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Siti Ifadatin
Department Biology, Faculty Of Mathematics And Natural Sciences, University Tanjungpura, Jl. Prof. Dr. H. Hadari Nawawi, Pontianak, West Kalimantan, Indonesia, 7811
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Earth & Planetary Sciences Education Energy Environmental Science Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Social Sciences Veterinary

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Anti-inflammatory Activity of Bajakah Stem (Spatholobus littoralis Hassk.) Ethanolic Extract in Carrageenan-Induced Paw Edema Mice Diah Wulandari Rousdy; Elvi Rusmiyanto Pancaning Wardoyo; Siti Ifadatin
Jurnal Biodjati Vol 7 No 1 (2022): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v7i1.14126

Abstract

Bajakah tampala plant (Spatholobus littoralis Hassk.) has been used for traditional medicine by the Kalimantan Dayak tribe in the treatment of cancer. This study aimed to find out the potential of ethanol extract of the stem of Bajakah tampala (Spatholobus littoralis Hassk.) as an anti-inflammatory agent in carrageenan-induced mice. The method used was a Completely Randomized Design with five treatments and five replications. The treatments consisted of a water-treated mouse as a negative control, sodium diclofenac 30,8 mg kg-1 as a positive control, and an extract of bajakah dose 2.5; 250; 1250 mg kg-1 BW. The dose of bajakah extract was given orally one hour before carrageenan induction. The inflammation induction used the Winter method by injecting 0.15 ml of 2% carrageenan suspension into the soles of mice. The diameter of edema was measured for 210 minutes. The results showed that the diameter of the mice soles showed a significant increase in all groups after the carrageenan injection. The value of AUC (Area Under the Curve) of bajakah extract dose (2.5; 250; 1250 mg kg-1) from the 150th minute to the 210th minute did not show significant differences from one another. The sodium diclofenac as positive control gave the lowest total AUC value of 236 mm.minute, followed by bajakah extract at a dose of 2.5 mg kg-1 BW of 239.22 mm.minute. The calculation results of the percentage of the inflammation inhibition showed that the administration of ethanol extract of the stem of Bajakah, Spatholobus littoralis, at the lowest dose of 2.5 mg kg-1 BW provide the best inflammation inhibition with 19.21% inhibitory value, nearly approaching the positive control of diclofenac sodium with an inhibitory value of 21.53%.
Co-Authors Ara, Chilliany Ari Hepi Yanti Diah Wulandari Rousdy Diah Wulandari Rousdy Dina Oktaviani Azra Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina, Firman Saputra I Wayan Bayu Anggara Wayan Irwan Lovadi Irwan Lovadi Istiani, Duwi Rida Junardi Junardi Juniarty, Syffa Kustiati Kustiati Laely Rizqi Meisia, Lili Mukarlina, Mukarlina Noerhandayani, Yunita Rafdinal Rafdinal Rahmawati Rahmawati Rahmawati, Rahmawati Renianda Rikhsan Kurniatuhadi, Rikhsan Risa Linda Riyandi Riyandi Riyati, Indri Riza Linda Rochmah, Febri Aini Rodiyeh, Rodiyeh Sabrawi, Salmiah Selly Marselina Teul Syarief Adiansyah Turnip, Masnur Wibowo, Anggi Zulfa Zakiah