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All Journal e-CliniC JURNAL BIOMEDIK Damianus Journal of Medicine Medical Scope Journal (MSJ) Narra J
Nurdjannah J. Niode
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Dual anti-inflammatory and antimicrobial effects of stingless bee propolis on second-degree burns Manginstar, Christian O.; Tallei, Trina E.; Salaki, Christina L.; Niode, Nurdjannah J.; Jaya, Hendra K.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.2359

Abstract

Propolis, a natural resinous product from stingless bees, is widely recognized for its anti-inflammatory and antimicrobial properties. However, its combined effects in addressing both inflammation and infection in second-degree burns have remained insufficiently explored. The study aimed to investigate the dual role of propolis in modulating inflammation and preventing bacterial infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in a second-degree burn model. Propolis was collected from stingless bees in Gowa, South Sulawesi, Indonesia, and extracted using methanol. Second-degree burns were induced in male Rattus norvegicus, which were then divided into three groups: one treated with propolis, another silver sulfadiazine (positive control), and third with NaCl (negative control). After seven days of treatment, the expression of tumor necrosis factor-alpha (TNF-α) and vascular endothelial growth factor (VEGF) proteins in wound samples was analyzed using immunohistochemistry. The antimicrobial activity of the propolis extract was assessed using the disc diffusion assay, followed by minimum inhibitory concentration (MIC) testing. Network pharmacology analysis was also conducted to assess the anti-inflammatory activity of propolis. Results showed that propolis significantly reduced TNF-α expression and increased VEGF expression, which might enhance VEGF-mediated angiogenesis, leading to improved wound healing compared to controls. The antimicrobial tests demonstrated strong activity against MRSA and P. aeruginosa, with inhibition zones correlating with higher extract concentrations. The MIC value of the propolis extract was 198.66 µg/µL against MRSA and 212.06 µg/µL against P. aeruginosa. Network pharmacology analysis revealed key proteins, including Jun proto-oncogene (JUN), estrogen receptor 1 (ESR1), signal transducer and activator of transcription 3 (STAT3), and proto-oncogene tyrosine-protein kinase Src (SRC), involved in the regulation of TNF-α and VEGF, further supporting the synergistic effects of propolis. This study demonstrates that stingless bee propolis effectively promotes tissue regeneration and prevents infection in second-degree burns, highlighting its potential as an alternative to conventional treatments for wound care.
Pengaruh Pajanan Sinar Matahari terhadap Penuaan Kulit Wajah Berdasarkan Penilaian Skin Analyzer pada Perempuan Minahasa di Sulawesi Utara Kairupan, Tara S.; Kapantow, Marlyn G.; Niode, Nurdjannah J.; Kapantow, Nova H.
Medical Scope Journal Vol. 8 No. 1 (2026): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v8i1.66243

Abstract

Abstract: Sun exposure is considered the predominant extrinsic contributor to skin aging. This was an observational analytical study with a cross-sectional design involving 177 Minahasan women aged 30-69 years residing in Manado City, Tomohon City, and Minahasa Regency, North Sulawesi Province, Indonesia. Participants were categorized into low sun exposure group (≤2 hours per day; n = 82) and high sun exposure group (≥5 hours per day; n = 95), based on the average daily exposure over the past ten years. Demographic data and sun exposure status were obtained through interviews and structured questionnaires. Facial skin aging was assessed using a skin analyzer, evaluating pores, wrinkles, pigmentation, and facial sebum. The results demonstrated that, overall, participants with high sun exposure had higher scores for pores, wrinkles, pigmentation, and U-area sebum than those with low sun exposure (all p<0.001), whereas no significant difference was observed in the T-area sebum (p=0.075). Age-stratified analysis showed consistent differences for wrinkles and U-area sebum across all age groups, while differences in pores and pigmentation were more pronounced in younger age groups. In conclusion, sun exposure contributes to facial skin aging and underscore the importance of photoprotection as a preventive strategy. Keywords: skin aging; skin analyzer; sun exposure    Abstrak: Pajanan sinar matahari merupakan faktor ekstrinsik utama yang berkontribusi pada penuaan kulit. Penelitian ini merupakan studi analitik observasional dengan desain potong lintang yang melibatkan 177 perempuan suku Minahasa berusia 30-69 tahun yang berdomisili di Kota Manado, Kota Tomohon, dan Kabupaten Minahasa, Sulawesi Utara. Subjek dikelompokkan menjadi kelompok pajanan rendah (≤ 2 jam per hari; n = 82) dan kelompok pajanan tinggi (≥ 5 jam per hari; n = 95), berdasarkan rerata pajanan harian selama 10 tahun terakhir. Data demografik dan status pajanan sinar matahari diperoleh melalui wawancara dan kuesioner terstruktur. Penuaan kulit wajah dinilai menggunakan skin analyzer dengan parameter pori, kerutan, pigmentasi, dan sebum wajah. Hasil penelitian menunjukkan bahwa secara keseluruhan, subjek dengan pajanan tinggi sinar matahari memiliki skor pori, kerutan, pigmentasi, dan sebum area-U yang lebih tinggi dibandingkan dengan subjek dengan pajanan rendah (seluruhnya p<0,001), sedangkan pada sebum area-T tidak ditemukan perbedaan yang bermakna (p=0,075). Analisis berdasarkan kelompok usia memperlihatkan bahwa perbedaan pada komponen kerutan dan sebum area-U konsisten ditemukan di semua kelompok usia, sedangkan perbedaan pada komponen pori dan pigmentasi lebih menonjol pada kelompok usia yang lebih muda. Simpulan penelitian ini ialah pajanan sinar matahari berkontribusi terhadap penuaan kulit wajah dan menegaskan pentingnya fotoproteksi sebagai strategi pencegahan. Kata kunci: penuaan kulit; skin analyzer; pajanan sinar matahari
Co-Authors Adji, Aryani Alson . Sambonu, Alson . Baguna, Tirsa Christina Salaki Dwi H. Danardono, Dwi H. Dwi Y.F. Isa, Dwi Y.F. Earlia, Nanda Fatimawali . Ferra O. Mawu, Ferra O. Grace M. Kapantow Gunawan, Ellen Herry E. J. Pandaleke Herry E.J. Pandaleke, Herry E.J. Herry E.J. Pandeleke, Herry E.J. Hizir Sofyan Idroes, Ghazi M. Jaya, Hendra K. Julian Jonathan, Julian Kairupan, Tara S. Kapantouw, Grace M. Kawengian, Shirley ES. Lorettha Wijaya Maharani, Ayu Mamuaja, Enricco H. Manginstar, Christian O. Marlyn G. Kapantow Marthen C. P. Wongkar, Marthen C. P. Maulana, Aga Maulydia, Nur B. Mellyanawati Mellyanawati Mikyal Bulqiah, Mikyal Muhammad Subianto Nana N. Jayadi, Nana N. Niken Ernaningtyas, Niken Nova Hellen Kapantow Noviandy, Teuku R. Palimbong, Florencia Pandjaitan, Marini C. Pieter L. Suling Preisy G. I. Tampi, Preisy G. I. Pusung, Andreas V. Putri, Devita Rinaldi Idroes Rotty, Linda WA. Siahaan, Romauli E. Silvia Nathalia Stella R. Nelwan Suhendra, Rivansyah Susanti, Ratna I. Thigita A. Pandaleke Trina E. Tallei, Trina E. Tumilaar, Jibrando Wibawa, Anthony S. Wungouw, Herlina IS. Yulianty Sanggelorang