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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Urology Jurnal Kedokteran Hewan
Basuki B. Purnomo
Department of Urology, Faculty of Medicine/Brawijaya University, Saiful Anwar Hospital, Malang.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Urinary Kidney Injury Molecule-1 (KIM-1) in Early Diagnosis of Acute Kidney Injury in Pediatric Critically Ill Paramastuty, Irma Lestari; Soebandiyah, Krisni; Purnomo, Basuki B.
Journal of Tropical Life Science Vol 6, No 1 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.01.06

Abstract

Acute kidney injury (AKI) often associated with a high hospital morbi-mortality rate in the intensive care unit patients. Kidney injury molecule-1 (KIM-1), has many characteristics of ideal biomarker for kidney injury. The aim of this study was to compared the temporal pattern of elevation urinary KIM-1 level following critically ill children with SCr as standart biomarker of AKI. Prospective analytic observational study was conducted during October to March 2014 in the Saiful Anwar General Hospital and Physiology Laboratory Brawijaya University. There were 13 critically ill as subjects. SCr and KIM-1 levels from all subjects were measured three times ( at admission, after 1st and 6th hour). Subjects were devided into AKI - non-AKI groups by SCr level and survivor - non survivor group at the and of the observations. Results showed that there were significantly increased levels of KIM-1 in the AKI and non-AKI and survivor-non survivor group at time point. However, we found that delta KIM-1 at time point increased significant in non AKI group and survivor group. KIM-1 at admission can diagnosed AKI in critically ill children. We conclude that urinary KIM-1 is a sensitive non-invasive biomarker to diagnosed acute kidney injury in critically ill children. Increase level of KIM-1 by time shows protective and good outcome in critically ill children.
Co-Authors a, Aulanni'am A, Aulanniam Amiruddin Amiruddin Arman Sayuti Dwinna Aliza Erdiansyah Rahmi Irma Lestari Paramastuty, Irma Lestari Krisni Soebandiyah, Krisni Kurnia Penta Seputra M. Aris Widodo Muhamad Agus Wibowo Muhammad Aris Widodo Muhammad Hambal Mulyadi Adam, Mulyadi Muslim Akmal Paksi Satyagraha Sutiman B. Sumitro Syafruddin s T. Armansyah Taufiq Nur Budaya Tongku Nizwan Siregar