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All Journal Sasambo Journal of Pharmacy Journal of Health Sciences and Medical Development Pharmacology And Pharmacy Scientific Journals (PAPS Journals) Nusantara Scientific Medical Research Journal Jurnal Kemitraan Responsif untuk Aksi Inovatif dan Pengabdian Masyarakat CERATA Journal of Pharmaceutical Science and Herbal Technology Jurnal Medika: Medika
Sriyanty Sadsyam
Universitas Megarezky
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Correlation of low body mass index and albumin level with the presence of liver dysfunction in newly diagnosed tuberculosis patients Sriyanty Sadsyam; Yulia Yusrini Djabir; Arif Santoso
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.49 KB) | DOI: 10.29303/sjp.v2i2.105

Abstract

Tuberculosis (TB) patients often experience reduced appetite or nutritional malabsorption leading to malnutrition, which manifests in excessive loss of muscle mass and low body mass index (BMI). Patients with protein malnutrition is associated with increased risk of drug-induced liver injury and may require a close monitoring during the course of antituberculosis (AT) treatment. The purpose of this study was to determine the correlation of low body mass index and albumin level with liver dysfunction in patients newly diagnosed with TB prior to receiving AT drugs. This study is a nonexperimental observational study with consecutive sampling technique by following a descriptive analytic design (cohort study). The subjects were patients in the National Lung Health Center Makassar who are newly diagnosed with TB and have not received any AT drug. The BMI data and blood samples were collected and analyzed to obtain Alanine aminotransferase (ALT), Aspartat aminotransferase (AST), and Albumin levels. It was found that out of 22 total patients, 3 (14%) of the TB patients experienced liver dysfunction characterized by high level of ALT and AST levels. Both patients had normal levels of albumin despite one of them had a low BMI. The statistical showed no correlation between the low BMI or albumin level with the presence of liver dysfunction. It is concluded that the presence of liver dysfunction is not correlated with low BMI or albumin level in newly diagnosed TB patients, and hence, are not considered as independent risk factors of liver dysfunction in this population.
Development and Physical Stability Test of Salak Fruit Peel Extract Mouthwash as a Plaque Preventative Nasrawati Basir; Nurfiddin Farid; Sriyanty Sadsyam; Andi Ulfiana Utari; Andi Bibit Utari Rahayu
Journal of Health Sciences and Medical Development Vol. 2 No. 02 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i02.262

Abstract

The study aims to investigate the formulation and physical stability of salak peel extract mouthwash as a plaque preventer. Salak is a plant from Indonesia with medicinal properties, and its peel is a waste product that contains nutritional values such as protein, carbohydrates, water and low fat. The method used in this study is an experimental laboratory method. The salak peel was extracted through maceration of 96% ethanol and formulated into mouthwash with different concentrations of 5%, 10%, and 15%. The stability of the formulation was tested through organoleptic, pH, specific density, viscosity and clarity tests. The results showed no difference before and after the cycling test in organoleptic, pH, specific density, viscosity, and clarity tests, indicating the physical stability of the formulation.
Antioxidant Evaluation of Facial Toner Formulations Containing Ethyl Acetate Fraction from Garcinia Mangostana L. Fruit using ABTS 2,2'-Azinobis 3-ethyl benzothiazoline 6-sulphonic Acid Method Sriyanty Sadsyam; Nielma Auliah; Wa Ode Wisna Anto Uko; Nasrawati Basir; Andi Ulfiana Utari
Journal of Health Sciences and Medical Development Vol. 2 No. 02 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i02.266

Abstract

The mangosteen fruit is rich in polyphenols, particularly xanthones, which have potent antioxidant effects. Given the various effects of facial toners and the growing demand for natural skincare products, mangosteen rind may serve as an alternative ingredient in facial toner formulations. This laboratory experimental study aimed to assess the antioxidant activity of facial toner preparations containing the ethyl acetate fraction of mangosteen rind (Garcinia mangostana L.) using the ABTS method at different concentrations (0.2%, 0.4%, and 0.6%). Four facial toner formulas were formulated, with Formula 1 being the control formula without any active substance and Formulas 2-4 containing the ethyl acetate fraction of mangosteen rind at different concentrations. The prepared formulas underwent physical and chemical stability tests, including organoleptic, homogeneity, pH, viscosity, and humidity tests, before and after six cycles of cycling. The antioxidant activity of the formulas was also evaluated using the ABTS method. The results showed no significant difference (p>0.05) in the organoleptic, viscosity, pH, and humidity tests before and after cycling. Formula 3 showed significant (p<0.05) antioxidant activity compared to the other formulas. Therefore, it can be concluded that the ethyl acetate fraction of mangosteen rind (Garcinia mangostana L.) can be formulated into a facial toner with potent antioxidant activity.
Antioxidant Effectiveness Test on The Formulation of Combination Facial Soap Ingredients of Ethanol Extract Lemon Peel Citrus limon and Forest Honey Apis dorsata Sriyanty Sadsyam; Nasrawati Basir; Arafah Nurfadillah; Nurhikmah Awaluddin; Selviana
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 2 No. 01 (2023): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (591.56 KB) | DOI: 10.58549/nsmrj.v2i01.69

Abstract

Citrus limon and Apis dorsata are claimed to have several active compounds namely: alkaloids, flavonoids, tannins and saponins. These compounds are known to have antioxidant activity in preventing skin damage due to free radicals and preventing premature aging. In this study, Citrus limon and Apis dorsata were formulated into facial soap ingredients. The purpose of this study was to find out whether the ethanol extract formulation in the lemon peel and the Apis dorsata forest honey has the effectiveness of antioxidants in preventing the free radicals. This research was an experimental study with physical and chemical evaluation of ingredients. The DPPH test was used to determine the antioxidant activity of the ingredients. This research used three types of formulation of Ethanol Ethanol Extract Formulation were lemon and honey forest, they were : FI (5%: 2%); FII (5%: 3%) and FIII (5%: 4%). The results of the DPPH test respectively were FI 6,16; FII 5,53 and FIII 4.39. The ingredients of Facial Soap Combination of Ethanol Extract Lemon Feel and Apis dorsata had the best antioxidant and antioxidant energy in Formula III with concentration of 5%: 4%
FORMULATION OF ANTI-ACNE MASK OF PAPAYA LEAF EXTRACT (Carica papaya L.) AND HONEY AGAINST Propionibacterium acn Wali, Putri; Asri SR, Muhammad; Sadsyam, Sriyanty
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Papaya leaves (Carica papaya L.) are ornamental plants that are very useful because they contain alkaloids, flavonoids, saponins, tannins and terpenoids. The alkaloids here have antibacterial properties. Honey is usually used as an antibacterial. Apart from being an antibacterial, honey is also an antioxidant because honey contains vitamin C. Acne (Acne vulgaris) is a skin disease caused by chronic inflammation with a complex pathogenesis, involving the sebaceous glands caused by the bacteria Propiobacerium acne. This research aims to determine whether the anti-acne mask formulation of papaya leaf extract and honey is physically and chemically stable and that the anti-acne mask formulation of papaya leaf extract and honey has anti-acne activity against Propionibacterium acne. This research is an experimental laboratory using the diffusion technique so that the well method is used to determine the diameter of the inhibition zone and for data analysis using the one-way ANOVA test. The results of research on the formulation of an anti-acne mask from papaya leaf extract and honey are physically and chemically stable. The anti-acne mask formulation of papaya leaf and honey extract has antibacterial activity against Propionibacterium acne with an inhibition zone of 17.2 mm (strong) in formulation 1, 19.6 mm (strong) in formulation 2, 19.8 (strong) in formulation 3 and 21.9 mm (very strong) on ​​the positive cotrol, namely benzolac (Benzolic peroxide).
Exploring the Potent Anti-Hyperglycemic Properties of Red Betel Leaf Ethanol Extract Fraction on Male Wistar Rats Upi, Andi Ulfiana Utari; Aliah, Ahmad Irsyad; Hasniah; Basir, Nasrawati; Sadsyam, Sriyanty
Journal of Health Sciences and Medical Development Vol. 2 No. 03 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i03.267

Abstract

Hyperglycemia is characterized by an increase in blood glucose levels exceeding 200 mg/dL, an initial symptom of diabetes mellitus. Hyperglycemia can be addressed through traditional treatment with Red Betel Leaf. Red betel leaf contains phytochemical compounds, including flavonoids. Flavonoid compounds in red betel leaves possess antioxidant properties. These antioxidants can scavenge hydroxyl radicals that damage the β cells of the pancreas, thereby maximizing insulin production. Empirically, the flavonoid content in red betel leaves has been shown to lower blood glucose levels and cure diabetes mellitus. An effectiveness test of the anti-hyperglycemic properties of the ethanol extract fraction of red betel leaf was conducted. This research aimed to determine the effectiveness of the ethanol extract fraction of red betel leaf on male white rats. The method employed in this study was laboratory experimentation. Fifteen rats were divided into five treatment groups: Group I, healthy control without treatment; Group II, negative control with Na.CMC administration; Group III, positive control with glibenclamide administration; Group IV, the polar group with polar extract suspension of red betel leaf administration; Group V, the nonpolar group with nonpolar extract suspension of red betel leaf administration. In conclusion, administering the polar fraction was more effective in reducing blood glucose levels than the nonpolar fraction.
POTENSI EKSTRAK ETANOL BUAH KELOR (Moringa oleifera L.) SEBAGAI BAHAN AKTIF SEDIAAN GEL TERHADAP PENYEMBUHAN LUKA DIABETES PADA TIKUS PUTIH JANTAN Sadsyam, Sriyanty; Awaluddin, Nurhikma; Suharniayanti, Suharniayanti
Pharmacology And Pharmacy Scientific Journals Vol. 4 No. 1: Juni, 2025, PAPS
Publisher : Unit Publikasi Ilmiah Perkumpulan Intelektual Madani Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51577/papsjournals.v4i1.692

Abstract

Ekstrak Buah Kelor (Moringa oleifera L.) memiliki senyawa alkaloid, flavonoid, tannin, fenol, yang dapat menyembuhkan luka diabetes pada tikus putih Jantan. Penelitian ini bertujuan untuk mengetahui bahwa ekstrak etanol buah kelor (Moringa oleifera L.) dapat dijadikan sediaan gel yang stabil secara fisika dan kimia dan untuk mengetahui pada konsentrasi efektif ektrak etanol buah kelor (Moringa oleifera L.) dapat menyembuhkan luka diabetes pada tikus putih Jantan. Metode penelitian ini dilakukan secara eksperimental laboratorium. Ekstrak buah kelor dimaserasi dengan pelarut etanol 96%, lalu hasil diekstraksi diambil 5%,10% dan 15% untuk dibuat menjadi sediaan gel penyembuh luka diabetes dengan variasi konsentrasi F1 (5%), F2 (10%), dan F3 (15%). Selanjutnya dilakukan pengujian pada luka diabetes pada tikus putih jantan. Hasil formulasi sediaan gel ekstrak buah kelor (Moringa oleifera L.) menunjukkan stabil pada pengujian organoleptik, homogenitas, pH, viskositas, daya lekat dan daya sebar. Hasil uji terhadap luka diabetes menunjukkan bahwa F1 memiliki persentase penurunan diameter luka 100% pada hari ke-19, sedangkan untuk F2 dan F3 memiliki persentase penurunan diameter luka 100% pada hari ke-18 dan hari ke-17. Hasil analisis statistik One Way ANOVA, menunjukkan perbedaan yang signifikan (p<0,05) persentase penurunan diameter luka diabetes pada tikus putih jantan dan konsentrasi efektif F3 (15%). Moringa fruit extract (Moringa oleifera L.) has alkaloid, flavonoid, tannin, and phenol compounds that can heal diabetic wounds in male white rats. This study aims to determine that moringa fruit ethanol extract (Moringa oleifera L.) can be used as a physically and chemically stable gel preparation and to determine the concentration of moringa fruit ethanol extract (Moringa oleifera L.) that is effective in healing diabetic wounds in male white rats. This research method was conducted experimentally in the laboratory. Moringa fruit extract was macerated using 96% ethanol solvent, then the extraction results were taken 5%, 10%, 15% to be used as a gel preparation as a diabetic wound healing gel with variations in concentration, namely F1 (5%). F2 (10%), and F3 (15%). Furthermore, testing was carried out on diabetic wounds in male white rats. The results of the formulation of moringa fruit extract gel preparation (Moringa oleifera L.) showed stable in organoleptical testing, homogeneity, pH, viscosity, adhesion and spreadability. The test results on diabetic wounds showed that F1 had a percentage decrease in wound diameter of 100% on day 19, while for F2 and F3 had a percentage decrease in wound diameter of 100% on day 18 and day 17. The results of One Way ANOVA statistical analysis, showed a significant difference (p<0.05) in the percentage of diabetic wound diameter reduction in male white rats and the effective concentration of F3 (15%).
Peran Apoteker Dalam Edukasi Obat Untuk Lansia di Desa Belabori Kab. Gowa Awaluddin, Nurhikma; Basir, Nasrawati; Sadsyam, Sriyanty; Awaluddin, Akbar
Jurnal Medika: Medika Vol. 4 No. 3 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/c3qm7k08

Abstract

Di Indonesia, populasi usia lanjut terus meningkat seiring dengan tingginya angka harapan hidup. Menurut Badan Pusat Statistik, jumlah penduduk lansia di Indonesia pada tahun 2024 diperkirakan mencapai lebih dari 26 juta orang. Lansia sering kali menghadapi berbagai tantangan kesehatan yang kompleks, termasuk penyakit kronis seperti diabetes, hipertensi, dan gangguan jantung. Selain itu, mereka juga cenderung menggunakan beberapa jenis obat secara bersamaan, yang dikenal sebagai polifarmasi. Polifarmasi dapat meningkatkan risiko terjadinya efek samping, interaksi antar obat, serta kesalahan penggunaan obat, yang semuanya dapat berdampak negatif pada kesehatan lansia. Dalam konteks ini, peran apoteker menjadi sangat vital. Apoteker memiliki pengetahuan mendalam tentang farmakologi, termasuk mekanisme kerja obat, interaksi obat, dan efek samping yang mungkin terjadi. Dengan pengetahuan ini, apoteker dapat memberikan edukasi yang tepat kepada lansia mengenai cara penggunaan obat yang aman dan efektif. Edukasi ini meliputi informasi mengenai dosis yang benar, waktu yang tepat untuk mengonsumsi obat, serta tanda-tanda efek samping yang perlu diwaspadai. Selain itu, apoteker juga dapat membantu lansia dalam memahami pentingnya mematuhi regimen pengobatan yang telah ditentukan oleh dokter, sehingga dapat mencegah komplikasi yang lebih serius. Pemeriksaan kesehatan secara berkala juga merupakan aspek penting dalam pengelolaan kesehatan lansia. Melalui pemeriksaan rutin, masalah kesehatan dapat terdeteksi lebih awal, sehingga penanganan yang tepat dapat dilakukan. Apoteker dapat berkontribusi dalam hal ini dengan mengedukasi masyarakat tentang pentingnya pemeriksaan kesehatan dan bagaimana cara mengakses layanan kesehatan yang ada. Dengan memberikan informasi yang akurat dan mudah dipahami, apoteker dapat memberdayakan lansia untuk mengambil keputusan yang lebih baik terkait kesehatan mereka.
The Antibacterial Activity Test of Methanol and N-Hexane Fractions of Yellow Pumpkin Fruit Extract (Cucurbita moschata Duch) Against Escherichia coli and Staphylococcus aureus Suleman, Abdul Wahid; Saparuddin Latu; Sriyanty Sadsyam; Safaruddin; Pradila
CERATA Jurnal Ilmu Farmasi Vol 16 No 1 (2025): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v16i1.1370

Abstract

Infectious diseases are still a major health problem in several countries, especially in developing countries. The medication used to treat bacterial infections is obtained by utilizing herbal plants obtained from natural ingredients. Pumpkin fruit extract (Cucurbita moschata) contains flavonoids. tannins, saponins, and alkaloids Pumpkin fruit is effective as an antidiabetic, an antihypertensive, an antitumor, an antibacterial, and an antioxidant. This study aims to determine the antibacterial activity of the methanol and n-hexane fractions of yellow pumpkin (Cucurbita moschata) fruit extract and at what concentration the methanol and n-hexane fractions of yellow pumpkin (Cucurbita moschata) fruit extract can have antibacterial activity against Escherichia coli and Staphylococcus aureus. This research uses laboratory-experimental research methods. Antibacterial testing in this research involved sterilization, making test solutions, and testing. The results of the antibacterial test on the inhibition zone of the methanol fraction of pumpkin fruit against Escherichia coli and Staphylococcus aureus bacteria at concentrations of 20%, 30%, and 40% were in the strong category, while the n-hexane fraction had an inhibition zone in the weak category for Escherichia coli and Staphylococcus aureus bacteria. Conclusion: The methanol and n-hexane fractions have antibacterial activity against Escherichia coli and Staphylococcus aureus, and the concentrations with antibacterial activity are 20%, 30%, and 40%.
Penguatan Literasi Sains Anak Usia Dini Melalui Peran Guru Model dalam Parent Teaching Day di TKIT Al Fityan Muis, Abdul; Suwardi, Wisda Zulaeha; Sadsyam, Sriyanty; Sari, Dewi Puspita; Ristiana, Evi
Jurnal Kemitraan Responsif untuk Aksi Inovatif dan Pengabdian Masyarakat Volume 3 Issue No. 1: July 2025
Publisher : Lontara Digitech Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61220/

Abstract

Literasi sains pada anak usia dini merupakan fondasi penting bagi kemampuan anak dalam memahami fenomena sederhana di lingkungan sekitar. Namun, hasil observasi awal di TKIT Al-Fityan menunjukkan bahwa sebagian anak masih mengalami kesulitan dalam membedakan habitat hewan, terutama ketika harus mengidentifikasi apakah hewan termasuk kelompok darat, air, atau udara. Kondisi tersebut menunjukkan perlunya strategi pembelajaran yang lebih konkret dan menarik. Kegiatan pengabdian masyarakat ini bertujuan untuk memperkuat literasi sains anak usia dini melalui penerapan Parent Teaching Day dengan melibatkan orang tua sebagai guru model. Metode pelaksanaan dilakukan dalam tiga tahapan, yaitu persiapan, pelaksanaan, dan evaluasi. Kegiatan berlangsung selama satu hari dengan melibatkan 30 santri kelas B9 Ummu Salamah. Media pembelajaran yang digunakan meliputi video habitat, flashcard hewan, serta lembar klasifikasi. Evaluasi dilakukan melalui observasi perilaku belajar, penilaian aktivitas klasifikasi, serta perbandingan pemahaman sebelum dan sesudah kegiatan. Hasil pelaksanaan menunjukkan adanya peningkatan signifikan pada kemampuan anak dalam mengenali habitat hewan. Anak mampu menyebutkan tiga jenis habitat (darat, air, udara) dengan ketepatan 85%, mengelompokkan hewan sesuai habitat dengan ketepatan 80%, serta menjawab pertanyaan terkait habitat dengan ketepatan 90%. Respons anak selama kegiatan juga menunjukkan antusiasme tinggi karena pembelajaran dikemas secara interaktif dan menggunakan media konkret. Kesimpulan kegiatan Parent Teaching Day efektif dalam meningkatkan literasi sains anak usia dini. Keterlibatan orang tua sebagai guru model serta penggunaan media visual memberikan pengalaman belajar bermakna dan membantu anak memahami konsep habitat hewan secara lebih mudah dan menyenangkan. Kegiatan ini direkomendasikan untuk dilaksanakan secara berkelanjutan dengan pengembangan tema sains lainnya.
Co-Authors Abdul Muis Abdul Wahid Suleman Aliah, Ahmad Irsyad Andi Bibit Utari Rahayu Andi Ulfiana Utari Andi Ulfiana Utari Arafah Nurfadillah Arif Santoso Asri SR, Muhammad Awaluddin, Akbar Dewi Puspita Sari Farid, Nurfiddin Nasrawati Basir Nielma Auliah Nurhikma Awaluddin Pradila Ristiana, Evi RR. Ella Evrita Hestiandari Safaruddin Saparuddin Latu Selviana Suharniayanti, Suharniayanti Wa Ode Wisna Anto Uko Wali, Putri Wisda Zulaeha Suwardi Yulia Yusrini Djabir