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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Global Medical and Health Communication The Indonesian Biomedical Journal Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Pengabdian UntukMu NegeRI Jurnal Gizi Klinik Indonesia Jurnal Kedokteran dan Kesehatan Unri Conference Series: Community Engagement
Mukhyarjon
Universitas Riau
Religion Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Profil dan Beberapa Faktor yang Berhubungan dengan Hemostasis Pasien Diabetes Melitus Tipe 2 Tak Terkontrol Mukhyarjon Muslim Ajin; Irza Wahid; Asman Manaf
Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2020): JURNAL KEDOKTERAN DAN KESEHATAN
Publisher : Faculty of Public Health, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/jkk.16.2.128-134

Abstract

Hiperkoagulasi merupakan salah satu faktor risiko terjadinya penyakit kardiovaskuler. Resistensi insulin dan hiperglikemia yang meningkat pada diabetes melitus tipe 2 (DMT2) tidak terkontrol, memainkan peran penting dalam patogenesis terjadinya hiperkoagulasi. Meskipun banyak studi telah dilakukan, namun penelitian pada subjek di Indonesia masih terbatas.  Penelitian ini bertujuan mengetahui profil dan faktor-faktor yang berhubungan dengan hemostasis pada pasien DMT2 tak terkontrol. Ini merupakan studi analitik observasional dengan rancangan potong lintang. Lima puluh pasien diabetes melitus (DM) tak terkontrol berpartisipasi pada penelitian ini. Variabel bebas meliputi umur, onset dan jenis kelamin, sedangkan variabel terikat adalah prothrombine time (PT), activated partial thromboplastin time (APTT), fibrinogen dan D-dimer. Data dianalisis menggunakan uji Chi-Square dan nilai p<0,05 dianggap bermakna. PT yang rendah tidak ditemukan pada penelitian ini sementara APTT yang rendah ditemukan pada 2% pasien. Hiperfibrinogenemia ditemukan pada 34% pasien dan D-dimer tinggi ditemukan pada 28% pasien. Terdapat hubungan hiperfibrinogenemia dengan onset DM namun tidak dengan umur dan jenis kelamin. D-dimer tinggi berhubungan dengan usia namun tidak dengan gender dan onset penyakit. Studi ini dapat disimpulkan bahwa hiperfibrinogenemia dan D-dimer tinggi sering ditemukan pada pasien DMT2 tidak terkontrol sehingga evaluasinya perlu dipertimbangkan terutama pada DMT2 yang disertai faktor-faktor risiko penyakit kardiovaskuler yang lain. 
Effects of Proteasome Inhibitor on Catalase Expression and Intima-media Thickness in the Aorta of Atherosclerotic Rats Ismawati Ismawati; Enikarmila Asni; Ilhami Romus; Mukhyarjon Mukhyarjon; Winarto Winarto; Muhammad Fadhillah Arif; M Derillovyandra Dwi Anugrah
Global Medical & Health Communication (GMHC) Vol 10, No 3 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v10i3.9508

Abstract

Various studies have been carried out to obtain proper management for atherosclerosis. Proteasome, a subcellular enzyme complex, is a potential therapeutic target for atherosclerosis. However, the effect of proteasome inhibitors on atherosclerosis still needs to be explored. It was an experimental study with a post-test-only control group design conducted at the Faculty of Medicine, Universitas Riau in Juni–November 2021. This study aimed to analyze the effects of proteasome inhibitors on catalase expression and intima-media thickness (IMT) in the thoracic aorta of atherosclerotic rats. Fifteen male Wistar rats were randomly divided into three groups (five rats per group), namely rats given standard feed (control, group I), rats induced atherosclerosis (group II), and rats induced atherosclerosis and given proteasome inhibitor (group III). The proteasome inhibitor, bortezomib, 50 µg/kgBW/day was given intraperitoneally on days one and three. After 4 days, rats were terminated, and the thoracic aorta was taken for the IMT analysis and catalase expression assessment using immunohistochemistry. Catalase expression was carried out quantitatively using Adobe Photoshop software. Analysis of variance test was used to compare the expression of catalase and IMT. A p value<0.05 was considered statistically significant. The results showed a significant decrease in IMT in group III compared to group II and an increase in catalase expression in group III compared to group II but not statistically significant. This study concludes that administration of bortezomib 50 µg/kgBW in atherosclerotic rats could inhibit thickening tunica intima-media in the thoracic aorta, although not significantly increasing the catalase expression.
Pelatihan dan Pemberdayaan Kader Posyandu dalam Pemanfaatan Makanan Fermentasi Tradisional Kuansing untuk Peningkatan Gizi Ibu Hamil dan Balita Ismawati, Ismawati; saryono, saryono; mukhyarjon, mukhyarjon; enikarmila Asni; Devi, Silvera; Anggraini, Suci; Suraya, Nabella; Kesya, Lunari; Salsabila, Dinda; Deanra, Cantika Natswa
Jurnal Pengabdian UntukMu NegeRI Vol. 9 No. 3 (2025): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v9i3.10439

Abstract

Stunting in children remains a health problem in Indonesia. One way to improve the nutritional status of the community to prevent stunting is by utilizing nutrient-rich traditional fermented foods. This community service activity aimed to enhance the knowledge and skills of Posyandu cadres in utilizing conventional fermented foods from Kuansing as a nutritional source for pregnant women and toddlers. The training was conducted on August 30, 2025, at the Gunung Toar Sub-district Multipurpose Hall, Kuantan Singingi Regency, attended by 26 Posyandu cadres. The methods included educational video screening, booklet distribution, interactive discussions, and demonstrations of traditional fermented products such as pekasam, sarobuong, and puduong. Evaluation results showed an increase in participants' knowledge scores from an average of 50 to 70 after the training. This activity demonstrates the effectiveness of science-based education in improving community nutrition awareness and preserving local fermented foods.
Revitalisasi Makanan Fermentasi Tradisional Kuantan Singingi melalui Pelatihan Berbasis IPTEKS Ismawati Ismawati; Saryono Saryono; Mukhyarjon Mukhyarjon; Enikarmila Asni; Silvera Devi; Suci Anggraini; Nabella Suraya; Lunari Kesya; Dinda Salsabila; Cantika Natswa Deanra
Unri Conference Series: Community Engagement Vol 7 (2025): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.7.531-536

Abstract

Malnutrition, especially among children under five, remains a significant public health concern in Indonesia, including Riau Province. One potential effort to address this issue is the utilization of traditional fermented foods from Kuantan Singingi Regency, such as pekasam, sarobuong, puduong, and cangkuok semaung. These foods are rich in nutrients, including protein, carbohydrates, amino acids, minerals, and probiotics beneficial to health; however, they are on the verge of extinction.This community service program aimed to revitalize traditional Kuansing fermented foods through a science and technology-based training approach. The program implementation involved video demonstrations of traditional food preparation, distribution of pocket books, and interactive discussions with health cadres, as well as pregnant and breastfeeding mothers, and mothers with toddlers.The results showed high enthusiasm among participants, demonstrated by their active involvement in discussions and question-and-answer sessions. The training not only improved participants’ knowledge but also fostered awareness and a sense of ownership of local food, while simultaneously opening opportunities for small-scale household businesses.
Efek Protektif Suplementasi Ekstrak Etanol Daun Seri (Muntingia calabura) Terhadap Perubahan Histologis Pankreas Tikus Yang Diinduksi Diet Tinggi Lemak Mukhyarjon Mukhyarjon; Irwan Irwan; Ismawati Ismawati
Jurnal Ilmu Kedokteran Vol 20, No 1 (2026): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v20i1.2026.59-64

Abstract

Diabetes mellitus is a major global health problem. Lipotoxicity is a key cause of insulin resistance that ultimately leads to pancreatic damage in type 2 diabetes mellitus. One plant with potential to prevent pancreatic damage is the Seri plant (Muntingia calabura). This study aimed to analyze the effect of ethanolic extract of Muntingia calabura leaves on pancreatic damage in rats induced by a high-fat diet (HFD). This was an experimental study with a post-test-only design. A total of 28 male Wistar rats weighing 120–200 grams were divided into four groups: K1 received standard feed (20 g/rat/day) and water ad libitum; K2 received a 50% high-fat diet (20 g/rat/day); K3 received the same HFD plus Muntingia calabura leaf extract (100 mg/kg/day); and K4 received HFD plus pioglitazone (6 mg/kg/day). Treatments were administered for 8 weeks, followed by termination for pancreatic histological examination. The variables studied were supplementation of Muntingia calabura ethanolic extract and the degree of pancreatic insulitis. Histological preparations were stained with hematoxylin-eosin, and insulitis was scored. Data were analyzed using IBM SPSS with Kruskal–Wallis and Mann-witney tests. Results showed no insulitis in K1, while mild insulitis was observed in K2, K3, and K4. A significant difference in histological scores was found between K1 and K2 (p = 0.03), whereas no significant differences were observed among other groups. In conclusion, 8 weeks of HFD induced mild insulitis in rats, while Muntingia calabura leaf extract and pioglitazone did not demonstrate protective effects against insulitis.
Co-Authors Abd. Rasyid Syamsuri Anggraini, Suci Asman Manaf Bet, Anwar Cantika Natswa Deanra Danang Nugroho Dani Rosdiana Deanra, Cantika Natswa Dewi Anggraini Dinda Salsabila Effendi, Dasril Enikarmila Asni Enikarmila Asni Enikarmila Asni Hendra Asputra Hetty Hirfawaty Ilhami Romus Ilhami Romus, Ilhami Imelda Tresia Pardede Imelda Tresia Pardede Irwan Irwan Irza Wahid Ismawati Ismawati Ismawati ismawati Ismawati Ismawati Jaro Shafi’i Kesya, Lunari Lunari Kesya M Derillovyandra Dwi Anugrah Muhammad Fadhillah Arif Nabella Suraya Nisa Faradisa Hernita Olivia Makmur Paramitha, Sonia Dinda Pardede, Imelda Tresia Prayogo Prayogo Putri, Wulan Amelia Riki Sukiandra Salsabila, Dinda Saryono Saryono Saryono Silvera Devi Siregar, Fajri Marindra Sonia Dinda Paramitha Suci Anggraini suraya, nabella Winarto Winarto wulan amelia putri