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All Journal e-CliniC JURNAL BIOMEDIK Damianus Journal of Medicine Narra J
Nurdjannah J. Niode
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Satu kasus nekrolisis epidermal toksik yang diduga disebabkan oleh kotrimoksasol Gunawan, Ellen; Wibawa, Anthony S.; Suling, Pieter L.; Niode, Nurdjannah J.
Jurnal Biomedik : JBM Vol 9, No 1 (2017): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.9.1.2017.15320

Abstract

Abstract: Toxic epidermal necrolysis (TEN) is an acute life-threatening muco-cutaneous reaction, characterized by extensive necrosis and detachment of the epidermis (>30% BSA). Drugs are often suspected as the main cause, one of which is trimethoprim- sulfamethoxazole (TMP-SMX). Management includes immediate termination of alleged drugs, supportive treatment such as maintenance of electrolyte balance, nutrition, analgesics, antibiotics and specific treatment of immunosuppressants with dexamethasone injection. We reported a female 36 yo who complained of dark red spots and flaky skin on the face, chest, abdomen, back, arms, and genitals associated with fever, dysphagia, and sore eyes. There was a history of cotrimoxazole consumption prior to the rashes. Skin examination revealed multiple, well defined, erythematous macula, numular to plaque-sized, multiple bullae, purpura, erosion, crusts, and epidermolysis on the face, chest, abdomen, back, and upper extremities. Patient also had vulval erosion and conjunctival hyperemia. Laboratory tests showed total protein 6.5 g/dL and albumin 3.2 g/dL. Patient was treated with intravenous RL:D 5%:NaCl 0.9% = 1:1:1 20 gtt/min, ranitidine injection 2x25 mg IV, ceftriaxone injection 1x2 gr IV, NaCl 0.9% moist dressing 3x30 minutes on erosions, polymyxin B sulphate, neomycin sulphate and dexamethasone eye drops 4x1gtt, artificial tears 6x1gtt, and tapered dexamethasone injection 4x10 mg IV. Diagnosis of TEN was established through anamnesis, physical examination, and laboratory examination. Patient showed clinical improvement within 2 weeks after the discontinuation of cotrimoxazole, and administration of supportive and specific treatment.Keywords: toxic epidermal necrolysis, cotrimoxazoleAbstrak: Nekrolisis epidermal toksik (NET) merupakan reaksi mukokutan akut yang mengancam jiwa, ditandai nekrosis dan pelepasan epidermis yang luas (>30% LPB). Obat diduga sebagai penyebab utama, salah satunya ialah golongan trimetoprim-sulfametoksazol (TMP-SMX). Penatalaksanaan meliputi penghentian segera obat yang diduga penyebab, penanganan suportif (keseimbangan elektrolit, nutrisi, analgetik, antibiotik) dan pengobatan spesifik (imunosupresan deksametason injeksi). Kami melaporkan kasus seorang perempuan 36 tahun dengan bercak merah kehitaman dan kulit terkelupas di wajah, dada, perut, punggung, kedua lengan, dan kelamin disertai demam, nyeri menelan, dan kemerahan pada mata. Riwayat konsumsi kotrimoksazol sebelum timbul ruam. Status dermatologikus: pada wajah, dada, perut, punggung, kedua lengan atas dan bawah terdapat makula eritematosa, batas tegas, multipel, ukuran numular-plakat; bula, purpura, erosi, krusta, dan epidermolisis. Terdapat erosi vulva erosi dan konjungtiva hiperemis bilateral. Pemeriksaan laboratorium: protein total 6,5 g/dL dan albumin 3,2 g/dL. Penanganan berupa IVFD RL:D 5%:NaCl 0.9% = 1:1:1 20 tetes/menit, injeksi ranitidin 2x25 mg IV, injeksi seftriakson 1x2 gr IV, kompres terbuka NaCl 0,9% 3x30 menit (luka), obat tetes mata (polimiksin B sulfat, neomisin sulfat dan deksametason) 4x1 tetes, airGunawan, Wibawa, Suling, Niode: Satu kasus nekrolisis epidermal toksis ... mata buatan 6x1 tetes dan injeksi deksametason 4x10 mg IV yang diturunkan secara bertahap sesuai perbaikan klinis. Diagnosis NET pada kasus ini ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Keadaan umum pasien membaik dalam 2 minggu setelah dilakukan penghentian obat yang diduga penyebab, penanganan suportif, dan pengobatan spesifik.Kata kunci: nekrolisis epidermal toksik, kotrimoksazol
LUPUS VULGARIS DENGAN LESI DISEMINATA Jayadi, Nana N.; Ernaningtyas, Niken; Niode, Nurdjannah J.; Wongkar, Marthen C. P.
JURNAL BIOMEDIK : JBM Vol 7, No 3 (2015): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.7.3.2015.9490

Abstract

Abstract: Lupus vulgaris (LV) is a chronic progressive form of paucibacillary cutaneous tuberculosis. Lesion is usually solitary in the form of nodes or erythematous plaques with an apple-jelly sign on diascopy. Disseminated LV is a rare form of cutanoeus tuberculosis with multiple lesions in several body areas. We reported a male of 40 years old with a suppurative wound on the left neck and reddish nodules on the face, neck, trunk, and limbs along with fever, night sweats, weight loss, and history of previous TB infections. There were multiple erythematous nodules and painful suppurating ulcers with enlargement of several lymph nodes. Apple-jelly sign appeared on diascopy. The FNAB showed specific granulamatous inflammation for TB with lymphocytes, epitheloid macrophages, and multinucleated giant cells. The histopathological finding showed tubercles surrounded by macrophages and lymphocytes. Anti-tuberculosis drugs category I were given for 6 months, ofloxacin, and open wound care compressed with NaCl 0.9%. In the third month of observation, there was significant improvement. Conclusion: This case was diagnosed as lupus vulgaris based on the history of lymphadenitis TB and scrofuloderma, lesions in several body area with positive diascopy test, the FNAB as well as the histopathologic result supporting the diagnosis of tuberculosis, and there was significant improvement after treatment with antiTB drugs.Keywords: lupus vulgaris, diseminata, tuberculosis, ofloksasinAbstrak: Lupus vulgaris (LV) merupakan tuberkulosis (TB) kutis pausibasiler kronis dan progresif. Lesi biasanya soliter, berupa nodus atau plak eritematosa dengan gambaran apple-jelly pada diaskopi. Lupus vulgaris diseminata merupakan bentuk TB kutis yang jarang ditemukan dengan lesi multipel pada beberapa area tubuh secara bersamaan. Kami melaporkan seorang laki-laki, 40 tahun, dengan luka bernanah pada leher kiri dan benjolan-benjolan kemerahan pada wajah, leher, badan, dan tungkai disertai demam, keringat malam, penurunan berat badan dan riwayat infeksi tuberkulosis sebelumnya. Pada pemeriksaan fisik tampak nodus eritematosa multipel disertai ulkus bernanah dan pembesaran beberapa kelenjar getah bening. Gambaran apple-jelly tampak pada diaskopi. Pemeriksaan FNAB menunjukkan gambaran radang granulomatik spesifik TB dengan adanya sel-sel radang limfosit, kelompok makrofag epiteloid, dan sel-sel datia Langhans. Pemeriksaan histopatologis memberikan gambaran tuberkel yang dikelilingi oleh makrofag dan limfosit. Terapi diberikan berupa OAT kategori I selama 6 bulan, ofloksasin, dan kompres terbuka dengan NaCL 0,9%. Pada bulan ketiga tampak perbaikan signifikan. Simpulan: Pada kasus ini, diagnosis lupus vulgaris ditegakkan berdasarkan adanya riwayat limfadenitis TB dan skrofuloderma, lesi di beberapa area tubuh sekaligus dengan pemeriksaan diaskopi positif, gambaran FNAB dan histopatologis menunjang diagnosis TB, dan pengobatan dengan OAT memberikan perbaikan bermakna.Kata kunci: lupus vulgaris, diseminata, OAT, ofloksasin
PROFIL KONDILOMA AKUMINATA DI POLIKLINIK KULIT DAN KELAMIN RSUP PROF.DR. R.D. KANDOU MANADO PERIODE JANUARI 2012 - DESEMBER 2012 Nelwan, Stella R.; Niode, Nurdjannah J.; Kapantow, Marlyn G.
e-CliniC Vol 2, No 1 (2014): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v2i1.3617

Abstract

Abstract: Condyloma acuminata, also known as genital warts, is a vegetation of certain types of Human Papilloma Virus(HPV), stalky with bumpy surface. This disease is a sexually transmitted disease, most HPV infections in anogenital area are acquired during sex. This was a descriptive retrospective study, where the data were collected from medical records and registers book of sexually transmitted disease (STD) in Dermatovenereology clinic of Prof. Dr. R. D. Kandou Hospital Manado. The result showed that in 2012, there were 27 new cases of condyloma acuminata, 2.46% of all new patients Most age group found was 25-44 years which was 13 patients (48.15%), with sex distribution mostly found in female patients which was 14 patients (51.85%). Most occupation found was private employees by 10 patients (37.04%). Most affected locations in female patients was vulva and vulva with vagina by 5 patients each of them (35.71%), where as in male patients was penis which was found in 4 patients. The result also showed that HIV was the most comorbid disease found in 3 patients (11.11%). Conclusion: In this study, most condyloma acuminata patients is in 25-44 age group, mostly found in female, most occupation was private employee, most location affected in female were vulva and vulva with vagina, while in male patients was penis, most therapy used was podophyllin. Most comorbid disease was HIV. Keywords: Condyloma acuminata, Human papilloma virus, female    Abstrak: Kondiloma akuminata (KA) adalah vegetasi oleh Human Papilloma Virus (HPV) tipe tertentu, bertangkai dengan permukaannya berjonjot. Penyakit ini tergolong infeksi menular seksual, kebanyakan infeksi HPV di daerah anogenital didapatkan melalui hubungan seksual. Penelitian ini bersifat deskriptif retrospektif; data diambil dari rekam medik dan buku register infeksi menular seksual bagian ilmu penyakit kulit dan kelamin RSU Prof. Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan pada tahun 2012 dari total kunjungan baru terdapat 27 kasus baru KA (2,46%). Kelompok umur terbanyak didapatkan adalah 25-44 tahun sebanyak 13 orang (48,15%) dengan jenis kelamin terbanyak perempuan sebanyak 14 orang (51,85%) Pada pekerjaan terbanyak pada pekerja swasta sebanyak 10 orang (37,04%) Lokasi lesi pada perempuan tersering di vulva dan vulva ditambah vagina masing-masing sebanyak 5 orang (35,71%), sedangkan pada laki-laki tersering di penis yaitu sebanyak 4 orang. Hasil penelitian juga didapatkan penyakit penyerta terbanyak adalah HIV sebanyak 3 orang (11,11%) . Simpulan: Dalam Penelitian ini, pasien KA terbanyak pada kelompok umur 25-44 tahun paling banyak pada perempuan, jenis pekerjaan pegawai, lokasi lesi pada perempuan tersering pada vulva dan vulva ditambah vagina sedangkan pada laki-laki tersering di penis, pengobatan tersering podofilin. Penyakit penyerta ada lah HIV. Kata kunci: Kondiloma Akuminta, Human papilloma virus, Perempuan.
Efektivitas Pemeriksaan Serologis Sifilis Baguna, Tirsa; Niode, Nurdjannah J.; Pandaleke, Herry E. J.
e-CliniC Vol 9, No 1 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.9.1.2021.32118

Abstract

Abstract: High prevalence of syphilis can be reduced by doing screening. Tests used for screening and diagnosis of syphilis are serological tests of syphilis consisting of nontreponemal tests and treponemal tests. Nontreponemal tests consist of Rapid Plasma Reagin (RPR) and Venereal Disease Research Laboratory (VDRL) meanwhile Treponemal tests consist of Treponema Pallidum Haemagglutination Assay (TPHA) and Treponema Pallidum Rapid (TP Rapid). This study was aimed to determine the effectiveness of syphilis serological tests. This was a literature review study using the keywords namely serology OR serological OR serologic AND syphilis in PubMed and ClinicalKey. The literatures were written in English and/or Indonesian, published in the last 10 years (2011-2020), and can be accessed in full text. The results obtained 25 literatures. High sensitivity was found in RPR of 9.1%-100%, VDRL of 44.4% -100%, and TP Rapid of 50.0%-100%. High specificity was found in TPHA of 99.7% and TP Rapid of 85.3% -100%. In conclusion, effective syphilis screening is performed with RPR and VDRL, while effective syphilis diagnostic is performed with TP Rapid and TPHA.Keywords: syphilis, serology tests, effectiveness of tests  Abstrak: Prevalensi kasus sifilis yang tinggi dapat diturunkan dengan adanya skrining. Pemeriksaan yang digunakan untuk skrining dan diagnosis sifilis ialah pemeriksaan serologis sifilis, terdiri atas pemeriksaan serologis non spesifik treponema dan pemeriksaan serologis spesifik treponema. Pemeriksaan serologis non spesifik treponema antara lain Rapid Plasma Reagin (RPR) dan Venereal Disease Research Laboratory (VDRL). Pemeriksaan serologis spesifik treponema antara lain Treponema Pallidum Haemagglutination Assay (TPHA) dan Treponema Pallidum Rapid (TP Rapid). Penelitian ini bertujuan untuk mengetahui efektivitas pemeriksaan serologis sifilis. Jenis penelitian ialah literature review menggunakan kata kunci serology OR serological OR serologic AND syphilis di PubMed dan ClinicalKey. Literatur yang digunakan memiliki bahasa Inggris dan/atau bahasa Indonesia, terbitan 10 tahun terakhir (2011-2020), dan dapat diakses teks lengkap. Sensitivitas tinggi ditemukan pada RPR sebesar 9,1%-100%, VDRL sebesar 44,4%-100%, dan TP Rapid sebesar 50,0%-100%. Spesifisitas tinggi ditemukan pada TPHA sebesar 99,7% dan TP Rapid sebesar 85,3%-100%. Simpulan penelitian ini ialah skrining sifilis efektif dilakukan dengan RPR dan VDRL, sedangkan diagnostik sifilis efektif dilakukan dengan TP Rapid dan TPHA.Kata kunci: sifilis, pmeriksaan serologis, efektivitas pemeriksaan
Efektivitas Pengobatan Topikal pada Pitiriasis Versikolor Pusung, Andreas V.; Suling, Pieter L.; Niode, Nurdjannah J.
e-CliniC Vol 9, No 1 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.9.1.2021.32119

Abstract

Abstract: Pityriasis versicolor is a chronic mild superficial fungal infection of the skin due to lipophilic fungi Malassezia. It commonly affects the face, neck, abdomen, proximal extremities, axilla, groin, and genitalia. The occurrence of this disease is not influenced by sex, albeit, age influences its incidence since it is more common in adolescents and young adults.Therefore, an effective, safe, and affordable treatment should be considered. The first-line therapy for pity-riasis versicolor is topical treatment, classified into specific and non-specific antifungal agents. This study was aimed to determine the efficacy of topical treatment in pityriasis versicolor. This was a literature review study using three databases, namely PubMed, ClinicalKey, and Google Scholar and the keywords of "topical treatment AND pityriasis versicolor". The results obtained 10 literatures that fulfilled the inclusion and exclusion criteria. Theseliteratures discussed about the efficacy of topical treatment in patients with pityriasis versicolor based on clinical and mycological cure rate and the highest percentage was more than 80% in each study. In conclusion, topical treatment was effective for pityriasis versicolor.Keywords: topical treatment, pityriasis versicolor Abstrak: Pitiriasis versikolor adalah penyakit jamur superfisial ringan akibat infeksi kulit kronis oleh jamur lipofilik genus Malassezia. Infeksi ini biasanya ditemukan pada wajah, leher, perut, ektremitas proksimal, aksila, lipat paha, dan genitalia. Kejadian penyakit ini tidak dipengaruhi oleh jenis kelamin, tetapi dapat dipengaruhi oleh usia, yaitu lebih banyak terjadi pada remaja dan dewasa muda. Pengobatan topikal merupakan terapi lini pertama untuk pitiriasis versikolor dan dibagi menjadi agen antijamur nonspesifik dan agen antijamur spesifik. Penelitian ini bertujuan untuk mengetahui efektivitas pengobatan topikal pada pitiriasis versikolor. Jenis penelitian ialah literature review dengan pencarian data menggunakan tiga database yaitu PubMed, ClinicalKey, dan Google Scholar. Kata kunci yang digunakan yaitu “topical treatment AND pityriasis versicolor”.Hasil seleksi berdasarkan kriteria inklusi dan eksklusi mendapatkan 10 literatur. Kasjian literatur penelitian menunjukkan efektivitas penggunaan pengobatan topikal pada pitiriasis versikolor berdasarkan penyembuhan klinis maupun penyembuhan mikologis dengan persentase tertinggi mencapai angka >80% pada masing-masing literatur. Simpulan penelitian ini ialah pengobatan topikal pada pitiriasis versikolor terbukti efektif.Kata kunci: pengobatan topikal, pitiriasis versikolor
Profil pitiriasis versikolor di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2013 Isa, Dwi Y.F.; Niode, Nurdjannah J.; Pandaleke, Herry E.J.
e-CliniC Vol 4, No 2 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i2.13042

Abstract

Abstract: Pityriasis versicolor is a chronic superficial fungal disease caused by Malasezzia furfur. Pityriasis versicolor can infect the face, neck, trunk, upper arms, underarms, and groin. Pityriasis versicolor is characterized by scaly patches of fine white or dark, irregular to regular shapes, and clear to diffuse limits. However, pityriasis versicolor is generally asymptomatic, therefore, commonly people do not realize that they are infected by that fungi. This study aimed to determine the profile of pityriasis versicolor at Dermatovenereology clinic of Prof. Dr. R. D. Kandou Hospital from January to December 2013. This was a retrospective descriptive study based on the number of cases, sex, age, occupation, color of lesion, location of lesion, and type of treatment. The results showed that there were 36 cases of pityriasis versicolor, mostly were males (58.3%), age groups 15-24 years and 25-44 years (30.6%), and private workers (27.8 %). Most lesions were hypopigmentation (80.6%), located on the body area and the combination of the face, trunk, and extremities (38.9%). The most commonly prescribed treatment was topical antifungal therapy (77.8%). Keywords: pityriasis versicolor Abstrak: Pitiriasis versikolor merupakan penyakit jamur superfisial kronik yang disebabkan oleh Malasezzia furfur. Pitiriasis versikolor dapat menginfeksi wajah, leher, badan, lengan atas, ketiak, dan lipat paha. Pitiriasis versikolor ditandai dengan adanya bercak-bercak bersisik halus berwarna putih atau gelap, bentuk tidak teratur sampai teratur, dan batas jelas sampai difus. Umumnya gejala pitiriasis versikolor asimtomatik sehingga terkadang penderita tidak menyadari telah terinfeksi penyakit tersebut. Penelitian ini bertujuan untuk mengetahui profil pitiriasis versikolor di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou periode Januari-Desember 2013. Jenis penelitian ini ialah deskriptif retrospektif berdasarkan jumlah kasus, jenis kelamin, umur, pekerjaan, warna lesi, lokasi lesi, dan jenis pengobatan. Hasil penelitian mendapatkan 36 kasus pitiriasis versikolor, terbanyak pada laki-laki (58,3%), kelompok usia 15-24 tahun dan 25-44 tahun (30,6%), dan pekerja swasta (27,8%). Lesi hipopigmentasi paling banyak ditemukan (80,6%) dengan lokasi lesi pada daerah badan dan kombinasi antara wajah, badan, ekstremitas (38,9%). Pengobatan yang paling sering diberikan ialah terapi antijamur topikal (77,8%).Kata kunci: pitiriasis versikolor
PROFIL HERPES ZOSTER DI POLIKLINIK KULIT DAN KELAMIN RSUP PROF. DR. R. D. KANDOU MANADO 2011-2013 Danardono, Dwi H.; Niode, Nurdjannah J.
Jurnal Biomedik : JBM Vol 7, No 3 (2015): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.7.3.2015.9486

Abstract

Abstract: Herpes zoster is a reactivation of varicella zoster virus (VZV) that affects the skin and mucosa. The incidence of herpes zoster increases with age. There are three main goals of treatment: overcoming the acute viral infection, relief from acute pain, and prevention of post-herpetic neuralgia. This study aimed to determine the profile of herpes zoster in the Dermatology Clinic of Prof. Dr. R. D. Kandou General Hospital for three years based on the number of new cases, gender, ages, dermatome locations, and treatment. This was a retrospective study using the medical records of the Dermatology Clinic of Prof. Dr. R. D. Kandou General Hospital during period January 2011- Desember 2013. The results showed that there were 96 (0.84%) herpes zoster patients of 11,367 new patients, consisted of 51 (53.11%) males and 45 (46.87%) females. The most frequent age group was 45-64 years with a number of 59 cases (61.46%). The most frequent dermatome location was on the left thoracic region with a number of 18 cases (18.75%). The most widely prescribed treatment was a combination of antiviral agent, analgesic drugs, roborantia, and topical medicine (powder/antibiotic cream), with a number of 43 cases (44.79%).Keywords: herpes zoster, morbidityAbstrak: Herpes zoster merupakan reaktivasi virus varicella zoster (VZV) yang menyerang kulit dan mukosa. Insiden herpes zoster meningkat seiring dengan bertambahnya usia. Terdapat tiga tujuan utama pengobatan yaitu: mengatasi infeksi virus akut, mengatasi nyeri akut, dan mencegah timbulnya neuralgia pasca-herpetik. Penelitian ini bertujuan untuk mengetahui profil herpes zoster di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado yang meliputi jumlah kasus baru, jenis kelamin, usia, lokasi dermatom, dan terapi. Metode penelitian ialah retrospektif dengan menggunakan catatan medis pasien baru herpes zoster yang berobat di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado selama periode Januari 2011 hingga Desember 2013. Hasil penelitian memperlihatkan terdapat 96 (0,84%) kasus herpes zoster dari 11.367 pasien baru yang terdiri dari 51 (53,11%) laki-laki dan 45 (46,87%) perempuan. Kelompok usia terbanyak ialah 45-64 tahun sejumlah 59 kasus (61,46%). Lokasi dermatom tersering pada regio torakalis sinistra sejumlah 18 kasus (18,75%). Terapi yang paling sering diberikan ialah kombinasi antivirus, analgetik, roboransia, dan pengobatan topikal (bedak/cream antibiotika) sejumlah 43 kasus (44,79%).Kata kunci: herpes zoster, morbiditas
Evaluation of atopic dermatitis severity using artificial intelligence Maulana, Aga; Noviandy, Teuku R.; Suhendra, Rivansyah; Earlia, Nanda; Bulqiah, Mikyal; Idroes, Ghazi M.; Niode, Nurdjannah J.; Sofyan, Hizir; Subianto, Muhammad; Idroes, Rinaldi
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.511

Abstract

Atopic dermatitis is a prevalent and persistent chronic inflammatory skin disorder that poses significant challenges when it comes to accurately assessing its severity. The aim of this study was to evaluate deep learning models for automated atopic dermatitis severity scoring using a dataset of Aceh ethnicity individuals in Indonesia. The dataset of clinical images was collected from 250 patients at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia and labeled by dermatologists as mild, moderate, severe, or none. Five pre-trained convolutional neural networks (CNN) architectures were evaluated: ResNet50, VGGNet19, MobileNetV3, MnasNet, and EfficientNetB0. The evaluation metrics, including accuracy, precision, sensitivity, specificity, and F1-score, were employed to assess the models. Among the models, ResNet50 emerged as the most proficient, demonstrating an accuracy of 89.8%, precision of 90.00%, sensitivity of 89.80%, specificity of 96.60%, and an F1-score of 89.85%. These results highlight the potential of incorporating advanced, data-driven models into the field of dermatology. These models can serve as invaluable tools to assist dermatologists in making early and precise assessments of atopic dermatitis severity and therefore improve patient care and outcomes.
Mechanistic insights into the anticancer, anti-inflammatory, and antioxidant effects of yellowfin tuna collagen peptides using network pharmacology Kairupan, Tara S.; Kapantow, Nova H.; Tallei, Trina E.; Niode, Nurdjannah J.; Sanggelorang, Yulianty; Rotty, Linda WA.; Wungouw, Herlina IS.; Kawengian, Shirley ES.; Fatimawali, Fatimawali; Maulydia, Nur B.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1885

Abstract

Marine-derived collagen peptides have been acknowledged for their therapeutic potential, especially in cancer therapy and inflammation management. The aim of this study was to investigate the molecular mechanisms that contribute to the anticancer, anti-inflammatory and antioxidant properties of yellowfin tuna collagen peptides (YFTCP) utilizing a network pharmacology approach. The YFTCP was extracted from the bones of yellowfin tuna (Thunnus albacares) and subsequently hydrolyzed with trypsin. Seventeen peptides were discovered using liquid chromatography in conjunction with high-resolution mass spectrometry (LC-HRMS). A network pharmacology method was utilized to investigate the interactions between the discovered peptides and their biological targets. Additionally, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to identify pertinent biological pathways involved in the anticancer, antioxidant, and anti-inflammatory effects of these peptides. GO analysis revealed key associations between YFTCP and critical cancer- and inflammation-related genes encoding proteins such as CCND1, SRC, AKT1, IL-1β, TNF, and PPARG, which exhibited significant interactions. These proteins are essential for the regulation of the cell cycle, the development of tumors, and the response to inflammatory stimuli. The KEGG analysis also revealed that YFTCP was involved in a number of critical pathways, such as endocrine resistance, cancer pathways, Kaposi sarcoma-associated herpesvirus infection, proteoglycans in cancer, and human cytomegalovirus infection. These findings highlight the potential use of YFTCP as a multifaceted therapeutic agent, indicating their role in regulating important biological pathways associated with cancer development and inflammation. This study provides new valuable insights into the pharmacological properties of YFTCP, paving the way for future studies and drug development focused on these bioactive peptides.
Vaksin Tungau Debu Rumah: Terobosan Baru untuk Mengatasi Tantangan Dermatitis Atopik Adji, Aryani; Niode, Nurdjannah J.; Wijaya, Lorettha; Putri, Devita
Bahasa Indonesia Vol 23 No 2 (2024): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v23i2.3830

Abstract

Pendahuluan: Dermatitis atopik (DA) adalah penyakit inflamasi kronis yang sering dikaitkan dengan alergen tungau debu rumah (TDR), terutama Dermatophagoides pteronyssinus. Penatalaksanaan saat ini belum memadai untuk memberikan perlindungan jangka panjang. Tujuan: Tinjauan ini bertujuan untuk mengeksplorasi potensi vaksin TDR sebagai terobosan baru dalam pengelolaan DA. Metode: Artikel ini disusun melalui telaah literatur dari jurnal, buku, dan dokumen relevan lainnya yang membahas DA, imunoterapi, dan vaksinasi terkait. Data dianalisis secara komprehensif untuk mendukung kesimpulan. Diskusi: Disfungsi sawar kulit dan respons imun yang dimediasi IgE adalah faktor utama dalam pathogenesis DA. Vaksinasi berbasis epitope TDR menawarkan peluang untuk pencegahan dengan efektivitas tinggi. Studi in sillico menunjukkan hasil menjanjikan, namun validasi lebih lanjut secara in vitro dan in vivo diperlukan. Pengembangan vaksin TDR multi-epitop dapat menjadi alternatif jangka panjang untuk DA. Simpulan: Vaksinasi TDR memiliki potensi besar sebagai strategi pencegahan primer untuk DA, namun penelitian lebih lanjut masih dibutuhkan untuk penerapan klinis.
Co-Authors Adji, Aryani Alson . Sambonu, Alson . Baguna, Tirsa Christina Salaki Dwi H. Danardono, Dwi H. Dwi Y.F. Isa, Dwi Y.F. Earlia, Nanda Fatimawali . Ferra O. Mawu, Ferra O. Grace M. Kapantow Gunawan, Ellen Herry E. J. Pandaleke Herry E.J. Pandaleke, Herry E.J. Herry E.J. Pandeleke, Herry E.J. Hizir Sofyan Idroes, Ghazi M. Jaya, Hendra K. Julian Jonathan, Julian Kairupan, Tara S. Kapantouw, Grace M. Kawengian, Shirley ES. Lorettha Wijaya Maharani, Ayu Mamuaja, Enricco H. Manginstar, Christian O. Marlyn G. Kapantow Marthen C. P. Wongkar, Marthen C. P. Maulana, Aga Maulydia, Nur B. Mellyanawati Mellyanawati Mikyal Bulqiah, Mikyal Muhammad Subianto Nana N. Jayadi, Nana N. Niken Ernaningtyas, Niken Nova Hellen Kapantow Noviandy, Teuku R. Palimbong, Florencia Pandjaitan, Marini C. Pieter L. Suling Preisy G. I. Tampi, Preisy G. I. Pusung, Andreas V. Putri, Devita Rinaldi Idroes Rotty, Linda WA. Siahaan, Romauli E. Silvia Nathalia Stella R. Nelwan Suhendra, Rivansyah Susanti, Ratna I. Thigita A. Pandaleke Trina E. Tallei, Trina E. Tumilaar, Jibrando Wibawa, Anthony S. Wungouw, Herlina IS. Yulianty Sanggelorang