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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Kedokteran Indonesia Omega: Jurnal Fisika dan Pendidikan Fisika JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Farmasi Sains dan Komunitas Health Notions Warta Pengabdian JFIOnline Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Abdi: Media Pengabdian Kepada Masyarakat Jurnal Layanan Masyarakat (Journal of Public Service) Berkala Ilmiah Kimia Farmasi Berkala Penelitian Hayati Journal of Tropical Pharmacy and Chemistry
Isnaeni
Departemen Ilmu Kefarmasian Fakultas Farmasi Universitas Airlangga, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Health Notions

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Optimation Ca-Alginate Beads as Drug Reservoir in the Patch System for Model AntiInflammatory Drug Esti Hendradi; Isnaeni Isnaeni; Rifaatul Mahmudah
Health Notions Vol 2, No 9 (2018): September
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.375 KB) | DOI: 10.33846/hn.v2i9.320

Abstract

The aim of this study was to optimize the use of Ca-Alginates beads as a drug reservoir in the patch system with and without freeze-drying process. Meloxicam, an anti-inflammatory non-steroidal drug, was used as a drug model. Ca-alginate beads were prepared by ionic gelation method using polymer alginate and cross-linker CaCl2. The beads were evaluated for its melting temperature, FTIR spectra, and entrapment efficiency. The FTIR study showed the loss of guluronic peaks of alginate caused by a cross-linking process with Ca2+, characteristics peaks of meloxicam still appeared indicating the compatibility of the drug with the polymers used. The using Ca-alginate beads without freeze-drying process as a drug reservoir resulted in a very wet patch that was difficult to dry, cracked surface, and pharmaceutically not acceptable. Meanwhile, patch using Ca-alginate beads with the freezedrying process as a drug reservoir demonstrated satisfactory characteristics with minimum weight variation among the patches that lead to giving uniformity in the drug content. Keywords: Ca-alginate, Freeze-dry, Patch, Meloxicam, Transdermal delivery
Co-Authors A'yun, Arini Qurrata Achmad Toto Poernomo Aditya Fridayanti Aditya Fridayanti Aditya Fridayanti Alief Putriana Rahman Alimsardjono, Lindawati Ambarini Indah Andri Astuti Andyanita Hanif Hermawati Anggita Mirzautika Aprelita Nurelli Dwiana Arie Ika Susanty Aryati Aryati Asri Darmawati Astrid Aulia Hamida Dahlang Tahir Diyah, Nuzul Wahyuning Djoko Agus Purwanto Dwi Riani Oktavia Palupi Esti Handayani Esti Hendradi Febri Annuryanti Fridayanti, Aditya Hadi Poerwono Hana Sofiana Maghfira Hanifah Ridha Rabbani Hepriyadi, Selvy Uftovia I Gede Edy Sagitha Idha Kusumawati Ifah Yulistyani Izza Rahmi Hidayah Juni Ekowati Kholis Amalia Nofianti Laili Irfanah Lisa Nathalie Luky Hayuning Les Mahfudz Mahfudz Marcellino Rudyanto Mega Ferdina Suwito Meliana Susanti Muhammad Agus Syamsur Rijal Muhammad Muslich Muhammad Mu’amar Fathoni Muhammad Yuwono Muhammad Yuwono Muhammad Yuwono Muhammad yuwono Nailatul Hidayah Ni Made Mertaniasih Nindya Pramesti Wardani Noor Erma Nasution Noor Erma Nasution Noor Erma Nasution Noor Erma Nasution Sugijanto Noor Erma NS Nuril Fikriyah Nurrosyidah, Iif Hanifa Primadi Avianto Pujianti, Efrin Pujianti, Efrin Putri, Radha Hartina Ramlan, Nurul Mutmainnah Riesta Primaharinastiti Rifaatul Mahmudah Siswandono, Siswandono Sonia Khoirun Nisa Sri Poedjiarti Sudjarwo Sudjarwo Sugijanto Sugijanto Sugijanto Randiman Sugiyartono, . Sugiyartono, . Suharjono, Suharjono Sukardiman Suko Hardjono Susanti Susanti Suzana Syahrani, Achmad Syamsul Arifin Tri Sundari Utari Ardiningdyah Widji Soeratri Yulistiani Yulistiani Zahratus Silmi Aliyah