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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Martabe : Jurnal Pengabdian Kepada Masyarakat ABDIMAS SILIWANGI Abditani : Jurnal Pengabdian Masyarakat Poltekita: Jurnal Pengabdian Masyarakat MEDIC MEdical Dedication International Journal Mathla'ul Anwar of Halal Issues Medical Sains : Jurnal Ilmiah Kefarmasian Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Sciences of Pharmacy Riset Informasi Kesehatan Jurnal Kedokteran Meditek Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Yuliawati
Jurusan Farmasi, Universitas Jambi
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Ethanolic Extract of Curcuma zedoaria Enhances Burn Wound Healing in Male White Rats Yuliawati, Yuliawati; Kasmadi, Fathnur Sani; Elisma, Elisma; Dewi, Hasna; Afryandes, Amelya; Puteri, Vanya Gita
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501488

Abstract

In addition to its widespread use as a culinary spice, white turmeric rhizome (Curcuma zedoaria (Christm.) Roscoe) exhibits important pharmacological activities, including anti-inflammatory, anticancer, and antioxidant effects. The rhizome contains secondary metabolites such as flavonoids, alkaloids, saponins, phenols, tannins, and terpenoids, which are believed to contribute to its potential efficacy in treating burns. This study used a fully randomized post-test-only control group design consisting of five treatment groups: P1 (5% ethanol extract of white turmeric rhizome), P2 (10%), P3 (15%), K⁺ (positive control: Bioplacenton), and K⁻ (negative control: Vaseline flavum). Parameters observed included reduction in burn wound diameter and collagen density, which were assessed through histological analysis. The results showed significant differences between treatment groups (p < 0.05). The 10% concentration showed the highest wound healing activity, reaching a healing rate of 54.72% and producing denser collagen compared to the other treatments. However, its effect did not exceed the positive control (Bioplacenton). The 5% concentration showed moderate healing activity (43.84%) with intermediate collagen density, while the 15% concentration produced the lowest effect. Overall, the findings indicate that the ethanol extract of white turmeric rhizome, particularly at a concentration of 10%, enhances burn wound healing and increases collagen formation, supporting its potential as a natural therapeutic agent for the treatment of burns.
Co-Authors Afryandes, Amelya Agung Giri Samudra Amalia Sakinah Anisya Persi Persi Asima Widyawaty Sinurat Ave Olivia Rahman Ave Olivia Rahman dewi, hasna Diah Tri Utami Elisma Elisma Elisma Elisma Emi Efrini Efriani Fitrianingsih Fitrianingsih Fitriyani Fitriyani Havizur Rahman herlina herlina Humaryanto Kiki Safitri Kristin Simamora Lili Andriani Lili Andriani M. Rifqi Efendi Maharini, Indri Melisa Putri Monic Sri Cahnia Monic Sri Cahnia Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhammad Faizal Fathurrohim Muhammad Syukri Puspa Dwi Pertiwi Puteri, Vanya Gita Rd. Halim Reza Yolandini Rofifah Dhia Savira Sani K, Fathnur Santi Perawati Siska Dwi Anggraeni Susi Widiawati, Susi Sutrisno , Deny Syamsul Arifin syamsurizal syamsurizal Uce Lestari Yesi Nursofia Nursofia