arifin Achmad Provinsi Riau Periode Juni-Agustus 2016 Dani Rosdiana; Mukhyarjon Mukhyarjon; Dewi Anggraini
Jurnal Ilmu Kedokteran Vol 11, No 1 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Implementation of antibiotic guideline as part of “Antibiotic Stewardship Programs (ASPs)”, can both optimize thetreatment of infections and reduce adverse events associated with antibiotic use, antibiotic resistance and savinghospitals funds. This study describes quantitative and qualitative evaluation and cost of antibiotic use afterimplementation of antibiotic guideline in Kenanga ward Arifin Achmad General Hospital.This research was a descriptiveprospective study. All inpatients given antibiotic in Kenanga ward from June – August 2016 were evaluated. Thequantitative antibiotic use was calculated with DDD (daily define dose) meanwhile Gyssens method was used tocalculate qualitative of antibiotic use. There were 137 patients fulfilled inclusion criteria. The most antibiotic usedwere ceftriaxone, ciprofloxacin, levofloxacin, meropenem and cefoperazone. There was increased consumption ofquinolone class antibiotics. The highest DDD’s antibiotic was ceftriaxone (96.5). Qualitative measurement showedthat rational antibiotic (Gyssens category 0) was 46%, irrational (Gyssens category I - IV) was 35 % and no indicationof antibiotic use (Gyssens category V) was 19%. The total cost of antibiotics in this period were Rp 41,444,766.Afterantibiotic guideline implementation, we found that the most frequent antibiotic was ceftriaxone and irrational use ofantibiotic was still high.

Correlation between Proteinuria and Glomerular Filtration Rate in Type 2 Diabetes Mellitus Dani Rosdiana; Mukhyarjon Mukhyarjon; Hendra Asputra; Nisa Faradisa Hernita; Olivia Makmur; Prayogo Prayogo; Hetty Hirfawaty
Majalah Kedokteran Bandung Vol 52, No 2 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Indonesia faces a double burden of communicable and non-communicable diseases, including metabolic and degenerative problems. Delay in the detection of diabetic nephropathy (DN) as one of the chronic microvascular complications is often seen, leading to the need for hemodialysis due to the end-stage renal disease (ESRD). An assessment of diabetes mellitus (DM) control target achievement, based on the guideline from the Indonesian Society of Endocrinology (Perkumpulan Endokrinologi Indonesia, PERKENI), and nephropathy early detection was performed in 54 Type-2 DM patients from 5 private hospitals in Pekanbaru Riau, Indonesia, from November 2018 to September 2019. Results showed poor achievement of DM control with 61.1% had abnormal body mass index, 57.5% had HbA1c>7%, and 77.7% had LDL serum >100 mg/dL. Nevertheless, most patients achieved good blood pressure control (74%). A high percentage of nephropathy-proteinuria was seen (40.7%) with 40.9% of them revealed renal insufficiency classified as chronic kidney disease (CKD) stage 3 and 4. There was a significant correlation between proteinuria and declined GFR (p=0.016), onset of DM (p=0.02), and diastolic blood pressure (p=0.03). No correlation was found between HbA1c and declined GFR, which may be due to the cross-sectional nature of the study. It will be interesting to perform a prospective study on proteinuria modification as a predictor of nephropathy early detection in DM patients since kidney biopsy and urine albumin creatinine ratio assessment are not available in primary health care services in remote areas. Korelasi antara Proteinuria dan Laju Filtrasi Glomerulus pada Diabetes Melitus Tipe 2Indonesia menghadapi beban ganda penyakit menular dan tidak menular, termasuk masalah metabolisme dan degeneratif. Keterlambatan dalam deteksi nefropati diabetik sebagai salah satu komplikasi mikrovaskular kronis sering terlihat, mengarah pada kebutuhan untuk hemodialisis karena penyakit ginjal stadium akhir (ESRD). Dari 54 pasien diabetes melitus (DM) tipe-2 tanpa keluhan edema, sesak, dan lemas dari 5 rumah sakit swasta di Pekanbaru, Riau, Indonesia, dari November 2018 hingga September 2019, dilakukan penilaian kontrol DM sesuai panduan Perkumpulan Endokrinologi Indonesia (PERKENI). Didapatkan hasil bahwa pencapaian kontrol DM masih buruk dengan 61,1% memiliki indeks massa tubuh abnormal 57,5% memiliki HbA1c >7%, dan 77,7% memiliki serum LDL >100 mg/dL. Namun demikian, sebagian besar pasien mencapai kontrol tekanan darah yang baik (74%). Pasien terdeteksi proteinuria >25 mg/dL mencapai 40,7% dengan 40,9% diantaranya mengalami gangguan filtrasi ginjal yang didefinisikan sebagai GFR <60 diklasifikasikan penyakit ginjal kronis tahap 3 dan 4. Walaupun secara statistik tidak ditemukan hubungan bermakna antara kontrol glikemik dengan insufisiensi renal, namun ditemukan hubungan yang bermakna antara nefropati dengan penurunan laju filtrasi glomerulus (GFR) (p=0.016), awitan DM (p=0,02), dan tekanan darah diastolik (p=0,03). Tidak ada hubungan bermakna antara HbA1c dan penurunan GFR yang mungkin disebabkan observasi sesaat. Akan menarik untuk melakukan studi prospektif pada modifikasi proteinuria sebagai prediktor deteksi dini nefropati pada pasien DM karena biopsi ginjal dan penilaian rasio albumin kreatinin urin tidak tersedia di layanan perawatan kesehatan primer di daerah terpencil.

CORRELATION OF STRESS HYPERGLYCEMIA WITH BARTHEL INDEX IN ACUTE NON-HEMORRHAGIC STROKE PATIENTS AT NEUROLOGY WARD OF RSUD ARIFIN ACHMAD PEKANBARU Jaro Shafi’i; Riki Sukiandra; Mukhyarjon "
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 1 (2016): Wisuda Februari 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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ABSTRACTThe raising of blood glucose that occurs due to disruption of the regulation of blood glucose which is part of the non-specific reaction to the occurrence of stress or tissues damage called stress hyperglycemia. Stress hyperglycemia is common in acute diseases such as stroke, which significantly affect patient outcomes that can be assessed with the Barthel Index. The aim of this study was to find out the relationship between stress hyperglycemia with Barthel index in patients with acute non-hemorrhagic stroke. This study using analytic observational method with cross sectional design. The sample are acute non-hemorrhagic stroke patients totaling 38 patients who conform the inclusion criterias. Results of the study of 38 patients, is the prevalence of stress hyperglycemia prevalence cases totaled 23 people (60.52%) in non-acute hemorrhagic stroke. Showed that Barthel Index acute non-hemorrhagic stroke patients are heavy dependence (21-61) of 21 patients (55.26%), followed by 3 patients (7, 89%) with a full dependence (0-20), 13 patients ( 34.21%) with moderate dependence (62-90) and 1 patient (2.63%) with mild dependence (91-99). There is no correlation between stress hyperglycemia with Brthel Index with the value of (r = 0.059) and the value of (p = 0.654). So, based on this research most of the respondents in this study suffered from stress hyperglycemia but there is no correlation between stress hyperglycemia with Barthel Index and most of the patients has a bad interpretation of Barthel Index. Keywords: Stress hyperglycemia, Barthel Index, non-hemorrhagic stroke acute,ADL

HUBUNGAN STRES HIPERGLIKEMIA DENGAN INDEKS BARTHEL PASIEN STROKE HEMORAGIK AKUT DI BANGSAL SARAF RSUD ARIFIN ACHMAD PROVINSI RIAU Danang Nugroho; Riki Sukiandra; Mukhyarjon "
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 1 (2016): Wisuda Februari 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRACTStress hyperglycemia is a condition of elevated blood glucose caused by disruption of the blood glucose regulation which is part of the non-specific reaction of stress or tissues damage. Stress hyperglycemia is common in acute diseases such as stroke, which significantly affect patient outcomes assessed with the Barthel Index. The purpose of this study is to find the correlation of stress hyperglycemia with Barhel index in patients with acute hemorrhagic stroke. Using observational analytic method with cross sectional design. The sample of this study are acute hemorrhagic stroke patients totaling 33 persons who confrom the inclusion criterias. Results of the study of 33 patients, found of stress hyperglycemia cases was 21 patients (63.6%) in acute hemorrhagic stroke. The discription of Barthel index in patients with acute hemorrhagic stroke are complete dependence (0-20) of 23 patients (69.69%), 10 patients (30, 30%) with severe dependence (21-61). There is positive correlation with moderate strength between stress hyperglycemia with Barthel Index in patients with acute hemorrhagic stroke (p = 0.001; r-0.513). The Conclusion is prevalence of stress hyperglycemia were 63.6% with the highest distribution of Barthel index is a full dependence totaling 23 patients (69.69%). There is positive correlation with moderate strength between stress hyperglycemia with Barthel Index in patients with acute hemorrhagic stroke (p = 0.001; r-0.513)Keywords: Stress hyperglycemia, Barthel Index, acute hemorrhagic stroke, ADL

Alpha Lipoic Acid Inhibits Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Type 2 Diabetic Mellitus Rat Models Ismawati Ismawati; Enikarmila Asni; Mukhyarjon Mukhyarjon; Ilhami Romus
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.906

BACKGROUND: Diabetes mellitus (DM) is associated with an accelerated atherosclerotic macrovascular disease affecting medium-sized arteries. Several evidences support the role of oxidative stress in atherogenesis. However, the role of alpha lipoic acid (ALA) to prevent atherosclerosis is still debatable. This study was conducted to determine the effect of 60 mg/kg/day ALA for 21 days toward the expression of intercellular adhesion molecule-1 (ICAM-1) in rat model.METHODS: Eighteen male rats were divided into three groups labelled as control group, type 2 DM (T2DM) group, and T2DM+ALA group. The T2DM rat models were created by intraperitoneally injecting 50 mg/kg streptozotocin, followed by 110 mg/kg nicotinamide. Immunohistochemistry was used to evaluate the ICAM- 1 expression in rats. Quantitative image analysis of immunohistochemical stains was done on the abdominal aorta using Adobe Photoshop CS3 to find the area percentage and intensity. Kruskal-Wallis and Mann-Whitney tests were used to compare the mean value of area percentage and intensity.RESULTS: There was an increase in area percentage and intensity of ICAM-1 expression. The highest area percentage of ICAM-1 expression was found in the DM group, while the lowest was found in the control group. There were significant differences in the area percentage and intensity between DM+ALA group and DM group, where the area percentage and intensity of ICAM-I in DM group was higher than the DM+ALA group.CONCLUSION: In conclusion, our results demonstrate that ALA inhibits the expression of ICAM-1 in T2DM rat models.KEYWORDS: atherosclerosis, ICAM-1, alpha lipoic acid

SEMINAR AWAM BAHAYA SINDROMA METABOLIK DAN CARA PENCEGAHANNYA DI KOTA SIAK SRI INDERAPURA, KABUPATEN SIAK, RIAU Fajri Marindra Siregar; Hendra Asputra; Mukhyarjon; Imelda Tresia Pardede
Panrita Abdi - Jurnal Pengabdian pada Masyarakat Vol. 5 No. 1 (2021): Jurnal Panrita Abdi - Januari 2021
Publisher : LP2M Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/pa.v5i1.7847

Abstract This community service was carried out at Siak Sri Inderapura, Siak Regency, Riau Province. The activity was done in the form of a lay seminar on metabolic syndrome hazards and how to prevent it which targeting the general public. This activity aims to educate the public about metabolic syndrome, its danger to health, and how to prevent it so that people are expected to be able to recognize the signs as early as possible. The service activity begins with filling out the pretest questionnaire, delivery of talks by a health expert and discussion between participants and speaker, then at the end of the event the participants return to fill in the posttest questionnaire. The results of this community service showed a significant increase in knowledge from participants of lay seminars "The dangers of metabolic syndrome and how to prevent it" in Siak Sri Inderapura, Siak Regency, Riau. Abstrak. Pengabdian masyarakat ini dilaksanakan di Kota Sri Inderapura, Kabupaten Siak, Provinsi Riau. Kegiatan ini berupa seminar awam dengan topik bahaya sindroma metabolik dan cara pencegahannya dengan sasaran masyarakat umum. Kegiatan ini bertujuan untuk mengedukasi masyarakat mengenai gejala sindroma metabolik, bahayanya terhadap kesehatan, dan cara pencegahannya sehingga diharapkan masyarakat dapat mengenali tanda-tandanya sedini mungkin. Kegiatan pengabdian diawali dengan pengisian kuisioner pretest, penyampaian materi oleh pakar kesehatan dan dilanjutkan proses tanya jawab antara peserta dan narasumber, selanjutnya pada akhir acara para peserta kembali diminta untuk mengisi kuisioner posttest. Hasil pengabdian masyarakat menunjukkan terdapat peningkatan pengetahuan yang signifikan dari peserta seminar awam “Bahaya sindroma metabolik dan cara pencegahannya” di Kota Siak Sri Inderapura, Kabupaten Siak, Riau.

Efek asam alfa lipoat terhadap insulitis pada tikus diabetes melitus tipe 2 Ismawati Ismawati; Mukhyarjon Mukhyarjon; Ilhami Romus; Sonia Dinda Paramitha
Jurnal Gizi Klinik Indonesia Vol 16, No 2 (2019): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Effect of alpha lipoic acid on insulitis in type 2 diabetic ratBackground: The damaging of β cell causes hyperglycemia. Β cell damaged as insulitis happens because of the increase of free radical and the decrease of endogen antioxidant that caused oxidative stress.Objective: The goal of this research was to find out the effect of alpha lipoic acid (ALA) on pancreas Langerhans island’s histopathology in type 2 diabetic rats.Methods: This was an experimental laboratory study with post test only design. Fifteen adult male rats of Wistar strain were segregated into three groups (n=5) labeled as control, type 2 diabetes (DM), and DM+ALA. The experiment was designed for 3 weeks. The measured parameter was insulitis level on pancreas Langerhans island of groups labeled.Results: The statistical test result showed there was the significant difference between control and type 2 diabetes group (p=0,005), but there was no significant difference between DM and DM+ ALA group (p=0,549).Conclusions: Although not statistically significant, giving ALA 60 mg/kg body weight for 3 weeks decreased the degree of insulitis in diabetic rats.

Co-Authors Abd. Rasyid Syamsuri Asman Manaf Bet, Anwar Danang Nugroho Dani Rosdiana Dewi Anggraini Effendi, Dasril Enikarmila Asni Hendra Asputra Hetty Hirfawaty Ilhami Romus Ilhami Romus, Ilhami Imelda Tresia Pardede Imelda Tresia Pardede Irza Wahid Ismawati ismawati Ismawati Ismawati Jaro Shafi’i M Derillovyandra Dwi Anugrah Muhammad Fadhillah Arif Nisa Faradisa Hernita Olivia Makmur Paramitha, Sonia Dinda Pardede, Imelda Tresia Prayogo Prayogo Putri, Wulan Amelia Riki Sukiandra Siregar, Fajri Marindra Sonia Dinda Paramitha Winarto Winarto wulan amelia putri

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