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All Journal e-NERS e-GIGI e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK Medical Scope Journal (MSJ)
Karel Pandelaki
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : JURNAL BIOMEDIK

 1 
HIPERTIROID PADA KEHAMILAN MOLA HIDATIDOSA Pangkahila, Erwin; Pandelaki, Karel
Jurnal Biomedik : JBM Vol 1, No 2 (2009): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.1.2.2009.826

Abstract

Abstract: We reported a suspected pregnancy associated with 2-month-vaginal bleeding in a 42-year-old female. She was diagnosed with hyperthyroidism associated with mola hydatidosa. The diagnosis of hyperthyroidism was based on anamnesis, and physical, labo-ratory, and radiological examinations. We found palpitation, weakness, loss of weight, much sweating, tachicardia, and some enlargement of the thyroid glands. The laboratory examina-tion  showed an increase of hCG and free T4, in addition to a decrease of TSHs. In the USG examination we found a snow-like pattern. The histopathological examination showed avas-cularization with hydrophic degeneration of the villi,  and cysterna formation, all of which concluded that it was a mola hydatidosa pregnancy. The patient was treated with PTU 100 mg and propanolol 10 mg three times daily for the hyperthyroidism, and a total hysterectomy operation for the mola hydatidosa pregnancy. Prognosis of the patient was dubious. Key words: hyperthyroid, mola hydatidosa, hCG, FT4, TSHs.     Abstrak: Telah dilaporkan seorang perempuan umur 42 tahun dengan dugaan kehamilan dan mengalami perdarahan  jalan lahir sejak dua bulan lalu, yang kemudian didiagnosis dengan hipertiroid pada mola hidatidosa. Diagnosis hipertiroid pada kehamilan mola hidatidosa dite-gakkan berdasarkan anamnesa, pemeriksaan fisik, laboratorium dan radiologi. Ditemukan ge-jala jantung berdebar, kelemahan badan, penurunan berat badan dan berkeringat banyak, serta tanda takikardi dan pembesaran ringan kelenjar tiroid.  Pemeriksaan laboratorium terdapat pe-ningkatan kadar hCG dan  T4 bebas serta penurunan kadar TSHs. Pemeriksaan USG tampak gambaran snow-like pattern dan histopatologi terdapat vili yang alami degenerasi hidropik, avaskuler dengan pembentukan sisterna yang menyimpulkan suatu kehamilan mola hidati-dosa. Pengobatan dengan pemberian PTU 100 mg dan propanolol 10 mg, kedua-duanya  tiga kali sehari untuk penanganan hipertiroid, serta dilakukan tindakan operasi histerektomi totalis untuk penanganan kehamilan mola hidatidosanya. Prognosis penderita adalah dubia. Kata kunci: hipertiroid, mola hidatidosa, hCG, FT4, TSHs.
ADIPONECTIN AND TUMOR NECROSIS FACTOR ALPHA LEVELS, AND THEIR CORRELATIONS WITH ENDOTHELIAL DYSFUNCTION IN CENTRAL OBESITY Wantania, Frans; Lefrandt, Reginald L.; Pandelaki, Karel
Jurnal Biomedik : JBM Vol 3, No 3 (2011): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.3.3.2011.876

Abstract

Abstract: Background: In obesity, macrophages that infiltrate into adipose tissues create an inflammatory condition.  Besides that, adipose tissues release proinflammatory cytokines such as TNF alpha. These cytokines promote LDL oxydation by ROS, and accelerate NO degradation resulting in endothelial dysfunction. Adiponectin which could prevent endothelial dysfunction is decreased secondarily to TNF alpha’s action. Objectives: To determine the serum levels of TNF alpha and adiponectin, and their correlations with the endothelial dysfunction. Methods: This was an observational, descriptive, and analytic study with cross sectional. Samples were students of senior high schools in Manado.  Sampling method was carried out consecutively until the required number was enough. Data consisted of age, blood pressure, waist circumference, body weight, lipid profile, creatinin, TNF alpha, adiponectin, and albumin creatinine ratio. We used the Spearman Correlation to analyze the data. Result: Over a 4-month period, there were 35 obese male subjects with ages of 16-18 years old. The average of body weights was 83.23 kg, and of waist circumferences was 103.94 cm.  Endothelial dysfunction was found in 5.72% of samples, high levels of TNF alpha in 68.57% of samples, and low levels of adiponectin in 62.8% of samples.  We found a significant positive correlation between TNF alpha and endothelial dysfunction (r=0.554, p<0.000), and an inverse correlation between adiponectin level and endothelial dysfunction (r = -0.349, p=0.020). Conclusion: There were high levels of TNF alpha in 68.57% of samples and low levels of adiponectin in 62.86% of samples. There was a significant correlation between TNF alpha level and endothelial dysfunction. There was an inverse correlation between adiponectin level and endothelial dysfunction. Key words: obesity, adiponectin TNF alpha, endothelial dysfunction.
Co-Authors Abda Abda Agens L. Panda Agustinus Rihando Rumbino Amudi, Tulus Arthur E. Mongan Aurelia S. R. Supit Berhandus, Catrien Bradley J. Waleleng Cerelia Sugeng Christianto A. Y Lumingkewas Christy Mintjelungan Christy N. Mintjelungan Daniel Ruscianto, Daniel Dwi A. Primadana, Dwi A. Dwi P. Palimbunga Emma S. Moeis, Emma S. Emma Sy. Moeis Enjalita Karujan Erwin Pangkahila Ezra G. R. Tambunan, Ezra G. R. Firginia Manoppo Frans E. N. Wantania, Frans E. N. Frans E. Wantania Frans Wantania Glorya Stevani Cicilia Loei Harlinda Haroen Irene Moudy Sumayku Kekenusa, Gita C. Kirojan, Debora Linda W. A Rotty Linda W. A. Rotty Lucyana Leonita Pongoh M. C. P. Wongkar M. C.P Wongkar Maria Simatupang Marthen C.P. Wongkar, Marthen C.P. Meggy R. Kowaas Meibie M Taghulihi Mentari Simbar Monica L. Meloh Murtiningsih, Made K. Nadyah Awad Ni Wayan Mariati Olyvia Octaviany Monoarfa Ongkowijaya, Jeffrey A. Ongkowijaya, Jeffry Patulak, Fitriyanti Pradika H. Koampa, Pradika H. Reginald L. Lefrandt Renata, Lucrezia Rivelino Hamel Rivelino S. Hamel Rixi Gahung, Rixi Rizkia Irianti Rotty, Linda W.A. Salsabila, Tasha Saraswati, Talitha D. Sarjono, Lillian Satriyani . Sedli, Bisuk P. Siti Chodijah Stella Palar Stephanie F. Emor Sumakul, Ridhel G. Tuegeh Destyana Veny Mandang Villarsi, Devinda Wariki, Windy M. V. Wongkar, Maarthen C.P. Wowor, Kartika Yauri, Livia F. Yohanes I Gede K.K Yuanita A. Langi Yuanita Langi