Article Per Year (5 Year)
p-Index From 2021 - 2026
0.835
P-Index
This Author published in this journals
All Journal e-NERS e-GIGI e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK Medical Scope Journal (MSJ)
Karel Pandelaki
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 41 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 27 Documents
Search
Journal : e-CliniC

 1   2   3 
HUBUNGAN KADAR HbA1c DENGAN KADAR PROFIL LIPID PADA PASIEN DIABETES MELLITUS TIPE 2 DI POLIKLINIK ENDOKRIN & METABOLIK RSUP PROF. DR. R. D. KANDOU MANADO Loei, Glorya Stevani Cicilia; Pandelaki, Karel; Mandang, Veny
e-CliniC Vol 2, No 1 (2014): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.2.1.2014.3614

Abstract

Abstract: Diabetes mellitus now really been treading worldwide era, and became the world's health problems. The main findings the study of diabetes by the Diabetes Control and Complications Trial (DCCT) has showed the importance of HbA1c. The study showed that reduce unemployment HbA1c can delay or prevent chronic complications. The purpose of this research is to know is there any relationship between HbA1c levels with the levels of lipid profile in type 2 DM patients. The method used in this study is a retrospective observational analytic by approach cross sectional using secondary data. The total sample of 36 patients seeking treatment at the Polyclinic Endocrine and Metabolic RSUP Prof. Dr. R. D. Kandou in Manado the period November 2012 - November 2013. The results of the analysis using Chi Square test shows that there are positive correlation between HbA1c levels with the levels of total cholesterol, LDL, HDL and Triglyceride levels but statistically not significant. Seeing the results, patients with type 2 diabetes have to do with good glycemic control. In order for the complications that occur can be prevented. Keywords: Type 2 Diabetes Mellitus, HbA1c, Lipid Profile    Abstrak: Diabetes mellitus kini benar- benar telah menapaki era kesejagatan, dan menjadi masalah kesehatan dunia. Temuan utama studi diabetes oleh Diabetes Control and Complication Trial (DCCT) telah menunjukan pentingnya tes HbA1c. Studi menunjukan bahwa menurunkan angka HbA1c dapat menunda atau mencegah komplikasi kronik. Tujuan penelitian ini adalah untuk mengetahui adakah hubungan antara kadar HbA1c dengan kadar profil lipid pada pasien DM tipe 2. Metode penelitian yang digunakan bersifat retrospektif observasional analitik dengan pendekatan potong lintang menggunakan data sekunder. Jumlah sampel sebanyak 36 pasien yang berobat di Poliklinik Endokrin dan Metabolik RSUP Prof. Dr. R. D. Kandou Manado periode November 2012 – November 2013. Hasil analisis menggunakan uji Chi Square menunjukan bahwa ada korelasi positif antara kadar HbA1c dengan kadar Kolesterol Total, kadar LDL, kadar HDL dan kadar Trigliserida namun hubungannya tidak signifikan. Melihat hasil yang ada, penderita DM tipe 2 harus melakukan kontrol glikemik dengan baik. Agar komplikasi- komplikasi yang bisa saja terjadi dapat kita cegah. Kata Kunci: Diabetes Mellitus Tipe 2, HbA1c, Profil Lipid
Hubungan antara lingkar pinggang dengan kadar hematokrit pada pria dewasa muda Villarsi, Devinda; Rotty, Linda W.A.; Pandelaki, Karel; Wantania, Frans E.
e-CliniC Vol 4, No 2 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.4.2.2016.14460

Abstract

Abstract: Central obesity plays an important role in the changes of blood circulation that can lead into several chronic diseases. The changes of blood circulation can be detected as earlier as possible by checking the hematocrit levels regularly. This study was aimed to determine the correlation between waist circumference and hematocrit levels in young adult males, This was a descriptive analytical study with a cross sectional design. Respondents were young adult males aged 20-28 years. This study was conducted from October 13 until November 11, 2016. Respondents were 38 young adult males consisting of 27 males with central obesity and 11 males without central obesity. The result of Spearman’s rho analysis of the correlation between waist circumference and hematocrit level resulted in r=0.156 and p=0.350. Conclusion: There was a weak positive correlation between waist circumference and hematocrit levels in young adult males but was not statistically significant.Keywords: central obesity, hematocrit, young adult men. Abstrak: Obesitas sentral berperan penting terhadap terjadinya perubahan aliran darah dalam tubuh manusia yang selanjutnya dapat menimbulkan beberapa penyakit kronik. Perubahan aliran darah dapat dideteksi sedini mungkin dengan melakukan pemeriksaan kadar hematokrit secara teratur. Penelitian ini bertujuan untuk mengetahui hubungan antara lingkar pinggang dengan kadar hematokrit pada laki-laki dewasa muda. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang. Responden penelitian ialah mahasiswa laki-laki berusia 20-28 tahun. Penelitian ini berlangsung dari tanggal 13 Oktober - 11 November 2016 dengan responden berjumlah 38 orang yang terdiri dari 27 mahasiwa obes sentral dan 11 mahasiswa non-obes sental. Hasil analisis uji Spearman’s rho antara lingkar pinggang dengan kadar hemoglobin dari 38 responden diperoleh koefisien korelasi r = 0,134 dengan nilai p = 0,422. Simpulan: Terdapat hubungan positif lemah yang tidak bermakna antara lingkar perut dan hemoglobin. Kata kunci: obesitas sentral, hematokrit, pria dewasa muda
Gambaran hasil produk kalsium dan fosfor pada pasien penyakit ginjal kronik stadium V di Ruang Hemodialisis RSUP Prof. Dr. R. D. Kandou Manado Yauri, Livia F.; Moeis, Emma S.; Pandelaki, Karel
e-CliniC Vol 4, No 2 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i2.14596

Abstract

Abstract: Chronic kidney disease (CKD) is a pathological process with various etiology that causes a progressive reduction in kidney and generally ended with renal failure. In chronic renal failure, there are usually chronic complications such as anemia and bone disease with low level of calcium serum, high level of phosphorus serum, and high paratyroid hormone. This study was aimed to obtain the description of the levels of calcium and phosphorus serum in CKD patients at the hemodialysis unit in Prof. R. D. Kandou Hospital Manado. This was a descriptive study based on patient medical records. Of the 75 patients, the majority of them were males (41 patients; 54.7%), aged > 60 years (27 patients; 36%), and had calcium serum level in normal limit (40 patients; 53.3%) and phosphorus serum level as hyperphosphatemia (61 patients; 81.3%).Keywords: CKD, calcium serum, phosphorus serum, hemodialysis Abstrak: Penyakit ginjal kronik (PGK) adalah suatu proses patofisiologi dengan etiologi beragam yang mengakibatkan penurunan fungsi ginjal secara progresif, dan umumnya berakhir dengan gagal ginjal. Pada gagal ginjal kronik, biasanya terdapat komplikasi kronik meliputi anemia serta penyakit tulang, biasanya dengan kadar kalsium rendah, fosfat tinggi dan hormon paratiroid tinggi. Penelitian ini bertujuan untuk mengetahui gambaran hasil produk kalsium dan fosfat pada pasien penyakit ginjal kronik stadium V di ruang hemodialisis. Jenis penelitian ialah deskriptif dengan menggunakan data rekam medik dan dikelompokkan berdasarkan jenis kelamin, umur, kadar kalsium, dan kadar fosfor serum, hasil produk kalsium dan fosfat. Dari 75 sampel, didapatkan terbanyak ialah pasein berjenis kelamin laki-laki sebanayak 41 orang (54,7%), rentang umur >60 sebanyak 27 orang (36%), dengan kadar kalsium serum normal sebanyak 40 orang (53,3%) dan kadar fosfor serum hiperfosfatemia yaitu 61 orang (81,3%). Kata kunci: penyakit ginjal kronik, hemodialisis, kalsium serum, fosfor serum.
Hubungan antara Literasi Kesehatan dengan Kualitas Hidup pada Penyan-dang Diabetes Melitus Tipe 2 di Rumah Sakit Umum GMIM Pancaran Kasih Manado Pongoh, Lucyana L.; Pandelaki, Karel; Wariki, Windy
e-CliniC Vol 8, No 2 (2020): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.8.2.2020.31495

Abstract

Abstract: People with diabetes mellitus tend to increase especially in low and middle income countries. Health literacy is an important construct in diabetes care, improvement of quality of life (QoL), and decrease of complications. This study was aimed to analyze the relationship between health literacy and QoL among people with type 2 diabetes mellitus (T2DM) at Gereja Masehi Injili di Minahasa (GMIM) Pancaran Kasih Hospital Manado. This was a descriptive and correlational analytical study with a cross sectional design. The population in this study were all T2DM patients who came for treatment at the Internal Medicine Polyclinic of the GMIM Pancaran Kasih Hospital in the period of November 2019 to February 2020. There were 132 patients as samples in this study. Data were carried out by using the HLS-EU-Q16 and QoL questionnaires, and were analyzed by using the Chi Square test with a significance level of p=0.05. The results showed that of health literacy variable, all respondents (100%) were easy in terms of literacy, meanwhile of QoL variable, 75.0% of respondents had good QoL. Moreover, the relationship between health literacy and QoL had a p value of 0.000. In conclusion, there was a significant relationship between health literacy and the QoL of people with T2DM at the GMIM Pancaran Kasih Hospital Manado.Keywords: literacy, quality of life, people with DM  Abstrak: Penyandang diabetes melitus (DM) di seluruh dunia cenderung meningkat terutama di negara berpenghasilan rendah dan menengah. Literasi kesehatan merupakan konstruksi penting dalam perawatan diabetes, peningkatan kualitas hidup, dan pengurangan komplikasi. Penelitian ini bertujuan untuk menganalisis hubungan literasi kesehatan dengan kualitas hidup penyandang diabetes melitus tipe 2 (DMT2) di RSU Gereja Masehi Injili di Minahasa (GMIM) Pancaran Kasih Manado. Jenis penelitian ialah deskriptif analitik korelasional dengan desain potong lintang. Populasi penelitian ialah seluruh pasien DMT2 yang berobat di Poliklinik Penyakit Dalam RSU GMIM Pancaran Kasih Manado pada periode bulan November 2019 sampai Februari 2020. Jumlah sampel penelitian ialah 132 pasien. Pengumpulan data dilakukan menggunakan kuesioner HLS-EU-Q16 dan Quality of Life. Analisis data penelitian menggunakan uji Chi Square dengan tingkat signifikansi p=0,05. Hasil penelitian menunjukkan bahwa untuk variabel literasi kesehatan, seluruh responden (100%) mudah dalam hal literasi dan untuk kualitas hidup, 75,0% responden memiliki kualitas hidup yang baik. Selain itu, hubungan literasi kesehatan dengan kualitas hidup mendapatkan p=0,000. Simpulan penelitian ini ialah terdapat hubungan bermakna antara literasi kesehatan dengan kualitas hidup penyandang DMT2 di RSU GMIM Pancaran Kasih Manado,Kata kunci: literasi, kualitas hidup, penyandang DM 
Hubungan antara hs-CRP, Adiponektin, Fetuin A terhadap Resistensi Insulin pada Pria Dewasa Muda dengan Obesitas Sentral Amudi, Tulus; Pandelaki, Karel; Palar, Stella
e-CliniC Vol 9, No 1 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.9.1.2021.32476

Abstract

Abstract: Obesity has quite a lot of risk factors for the incidence of metabolic diseases such as insulin resistance, diabetes mellitus, dyslipidemia, and metabolic syndrome. The accumulation of adipocytes causes the formation of chronic inflammatory mediators, and disrupts adipokine derived from adipocytes. These inflammatory mediators cause hepatocytes to secrete several types of proteins such as C-reactive protein and fetuin A into the blood circulation that are thought to cause insulin resistance in obesity cases. This study was aimed to determine the relationship among levels of hs-CRP, adiponectin, and fetuin A, and insulin resistance in adult male subjects with central obesity. This was an observational study with a cross sectional design. Subjects were young adult males with central obesity at Prof. Dr. R. D. Kandou Hospital, Manado. The results showed that 30 subjects had a mean hs-CRP level of 0.18 mg/dL (±0.16) which was higher than normal value. There was a positive and significant correlation between hs-CRP and HOMA-IR (r=0.380, p<0.023). There was a negative and insignificant correlation between adiponectin and Homa IR (r =-0.278, p=0.136), and there was no significant correlation between fetuin A and HOMA IR (r -0.048, p=0.801). In conclusion, among young adult males with central obesity there was an increase in hs-CRP level above normal value and there was a significant relationship between increased hs-CRP and insulin resistanceKeywords: fetuin-A, high sensitive C-reactive protein, adiponectin, HOMA-IR, central obesity Abstrak: Obesitas memiliki faktor risiko yang cukup banyak terhadap kejadian penyakit metabolik seperti resistensi insulin, diabetes melitus, dislipidemia, dan sindrom metabolik. Akumulasi adiposit menyebabkan terbentuknya mediator inflamasi kronik sehingga sintesis adipokin oleh adiposit terganggu. Mediator inflamasi tersebut juga menyebabkan hepatosit menyekresi beberapa jenis protein seperti C-reaktif protein dan fetuin A ke dalam sirkulasi darah yang diduga meyebabkan resistensi insulin pada kasus obesitas. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar hs-CRP, adiponektin, dan fetuin A dengan resistensi insulin pada subjek pria dewasa dengan obesitas sentral. Jenis penelitian ialah observasional dengan desain potong lintang. Subyek penelitian ialah pria dewasa muda dengan obesitas sentral di RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian mendapatkan 30 subyek dengan rerata kadar hs-CRP 0,18 mg/dl (±0,16) lebih tinggi dari nilai normal. Terdapat hubungan korelasi positif dan bermakna antara hs-CRP dan HOMA-IR (r=0,380, p<0,023); hubungan korelasi negatif dan tidak bermakna antara adiponektin dan Homa IR (r=-0,278, p=0,136); tidak didapatkan hubungan bermakna antara Fetuin A dengan HOMA IR (r=-0.048 dan p=0,801). Simpulan penelitian ini ialah pada pria dewasa muda dengan obesitas sentral terdapat peningkatan kadar hs-CRP melebihi nilai normal dan terdapat hubungan bermakna antara peningkatan hs-CRP dengan resistensi insulin.Kata kunci: fetuin-A, high sensitive C-reactive protein, adiponectin, HOMA-IR, obesitas sentral
Gaya Hidup sebagai Faktor Risiko Diabetes Melitus Tipe 2 Murtiningsih, Made K.; Pandelaki, Karel; Sedli, Bisuk P.
e-CliniC Vol 9, No 2 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v9i2.32852

Abstract

Abstract: Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by insulin resistance and beta cell dysfunction. It is ranked as the seventh of top 10 causes of death worldwide, and the highest prevalence of cases is T2DM. The dominant lifestyle that triggers T2DM is diet and physical inactivity. This study was aimed to determine whether lifestyle was a risk factor of T2DM. This was a literature review study using two databases, namely Pubmed and Google Scholar. The keywords used were "lifestyle risk factors and type 2 diabetes mellitus". There were 10 literatures obtained based on inclusion and exclusion criteria. The results showed that lifestyle such as unhealthy eating pattern and less physical activity significantly influence the risk factors of T2DM. In conclusion, lifestyles such as unhealthy foods and less physical activity are at high risk of suffering from T2DM.Keywords: risk factors, lifestyle, type 2 diabetes mellitus (T2DM)  Abstrak: Diabetes melitus tipe 2 (DMT2) merupakan penyakit metabolisme yang disebabkan karena resistensi insulin dan disfungsi sel beta pankreas. DM berada diperingkat ke tujuh sebagai 10 penyakit penyebab kematian di dunia, denganDMT2 sebagai prevalensi kasus tertinggi. Pola hidup yang dominan menjadi pencetus DMT2 ialah pola makan dan aktivitas fisik. Penelitian ini bertujuan untuk mengetahui gaya hidup sebagai faktor risiko DMT2. Jenis penelitian ialah literature review. Pencarian data menggunakan dua database yaitu Pubmed dan Google Scholar. Dengan kata kunci yaitu “faktor risiko gaya hidup dan diabetes melitus tipe 2”. Setelah diseleksi, didapatkan 10 literatur berdasarkan kriteria inklusi dan eksklusi. Hasil penelitian mendapatkan bahwa gaya hidup seperti pola makan yang tidak sehat dan pola aktivitas fisik kurang secara bermakna berpengaruh terhadap terjadinya faktor risiko DMT2. Simpulan penelitian ini ialah gaya hidup dengan mengonsumsi makanan tidak sehat dan aktivitas fisik yang kurang memiliki risiko tinggi mengalami DMT2.Kata kunci: faktor risiko, gaya hidup, diabetes melitus tipe 2 (DMT2)
Hubungan Kadar Vitamin D dan Kadar C-Reactive Protein dengan Klinis Pasien Coronavirus Disease 2019 Berhandus, Catrien; Ongkowijaya, Jeffrey A.; Pandelaki, Karel
e-CliniC Vol 9, No 2 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v9i2.33043

Abstract

Abstract: COVID-19 patients could experience many respiratory symptoms accompanied with increased inflammatory markers, such as C-reactive protein (CRP). Vitamin D is known to have a positive effect on immune system by decreasing inflammatory process. This study was aimed to evaluate the relationship between vitamin D and CRP concentration and clinical severity, and the correlation between vitamin D concentration and CRP concentration in COVID-19 patients. This was an observational and analytical study with a cross-sectional design conducted at Prof. dr. R. D. Kandou hospital. A total of 40 subjects with COVID-19 were included. Clinical severity was classified into moderate and severe. All subjects underwent vitamin D and CRP concentration examination. The results showed that there was a significant relationship between vitamin D level and clinical severity of patients with COVID-19 (p=0.0001). There was a significant relationship between CRP level and clinical severity of patients with COVID-19 (p=0.0001). Moreover, there was a negative correlation between vitamin D concentration and CRP concentration (r=-0.49, p=0.001). In conclusion, vitamin D insufficiency or deficiency is related to CRP increament and clinical severity of patients with COVID-19.Keywords: coronavirus disease 2019, vitamin D, C-reactive protein (CRP), clinical severityAbstrak: Penderita COVID-19 mengalami berbagai gejala pernapasan disertai dengan pening-katan beberapa penanda inflamasi, salah satunya C-reactive protein (CRP). Vitamin D diketahui memiliki efek positif terhadap sistem imun tubuh dengan cara meredam proses inflamasi berlebihan. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara kadar vitamin D dan kadar CRP dengan klinis COVID-19, dan korelasi antara kadar vitamin D dengan kadar CRP. Jenis penelitian ini ialah studi analitik observasional dengan desain potong lintang yang dilakukan di RSUP Prof. dr. R. D. Kandou. Total sampel sebanyak 40 pasien dengan diagnosis COVID-19. Gejala klinis pasien dibagi menjadi sedang dan berat. Pemeriksaan kadar vitamin D dan kadar CRP dilakukan pada seluruh sampel. Hasil penelitian mendapatkan hubungan bermakna antara kadar vitamin D dengan klinis pasien COVID-19 (p=0,0001), dan antara kadar CRP dengan klinis pasien COVID-19 (p=0,0001). Terdapat korelasi negatif antara kadar vitamin D dengan kadar CRP (r=-0,49, p=0,001). Simpulan penelitian ini ialah insufisiensi atau defisiensi vitamin D berhubungan dengan peningkatan CRP dan klinis pasien COVID-19.Kata kunci: coronavirus disease 2019, vitamin D, C-reactive protein (CRP), gejala klinis
Co-Authors Abda Abda Agens L. Panda Agustinus Rihando Rumbino Amudi, Tulus Arthur E. Mongan Aurelia S. R. Supit Berhandus, Catrien Bradley J. Waleleng Cerelia Sugeng Christianto A. Y Lumingkewas Christy Mintjelungan Christy N. Mintjelungan Daniel Ruscianto, Daniel Dwi A. Primadana, Dwi A. Dwi P. Palimbunga Emma S. Moeis, Emma S. Emma Sy. Moeis Enjalita Karujan Erwin Pangkahila Ezra G. R. Tambunan, Ezra G. R. Firginia Manoppo Frans E. N. Wantania, Frans E. N. Frans E. Wantania Frans Wantania Glorya Stevani Cicilia Loei Harlinda Haroen Irene Moudy Sumayku Kekenusa, Gita C. Kirojan, Debora Linda W. A Rotty Linda W. A. Rotty Lucyana Leonita Pongoh M. C. P. Wongkar M. C.P Wongkar Maria Simatupang Marthen C.P. Wongkar, Marthen C.P. Meggy R. Kowaas Meibie M Taghulihi Mentari Simbar Monica L. Meloh Murtiningsih, Made K. Nadyah Awad Ni Wayan Mariati Olyvia Octaviany Monoarfa Ongkowijaya, Jeffrey A. Ongkowijaya, Jeffry Patulak, Fitriyanti Pradika H. Koampa, Pradika H. Reginald L. Lefrandt Renata, Lucrezia Rivelino Hamel Rivelino S. Hamel Rixi Gahung, Rixi Rizkia Irianti Rotty, Linda W.A. Salsabila, Tasha Saraswati, Talitha D. Sarjono, Lillian Satriyani . Sedli, Bisuk P. Siti Chodijah Stella Palar Stephanie F. Emor Sumakul, Ridhel G. Tuegeh Destyana Veny Mandang Villarsi, Devinda Wariki, Windy M. V. Wongkar, Maarthen C.P. Wowor, Kartika Yauri, Livia F. Yohanes I Gede K.K Yuanita A. Langi Yuanita Langi