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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Majalah Kesehatan FKUB Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) ISM (Intisari Sains Medis) : Jurnal Kedokteran Heart Science Journal Asian Journal of Health Research
Nugrahanti Prasetyorini
Laboaratorium Obstetri Ginekologi Fakultas Kedokteran Universitas Brawijaya/ RS. Dr. Saiful Anwar
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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JUMLAH SEL TROFOBLAS YANG MENGALAMI APOPTOSIS PADA PRE EKLAMPSIA/EKLAMPSIA LEBIH TINGGI DIBANDINGKAN KEHAMILAN NORMAL Keman, Kusnarman; Prasetyorini, Nugrahanti; Langgar, Madeline J.
Jurnal Kedokteran Brawijaya Vol 24, No 2 (2008)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1335.644 KB) | DOI: 10.21776/ub.jkb.2008.024.02.8

Abstract

Hypoxia exposed trophoblast cells will cause apoptotic process, that correlate with up-regulation of p53 and Bax protein expression; and down-regulation of anti-apoptotic Bcl-2 protein. Apoptotic process and up-regulation of p52, and down-regulation of anti-apoptotic Bcl-2; also find both on trophoblastic samplefrom preeclampsia/ eclampsia complicated pregnancy, and  normal pregnancy. The aim of this study is, to prove that the amount of apoptotic trophoblast cells on trophoblast tissue sample from preeclampsia/ ecclampsia complicated pregnancy, were higher then those of normal pregnancy. This research was laboratory cross sectional study, that observed immunohystochemically, p53 and BCl-2 protein expression; also the DNA-fragmented technically (TUNEL) to detect apoptotic  cells on trophoblastic samples from preeclampsia/ eclampsia complicated pregnancy, compare by the normal pregnancy. On this study, we found that the amount of trophoblast cells that expressed of p53 protein (22.70 ± 2.90), were higher then those of normal pregnancy. (8.2 ± 4.99). The different was statistically significant. (t test; p  ≤0.000). We also found that an apoptotic process on trophoblast cells of preeclampsia/ eclampsia placenta (15.3 ± 3,56) were higher  then those of normal pregnancy (4.7 ± 1.89). The different was statistically significant. (t test; p ≤0.000).
EVALUASI IN VITRO AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN SELADA AIR (Nasturtium officinale) TERHADAP BAKTERI METHICILLIN-RESISTANT Staphylococcus aureus Insanitaqwa, Aleyda Zahratunany; AS, Noorhamdani; Prasetyorini, Nugrahanti
Majalah Kesehatan FKUB Vol 8, No 3 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.03.2

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) adalah bakteri patogen penyebab infeksi nosokomial yang dapat menyerang beberapa sistem organ dan bersifat resisten terhadap beberapa antibiotik beta laktam seperti penisilin, sepalosporin, dan karbapenem. Prevalensi infeksi Staphylococcus aureus terus meningkat seiring dengan banyaknya prevalensi infeksi nosokomial dan meningkatnya tingkat resistensi Staphylococcus aureus terhadap beberapa antimikroba sehingga dibutuhkan suatu alternatif terapi yang dapat menggantikan atau meningkatkan efektivitas kerja antibakteri yang sudah ada. Ekstrak etanol daun selada air mengandung flavonoid, tannin, saponin, dan steroid yang dapat berperan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri pada ekstrak etanol daun selada air (Nasturtium officinale) terhadap MRSA secara in vitro. Rancangan penelitian yang digunakan adalah experimental post test only control group design dengan metode uji aktivitas antibakteri difusi sumuran. Ekstrak etanol daun selada air yang digunakan yaitu ekstrak dengan konsentrasi 30%, 60%, 75%, 90%, 100%, dan 0% sebagai kontrol negatif dengan pengulangan sebanyak empat kali. Hasil penelitian menunjukkan perbedaan yang signifikan (p = 0,000) dengan diameter zona hambat terbesar dicapai pada aplikasi konsentrasi ekstrak 100% yaitu 9,88±0,27 mm, diikuti dengan konsentrasi ekstrak 90% sebesar  8,97±0,21 mm, konsentrasi ekstrak 75% sebesar 7,90±0,61 mm,  konsentrasi ekstrak 60% sebesar 7,19±0,13 mm, dan konsentrasi ekstrak 30% sebesar 6,16±0,12 mm. Oleh karena itu, dapat disimpulkan bahwa ekstrak etanol daun selada air memiliki aktivitas antibakteri terhadap MRSA secara in vitro.  
Risk of Malignancy Index 4 (RMI4) and Risk of Malignancy Index 3 (RMI3) as Diagnostic Tests for Adnexal Tumor: Risk of Malignancy Index 4 (RMI4) dan Risk of Malignancy Index 3 (RMI3) sebagai Alat Diagnostik untuk Tumor Adneksa Tatit Nurseta; Yahya Irwanto; Nugrahanti Prasetyorini; Bambang Rahardjo; I Wayan Subage
Indonesian Journal of Obstetrics and Gynecology Volume 8 No. 4 October 2020
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v8i4.1342

Abstract

Objective: Comparing scoring with RMI3 and RMI4 in establishing the diagnosis of adnexal tumour in RSUD Dr. Saiful Anwar Malang.Methods: Prospective cohort study with samples of all patients suspected of having an adnexal tumour diagnosed in gynecology policlinic using gynecological oncology policlinic medical records at RSUD Dr. Saiful Anwar in the form of age, demographics, menopause status, Ca125, ultrasound results.Results: Between the RMI3 results and the results of histopathology, a contingency coeffi cient of 0.596 was obtained with a p-value of 0.000015 (p <0.05), with a PPV of 83%, an NPV of 91%. Between the RMI4 results and the histopathology results, a contingency coeffi cient of 0.657 with a p-value of 0.0000004 (p <0.05) was obtained, with a PPV of 92%, NPV of 95%. On the ROC curve, the area of the predicted results using the RMI4 score is higher than the RMI3 score.Conclusions: Using the RMI4 score results in more accurate predictions than the RMI3 score in detecting adnexal tumour malignancies.Keywords: adnexal tumours, diagnostic tests, ovarian tumours, risk of malignancy index, ultrasound. Abstrak Tujuan: Membandingkan Skoring RMI3 dan RMI4 dalam menegakkan diagnosis tumor adneksa di RSUD dr. Saiful Anwar Malang.Metode: penelitian kohort prospective dengan sampel semua pasien yang dicurigai menderita tumor adneksa yang didiagnosis di poli Ginekologi menggunakan data rekam medis poli Ginekologi Onkologi RSUD dr. Saiful Anwar berupa usia, demografi , status menopause, Ca125, hasil USG.Hasil: Antara hasil RMI3 dengan hasil hispatologi, didapatkan koefi sien kontingensi sebesar 0,596 dengan p-value 0,000015 (p<0,05), dengan PPV 83%, NPV 91%. Antara hasil RMI4 dengan hasil histopatologi, didapatkan koefisien kontingensi sebesar 0,657 dengan p-value 0,0000004 (p<0,05), dengan PPV 92%, NPV 95%. Pada kurva ROC, luas area hasil prediksi dengan menggunakan skor RMI4 lebih tinggi daripada skor RMI3.Kesimpulan: Menggunakan skor RMI4 menghasilkan prediksi yang lebih tepat daripada skor RMI3 dalam mendeteksi keganasan tumor adneksa.Kata kunci: risk of malignancy index, tumor adneksa, tumor ovarium, uji diagnostik, USG.
Efektivitas multi drug therapy pada transmisi morbus hansen transplasental Dhelya Widasmara; Santosa Basuki; Dea Florensia; Ade Setyagraha; Nugrahanti Prasetyorini
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (420.566 KB) | DOI: 10.15562/ism.v11i2.713

Abstract

Introduction: The evidence of transplancental transmission of Morbus Hansen (MH) in animal models is a challenge for MH treatment in pregnancy because it brings anxiety for patients and their fetuses. Case: A 31-year-old pregnant woman, first trimester, came with complaints of reddish numbness rash on her hands since 2 years ago. Dermatological examination showed erythematous plaque, multiple, well-defined, irregular borders with hypoaesthesia. There were right and left ulnar nerve enlargement. Acid Fast Bacteria (AFB) from ear lobes and lesion revealed Bacterial Index +2 and Morphological Index 10%. Histopathological examination showed gren zone which indicate MH type BL. Patient was diagnosed with MH Multi Basiler (MB) on G3P2002Ab000 and given MDT MHMB. Postpartum IgM and IgG anti-PGL-1 examination of cord blood and infant blood, also PCR examination of cord blood and amnion showed negative results. Histopathological examination found no AFB on the umbilical cord and placenta. Conclusion: MDT is effective in preventing transplacental transmission of MH from mother to fetus.
In Vivo Studies Exploring the Impact of IUGR in Rat Models on Offspring Malnutrition: A Systematic Review Sukandar, Umar Gunarsa; Prasetyorini, Nugrahanti
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.194

Abstract

Introduction: Intrauterine growth restriction (IUGR), stemming from inadequate fetal nutrition due to maternal or placental factors, affects 10–15% of pregnancies worldwide. Animal models reflect human IUGR, showing malnutrition-associated outcomes like impaired growth, reduced body weight, delayed puberty, and disruptions in genetic and hormonal processes. Despite extensive research, gaps persist in understanding how IUGR impacts fetal outcomes, particularly regarding malnutrition-related outcomes. Material and Methods: The literature search was conducted in four databases. Several outcomes were analyzed, including the timing of puberty, weight and body composition, and organ development, which represented the IUGR rat's malnutrition condition. Throughout the identification process, 11 articles were included in the systematic review. Results: Research consistently demonstrates that IUGR in rat models results in delayed puberty, characterized by delayed vaginal opening and lower body weights compared to controls across early and later developmental stages. Additionally, IUGR adversely affects organ development, with studies showing reduced brain weights, diminished ovarian and mammary gland development, and altered sizes of reproductive organs. Furthermore, IUGR disrupts hormonal and genetic profiles, as evidenced by changes in ovarian follicle counts, altered gene expressions related to testicular development, and dysregulated metabolic pathways. All malnutrition-related outcomes significantly differed between IUGR and control rats (p < 0.05). Conclusion: IUGR in rat models consistently induces developmental delays and physiological impairments in offspring, characterized by delayed puberty, reduced body weights, and compromised organ development, highlighting the adverse consequences of malnutrition associated with IUGR.
Effect of Curcumin on Nitric Oxide and Endothelin-1 Levels in L-NAME-Induced Preeclamptic Wistar Rat Rahardjo, Bambang; Dewi, Ratih Frastika; Wiyasa, I Wayan Arsana; Handayani, Puspita; Prasetyorini, Nugrahanti; Wibisono, Hermawan
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3700

Abstract

Preeclampsia is a pregnancy disorder marked by the onset of hypertension after the 20th week, posing risks such as cardiovascular disease. Curcumin, a commonly consumed herbal medicine, has been investigated as a potential antihypertensive agent in mouse models of preeclampsia. This study took place in the Bioscience Laboratory of Universitas Brawijaya from March to August 2023, employing a true experimental design with various groups of mice receiving different treatments. Nitric oxide (NO) and endothelin-1 (ET-1) levels were measured using calorimetry and ELISA. The rats were divided into five groups: positive control, negative control and P1, P2, and P3 as the treatment groups. Treatment grups received fifferent curcumin doses of 30mg/kgBW/day, 50mg/kgBW/day, and 100mg/kgBW/day for P1, P2, and P3, respectively. Data analysis using the One-Way ANOVA and Post Hoc LSD revealed that curcumin at 100mg/kgBW/day significantly increased the NO level of 47.75±22.6 and decreased the ET-1 level of 67.03±24.47 when compared to the positive control (p<0.05). However, the 30mg/kgBW/day and 50mg/kgBW/day doses did not significantly affect the NO and ET levels. In conclusion, curcumin supplementation shows positive effects on NO and ET-1 levels in L-NAME-induced preeclamptic Wistar rats, highlighting its potential as an effective intervention for managing this pregnancy-related disorder.
Pregnancy with Bidirectional Dominant Left-To-Right Shunt due to Ventricular Septal Defect and Large Secundum Atrial Septal Defect with Left-To-Right Shunt: A Case Report Destikatari, Lovin; Prasetyorini, Nugrahanti; Putri, Valerinna Yogibuana Swastika
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.218

Abstract

Introduction: Congenital heart disease (CHD) is the most common birth defect in humans, affecting approximately 0.8% of all live births. The spectrum of defects is broad, ranging from complex defects that lead to severe disability and death in infancy, to mild defects that may only be discovered later in asymptomatic adults. Case Presentation: This case report discusses a 21-year-old female in her second pregnancy was diagnosed with complex congenital heart disease after presenting with shortness of breath. Pulmonary hypertension was established by echocardiography. The woman did not obtain proper therapy since she was not aware of her cardiac problem during her pregnancy. There were no fetal abnormalities found during prenatal exams. At 38 weeks gestation, an IUD-assisted cesarean surgery was scheduled. While a cesarean section is performed on individuals with certain problems, the majority of CHD cases may be successfully delivered vaginally. Another crucial factor to take into account is the choice of postpartum contraception. Conclusion: A personalized strategy is needed to manage congenital heart disease throughout pregnancy. This includes risk education, careful observation, and modification of interventions to guarantee the best possible results for both mother and child.
Elevated Blood Pressure in Rat Offspring with Induced Intrauterine Growth Restriction: A Systematic Review Patridina, Geneung; Prasetyorini, Nugrahanti
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.244

Abstract

Introduction: Intrauterine growth restriction (IUGR), often caused by placental insufficiency, is a significant obstetric issue associated with adverse long-term health outcomes, including hypertension. This systematic review investigates the association between induced IUGR and elevated blood pressure in rat offspring.    Material and Methods: A systematic search of PubMed, SpringerLink, and the Cochrane Library was conducted on February 10, 2023, following PRISMA guidelines. Studies were included if they involved rat models of placental insufficiency-induced IUGR with documented birth weight reduction and blood pressure measurements compared to a control group. Data were extracted for meta-analysis using Review Manager 5.    Results: Eight studies met the inclusion criteria. Meta-analysis revealed a significant increase in both mean arterial pressure (MAP) (Mean Difference: 9.84, 95% CI: 2.69–16.99, p = 0.007) and systolic blood pressure (SBP) (Mean Difference: 13.09, 95% CI: 7.87–18.32, p < 0.00001) in IUGR offspring compared to controls. The increase in SBP was more pronounced in male offspring than in females.    Conclusion: Induced IUGR in rats leads to significantly elevated blood pressure, with a greater effect observed in males. Rat models provide valuable insights into the developmental origins of hypertension, though they may overestimate the effect and not fully replicate the human condition. The endothelin system and sex hormones are implicated in this sexually dimorphic response.
Idiopathic Pulmonary Arterial Hypertension Newly Diagnosed in Pregnancy with Anemia and Threatened Preterm Labor Harumsari, Stefani; Rahardjo, Bambang; Prasetyorini, Nugrahanti; Dwijayasa, Pande Made; Yogibuana, Valerinna; Rohman, Mohammad Saifur
Heart Science Journal Vol. 3 No. 4 (2022): Prevention, Screening dan Rehabilitation : The Back Bone of Quality Care Improv
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.04.7

Abstract

Background: Pulmonary hypertension (PH) is a rare cardiovascular disorder that leads to right heart failure (RHF). Although most PH occurs secondary to congenital heart disease (CHD), PH can occur primarily due to pulmonary arterial vasculature abnormalities, known as Idiopathic pulmonary arterial hypertension (IPAH). In addition, the physiologic changes during pregnancy can potentially lead to worsening PAH and confer a poor prognosis. Therefore, when the mother refuses termination, a multidisciplinary team should manage the pregnancy and delivery to improve maternal and fetal outcomes.Objectives: This case report aimed to describe the importance of early diagnosis and treatment in PAH.Case reports: We reported a case of a 24-year-old woman with idiopathic pulmonary arterial hypertension (IPAH) that was newly diagnosed at 25 weeks of pregnancy and previously misdiagnosed with patent ductus arteriosus (PDA). This pregnancy was complicated with anemia and threatened preterm labor. Sildenafil was used as a vasodilator to reduce the symptoms of PAH. Unfortunately, the pregnancy was terminated at 29 weeks because of PPROM after considering giving lung maturation and neuroprotectant to the fetus. The patient was discharged without complication, but the baby died after eight days of intensive care due to HMD II, which led to respiratory failure.Conclusion: PAH in pregnancy is a life-threatening condition if untreated. Continuous treatments can help control the symptoms and avoid further complications for both mother and baby.
Co-Authors Ade Setyagraha Bambang Rahardjo Dea Florensia Destikatari, Lovin Dewi, Ratih Frastika Dhelya Widasmara Harumsari, Stefani I Wayan Subage Insanitaqwa, Aleyda Zahratunany Kusnarman Keman Madeline J. Langgar Mohammad Saifur Rohman Noorhamdani AS Pande Made Dwijayasa Patridina, Geneung Puspita Handayani Putri, Valerinna Yogibuana Swastika Santosa Basuki Sukandar, Umar Gunarsa Tatit Nurseta Wibisono, Hermawan Wiyasa, I Wayan Arsana Yahya Irwanto Yogibuana, Valerinna